Chii chinonzi Saquinavir: Zvazvinoshandiswa, Dosage, Side Effects uye Zvimwe

Saquinavir mushonga unopiwa nachiremba unoshandiswa kurapa hutachiona hweHIV muvanhu vakuru nevana. Iwo wekirasi yemishonga inonzi protease inhibitors, iyo inoshanda nekudzivisa enzyme iyo HIV inoda kuti iwedzere uye kupararira mumuviri wako.

Mushonga uyu wave uchibatsira vanhu vane HIV kurarama hupenyu hune hutano kwemakore anopfuura makumi maviri. Kana ichishandiswa sechikamu chekurapa pamwe chete nemimwe mishonga yeHIV, saquinavir inogona kuderedza zvakanyanya huwandu hwehutachiona muropa rako uye kubatsira kusimbisa immune system yako.

Chii chinonzi Saquinavir?

Saquinavir mushonga weantiviral wakagadzirirwa kurwisa hutachiona hweHIV. Yakanga iri imwe yeiyo yekutanga protease inhibitors yakabvumidzwa kurapwa kweHIV uye inoramba iri sarudzo yakakosha mukutarisirwa kweHIV nhasi.

Mishonga inoshanda nekunangana neprotein chaiyo iyo HIV inoshandisa kugadzira makopi matsva ayo. Nekudzivisa protein iyi, saquinavir inobatsira kuderedza kugona kwehutachiona kuzvibereka uye kukuvadza immune system yako. Funga nezvazvo sekumisa maitiro ekuwanda kwehutachiona.

Saquinavir inogara ichishandiswa pamwe chete nemimwe mishonga yeHIV, kwete yega. Iyi nzira, inonzi combination antiretroviral therapy kana CART, ndiyo nzira yakajairika yekurapa HIV nekuti inorwisa hutachiona kubva kumakona akawanda.

Chii chinonzi Saquinavir chinoshandiswa?

Saquinavir inopiwa kurapa hutachiona hweHIV-1 muvanhu vakuru nevana vanorema angangoita makirogiramu makumi maviri nemashanu. Icho chikamu chechirongwa chekurapa chakazara chinovavarira kudzora hutachiona uye kuchidzivirira kubva pakuenderera mberi kuAIDS.

Chiremba wako angakurudzira saquinavir kana uri kutanga kurapwa kweHIV kekutanga kana kana uchida kuchinja kubva kune imwe mishonga nekuda kwezvimwe zvinokonzeresa kana kuramba. Chinangwa ndechekucheka viral load yako kusvika isinganzwisisike, zvinoreva kuti hutachiona huchiripo asi pamatanho akaderera zvekuti bvunzo dzakajairika hadzigone kuipima.

Kana huwandu hwehutachiona hwako husingaonekwe, unogona kurarama hupenyu hwakajairika uye hauzopfuudziri HIV kuvabati vepabonde. Pfungwa iyi, inozivikanwa se "isingaonekwe yakaenzana nekusapfuudzwa" kana kuti U=U, yakashandura mafungiro edu ekurapa nekudzivirira HIV.

Saquinavir Inoshanda Sei?

Saquinavir inoshanda nekudzivisa HIV protease, enzyme inoshanda semagetsi emamorekuru mukugadzirwa kwehutachiona. Pasina enzyme iyi, HIV haigoni kuunganidza zvakanaka zvikamu zvitsva zvehutachiona, izvo zvinononotsa zvakanyanya hutachiona.

Kana HIV ikapinda mumasero ako, inotora michina yako yemasero kuti igadzire makopi ayo. Munguva iyi, hutachiona hunogadzira cheni refu dzemapuroteni anoda kuchekwa kuita zvidimbu zvidiki, zvinoshanda. HIV protease inoita basa iri rekucheka, asi saquinavir inopinda uye inodzivirira enzyme kuti isashande zvakanaka.

