Chii chinonzi Tafamidis: Zvinoshandiswa, Dosage, Side Effects uye Zvimwe

Tafamidis mushonga wakakosha wakagadzirirwa kunonotsa kufambira mberi kwezvimwe zvisingawanzoitiki zvemwoyo uye tsinga dzemamiriro ezvinhu anokonzerwa nekuchengetwa kwemapuroteni asina kujairika. Mushonga uyu unopiwa nachiremba unoshanda nekugadzirisa puroteni inonzi transthyretin, ichiidzivirira kubva pakuparara uye kuumba mapundu anokuvadza mumuviri wako.

Kana chiremba wako akakupa tafamidis, unogona kunge uri kubata mamiriro anokanganisa maitiro emuviri wako anogadzirisa puroteni iyi yakakosha. Kunyange zvazvo mamiriro aya akakomba, kuva nemukana wekurapa unoshanda kunogona kupa tariro uye kubatsira kuchengetedza hupenyu hwako kwenguva yakareba.

Chii chinonzi Tafamidis?

Tafamidis is protein stabilizer inodzivirira transthyretin kubva pakuzaruka uye kukonzera kukuvadza kumoyo wako netsinga. Funga nezvazvo seglue yemamorekuru inochengeta puroteni iyi muchimiro chayo chakakodzera, chakasimba.

Mushonga uyu ndewechikamu chinonzi transthyretin stabilizers, zvichiita kuti uve mushonga wekutanga werudzi rwawo wakabvumirwa kurapa mamwe mafomu eamyloidosis. Chiropa chako chinogadzira zvakasikwa puroteni ye transthyretin, asi mune vamwe vanhu, puroteni iyi inova isina kugadzikana uye inoumba deposits inokuvadza mumuviri.

Tafamidis inouya nenzira mbiri: makapisi enguva dzose uye vhezheni itsva, ine simba rakawanda inonzi tafamidis meglumine. Zvose zvinoshanda nenzira imwechete asi zvakasiyana musimba uye dosing frequency.

Chii chinonzi Tafamidis chinoshandiswa?

Tafamidis inorapa mamiriro maviri makuru: transthyretin amyloid cardiomyopathy uye hereditary transthyretin amyloidosis ine polyneuropathy. Zvose zvinobatanidza puroteni imwechete ine matambudziko asi zvinokanganisa zvikamu zvakasiyana zvemuviri wako.

Mu transthyretin amyloid cardiomyopathy, iyo isina kugadzikana puroteni inochengetwa zvakanyanya mumhasuru dzemoyo wako, ichiita kuti ive yakaoma uye isakwanise kupomba ropa nemazvo. Mamiriro aya anogona kukonzera kufema, kuneta, uye kuzvimba mumakumbo ako nemudumbu.

Hereditary transthyretin amyloidosis ine polyneuropathy inonyanya kukanganisa tsinga dzako dzemumativi, zvichikonzera kuoma mitezo, kunzwa kupisa, uye kusava nesimba mumaoko ako netsoka. Fomu iyi inopfuudzwa kuburikidza nemhuri uye inowanzo kutanga pauzima.

Chiremba wako achasimbisa kuongororwa kwako kuburikidza nemiedzo yakatarwa, kusanganisira kuyedzwa kwemajini uye kuongororwa kwemoyo kwakakosha kana zvidzidzo zvet singa. Mamiriro aya haawanzoitiki, achikanganisa vanhu vashoma zviuru pasi rose, asi anogona kukanganisa zvikuru hupenyu hwako hwezuva nezu zuva pasina kurapwa kwakakodzera.

Maitiro Anoita Tafamidis?

Tafamidis inoshanda nekubatanidza kune transthyretin protein uye kuichengeta yakagadzikana muropa rako. Izvi zvinodzivirira protein kubva pakuparara uye kuumba mapundu anonamira anokuvadza nhengo dzako.

Pasi pemamiriro akajairika, transthyretin inotakura mahomoni ethyroid uye vhitamini A mumuviri wako wese. Zvisinei, muvanhu vane amyloidosis, protein iyi inova isina kugadzikana uye inokanganisa, ichigadzira matura anokuvadza anonzi amyloid fibrils.

Mishonga inoshanda semuenzaniso wekugadzika, ichivhara protein muchimiro chayo chakarurama. Izvi hazvipesanisi kukuvadzwa kwakatoitika, asi zvinononotsa zvakanyanya kuumbwa kwematura matsva eprotein, zvichibatsira kuchengetedza basa re nhengo dzako nekufamba kwenguva.

