Chii chinonzi Tafasitamab: Zvayakashandiswa, Mushonga, Zvazvinokonzeresa uye Zvimwe

Tafasitamab mushonga wekenza wakagadzirirwa zvakananga marudzi akati wandei ekenza yeropa. Mushonga uyu ndewemukirasi wemishonga inonzi monoclonal antibodies, iyo inoshanda semabhomba anotungamirirwa kuti atsvage uye kurwisa masero ekenza achisiya masero ane hutano akawanda ega.

Kana iwe kana mumwe munhu waunoda akanyorerwa tafasitamab, unogona kunge uine mibvunzo yakawanda pamusoro pezvaunotarisira. Mushonga uyu unomiririra kufambira mberi kwakakosha mukurapa kenza yeropa, uye kunzwisisa mashandiro awo kunogona kukubatsira kuti unzwe wakagadzirira rwendo rwako rwekurapa.

Chii chinonzi Tafasitamab?

Tafasitamab ndeye antibody yakagadzirwa murabhoritari iyo inotarisa protein yakati wandei inowanikwa pamasero ekenza. Funga nezvayo sechinhu chakakosha chinokodzera chete mukukiya kunowanikwa pamasero ekenza, ichibatsira immune system yako kuziva uye kuparadza masero aya anokuvadza zvakanyanya.

Mushonga uyu unopihwa kuburikidza neIV infusion, zvinoreva kuti unotumirwa zvakananga muropa rako kuburikidza nemuviri. Izvi zvinobvumira mushonga kuti ufambe mumuviri wako kuti usvike kumasero ekenza kwavanogona kunge vakavanda.

Tafasitamab inozivikanwawo nezita rayo rekuti Monjuvi. Zita rakazara remakemikari rinosanganisira "cxix" iyo inoreva nzira chaiyo iyo iyi vhezheni yemushonga inogadzirwa.

Chii chinonzi Tafasitamab chinoshandiswa?

Tafasitamab inobvumidzwa zvakananga kurapa rudzi rwekenza yeropa inonzi diffuse large B-cell lymphoma (DLBCL). Kenza iyi inokanganisa lymphatic system yako, iyo iri chikamu chemuviri wako chinorwisa hutachiona.

Chiremba wako anowanzo nyora mushonga uyu kana lymphoma yadzoka mushure mekurapwa kwapfuura kana isina kupindura zvakanaka kune mamwe marapirwo. Inowanzo shandiswa pamwe chete nemumwe mushonga unonzi lenalidomide kuti kurapwa kuve kunoshanda zvakanyanya.

Mushonga uyu wakagadzirirwa vanhu vakuru vane maseru ekenza anoongororwa zvakanaka kune protein inonzi CD19. Chikwata chako chekurapa chichaongorora zvakanyanya kuti chione kuti tafasitamab ndiyo sarudzo yakakodzera yerudzi rwako rwe lymphoma.

Maitiro Anoita Tafasitamab?

Tafasitamab inoshanda nekunamatira kune protein inonzi CD19 iyo iri pamusoro pemamwe maseru ekenza. Kana yanamatira, inotumira chiratidzo kuhurongwa hwako hwekudzivirira muviri kuti hurwise uye huparadze maseru aya.

Mushonga uyu unoonekwa semushonga wekenza une simba rakati rebei. Une simba rakakwana rekunangana nemaseru ekenza asi kazhinji inokonzera mashoma matambudziko akakomba kupfuura mishonga yechinyakare ye chemotherapy.

Kurapa kunoshanda nenzira mbiri huru. Chekutanga, inotadzisa zvakananga zviratidzo zvinobatsira maseru ekenza kurarama nekukura. Chechipiri, inokoka maseru ako echisikigo ekudzivirira muviri kuti ajoinhe kurwisa kenza.

Ndingatora Sei Tafasitamab?

Tafasitamab inopiwa chete kuburikidza neIV infusion panzvimbo yekurapa, saka hauzotore mushonga uyu kumba. Chikwata chako chehutano chichabata nekugadzirira kwese uye kutungamira iwe.