Nekuda kweizvi, hutachiona hunogadzira zvikamu zvakakanganisika zvisingagoni kupinda mumasero matsva. Izvi zvinopa immune system yako mukana wekupora uye kurwisa hutachiona. Saquinavir inotorwa semushonga weHIV une simba zvine mwero unoshanda zvakanyanya kana ukabatana nemimwe mishonga inorwisa antiretroviral.

Ndinofanira Kutora Sei Saquinavir?

Tora saquinavir sezvinorayirwa nachiremba wako, kazhinji kaviri pazuva nezvokudya. Mushonga unoshanda zvakanyanya kana paine chikafu mudumbu rako, sezvo izvi zvinobatsira muviri wako kutora mushonga zvakanyanya.

Unofanira kutora saquinavir mukati memaawa maviri mushure mekudya chikafu chakazara, kwete kungodya zvishoma. Chikafu chinobatsira kuwedzera huwandu hwemushonga hunopinda muropa rako. Kana ukatora mudumbu risina chinhu, muviri wako haugone kutora mushonga wakakwana kurwisa HIV zvinobudirira.

Nguva dzose tora saquinavir ne ritonavir, mumwe mushonga weHIV unobatsira kusimudzira kushanda kwe saquinavir. Musanganiswa uyu, unowanzozivikanwa se "saquinavir/ritonavir," unoona kuti saquinavir inogara muhurongwa hwako kwenguva refu uye inoshanda zvakanyanya kurwisa hutachiona.

Edza mishonga yako panguva imwe chete zuva rega rega kuti uchengetedze huwandu hwakagadzikana hwemushonga muropa rako. Kugadza zviyeuchidzo zvefoni kana kushandisa chirongwa chemishonga kunogona kukubatsira kuti urambe uri munzira nechirongwa chako chemishonga.

Ndingatora Saquinavir Kwenguva Yakareba Sei?

Uchada kutora saquinavir kwehupenyu hwako semumwe wekurapa kwako HIV. Kurapa HIV ibasa renguva refu nekuti hutachiona hunoramba huripo mumuviri wako kunyangwe huchidzivirirwa kusvika pamatanho asinganzwisisike.

Kumisa saquinavir kana chero mushonga weHIV kunobvumira hutachiona kuti huwedzere zvakare, zvichikonzera kuramba kwemishonga uye kufambira mberi kwechirwere. Kunyangwe iwe uchinzwa uine hutano hwakakwana, zvakakosha kuti uenderere mberi nekutora mushonga wako sezvakanyorwa.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa kweropa nguva dzose kunoyera huwandu hwehutachiona hwako uye CD4 cell count. Iyi bvunzo inobatsira kuona kuti mushonga uri kushanda sei uye kana kuchinjwa kupi nekupi kuchirongwa chako chekurapa kuchidikanwa.

Vamwe vanhu vanogona kuda kuchinja kune mimwe mishonga yeHIV nekufamba kwenguva nekuda kwemigumisiro, kusangana kwemishonga, kana kuramba. Zvisinei, chinangwa chinogara chiri chekuchengetedza kurapwa kunoenderera mberi nemishonga inoshanda inochengetedza hutachiona hwakadzvanyirirwa.

Ndezvipi Zvipingamupinyi zveSaquinavir?

Semishonga yese, saquinavir inogona kukonzera migumisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Mazhinji emigumisiro inogoneka uye inowanzoita nani sezvo muviri wako uchigadzirisa kumishonga mumavhiki mashoma ekutanga ekurapa.

Heano migumisiro yakajairika yaungasangana nayo paunenge uchitora saquinavir:

• Kusvotwa uye dumbu rinogumbuka
• Dhayareya kana zvigaro zvakasununguka
• Kutemwa nemusoro
• Kuneta kana kunzwa kuneta
• Kuchinja mukuravira
• Mild skin rash

Zviratidzo izvi zvinowanzoita zvinyoro uye zvinowanzoita nani nekufamba kwenguva. Kutora saquinavir nechikafu kunogona kubatsira kuderedza migumisiro ine chekuita nedumbu.

