Chii chinonzi Tacrine: Zvayinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe Zvakawanda

Tacrine yaive mushonga waimboshandiswa kurapa chirwere cheAlzheimer, asi haichawanikwi munyika zhinji nekuda kwematambudziko akakomba echiropa. Mushonga uyu wakagadzirirwa kubatsira kuvandudza ndangariro uye hunyanzvi hwekufunga muvanhu vane dementia nekudzivisa enzyme inoputsa acetylcholine, kemikari yehuropi yakakosha ye ndangariro.

Nepo tacrine yakaita nhoroondo seyekutanga kurapwa kweAlzheimer's disease yakatenderwa neFDA muna 1993, vanachiremba vakawana kuti inogona kukonzera kukuvadzwa kwakanyanya kwechiropa. Nyika zhinji kubvira zvakadaro dzakabvisa pamusika, uye dzimwe nzira dzakachengeteka dziripo ikozvino dzekurapa zviratidzo zve dementia.

Chii chinonzi Tacrine?

Tacrine ndeyeboka remishonga inonzi cholinesterase inhibitors. Inoshanda nekudzivirira kuparara kwe acetylcholine, neurotransmitter inobatsira maseru etsinga kutaurirana nemumwe nemumwe muuropi.

Mushonga uyu pakutanga wakagadzirwa kubatsira kunonotsa kufambira mberi kwekurasikirwa nendangariro uye kuvhiringidzika muvarwere veAlzheimer. Zvisinei, kushandiswa kwayo kwakaganhurirwa nekuda kwekunetseka kwakakosha kwekuchengetedza, kunyanya njodzi yechiropa chepfu iyo inogona kuva inotyisa upenyu.

Chii chinonzi Tacrine chinoshandiswa?

Tacrine yaive yakanyorwa zvakanyanya ye mild kusvika pakati nepakati chirwere cheAlzheimer. Vanachiremba vaishandisa kubatsira varwere kuchengetedza kugona kwavo kwepfungwa kwenguva yakareba uye zvinogona kunonotsa kudzikira mukushanda kwemazuva ese.

Mushonga uyu dzimwe nguva waifungidzirwawo kune dzimwe mhando dze dementia, kunyangwe izvi zvaive zvisingawanzoitiki. Zvakakosha kuziva kuti tacrine haiporesi chirwere cheAlzheimer kana kumisa kufambira mberi kwayo zvachose - inongopa rubatsiro rwemunguva pfupi kune vamwe varwere.

Tacrine inoshanda sei?

Tacrine inoshanda nekudzivisa enzyme inonzi acetylcholinesterase muuropi hwako. Iyi enzyme inowanzo putsa acetylcholine, mutumwa wemakemikari akakosha endangariro nekudzidza.

Nokudzivirira kuparara uku, tacrine inobatsira kuchengetedza mazinga epamusoro e acetylcholine muuropi. Izvi zvinogona kuvandudza kwenguva pfupi kutaurirana pakati pemasero etsinga, izvo zvinogona kubatsira nekurangarira, kutarisisa, uye hunyanzvi hwekufunga. Zvisinei, tacrine inoonekwa semushonga usina simba zvichienzaniswa nemishonga mitsva yekurapa dementia, uye mhedzisiro yayo haina kukwana.

Ndingatora sei Tacrine?

Dai tacrine yaivepo, inowanzo torwa nemuromo kanina kana pazuva, kazhinji pakati pemadyiro. Kuitora mudumbu risina chinhu kunobatsira muviri wako kutora mushonga zviri nani.

Mushonga unozofanirwa kutanga pamwero wakaderera uye zvishoma nezvishoma kuwedzera kwemavhiki akati wandei. Kuwedzera uku kunobatsira kuderedza mhedzisiro, kunyanya kusvotwa nekutsvuka. Kuyedzwa kweropa nguva dzose kwaizova kwakakosha kuti utarise basa rechiropa, sezvo kukuvara kwechiropa kunogona kuitika pasina zviratidzo zvinooneka.

Ndingatora Tacrine Kwenguva Yakareba Sei?

Kureba kwekurapa kwe tacrine kwaizoenderana nekuti unopindura sei kumushonga uye kana iwe ukagadzira mhedzisiro. Vamwe varwere vanogona kuona mabhenefiti mukati memavhiki mashoma, nepo vamwe vangada mwedzi yakati wandei kuti vaone kuvandudzwa.