Tafamidis inoonekwa semushonga wakasimba zvine mwero une chiito chakatarwa. Haisi mushonga, asi zvidzidzo zvekiriniki zvinoratidza kuti zvinogona kunonotsa zvakanyanya kufambira mberi kwechirwere uye kuvandudza huwandu hwekupona kana zvikatanga kare muchirwere ichi.

Ndinofanira Kutora Sei Tafamidis?

Tora tafamidis sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva uine kana pasina chikafu. Madosi akajairika i20mg zuva rega rega (kapsule imwe) kana 61mg zuva rega rega (makapsule mana), zvichienderana nemamiriro ako chaiwo uye mafomu akanyorwa.

Unogona kutora mushonga uyu nemvura, mukaka, kana muto - chikafu hachina zvachinokanganisa nzira iyo muviri wako unotora nayo. Zvisinei, edza kuutora panguva imwechete zuva rega rega kuti uchengetedze mazinga akafanana muropa rako.

Momedza makapisi ese asina kuvhura, kuputsa, kana kuatsenga. Kana uine dambudziko rekumedza makapisi, taura nachiremba wako nezve dzimwe nzira, sezvo mushonga uchida kutora zvakanaka kuti ushande zvakanaka.

Chengeta mushonga wako pakupisa kwemumba, kure nemvura uye kupisa. Uchengete mumudziyo wawo wekutanga une packet ye desiccant kudzivirira kukuvadzwa nemvura, izvo zvinogona kukanganisa simba remushonga.

Ndingatora Tafamidis Kwenguva Yakareba Sei?

Tafamidis inowanzoita kurapwa kwenguva refu kwaunoda kuenderera mberi kwenguva refu kuti uchengetedze mhedzisiro yayo yekudzivirira. Sezvo ichinonotsa kufambira mberi kwechirwere panzvimbo yekuchiporesa, kumisa mushonga kunobvumira matura eprotein anokuvadza kuti atangezve kuumbwa.

Chiremba wako achatarisa mhinduro yako kuburikidza nekutarisa nguva dzose, bvunzo dzeropa, uye zvidzidzo zve imaging. Izvi zvinobatsira kuongorora kana mushonga uri kunonotsa kufambira mberi kwechirwere chako zvakanaka uye kana chero kugadzirisa muyero kuchidiwa.

Vanhu vazhinji vanopindura zvakanaka ku tafamidis vanoenderera mberi vachiutora kwemakore. Zvakanakira mushonga zvinova pachena nekufamba kwenguva, nezvidzidzo zvinoratidza misiyano yakakosha mukufambira mberi kwechirwere mushure memwedzi gumi nemiviri kusvika gumi nemasere yekurapa nguva dzose.

Usambomira kutora tafamidis usati wataurirana nachiremba wako kutanga. Kumisa kamwe kamwe hakuzokonzeri zviratidzo zvinotyisa zvekubvisa, asi zvichabvumira mamiriro ako kuti afambire mberi nekukurumidza kupfuura kana ukaenderera mberi nekurapa.

Ndezvipi Zvakaipa zveTafamidis?

Vanhu vazhinji vanotsungirira tafamidis zvakanaka, nemhedzisiro yakaipa ichiwanzoita nyoro uye inodzoreka. Mushonga une chimiro chekuchengetedza chakanaka zvichienzaniswa nemamwe marapirwo ezvirwere zvisingawanzoitiki.

Hezvino zvinowanzoziviswa zvinoitika zvaungasangana nazvo:

• Matambudziko ekugaya chikafu senausea, manyoka, kana kusagadzikana mudumbu
• Musoro kana dzungu
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Zvirwere zvepamusoro zvekufema
• Zvirwere zvegumbo remvura

Izvi zvinowanzoitika zvinowanzoita zviri nani sezvo muviri wako uchigadzirisa mushonga mumavhiki mashoma ekutanga ekurapa.