Vamwe vanhu vanogona kusangana nemigumisiro yakakomba asi isingawanzoitiki inoda kutariswa kwechiremba:

• Maitiro akakomba ekuita allergic ane rash, kuzvimba, kana kuoma kufema
• Matambudziko echiropa, kusanganisira hepatitis
• Kuchinja mumoyo rhythm
• Manyoka akakomba asingavandudzi
• Kubuda ropa kusingaite kana kupwanya
• Kurwadziwa mudumbu kunoramba kuripo

Bata chiremba wako nekukurumidza kana ukaona chero migumisiro yakakomba iyi. Vanogona kubatsira kuona kana zviratidzo zvine chekuita nemishonga uye kugadzirisa kurapwa kwako kana zvichidikanwa.

Kushandiswa kwenguva refu kwe saquinavir kunogona zvakare kutungamira kune mamwe shanduko dzemetabolic, kusanganisira shanduko mumazinga echolesterol, shuga yeropa, uye kuparadzirwa kwemafuta emuviri. Kuongorora nguva dzose kunobatsira kubata nekugadzirisa shanduko idzi pakutanga.

Ndiani Asingafaniri Kutora Saquinavir?

Saquinavir haina kukodzera munhu wese, uye mamwe mamiriro ezvinhu kana mishonga inogona kukuitira kuti usashandise. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wanyora mushonga uyu.

Haufaniri kutora saquinavir kana uine allergic kumushonga kana chero zvinhu zvawo. Zviratidzo zvekuita allergic zvinosanganisira rash, kukwenya, kuzvimba, dzungu rakanyanya, kana kuoma kufema.

Vanhu vane mamwe mamiriro emoyo vanofanira kushandisa saquinavir nekuchenjerera zvakanyanya kana kuizvidza zvachose. Mushonga unogona kukanganisa chiitiko chemagetsi emoyo wako, zvichikonzera matambudziko ane njodzi erhythm muvanhu vanotambura.

Heano mamiriro chaiwo apo saquinavir inogona kusakurudzirwa:

• Chirwere chechiropa chakakomba kana kutadza kwechiropa
• Mamwe matambudziko emoyo rhythm
• Kutora mishonga chaiyo inopindirana nesaquinavir nenzira ine njodzi
• Chirwere cheitsvo chakakomba
• Nhoroondo yeQT interval yakareba paECG

Kana wakazvitakura kana kuronga kuzvitakura, kurukurai njodzi nemabhenefiti nachiremba wenyu. Kunyange zvazvo kurapa HIV panguva yekuzvitakura kuchikosha, chiremba wenyu anogona kusarudza mamwe mishonga yeHIV ine ruzivo rwakawanda rwekuchengeteka panguva yekuzvitakura.

Nguva dzose udzai chiremba wenyu nezve mishonga yose, zvinowedzera, uye zvigadzirwa zvemiti yamuri kutora, sezvo saquinavir inogona kushamwaridzana nemamwe madhiragi mazhinji.

Mazita eSaquinavir Brand

Saquinavir inowanikwa pasi pezita rekuti Invirase. Iyi ndiyo fomu yakanyanya kunyorerwa ye saquinavir uye inouya muchimiro chemakapsule ekushandiswa nemuromo.

Pakutanga paive neimwe fomu inonzi Fortovase, asi vhezheni iyi haichawanikwi. Invirase ndiyo ikozvino fomu yakajairika inoshandiswa mumaitiro ekurapa HIV.

Mavhezheni e generic e saquinavir anogonawo kuwanikwa, zvichienderana nenzvimbo yenyu uye inishuwarenzi. Muzvinemishonga wenyu anogona kukubatsira kunzwisisa kuti ndeipi vhezheni yamuri kugamuchira uye kuona kuti muri kutora fomu chaiyo.

Saquinavir Alternatives

Mamwe mishonga yeHIV anogona kushanda semamwe maitiro e saquinavir, zvichienderana nezvido zvenyu zvakakosha uye mamiriro ezvinhu ekurapa. Kurapa kwemazuva ano kweHIV kunopa sarudzo dzakawanda dzinobudirira dzinogona kuve dziri nyore kana dzichishivirirwa zviri nani.

