Chii chinonzi Selegiline: Zvinoshandiswa, Dosage, Side Effects uye Zvimwe

Selegiline mushonga unopiwa nachiremba unobatsira kudzora zviratidzo zvechirwere cheParkinson nekudzivirira dopamine muuropi hwako. Mushonga uyu unoshanda zvakasiyana nemamwe marapirwo eParkinson nekuti unovharira enzyme inoputsa dopamine, kemikari yeuropi yaunoda kuti uende zvakanaka uye kubatana.

Chiremba wako angakupa selegiline kana mushonga wako weParkinson uripo usingashande zvakanaka sezvawaigara uchiita. Inoonekwa semushonga unotsigira unogona kubatsira kuwedzera mabhenefiti emushonga wako mukuru, kukupa maawa akanaka mazhinji masikati.

Chii chinonzi Selegiline?

Selegiline ndeyeboka remishonga inonzi MAO-B inhibitors, zvinoreva kuti inovharira enzyme chaiyo muuropi hwako inonzi monoamine oxidase B. Iyi enzyme inowanzo putsa dopamine, asi kana uine chirwere cheParkinson, watove nedopamine shoma kupfuura yaunoda.

Funga nezve selegiline sechivharo chinodzivirira dopamine yako yasara. Nekuvharira enzyme inoparadza dopamine, yakawanda yemakemikari aya akakosha ehuropi anoramba aripo kuti abatsire kudzora kufamba kwako uye kuderedza tremors.

Mushonga uyu unouya mumahwendefa enguva dzose uye mahwendefa anonyungudika mumuromo anonyungudika parurimi rwako. Chiremba wako achasarudza fomu rakanakisa zvichienderana nezvido zvako zvakakosha uye kuti unokwanisa sei kumedza mapiritsi.

Chii chinonzi Selegiline chinoshandiswa?

Selegiline inonyanya kushandiswa kurapa chirwere cheParkinson, kunyanya kana zviratidzo zvako zvisingadzorwe zvizere nelevodopa uye carbidopa chete. Inobatsira kudzora zviratidzo zvemotokari zvakaita setremors, kuoma, uye kufamba zvishoma nezvishoma izvo zvinoita kuti mabasa ezuva nezuva ave nematambudziko.

Chiremba wako angawedzera selegiline kuronga kwako kurapwa paunotanga kusangana nenguva dzekuti “kupfeka”. Aya ndiwo nguva apo mushonga wako mukuru weParkinson unotanga kurasikirwa nemhedzisiro yawo usati watora mushonga wako unotevera, uchikusiya nezviratidzo zvakawedzerwa.

Dzimwe nguva vanachiremba vanonyora selegiline mumatanho ekutanga echirwere cheParkinson. Muzviitiko izvi, zvinogona kubatsira kunonotsa kufambira mberi kwezviratidzo uye kunonotsa kudiwa kwemishonga yakasimba selevodopa.

Mishonga iyi inogonawo kubatsira kuderedza shanduko muzviratidzo zvako zuva rese. Vanhu vazhinji vane chirwere cheParkinson vanoona zviratidzo zvavo zvichichinja zvakanyanya kubva paawa neawa, uye selegiline inogona kubatsira kupfavisa izvi zvakakwira nekudzika.

Selegiline Inoshanda Sei?

Selegiline inoshanda nekudzivisa MAO-B, enzyme inoputsa dopamine muuropi hwako. Paunenge uine chirwere cheParkinson, maseru ehuropi anogadzira dopamine zvishoma nezvishoma anofa, saka kuchengetedza dopamine yaunayo yakakosha pakugadzirisa zviratidzo.

Mishonga iyi inoonekwa seyepakati pesimba maererano nekurapa kweParkinson. Haina simba selevodopa, iyo inowanzonzi goridhe standard, asi yakatarwa zvakanyanya uye inogona kupa zororo rinoreva zviratidzo zvine mashoma mativi emhedzisiro.

Mhedzisiro yekudzivirira ye selegiline inogara kwemazuva akati wandei mushure mekuitora. Izvi zvinoreva kuti enzyme inoramba yakavharwa kunyangwe mushonga wabuda muropa rako, ichipa mhinduro dzinogara kwenguva refu kupfuura mamwe madhiragi eParkinson.

Kusiyana nemamwe mishonga yeParkinson inotsiva dopamine yakashaikwa, selegiline inobatsira kuchengetedza kugadzirwa kwako kwemuviri kwe dopamine. Iyi nzira inogona kuve yakapfava pane yako system uye inogona kukonzera mashoma matambudziko nekufamba kwenguva.

Ndinofanira Kutora Sei Selegiline?