Kunyange zvazvo zvisingawanzoitiki, vamwe vanhu vanogona kusangana nezvinetso zvakakomba zvinoda kutariswa kwechiremba nekukurumidza:

• Kusagadzikana kwakanyanya kwemuviri nekutsvuka, kuzvimba, kana kuoma kufema
• Kubuda ropa kusingajairiki kana kupwanya
• Kurwadziwa mudumbu kwakanyanya
• Zviratidzo zvematambudziko echiropa sekusviba kweganda kana maziso
• Zviratidzo zvemtima zvakakomba kana kuwedzera

Bata chiremba wako nekukurumidza kana ukaona chero chimwe chezvinetso zvakakomba izvi. Vanhu vazhinji vanogona kuramba vachitora tafamidis zvakachengeteka nekutarisa kwakakodzera uye rutsigiro.

Ndiani Asingafaniri Kutora Tafamidis?

Tafamidis haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakakodzera mamiriro ako chaiwo. Vanhu vane allergies inozivikanwa kune tafamidis kana chero chimwe chezvinhu zvayo vanofanira kudzivisa mushonga uyu.

Chiremba wako achashandisa kungwarira kwakanyanya kana uine chirwere chechiropa chakakomba, sezvo muviri wako ungasaite mushonga zvakanaka. Kunyange zvazvo matambudziko echiropa asina kukomba asingakubvise otomatiki, anogona kuda kugadziridzwa kwemadosi kana kutariswa pedyo.

Vakadzi vane pamuviri havafaniri kutora tafamidis, sezvo mhedzisiro yayo pavacheche vari kukura isinganzwisiswi zvizere. Kana uri kuronga kuva nepamuviri kana kuona kuti une pamuviri uchitora mushonga uyu, kurukura dzimwe nzira nachiremba wako nekukurumidza.

Vanamai vanoyamwisa vanofanirawo kudzivisa tafamidis, sezvo zvisingazivikanwi kana mushonga uyu uchipinda mumukaka wemazamu. Chiremba wako anogona kukubatsira kuyera mabhenefiti nenjodzi kana uri kuyamwisa.

Vanhu vane chirwere chakakomba cheitsvo vangada kugadziriswa kwemishonga, kunyangwe matambudziko eitsvo akapfava kusvika pakati nepakati kazhinji haavharidzire kushandiswa kwetafamidis. Chiremba wako achatarisa kushanda kweitsvo dzako nguva dzose panguva yekurapa.

Mazita eBrand eTafamidis

Tafamidis inowanikwa pasi pemazita maviri makuru ebrand: Vyndaqel naVyndamax. Zvese zvine chinhu chimwe chete chinoshanda asi zvinosiyana mukuumbwa kwavo uye kuyera.

Vyndaqel ine tafamidis meglumine uye inouya mumakapsule e20mg, anowanzo torwa kamwe chete pazuva. Iyi ndiyo yaive vhezheni yekutanga yakatenderwa uye inoramba ichinyorwa zvakanyanya kune zvese mwoyo uye tsinga dzehurema.

Vyndamax ine tafamidis (isina meglumine) mumakapsule e61mg, anotorwawo kamwe chete pazuva. Iyi fomu itsva yakaenzana nemakapsule mana eVyndaqel uye inowanzo fambiswa nekuda kwechirongwa chayo chiri nyore chekuyera.

Mabhurandi ese ari maviri anoshanda zvakaenzana - sarudzo pakati pawo inowanzoenderana nekuda kwechiremba wako, inishuwarenzi yako, uye iyo fomu iri nyore kwauri kutora nguva dzose.

Zvimwe Zvinhu zveTafamidis

Parizvino, kune zvishoma zvimwe zvinotsiva tafamidis yekurapa transthyretin amyloidosis. Kushomeka kwezvirwere izvi zvinoreva kuti sarudzo dzekurapa dzinoramba dzakaganhurirwa, zvichiita kuti tafamidis ive yakakosha.

Kune nhaka ye transthyretin amyloidosis ine polyneuropathy, patisiran uye inotersen ndiyo RNA kupindira kurapa kunoshanda zvakasiyana kubva ku tafamidis. Mishonga iyi inoderedza kugadzirwa kweprotein ye transthyretin panzvimbo pekuigadzirisa.

Kuiswa kwechiropa kunogona kufungwa kune vamwe vanhu vane nhaka yechirwere, sezvo chiropa chichigadzira yakawanda yeprotein ine matambudziko. Zvisinei, kuvhiyiwa kukuru uku kwakakodzera chete kune varwere vakasarudzwa zvakanyatsonaka uye hazvibatsiri nezviratidzo zvine chekuita nemoyo.