Mamwe ma protease inhibitors anoshanda zvakafanana ne saquinavir anosanganisira darunavir, atazanavir, uye lopinavir. Aya mishonga anovharisa enzyme imwechete yeHIV asi anogona kuve nemaprofayiri akasiyana emigumisiro kana zvirongwa zvekushandisa.

Chiremba wenyu anogonawo kufunga nezve mishonga kubva kumakirasi akasiyana emishonga, senge integrase inhibitors senge dolutegravir kana raltegravir, kana non-nucleoside reverse transcriptase inhibitors senge efavirenz kana rilpivirine.

Mishonga mitsva yeHIV yakawanda inowanikwa mumaitiro emapiritsi rimwe chete anosanganisa madhiragi akawanda mupiritsi rimwe rinotorwa kamwe pazuva. Izvi zvingasarudzwa zvinogona kuve nyore kupfuura kutora mapiritsi akawanda kaviri pazuva, izvo zvinogona kuvandudza kutevedzera kurapwa.

Ko Saquinavir Zviri Nani Kudarika Mamwe Mishonga yeHIV?

Saquinavir yaive yekutanga payakabvumidzwa, asi mishonga mitsva yeHIV inowanzo paunza zvakanakira maererano nekureruka, mhedzisiro, uye kusangana kwemishonga. Mishonga yeHIV yakanakisa inoenderana nemamiriro ako, nhoroondo yako yekurapa, uye zvaunofarira.

Kana ichienzaniswa ne protease inhibitors itsva senge darunavir, saquinavir inoda kuiswa kakawanda uye ine mukana wakawanda wekusangana kwemishonga. Zvisinei, inoramba iri sarudzo inoshanda kune vanhu vasingakwanise kutora mamwe mishonga nekuda kwekudzivirira kana allergies.

Mitemo yemazuva ano yekurapa HIV inowanzo kuraira mishonga mitsva sesarudzo dzekutanga nekuti dzinowanzo shivirirwa uye dziri nyore. Zvisinei, saquinavir ichine nzvimbo mukutarisirwa kweHIV, kunyanya kune vanhu vane ruzivo rwakawanda rwekurapa kana kuramba kwemishonga.

Chiremba wako achafunga nezvezvinhu zvakaita semaitiro ako ekuramba hutachiona, mamwe mishonga yaunotora, mhedzisiro inogona kuitika, uye mararamiro ako paunenge uchisarudza iyo yakanakisa HIV regimen kwauri.

Mibvunzo Inowanzo Bvunzwa Nezve Saquinavir

Ko Saquinavir Yakachengeteka Kune Vanhu vane Chirwere chechiropa?

Saquinavir inoda kunyatso tariswa kune vanhu vane chirwere chechiropa, sezvo mushonga uyu uchigadziriswa nechiropa uye unogona kuwedzera matambudziko echiropa. Chiremba wako achada kuongorora kuoma kwechiropa chako asati akurudzira saquinavir.

Kana uine chirwere chechiropa chinyoro, chiremba wako anogona kuramba achikurudzira saquinavir asi achatarisa basa rechiropa chako zvakanyanya kuburikidza nekuongororwa kweropa nguva dzose. Vanhu vane chirwere chechiropa chakakomba kana kutadza kwechiropa vanowanzo kutadza kutora saquinavir zvakachengeteka.

Gara uchizivisa chiremba wako nezve nhoroondo yehepatitis, chirwere chechiropa, kana kushandiswa kwakanyanya kwedoro. Vanogona kuda kugadzirisa muyero wako kana kusarudza imwe mishonga yeHIV yakachengeteka kune chiropa chako.

Ndoita Sei Kana Ndikatora Saquinavir Yakawanda Netsaona?

