Chii chinonzi Selpercatinib: Zvazvinoshandiswa, Madosi, Mativi eMuviri uye Zvimwe

Selpercatinib mushonga wekenza unovharira mapuroteni akati wandei anobatsira tuma tumor tumwe kukura. Mushonga uyu unotorwa nemuromo unomiririra kubudirira kukuru kuvanhu vane kenza yepapfupa uye kenza yegurokuro vane shanduko dzakakosha dze genetic dzinonzi RET alterations.

Kana chiremba wako akakupa selpercatinib, unenge uchibata nekenza yakaratidza mamakisi aya chaiwo e genetic. Mushonga uyu unoshanda zvakasiyana nechemotherapy yechinyakare nekunangisa maseru ekenza chete ane shanduko idzi, izvo zvinowanzoita kuti uve nemigumisiro mishoma kwauri.

Chii chinonzi Selpercatinib?

Selpercatinib ndeyeboka remishonga inonzi RET inhibitors. Yakagadzirirwa kuvharira mapuroteni asina kujairika eRET anokurudzira kukura kwekenza mune vamwe varwere.

Mushonga uyu unouya semakapsule aunotora nemuromo. Yakagadzirwa zvakanyanya kuburikidza nekutsvagisa mishonga chaiyo, zvinoreva kuti masayendisiti akaiumba kuti inangise dambudziko chairo re molecular rinotyaira rudzi rwako rwekenza. Iyi nzira yakatarwa inowanzo shanda zvirinani pane kurapwa kwekare kunokanganisa maseru ane hutano zvakare.

Funga nezve selpercatinib sechinhu chakakosha chinoenderana nekiyi chaiyo. Iyo "kiyi" ndiyo RET protein mumaseru ako ekenza, uye mushonga uyu wakagadzirirwa kuti uenderane zvakakwana uye kumisa kenza kubva pakukura.

Chii chinonzi Selpercatinib chinoshandiswa?

Selpercatinib inorapa mhando dzakasiyana dzekenza dzine RET gene shanduko. Chiremba wako achange aedza tumor yako kuti asimbise shanduko idzi dze genetic asati akupa mushonga uyu.

Mushonga uyu unonyanya kushandiswa kune non-small cell lung cancer (NSCLC) ine RET gene fusions. Izvi zvinotora anenge 1-2% yeese kenza yepapfupa, asi kune varwere vane rudzi urwu rwakakosha, selpercatinib inogona kushanda zvakanyanya.

Zvakare zvinobvumirwa kurapa kenza yethyroid ye medullary uye mamwe marudzi ekenza yethyroid ane RET mutations. Izvi zvinomiririra marudzi akasiyana ekenza yethyroid anopindura zvakanaka kurapwa kunotarisa RET.

Uyezve, selpercatinib inogona kushandiswa kune mamwe marudzi e tumor akasimba ane RET gene alterations. Chiremba wako weoncologist achasarudza kana rudzi rwekenza yako rwakakodzera kurapwa uku zvichibva pamigumisiro yekuyedzwa kwemajini.

Selpercatinib Inoshanda Sei?

Selpercatinib inovharira nzira ye RET protein iyo maseru ekenza anoshandisa kukura nekuzviparadzanisa. Kana mapuroteni e RET akava asina kujairika nekuda kwekuchinja kwemajini, anotumira nguva dzose

Momedza makapisi ese asina kuvhura, kuputsa, kana kutsenga. Kana uine dambudziko rekumedza mapiritsi, taura nechikwata chako chekuchengetwa kwehutano nezve nzira dzinogona kubatsira, asi usachinje makapisi iwe pachako.

Kana ukarutsa mushure mekutora mushonga, usatore mumwe mushonga ipapo ipapo. Mirira kusvika panguva yako inotevera yakarongwa yekutora mushonga. Ramba uchitora mushonga kunyangwe ukatanga kunzwa zviri nani, sezvo mishonga yekenza ichishanda zvakanaka kana ichitorwa nguva dzose.