Tora selegiline sezvinorayirwa nachiremba wako, kazhinji kamwe kana kaviri pazuva uine kana pasina chikafu. Iyo yakajairika yekutanga dose i5mg kaviri pazuva, inotorwa nekudya kwemangwanani uye kwemasikati kudzivirira matambudziko ekurara.

Kana iwe uchitora mahwendefa anonyungudika nemuromo, isa pa rurimi rwako uye uvatendere kuti vanyungudike zvachose. Usatsenga, kupwanya, kana kumedza mahwendefa aya ese, sezvo izvi zvinogona kukanganisa mashandiro emishonga.

Nguva inokosha nekuda kwe selegiline nekuti inogona kukanganisa hope kana ikatorwa kare zvikuru masikati. Tora mushonga wako wekupedzisira usati wasvika 2 PM kudzivirira kusavata kana kusagadzikana panguva yekurara.

Unogona kutora selegiline uine kana usina chikafu, asi kuitora nechikafu chidiki kunogona kubatsira kuderedza dumbu. Dzivisa kuitora nezvikafu zvikuru zvine chikafu chakawanda che tyramine-rich senge chizi yakakura, nyama yakaporeswa, kana zvigadzirwa zvakaviriswa.

Usamira kamwe kamwe kutora selegiline usina kutanga wataura nachiremba wako. Zviratidzo zvako zveParkinson zvinogona kuwedzera nekukurumidza kana ukamisa mushonga kamwe kamwe.

Ndingatora Selegiline Kwenguva Yakareba Sei?

Vanhu vazhinji vane chirwere cheParkinson vanotora selegiline kwemakore mazhinji sechikamu chechirongwa chavo chekurapa kwenguva refu. Mushonga unoshanda zvakanyanya kana ukatorwa nguva dzose, uchibatsira kuchengetedza mazinga e dopamine akagadzikana muuropi hwako.

Chiremba wako achatarisa nguva dzose kuti selegiline iri kushanda sei kwauri kuburikidza nekugadzwa kwekutevera. Vachaongorora kana zviratidzo zvako zvichidzorwa zvakanaka uye kana chero shanduko kuchirongwa chako chekurapa zvichidikanwa.

Vamwe vanhu vanogona kuda kutora selegiline kweupenyu hwavo hwese, kunyanya kana ichivandudza zvakanyanya hupenyu hwavo uye kudzora zviratidzo. Izvi zvakajairika zvachose uye zvinotarisirwa kune mamiriro ekusingaperi sechirwere cheParkinson.

Kureba kwekurapa kunoenderanawo nekuti mamiriro ako anofambira sei uye kana mamwe mishonga achidikanwa. Chiremba wako anogona kuwedzera mamwe marapirwo kana kugadzirisa muyero wako we selegiline sezvo zvaunoda zvichichinja nekufamba kwenguva.

Ndezvipi Zvakaipa ZveSelegiline?

Semishonga yese, selegiline inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Mhedzisiro yakajairika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Heano mhedzisiro yaungasangana nayo, kutanga neiyo yakajairika:

• Kusvotwa uye dumbu kurwadziwa
• Kutadza kufema kana kunzwa musoro uchirwadza
• Kutadza kurara kana kurota zvakajeka
• Muromo wakaoma
• Musoro
• Kuvhiringika kana kufungidzira
• Kuwedzera kufamba kusingadiwi

Izvi zvinowanzoitika zvinowanzoenda mukati memavhiki mashoma sezvo muviri wako uchijaira mushonga. Kana vakaenderera mberi kana kuva dambudziko, chiremba wako anogona kugadzirisa muyero wako kana nguva yekubatsira.

Zvimwe zvinokuvadza asi zvisingawanzoitiki zvinogona kusanganisira shanduko dzakanyanya dzemanzwiro, kurwadziwa muchipfuva, kana kuwedzera kamwe kamwe kweropa. Izvi zvinoda kutarisirwa kwekurapa nekukurumidza uye zvinowanzoitika kana iwe uchidya zvimwe zvekudya kana kutora mamwe mishonga inosangana ne selegiline.

Vamwe vanhu vanowana zvinonzi "cheese effect" kana vakadya huwandu hukuru hwezvokudya zvakapfuma tyramine vachitora selegiline. Izvi zvinogona kukonzera njodzi dzemuviri weropa, kunyangwe zvisingawanzoitiki pamadosi anowanzo shandiswa kuParkinson's disease.

Ndiani Asingafaniri Kutora Selegiline?

Vamwe vanhu vanofanira kudzivisa selegiline nekuti inogona kusangana nengozi nemamwe mishonga kana mamiriro ehutano. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa uye mishonga iripo usati wairaira.