Kana ukatora saquinavir yakawanda kupfuura yakanyorerwa netsaona, fonera chiremba wako kana nzvimbo yekubatsira kana muchetura nekukasira. Kutora saquinavir yakawanda kunogona kuwedzera njodzi yako yezvinetso zvakakomba, kunyanya matambudziko emoyo.

Usaedze kutsiva overdose nekusvetuka mushonga wako unotevera. Pane kudaro, dzokera kune yako yakajairika dosing schedule sezvakarairwa nachiremba wako. Vanogona kuda kukutarisa zvakanyanya kana kuita mamwe maedzo kuti uve nechokwadi chekuti wakachengeteka.

Chengeta saquinavir mumudziyo wayo wekutanga uye uichengete zvakachengeteka kure nevana nemhuka. Kushandisa chirongwa chemishonga kunogona kubatsira kudzivirira overdoses netsaona nekuita kuti zvive pachena kana iwe watotora yako zuva nezuva.

Ndoita Sei Kana Ndikakanganwa Dose yeSaquinavir?

Kana ukakanganwa dose ye saquinavir, itore paunorangarira, chero zvakadaro mukati me6 maawa eiyo yako yakarongwa dose nguva. Kana maawa anopfuura 6 apfuura, svetuka dose yakakanganwa uye tora yako inotevera yakarongwa dose panguva yakajairika.

Usambofa wakatora dose kaviri kuti utsigire imwe yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinetso. Kukanganwa doses dzimwe nguva hakuzokukuvadzi nekukasira, asi edza kutora mushonga wako nguva dzose sezvinobvira kuti uchengetedze kubviswa kweHIV kunobudirira.

Kana iwe uchikanganwa doses kazhinji, taura nachiremba wako nezve nzira dzekuvandudza kutevedzera. Vanogona kukurudzira kushandisa maapplication efoni, zvirongwa zvemapiritsi, kana kunyange kuchinja kune imwe HIV regimen iri nyore kurangarira.

Ndingamira Rini Kutora Saquinavir?

Haufanire kumbomira kutora saquinavir usati wambotaura nachiremba wako. Kurapa HIV ndekwehupenyu hwese, uye kumisa mishonga kunogona kutungamira mukudzoka kwehutachiona, kuramba kwemishonga, uye kufambira mberi kwechirwere.

Chiremba wako angakurudzira kuchinja kubva ku saquinavir kuenda kune rimwe mushonga weHIV kana ukaona matambudziko asingashiviriki, kusangana kwemishonga, kana kana dzimwe nzira itsva, dziri nyore dzikawanikwa. Zvisinei, unozofanira kuchinjira zvakananga kumushonga mutsva pasina mukana mukurapa.

Kunyange kana huwandu hwehutachiona hwako hukava husingaonekwe uye hukaramba hwakadaro kwemakore, unozofanira kuramba uchitora mishonga yeHIV. Hutachiona hunoramba huripo mumuviri wako mumareservoirs ayo mishonga iripo ikozvino isingakwanisi kubvisa zvachose.

Ndingatora Saquinavir nemimwe mishonga here?

Saquinavir inogona kusangana nemimwe mishonga yakawanda, saka zvakakosha kuti uudze chiremba wako nezvezvose zvauri kutora, kusanganisira mishonga inopiwa nachiremba, mishonga isingapiwi nachiremba, uye zvinowedzerwa.

Dzimwe mishonga dzinogona kuwedzera mazinga e saquinavir muropa rako, zvichikonzera matambudziko ane njodzi. Vamwe vanogona kuderedza kushanda kwe saquinavir, vachibvumira HIV kuwanda. Chiremba wako angangoda kugadzirisa zviyero kana kusarudza dzimwe mishonga kudzivirira kusangana uku.

Mishonga yakajairika inosangana ne saquinavir inosanganisira mamwe maantibiotics, mishonga yekurwisa fungal, mishonga yemoyo, uye mamwe maantidepressants. Nguva dzose tarisa nachiremba wako kana wezve mishonga usati watanga chero mushonga mutsva uchitora saquinavir.