Ndingatora Selpercatinib Kwenguva Yakareba Sei?

Iwe unowanzo tora selpercatinib kwenguva yakareba sezvo ichishanda uye uchichigamuchira zvakanaka. Izvi zvinogona kuva mwedzi kana kunyange makore, zvichienderana nekuti kenza yako inopindura sei.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa nguva dzose uye bvunzo dzeropa. Misangano iyi inobatsira kuona kana mushonga uri kuderedza bundu rako kana kurichengeta rakagadzikana. Chero bedzi selpercatinib ichibatsira kudzora kenza yako pasina kukonzera matambudziko akakomba, iwe ungangodaro ucharamba uchiitora.

Vamwe varwere vanotora mushonga uyu kwenguva yakareba vaine hupenyu hwakanaka. Vamwe vangada kugadzirisa dosi kana kuzorora kana matambudziko akavaomera. Oncologist wako achashanda newe kuti uwane chiyero chakakodzera.

Usambomira kutora selpercatinib usati wataurirana nachiremba wako kutanga. Kunyangwe iwe ukanzwa zvakanaka, mushonga unogona kunge uchiri kushanda kudzora masero ekenza aunotadza kuona kana kunzwa.

Ndezvipi Zvipingamupinyi zveSelpercatinib?

Vanhu vazhinji vanotora selpercatinib vanowana zvimwe zvinokanganisa, asi zvinowanzo manejwa nerutsigiro rwakakodzera. Mashoko akanaka ndechokuti matambudziko akakomba haawanzoitiki kupfuura chemotherapy yechinyakare.

Heano matambudziko anowanzoitika aunogona kusangana nawo, uye zvakakosha kuziva kuti chikwata chako chekuchengetwa kwehutano chinogona kubatsira manejimendi yega yega:

• Muromo wakaoma unoitika kune vanenge 60% yevarwere asi unogona kudzora nekunwa mvura kakawanda nekuchengeta muromo.
• Manyoka anokanganisa vanenge hafu yevarwere uye anowanzoita zvakanaka nekuchinja kudya uye mishonga.
• High blood pressure inokura mune vanenge 40% yevarwere uye inogona kudzora nemishonga yekudzikisa BP.
• Kuneta kwakajairika uye kunowanzoita zviri nani muviri wako paunojaira mushonga.
• Kuzvimba mumaoko, tsoka, kana kumeso kunoitika mune vanenge 30% yevarwere.
• Mavanga kana shanduko dzeganda zvinokanganisa vamwe varwere asi zvinowanzoita zvishoma.

Izvi zvinokonzeresa hazviitike kune vese, uye kana zvikaitika, zvinowanzoita zvishoma kusvika pakati nepakati. Chikwata chako chehutano chichakutarisa zvakanyanya uye chinogona kugadzirisa chirongwa chako chekurapa kana zvichidikanwa.

Zvisingawanzoitiki asi zvakanyanya kukonzeresa zvinogona kusanganisira matambudziko echiropa, shanduko dzemoyo, kana maitiro akakomba eganda. Chiremba wako achatarisa izvi kuburikidza nekuongororwa kweropa nguva dzose uye kuongororwa.

Zvimwe zvisingawanzoitiki asi zvakakomba zvinokonzeresa zvinosanganisira kubuda ropa zvakanyanya, matambudziko emapapu, kana maitiro akakomba ekuita allergic. Kunyangwe izvi zvisingawanzoitiki, zvakakosha kuti utaure nechikwata chako chehutano nekukasira kana uine zviratidzo zvisingajairiki sekufema kwakaoma, kurwadziwa kwakanyanya muchipfuva, kana kubuda ropa kusingajairiki.

Ndiani Asingafaniri Kutora Selpercatinib?

Selpercatinib haisi yemunhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri. Vanhu vane mamwe mamiriro emoyo kana matambudziko echiropa vangangoda kuongororwa kwakakosha kana dzimwe nzira dzekurapa.