Usati wapiwa infusion yega yega, iwe unowanzo gamuchira pre-medications kubatsira kudzivirira maitiro ekuita allergic. Izvi zvinogona kusanganisira antihistamines, fever reducers, kana steroids. Chikwata chako chekurapa chichakutarisa zvakanyanya panguva uye mushure me infusion yega yega.

Haufaniri kutevera chero zvirambidzo zvakakosha zvekudya ne tafasitamab. Zvisinei, zvakakosha kuti ugare uine mvura yakawanda usati wapiwa uye mushure mekurapa kwako. Chikwata chako chehutano chinogona kupa gwara rakatarwa nezvekudya nekunwa pamazuva ekurapa.

Ndingatora Tafasitamab Kwenguva Yakareba Sei?

Nzira yekurapa inowanzoitwa ne tafasitamab inotora mwedzi inenge gumi nemiviri, kunyangwe izvi zvichigona kusiyana zvichienderana nekuti unopindura sei kumushonga. Chirongwa chako chekurapa chinogona kusanganisira infusions mumasvondo mashoma panguva ino.

Chiremba wako achagara achiongorora kufambira mberi kwako kuburikidza nemiedzo yeropa uye imaging scans. Izvi zvekutarisa zvinobatsira kuziva kana kurapwa kuri kushanda nemazvo uye kana kuchidikanwa kugadzirisa.

Sarudzo yekuramba kana kumisa kurapwa zvinoenderana nezvinhu zvakawanda, kusanganisira kuti gomarara rinopindura sei, mhedzisiro yaunowana, uye hutano hwako hwese. Chikwata chako chekurapa chichashanda pedyo newe kuti uite zvisarudzo izvi.

Ndezvipi Zvipingamupinyi zveTafasitamab?

Kufanana nemamwe marapirwo egomarara, tafasitamab inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Kunzwisisa zvekutarisira kunogona kukubatsira kugadzirira uye kuziva nguva yekubata chikwata chako chehutano.

Mhedzisiro inowanzoitika yaungasangana nayo inosanganisira kuneta, izvo zvinogona kubva pakuneta zvishoma kusvika pakuneta kukuru. Vanhu vazhinji vanoonawo shanduko muhuwandu hweropa ravo, izvo chikwata chako chekurapa chichatarisa zvakanyanya kuburikidza nemiedzo yeropa nguva dzose.

Heano mhedzisiro inowanzoziviswa:

• Kuneta uye kusimba
• Kuderera kwemasero machena eropa (kuwedzera njodzi yekutapukirwa)
• Kuderera kwemasero matsvuku eropa (anemia)
• Kuderera kwepletelet (kuchikanganisa kuumbwa kweropa)
• Dhayareya
• Kuderera kwechido
• Kukosora
• Fivha

Mhedzisiro iyi inowanzo manejwa nerutsigiro rwakakodzera rwekurapa uye kuongorora. Chikwata chako chehutano chine ruzivo rwekubatsira varwere kuburikidza nematambudziko aya.

Vamwe vanhu vanogona kusangana nemhedzisiro yakakomba asi isingawanzoitiki. Izvi zvinoda kutariswa kwekurapa nekukurumidza uye zvinosanganisira hutachiona hwakakomba, kubuda ropa kwakanyanya, kana maitiro akakomba ekugadzirisa panguva yekuiswa.

Mhedzisiro isingawanzoitiki asi yakakomba inogona kusanganisira:

• Zvirwere zvakakomba nekuda kwe immune system yakaremara
• Tumor lysis syndrome (kuparara nekukurumidza kwemasero ekenza)
• Maitiro akakomba ekuita allergic
• Progressive multifocal leukoencephalopathy (chirwere cheuropi chisingawanzoitiki)
• Hepatitis B reactivation muvanhu vakambobatwa nacho

Chikwata chako chekurapa chichatarisa zvakanyatsoona matambudziko aya asingawanzoitiki uye chichatora matanho ekuadzivirira pazvinogoneka. Usazeza kuzivisa chero zviratidzo zvisinganzwisisike, zvisinei kuti zvingaite sezvidiki sei.