Kurapa kwaizoramba kuchienderera mberi chero mabhenefiti achipfuura njodzi. Zvisinei, kutarisa nguva dzose matambudziko echiropa kwaizova kwakakosha, uye mushonga unozofanirwa kumiswa nekukasira kana mazinga e enzyme yechiropa akakwira.

Ndezvipi Zvakaipa zveTacrine?

Tacrine inogona kukonzera mhedzisiro yakati wandei, kubva pakati nepakati kusvika kune zvakanyanya. Kunetseka kukuru ndiko kukuvadzwa kwechiropa, izvo zvinogona kuva njodzi kuhupenyu uye ndicho chikonzero chikuru nei mushonga uyu wakabviswa mumisika yakawanda.

Heano mhedzisiro yakajairika yaungasangana nayo:

• Kusvotwa nekutsvuka
• Manyoka
• Kurasikirwa nechido
• Kurwadziwa mudumbu
• Dizziness
• Musoro
• Kuneta

Matambudziko akakomba anoda kutariswa kwechimbichimbi kwechiremba anosanganisira:

• Kusvava kweganda kana maziso (jaundice)
• Weti yakasviba
• Kurwadziwa kwakanyanya mudumbu
• Kuneta kana kushaya simba zvisinganzwisisike
• Kushaya chido chekudya kwemazuva akati wandei
• Kurova kwemoyo kunonoka
• Kutadza kufema

Zviratidzo izvi zvakakomba zvinogona kuratidza kukuvadzwa kwechiropa kana mamwe matambudziko anogona kuva nenjodzi anoda kutariswa kwechimbichimbi kwechiremba.

Ndiani Asingafaniri Kutora Tacrine?

Mapoka akati wandei evanhu anofanira kudzivisa tacrine nekuda kwenjodzi yakawedzerwa yematambudziko akakomba. Chero ani zvake ane chirwere chechiropa chiripo kana nhoroondo yematambudziko echiropa haafaniri kutora mushonga uyu.

Zvimwe zvirwere zvinoita kuti tacrine isakodzere zvinosanganisira:

• Chirwere chechiropa chiri kushanda kana ma enzymes echiropa akakwira
• Matambudziko emoyo akakomba kana kurova kwemoyo kusingaenderane
• Maronda emudumbu ari kushanda
• Asthma yakakomba kana matambudziko ekufema
• Kuvharika kweweti
• Zvirwere zvekurwara

Vakadzi vane pamuviri nevanooyamwisa vanofanirawo kudzivisa tacrine, sezvo migumisiro yayo pavacheche vari kukura isinganzwisisike zvakanaka.

Mazita eTacrine Brand

Tacrine yakatanga kutengeswa pasi pezita rekuti Cognex muUnited States. Iri ndiro zita guru remhando raishandiswa apo mushonga uyu waivapo.

Zvisinei, kubvira tacrine yabviswa mumisika yakawanda nekuda kwekunetseka kwekuchengeteka, mazita emhando aya haachashandiswi. Kana uri kutsvaga kurapwa kwe dementia, chiremba wako anogona kukurudzira dzimwe nzira itsva, dzakachengeteka.

Zvimwe Zvinhu Zvitsva zveTacrine

Dzimwe nzira dzakachengeteka uye dzinoshanda zvakanyanya kune tacrine dziripo ikozvino dzekurapa chirwere cheAlzheimer nedzimwe mhando dze dementia. Mishonga mitsva iyi ine maprofiles akachengeteka uye anowanzo shanda zvakanyanya.

Zvimwe zvinhu zvitsva zvinosanganisira:

• Donepezil (Aricept) - zvakare inhibitor ye cholinesterase asi yakachengeteka zvikuru
• Rivastigmine (Exelon) - inowanikwa semapiritsi kana mapatches
• Galantamine (Razadyne) - imwe inhibitor ye cholinesterase
• Memantine (Namenda) - inoshanda zvakasiyana nekudzivisa NMDA receptors
• Aducanumab (Aduhelm) - sarudzo itsva, ine gakava

Dzimwe nzira idzi dzinofarirwa nekuti dzinokonzera mashoma mativi emuviri akakomba uye haatungamiri njodzi imwechete yekukuvadzwa kwechiropa iyo yakaita kuti tacrine ive nenjodzi.