Pakuita manejimendi ezviratidzo, chiremba wako anganyora mishonga yekubatsira nekukundikana kwemoyo, kurwadziwa kwetsinga, kana mamwe matambudziko. Kurapa uku kunotsigira kunoshanda pamwe chete ne tafamidis kuvandudza hupenyu hwako.

Gene therapy nemamwe marapirwo ekuyedza ari kudzidzwa, asi tafamidis inoramba iri yekutanga kurapwa kwakaratidzwa kudzora kufambira mberi kwechirwere muvanhu vazhinji.

Ko Tafamidis Zviri Nani Kupfuura Zvimwe Zvirwere Here?

Tafamidis inopa zvakanakira zvakasiyana seyekutanga mishonga yemuromo yakaratidzwa kudzora kufambira mberi mu transthyretin amyloidosis. Kune vanhu vazhinji, inopa sarudzo yekurapa inoshanda iri nyore kubata pane imwe nzira yekujekesa.

Kana ichienzaniswa ne patisiran uye inotersen, tafamidis ine mashoma matambudziko akakomba uye haidi kuongororwa nguva dzose kwekuita chiropa chepfu kana shanduko yeropa. Izvi zvinoita kuti ive sarudzo yakachengeteka kwenguva refu kune vanhu vazhinji.

Fomula yemuromo inopa tafamidis mukana wakakura wekunyaradza pamusoro pekurapa kunojekesa. Unogona kuitora kumba usingashanyire kiriniki, zvichiita kuti zvive nyore kuchengetedza kurapwa kwakagadzikana.

Zvisinei, kurapwa

Chiremba wako achatarisa kushanda kwemoyo wako nguva dzose paunenge uchitora tafamidis. Mushonga uyu hauwanzokanganisa mamwe mamiriro emoyo uye unogona kubatsira kuchengetedza kushanda kwemoyo nekudzivirira mamwe mapuroteni.

Ndingaita Sei Kana Ndakatora Tafamidis Yakawanda Netsaona?

Kana netsaona ukatora tafamidis yakawanda, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira. Kunyange zvazvo ruzivo rwekuwandisa rwakaganhurirwa nekuda kwekuti mushonga uyu mutsva, zvakakosha kuwana gwara rekurapa.

Usayedze kuzviita kurutsa kana kutora mamwe mishonga yekurwisa kuwandisa. Chengeta rekodhi rekuti wakatora mushonga wakawanda sei uye riini, sezvo ruzivo urwu ruchabatsira vanachiremba kuona nzira yakanakisisa yekutora.

Ndingaita Sei Kana Ndakakanganwa Dose yeTafamidis?

Kana ukakanganwa dose, itore paunorangarira, kunze kwekunge yava nguva yekuenda kune yako inotevera dose yakarongwa. Muchiitiko ichocho, skip dose yakakanganwa uye uenderere mberi nechirongwa chako chetsika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Kana iwe uchikanganwa madosi kazhinji, funga kuseta zviyeuchidzo zvefoni kana kushandisa chirongwa chemushonga kubatsira kuchengetedza kurapwa kwakagadzikana.

Ndingamira Rini Kutora Tafamidis?

Unofanira kungomira kutora tafamidis pasi pekutungamirirwa nachiremba wako. Sezvo iri kurapwa kwenguva refu kwechirwere chinofambira mberi, kumira kazhinji hakukurudzirwi kunze kwekunge uine mhedzisiro yakakomba kana mamiriro ako achichinja zvakanyanya.

Chiremba wako angangofunga kumira kana ukaita mamwe matambudziko ehutano anoita kuti kurapwa kuenderere mberi kusachengeteka, kana kana kuongorora nguva dzose kuchiratidza kuti mushonga hausi kupa mabhenefiti anodiwa kune mamiriro ako chaiwo.

Ndingatora Tafamidis nemimwe mishonga here?

Tafamidis kazhinji haina hukama hwakawanda nemimwe mishonga, zvichiita kuti ienderane nemishonga yakawanda yaungada yeimwe mamiriro. Zvisinei, gara uchizivisa chiremba wako nezve mishonga yese, zvinowedzerwa, uye zvigadzirwa zvemiti zvauri kutora.

Chiremba wako achatarisa runyorwa rwako rwemishonga kuti ave nechokwadi chekuti hapana hukama hunonetsa. Dzimwe mishonga dzinogona kuda kugadziriswa kwenguva kana kuchinjwa kwemadosi kuti ishande zvakanaka ne tafamidis.