Haufanire kutora selpercatinib kana uine allergic kwairi kana chero zvinosanganiswa zvayo. Kana wakambove nemaitiro akakomba ekuita allergic kumishonga yakafanana, ita shuwa kuti unokurukura izvi ne oncologist wako.

Vakadzi vane pamuviri havafaniri kutora selpercatinib sezvo ichigona kukuvadza mwana ari kukura. Kana uri kuronga kuva nepamuviri, unogona kuva nepamuviri, kana uri kuyamwisa, kurukura izvi nachiremba wako usati watanga kurapwa.

Vanhu vane chirwere chechiropa chakakomba vangada kugadziriswa kwemishonga kana mamwe marapirwo. Chiremba wako achatarisa kushanda kwechiropa chako usati watanga selpercatinib uye achachitarisa nguva dzose panguva yekurapa.

Kana uine nhoroondo yematambudziko emoyo, chiremba wako achaongorora kana mabhenefiti achikunda njodzi. Vamwe varwere vangada kuwedzera kutarisa kwemoyo vachitora mushonga uyu.

Zita reSelpercatinib Brand

Selpercatinib inotengeswa pasi pezita rekuti Retevmo. Ungaona zita rimwe chete pabhodhoro rako remishonga kana mumarekodhi ekurapa.

Retevmo inogadzirwa naEli Lilly and Company. Mushonga uyu wakabvumidzwa neFDA muna 2020, zvichiita kuti uve mutsva asi wakadzidzwa zvakanaka kurapa.

Kunyangwe mushonga wako uchiti selpercatinib kana Retevmo, uri kuwana mushonga mumwe chete. Dzimwe makambani einishuwarenzi kana makemisi angashandisa zita rimwe kana rimwe, asi chinhu chinoshanda uye kushanda zvakafanana.

Zvimwe Zvinhu zveSelpercatinib

Kana selpercatinib isiri iyo yakakunakira, dzimwe nzira dzekurapa dziripo zvichienderana nerudzi rwako rwegomarara uye chimiro chemajini. Chiremba wako weoncologist achabatsira kuona nzira yakanakisa.

Kune RET-positive lung cancer, mamwe marapirwo akatarisirwa sepralsetinib (Gavreto) anogona kuve sarudzo. Uyu mumwe RET inhibitor anoshanda zvakafanana ne selpercatinib asi anogona kuve nemhedzisiro yakasiyana.

Chemotherapy yechinyakare inoramba iri sarudzo yevakawanda varwere, kunyangwe kazhinji iine mhedzisiro yakawanda. Mishonga yeImmunotherapy se pembrolizumab inogonawo kufungwa zvichienderana nemaitiro ako etumor.

Kune gomarara rethyroid, dzimwe nzira dzinogona kusanganisira mamwe marapirwo akatarisirwa se cabozantinib kana vandetanib. Radioactive iodine therapy inogona kuve sarudzo yerudzi rwakati rwegomarara rethyroid.

Miedzo dzekiriniki dzinowanzo paunza mukana wekurapa kwemazuva ano. Chiremba wako weoncologist anogona kukubatsira kuti uongorore kana chero miedzo iripo ingave yakakodzera kumamiriro ako ezvinhu.

Selpercatinib iri nani pane mamwe maRET Inhibitors here?

Selpercatinib na pralsetinib vese vanoshanda maRET inhibitors, asi vane misiyano ingaita kuti mumwe akukodzere iwe kupfuura mumwe. Chiremba wako achafunga nezve mamiriro ako chaiwo paanenge achisarudza pakati pavo.

Selpercatinib ndiyo yekutanga selective RET inhibitor yakatenderwa, saka vanachiremba vane ruzivo rwakawanda vachishandisa. Miedzo yekiriniki yakaratidza mhinduro dzinoshamisa, nevakawanda varwere vachiona bundu ravo richideredzwa zvakanyanya.

Mhedzisiro yezvinhu zvakasiyana zvishoma pakati pemishonga miviri iyi. Vamwe varwere vanotsungirira imwe zviri nani pane imwe, izvo zvinogona kuve chinhu chakakosha mukusarudza kurapwa.