Haufaniri kutora selegiline kana iwe uchishandisa mamwe antidepressants, kunyanya SSRIs, SNRIs, kana tricyclic antidepressants. Musanganiswa unogona kukonzera mamiriro akakomba anonzi serotonin syndrome, anogona kuva anotyisa upenyu.

Vanhu vanotora opioid pain medications senge meperidine, tramadol, kana methadone vanofanirawo kudzivisa selegiline. Aya masanganiswa anogona kukonzera zviitiko zvakakomba zvinosanganisira fivha yakanyanya, kuoma kwemhasuru, uye shanduko dzinotyisa muropa.

Kana uine chirwere chakakomba chechiropa, chiremba wako anogona kusarudza mumwe mushonga nekuti selegiline inogadziriswa nechiropa. Saizvozvowo, vanhu vane chirwere chakakomba cheitsvo vanogona kuda kugadzirisa muyero kana mamwe marapirwo.

Nguva dzose udza chiremba wako nezve mishonga yose yaunotora, kusanganisira mishonga inotengwa pasina chiremba, zvinowedzera, uye mishonga yemakwenzi. Kunyange zvigadzirwa zvinoita sezvisina njodzi zvakaita seSt. John's wort zvinogona kushamwaridzana nengozi ne selegiline.

Mazita eBrand eSelegiline

Selegiline inowanikwa pasi pemazita akati wandei ebrand, Eldepryl ndiyo inonyanya kuzivikanwa. Iri ndiro zita rekutanga rebrand reiyo yakajairika piritsi fomu ye selegiline iyo vanachiremba vanga vachiraira kwemakumi emakore.

Zelapar ndiro rimwe zita rebrand, kunyanya remapiritsi anonyungudika mumuromo anonyungudika parurimi rwako. Mapiritsi aya anowanzoita nyore kune vanhu vane dambudziko rekumedza mapiritsi nekuda kwechirwere cheParkinson.

Mhando dzese dze selegiline dzinowanikwa zvakanyanya uye dzinobata zvakanyanya semhando dzemazita ebrand. Murapi wako wemishonga anogona kukuudza kuti ndeipi vhezheni yaunogamuchira uye kupindura chero mibvunzo nezve misiyano pakati pemhando.

Chinhu chinoshanda ndicho chimwe chete zvisinei nezita rebrand, saka kuchinja pakati pevagadziri vakasiyana kazhinji hakukanganisi kuti mushonga unoshanda sei kwauri.

Zvimwe Zvinhu zveSelegiline

Kana selegiline isiri iyo yakakunakira, mamwe mishonga akati wandei anogona kubatsira kubata zviratidzo zvechirwere cheParkinson. Chiremba wako angangofunga rasagiline, iyo itsva MAO-B inhibitor inoshanda zvakafanana ne selegiline asi inogona kuve nemigumisiro mishoma.

Dopamine agonists senge pramipexole kana ropinirole inoshanda zvakasiyana nekukurudzira zvakananga dopamine receptors muuropi hwako. Mishonga iyi inogona kuve imwe nzira inoshanda, kunyanya mumatanho ekutanga echirwere cheParkinson.

COMT inhibitors senge entacapone kana tolcapone ndiyo imwe sarudzo inobatsira kuwedzera mhedzisiro ye levodopa. Izvi zvinoshanda nekudzivisa imwe enzyme inoputsa levodopa isati yasvika muuropi hwako.

Chiremba wako angangofungawo nezve amantadine, ine nzira dzakawanda dzekubatsira nezviratidzo zveParkinson uye inogona kubatsira zvakanyanya kuderedza kufamba kusingadiwi kunokonzerwa nemimwe mishonga.

Imwe nzira yakanaka zvinoenderana nezviratidzo zvako zvakananga, mimwe mishonga yaunotora, uye kuti muviri wako unoita sei kumishonga yakasiyana. Chiremba wako achashanda newe kuti awane musanganiswa unoshanda zvakanyanya.

Ko Selegiline Ari Nani Kudarika Rasagiline?

Ose ari maviri selegiline ne rasagiline maMAO-B inhibitors anoshanda nenzira dzakafanana, asi ane misiyano yakakosha. Rasagiline imishonga itsva inogona kukonzera mashoma mativi uye kusangana kwemishonga pane selegiline.

Selegiline yanga ichishandiswa kwenguva refu uye ine tsvakurudzo yakawanda inotsigira kushanda kwayo, kunyanya kana yakasanganiswa ne levodopa. Inowanikwawo mumhando dzakawanda, kusanganisira mahwendefa anonyungudika mumuromo ayo vamwe vanhu vanowana zviri nyore kutora.

Rasagiline inogona kunge isingakonzere matambudziko ekurara nekuti haiputsike mumuviri wako kuita zvinhu zvakaita seamphetamine. Izvi zvinoita kuti ive sarudzo iri nani kune vanhu vanonzwa kune zvinokurudzira.