Ko Tacrine Ari Nani Kudarika Donepezil?

Donepezil inowanzofungidzirwa kuti iri nani kune tacrine munzira dzese. Kunyange zvese zvinorapa zvichishanda nemaitiro akafanana, donepezil ine chimiro chekuchengetedza chiri nani uye chiri nyore kutora.

Donepezil inongoda kutora kamwe chete pazuva, ichienzaniswa ne tacrine's mana pazuva dosing. Zvakanyanya kukosha, donepezil haikonzeri matambudziko akakomba echiropa akaita kuti tacrine ive nenjodzi. Zvidzidzo zvakaratidzawo kuti donepezil inoshanda zvakanyanya se tacrine pakurapa zviratidzo zveAlzheimer, kana kwete zvakanyanya.

Mibvunzo Inowanzo Bvunzwa Nezve Tacrine

Q1. Ko Tacrine Yakachengeteka Here Kune Zvirwere Zvemoyo?

Tacrine inogona kuva nedambudziko kune vanhu vane chirwere chemoyo nekuti inogona kuderedza kumhanya kwemoyo wako uye zvinogona kuwedzera mamwe mamiriro emoyo. Kana uine matambudziko emoyo, tacrine inogona kukonzera kuti moyo wako urove zvishoma nezvishoma kana zvisina kujairika.

Mishonga inogonawo kuderedza BP, izvo zvinogona kuva nenjodzi kana iwe ukatove nematambudziko emoyo. Ichi chimwe chikonzero nei vanachiremba zvino vachifarira dzimwe nzira dzakachengeteka se donepezil kune varwere vane dementia uye chirwere chemoyo.

Q2. Ndoitei Kana Ndikashandisa Tacrine Yakawandisa Netsaona?

Kana iwe uchifungidzira overdose ye tacrine, tsvaga rubatsiro rwekurapa nekukurumidza. Zviratidzo zve overdose zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, kutukwa kwakanyanya, kumhanya kwemoyo kunonoka, BP yakaderera, uye kuoma kufema.

Kupfuuridza muyero wemushonga kunogona kuisa upenyu panjodzi, kunyanya nekuda kwekukwanisa kwa tacrine kukuvadza chiropa. Usaedze kurapa kupfuuridza muyero wemushonga kumba - fonera masevhisi ekukurumidzira kana kuenda kuchipatara chekukurumidzira ipapo ipapo.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeTacrine?

Kana ukakanganwa dose ye tacrine, itore paunorangarira, kunze kwekunge yava nguva yekuita dose yako inotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chemazuva ese.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemigumisiro. Kana iwe uchikanganwa madosi kazhinji, funga kushandisa murongi wemapiritsi kana kuseta zviyeuchidzo zvefoni.

Q4. Ndingamira Rini Kutora Tacrine?

Unofanirwa kungomira kutora tacrine pasi pekutariswa kwachiremba wako. Mushonga unofanirwa kumiswa nekukasira kana ukawana zviratidzo zvematambudziko echiropa, sekusviba kweganda kana maziso, weti yakasviba, kana kurwadziwa kwakanyanya mudumbu.

Chiremba wako achakurudzirawo kumira kana mushonga usingabatsiri zviratidzo zvako kana kana migumisiro ikava inonetsa zvakanyanya. Kuyedzwa kweropa nguva dzose kwakakosha kuti utarise kukuvadzwa kwechiropa, uye mhedzisiro kubva kumiyedzo iyi ichabatsira kuona kuti ungamira rini mushonga.

Q5. Tacrine Inogona Kutorwa Nemimwe Mishonga Here?

Tacrine inogona kuita pamwe chete nemimwe mishonga yakawanda, zvichikonzera migumisiro inotyisa. Zvine njodzi zvakanyanya kusanganisa tacrine nemimwe mishonga inokanganisa chiropa, moyo, kana tsinga dzemuviri.

Nguva dzose zivisa chiremba wako nezve mishonga yese, zvinowedzera, uye mishonga yemakwenzi yaunotora usati watanga tacrine. Dzimwe hukama hunogona kuva hwakakomba, kusanganisira kuwedzera njodzi yekukuvadzwa kwechiropa kana shanduko dzinotyisa mumoyo rhythm.