Mishonga yese miviri yakaratidza kushanda zvakafanana mumiedzo yekiriniki, saka sarudzo inowanzoenderana nezvinhu zvakaita semamwe mamiriro ako ehutano, mikana yekudyidzana kwemishonga, uye zvaunofarira nezve mhedzisiro.

Mibvunzo Inowanzo Bvunzwa Nezve Selpercatinib

Selpercatinib Yakachengeteka Kune Vanhu vane Chirwere chemoyo here?

Selpercatinib inogona kushandiswa kune vanhu vane chirwere chemoyo, asi inoda kunyatso tariswa. Mishonga dzimwe nguva inogona kukanganisa rhythm yemoyo kana blood pressure, saka cardiologist wako uye oncologist vachashanda pamwe chete kuti vakutarise zvakanyanya.

Kana uine matambudziko emoyo aripo, chiremba wako anogona kuraira mamwe miedzo yemoyo usati watanga kurapwa uye kutarisisa basa remoyo wako nguva dzose. Varwere vazhinji vane mamiriro emoyo vanogona kutora selpercatinib zvakachengeteka nekutariswa kwakakodzera kwekurapa.

Ndoita Sei Kana Ndikatora Selpercatinib yakawandisa netsaona?

Kana ukatora selpercatinib yakawanda kupfuura yakanyorwa netsaona, fonera chiremba wako kana nzvimbo inobata chepfu nekukasira. Usaedze kuzviita kuti urutse kunze kwekunge wataurirwa zvakananga kuti uite saizvozvo nenyanzvi dzezvekurapa.

Kutora yakawanda kunogona kuwedzera njodzi yako yezvinhu zvisingadiwi, kunyanya matambudziko emoyo kana manyoka akakomba. Chikwata chako chehutano chichakupa zano rekuti chii chekucherechedza uye kana uchida kutarisirwa kwekurapa nekukasira.

Ndoitei Kana Ndikakanganwa Dose yeSelpercatinib?

Kana ukakanganwa dose uye zvapfuura maawa asingasviki 6 kubva panguva yako yakarongwa, itore paunorangarira. Kana zvapfuura maawa anopfuura 6, siya dose yakakanganwa uye tora dose yako inotevera panguva yakajairika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yezvinhu zvisingadiwi pasina kupa rubatsiro rwakawedzerwa. Kana iwe uchikanganwa madosi kazhinji, funga kuisa zviyeuchidzo zvefoni kana kushandisa chirongwa chemapiritsi.

Ndingamira Rini Kutora Selpercatinib?

Unofanira kungomira kutora selpercatinib chete kana chiremba wako achikurudzira izvozvo. Sarudzo iyi inowanzoenderana nekuti mushonga uri kushanda sei uye kana uri kusangana nezvinhu zvisingadiwi zvinogoneka.

Chiremba wako achashandisa ma scans enguva dzose uye bvunzo dzeropa kuti aongorore mhinduro yako kumushonga. Kana kenza yako ikafambira mberi pasinei nemushonga, kana kana zvinhu zvisingadiwi zvikava zvakanyanya, oncologist wako achakurukura kumisa mushonga uye kuongorora dzimwe sarudzo.

Ndinganwa Doro Here Ndichitora Selpercatinib?

Kunwa doro zvine mwero kunogamuchirwa zvakajairika uchitora selpercatinib, asi zviri nani kukurukura izvi nachiremba wako. Doro rinogona kuwedzera zvimwe zvinhu zvisingadiwi zvakaita sekuneta kana kukanganisa basa rechiropa chako.

Sezvo selpercatinib inogona kukanganisa chiropa chako, uye doro rinoitawo saizvozvo, chiremba wako anogona kukurudzira kuderedza kunwa doro. Iva akatendeseka nechikwata chako chehutano nezve tsika dzako dzekunwa kuitira kuti vakwanise kukupa zano rakagadzirirwa iwe pachako.