Ndiani Asingafaniri Kutora Tafasitamab?

Tafasitamab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakachengeteka kwauri. Vanhu vane mamiriro ezvinhu akati kana mamiriro ehutano vanogona kudiwa kudzivisa mushonga uyu kana kuda kutariswa kwakakosha.

Haufaniri kugamuchira tafasitamab kana wakambove ne allergic reaction yakakomba kumushonga uyu kana chero zvikamu zvawo munguva yakapfuura. Chiremba wako achavawo akangwarira kana uine nhoroondo ye allergic reactions yakakomba kune mamwe ma monoclonal antibodies.

Chikwata chako chekurapa chichanyatso tarisa kana uine chero mamiriro aya:

• Zvirwere zviri kushanda, kunyanya zvirwere zvakakomba zvebhakitiriya, hutachiona, kana fungal
• Nhoroondo ye hepatitis B infection
• Immune system yakaremara zvakanyanya
• Kuzvitakura kana kuronga kuva nepamuviri
• Kuyamwisa
• Zvinodiwa zvejekiseni remararamiro

Kana wakazvitakura kana kuronga kuva nepamuviri, mushonga uyu unogona kukuvadza mwana wako ari kukura. Chikwata chako chekuchengetedza hutano chichakurukura nzira dzakachengeteka dzekudzivirira pamuviri uye sarudzo dzekuronga mhuri newe.

Zita reTafasitamab Brand

Tafasitamab inotengeswa pasi pezita rekuti Monjuvi muUnited States. Zita iri ndiro raunowanzoona pamarongero ako ekurapa uye mapepa e inishuwarenzi.

Mushonga uyu unogadzirwa neMorphoSys uye unotengeswa pamwe chete neIncyte Corporation. Paunenge uchikurukura nezvekurapa kwako nekambani dzeinishuwarenzi kana vamwe vanopa hutano, mazita ese ari maviri (tafasitamab uye Monjuvi) anoreva mushonga mumwe chete.

Zvimwe Zvingashandiswa Panzvimbo peTafasitamab

Pane dzimwe nzira dzakawanda dzekurapa lymphoma hombe yeB-cell, asi sarudzo yakanakisa inoenderana nemamiriro ako chaiwo. Chiremba wako achafunga zvinhu zvakaita sehutano hwako hwese, kurapwa kwawakaitwa kare, uye kuti kenza yako inopindura sei.

Kurapa kwakasiyana kungasanganisira kusanganiswa kwechemotherapy yechinyakare seR-CHOP kana mamwe marapirwo matsva akatarwa. CAR T-cell therapy inomiririra imwe sarudzo yepamusoro kune vamwe varwere, kunyangwe ichida nzvimbo dzekurapa dzakakosha.

Vamwe vanhu vangabatsirwa nekuedzwa kwekiriniki vachiedza kurapwa kutsva kwejekerere. Chiremba wako weoncologist anogona kukubatsira kunzwisisa kana chero zvidzidzo zvekutsvagisa zvakakodzera mamiriro ako.

Ko Tafasitamab Ari Nani Pane Rituximab?

Tafasitamab na rituximab ese ari maviri monoclonal antibodies anoshandiswa kurapa kenza yeropa, asi anoshanda nenzira dzakasiyana zvishoma uye anoshandiswa mumamiriro akasiyana. Kuenzanisa haisi nguva dzose yakatwasuka nekuti anowanzo shandiswa pazvikamu zvakasiyana zvekurapa.

Rituximab yanga iripo kwenguva refu uye inowanzo shandiswa sechikamu chekutanga-mutsara wekurapa kusanganiswa. Tafasitamab inowanzo chengeterwa mamiriro apo kenza yakadzoka kana isina kupindura zvakanaka kumishonga yekutanga.