Hapana mushonga wakanyatso

Kana uine chirwere chemoyo, chiremba wako angangokutangisa mushonga mudiki wozoiwedzera zvishoma nezvishoma. Vachadawo kukuona kakawanda mumwedzi mishoma yekutanga kuti vaone kuti moyo wako uri kupindura sei kumushonga.

Udza chiremba wako nekukasira kana ukaona kurwadziwa muchipfuva, kurova kwemoyo kusingaite zvakanaka, kana kufema kwakaoma zvisingaite paunenge uchitora selegiline. Zviratidzo izvi zvinogona kuratidza kuti mamiriro emoyo wako anoda kuongororwa zvakanyanya kana kugadziriswa kwemushonga.

Q2. Ndingaita Sei Kana Ndakashandisa Selegiline Yakawandisa Netsaona?

Kana netsaona ukatora selegiline yakawandisa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira, kunyangwe ukanzwa zvakanaka. Zviratidzo zvekuwandisa zvinogona kusazviratidza nekukasira asi zvinogona kusanganisira kurwadziwa kwemusoro kwakanyanya, kurwadziwa muchipfuva, kana shanduko dzinotyisa mudzihwa reropa.

Usaedze kuzviita kuti urutse kana kutora mimwe mishonga yekurwisa kuwandisa. Asi, tora bhodhoro remushonga wako uende kuchipatara chekukurumidzira kana chiremba wako achikurudzira.

Chengeta runyorwa rwemishonga yako yese newe, kusanganisira chiyero chaicho cheselegiline yawakatora. Ruzivo urwu ruchabatsira nyanzvi dzezvekurapa kupa kutarisirwa kwakanaka kana iwe uchida kurapwa kwekukurumidzira.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeSelegiline?

Kana ukakanganwa dose ye selegiline, itore paunenge uchiziva, kunze kwekunge yatove masikati kana manheru. Kutora selegiline kunonoka muzuva kunogona kukanganisa kurara kwako.

Kana yatopfuura 2 PM paunoyeuka dose yako yakakanganwa, isvetuke utore dose yako inotevera panguva yakajairika. Usaite kaviri dose kuti ugadzirise iyo yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemigumisiro.

Kukanganwa dose dzimwe nguva hakuzokukuvadzi, asi edza kuchengetedza chirongwa chine hukama hwekutonga zviratidzo zvakanaka. Funga nezvekuseta zviyeuchidzo zvefoni kana kushandisa chirongwa chemushonga kuti zvikubatsire kuyeuka.

Q4. Ndingamira Rini Kutora Selegiline?

Usambomira kutora selegiline kamwe kamwe usina kutanga wataura nachiremba wako. Zviratidzo zvako zveParkinson zvinogona kuwedzera nekukurumidza kana ukamisa mushonga kamwe kamwe, uye unogona kusangana nemigumisiro yakaita seyekubvisa.

Chiremba wako achakubatsira kuderedza zvishoma nezvishoma muyero wako kwemavhiki akati wandei kana kumisa selegiline zvichidikanwa. Iyi nzira yekuderedza zvishoma nezvishoma inobatsira kudzivirira kudzoka kamwe kamwe kwezviratidzo uye inobvumira muviri wako kuti ujairire.

Sarudzo yekumisa selegiline inowanzoitika kana migumisiro yechipiri yave kunetsa zvakanyanya kana kana mamwe marapirwo ava akakodzera mamiriro ako. Chiremba wako achashanda newe kuti awane imwe nzira yakanakisisa asati amisa selegiline.

Q5. Ndinganwe Doro Ndichitora Selegiline?

Zvakanakisa kuderedza kunwa doro uchitora selegiline, sezvo doro rinogona kuwedzera mamwe migumisiro yechipiri senge dzungu uye kuvhiringidzika. Zvinyoro zvidiki zvedoro zvinowanzoita zvakanaka, asi dzivisa kunwa zvakanyanya kana kunwa zvakanyanya.

Chenjerera zvakanyanya newaini tsvuku nebhia, sezvo izvi zvine tyramine, iyo inogona kuita ne selegiline kukonzera kuwedzera kunotyisa kweropa. Mweya wakajeka senge vodka kana gin kazhinji ndiyo sarudzo dzakachengeteka kana ukasarudza kunwa.

Taura nachiremba wako nezve tsika dzako dzekunwa doro kuti vakwanise kukupa zano rako pachako. Vanogona kukurudzira kudzivisa doro zvachose kana uri kusangana nemimwe migumisiro yechipiri kana kutora mamwe mishonga inodyidzana nedoro.