Chiremba wako achasarudza mushonga wakakodzera zvichienderana nerudzi rwako rwe lymphoma, nhoroondo yako yekurapa, uye hutano hwako hwese. Mishonga yese iri miviri yakaratidza kushanda mukuita kwavo kwakatarwa, uye sarudzo

Tafasitamab inogona kushandiswa zvakachengeteka muvanhu vane chirwere chemoyo, asi chiremba wako wemoyo uye oncologist vachada kushanda pamwechete kuti vakutarise zvakanyatsonaka. Mushonga hauna kunangana zvakananga nenyama yemoyo, asi kurapwa kwekenza dzimwe nguva kunogona kukanganisa hutano hwemoyo nemitsipa yeropa.

Chikwata chako chekurapa chinogona kuita bvunzo dzekushanda kwemoyo usati watanga kurapwa uye kukutarisa mukati mekurapwa. Kana uine matambudziko makuru emoyo, vanogona kuchinja chirongwa chako chekurapa kana kupa mamwe matanho ekudzivirira moyo.

Ndingaita Sei Kana Ndikakanganwa Kuwana Tafasitamab Infusion?

Sezvo tafasitamab ichipiwa panzvimbo yekurapa, kukanganwa dose kazhinji kunoitika nekuda kwematambudziko ekuronga kana nyaya dzehutano. Bata chikwata chako chehutano nekukurumidza kana uchida kukanganwa kana kuronga zvakare musangano.

Chikwata chako chekurapa chichakubatsira kuronga zvakare nekukurumidza sezvazvinogona. Vanogona kuchinja chirongwa chako chekurapa zvishoma, asi zvakakosha kuti usapfuure madhizi pasina gwara rekurapa, sezvo izvi zvinogona kukanganisa kuti kurapwa kwako kunoshanda sei.

Ndingamira Rini Kutora Tafasitamab?

Sarudzo yekumisa tafasitamab inoenderana nekuti kenza yako inopindura sei kurapwa uye maitiro aunoita. Vanhu vazhinji vanopedzisa anenge mwedzi gumi nemiviri yekurapwa, asi izvi zvinogona kusiyana.

Chiremba wako achashandisa scans dzenguva dzose uye bvunzo dzeropa kuti atarise kufambira mberi kwako. Kana kenza ikanyangarika kana kusazivikanwa, unogona kupedzisa chirongwa chekurapa chakarongeka. Kana matambudziko akakomba akaitika, chiremba wako anogona kukurudzira kumisa nekukurumidza uye kuchinjira kune imwe nzira.

Ndingagamuchira Majekiseni Ndiri Kutora Tafasitamab Here?

Unofanira kudzivisa majekiseni mhenyu uchigamuchira tafasitamab nekuti mushonga unokanganisa immune system yako. Zvisinei, majekiseni asina basa (semujekiseni wefuru) anowanzo chengeteka uye anowanzo kurudzirwa.

Vashandi venyu vezveutano vachakupa gwara rakajeka pamusoro pemajekiseni api akachengeteka panguva yekurapwa kwenyu. Vanogona kukurudzira kuwana mamwe majekiseni musati matanga tafasitamab kana kumirira kusvikira mushonga wenyu wapedzwa.

Ko Tafasitamab Ichakanganisa Kugona Kwangu Kushanda Kana Kutyaira Here?

Vanhu vazhinji vanogona kuramba vachishanda nekutyaira vachigamuchira tafasitamab, kunyangwe iwe ungada kuita zvimwe zvigadziriso. Kuneta ndechimwe chezvinhu zvinowanzoitika zvinogona kukanganisa simba rako uye kufunga kwako.

Rongera kuchinja-chinja muchirongwa chako, kunyanya pamazuva ekurapa uye zuva mushure mekuiswa. Vamwe vanhu vanonzwa vaneta kwezuva kana maviri mushure mekurapa kwega kwega, nepo vamwe vachichengetedza simba ravo rakajairika mukati mekurapa.