Chii chinonzi Tagraxofusp-erzs: Zvinoshandiswa, Mishonga, Migumisiro, nezvimwe

Tagraxofusp-erzs mushonga wekenza unotariswa uyo unobatsira kurwisa kenza yeropa isingawanzoitiki inonzi blastic plasmacytoid dendritic cell neoplasm (BPDCN). Kurapa uku kwakakosha kunoshanda nekunamatira kumapuroteni akati wandei pamaseru ekenza uye kuendesa chepfu inovauraya kubva mukati. Yakagadzirirwa vanhu vakuru nevana vane rudzi urwu rwekenza yeropa, ichipa tariro kana dzimwe nzira dzekurapa dzisingakodzeri.

Chii chinonzi Tagraxofusp-erzs?

Tagraxofusp-erzs mushonga wekenza unopiwa nachiremba uyo unosanganisa zvikamu zviviri zvine simba kurwisa maseru ekenza. Chikamu chekutanga chinoita semutsvaki akatungamirirwa, achitsvaga uye kunamatira kumapuroteni akati wandei anonzi CD123 receptors pamaseru ekenza. Chikamu chechipiri chinoendesa chepfu inoparadza maseru aya akatarwa ichisiya maseru ane hutano asina kukuvadzwa zvakanyanya.

Mishonga iyi ndeyeboka remishonga inonzi CD123-directed cytotoxins. Funga nezvayo sebhomba rakapinza rinogona kusiyanisa pakati pemasero ane hutano nemasero ekenza. Mushonga uyu unopihwa kuburikidza neIV infusion, zvichiita kuti ufambe mumuviri wako kuti usvike kumasero ekenza kwavanogona kuvanza.

Vashandi vehutano vako vachagadzirira uye kupa mushonga uyu munzvimbo yekurapa kwaunogona kunyatsotariswa. Iyi nzira yekuchenjerera inobatsira kuona kuchengeteka kwako uye inobvumira mhinduro nekukasira kana chero migumisiro ikaitika panguva yekurapa.

Chii chinonzi Tagraxofusp-erzs chinoshandiswa?

Tagraxofusp-erzs inobvumirwa zvakanyanya kurapa blastic plasmacytoid dendritic cell neoplasm (BPDCN) muvanhu vakuru nevana vane makore maviri zvichikwira. BPDCN ikenza yeropa isingawanzoitiki uye ine hasha inokanganisa maseru akakosha ekudzivirira muviri anonzi plasmacytoid dendritic cells.

Kenza iyi inowanzoonekwa semavanga paganda, ma lymph nodes akazvimba, kana kukanganisa muviri wemapfupa neropa. Nekuti BPDCN haina kuwanda, ichikanganisa vanhu vashoma kudarika 1 kubva pa100,000, pakanga pasina nzira dzakawanda dzekurapa dziripo vasati vagadzira mushonga uyu.

Chiremba wako anogona kukurudzira kurapwa uku kana wakaongororwa uine BPDCN uye mamwe marapirwo asina kushanda kana kusakodzera mamiriro ako. Mushonga uyu wakaratidza kuvimbisa mumiedzo yekiriniki, nevakawanda varwere vachiona kuvandudzwa kukuru muzviratidzo zvavo zvekenza.

Tagraxofusp-erzs Inoshanda Sei?

Tagraxofusp-erzs inoshanda kuburikidza nemaitiro maviri akadzama anovavarira maseru ekenza nekururama kunoshamisa. Mushonga uyu wakagadzirirwa kutsvaga uye kubatanidza kune CD123 receptors, izvo zvinowanikwa muhuwandu hukuru pamasero ekenza eBPDCN asi hazviwanzoitika pamasero ane hutano.

Kana mushonga wabatanidzwa kune aya ma receptors, sero rekenza rinobatsira chaizvo maitiro acho nekukwevera mushonga mukati kuburikidza nemaitiro echisikigo anonzi endocytosis. Funga nezvazvo sekunge sero rekenza risingazivi richivhura gonhi rayo kuti rirege mushonga uchienda mukati.

Mukati mesero rekenza, mushonga unoburitsa mutoro wayo une chepfu, iyo inokanganisa kugona kwesero kugadzira mapuroteni akakosha kurarama. Izvi zvinotungamira kurufu rwesero rekenza uku uchideredza kukuvadzwa kumasero ane hutano asina ma CD123 receptors akawanda.

Nzira iyi inotarwa inoonekwa seyakasimba uye inoshanda yeBPDCN, kunyangwe ichigona kukonzera migumisiro yakakomba nekuti mamwe masero ane hutano zvakare ane CD123 receptors, kunyanya muchiropa nemidzi yeropa.

Ndingatora Sei Tagraxofusp-erzs?

Tagraxofusp-erzs inopiwa se intravenous (IV) infusion zvakananga muropa rako panzvimbo yekurapa. Hauzive kutora mushonga uyu kumba, uye unofanirwa kugadzirirwa uye kupihwa nevanachiremba vakadzidziswa vanonyanya kurapa kenza.

Nzira yekurapa inowanzoitika inosanganisira kugamuchira mushonga kamwe chete pazuva kwemazuva mashanu ekutanga e21-day cycle. Chikwata chako chehutano chichaisa IV line mutsinga muruoko rwako kana kuburikidza necentral line kana uine imwe. Infusion inowanzo tora maminitsi gumi nemashanu kuti apedze.

Usati wapiwa infusion yega yega, uchagamuchira pre-medications kubatsira kudzivirira allergic reactions nemamwe mativi. Izvi zvinogona kusanganisira antihistamines, corticosteroids, uye fever reducers. Chikwata chako chekurapa chichatarisa zviratidzo zvako zvakakosha zvakanyanya panguva uye mushure mekuiswa.

Haufaniri kunetseka nezve zvirambidzo zvekudya usati wapiwa kurapwa kwako, asi kugara uine mvura yakawanda kwakakosha. Chikwata chako chehutano chinogona kukurudzira kunwa mvura yakawanda mumazuva anotungamira kurapwa kwako kubatsira itsvo dzako kugadzirisa mushonga nemazvo.

Ndingatora Tagraxofusp-erzs kwenguva yakareba sei?

Kureba kwekurapa kwako tagraxofusp-erzs kunoenderana nekuti kenza yako inopindura sei uye kuti unotsungirira sei mushonga. Varwere vazhinji vanogamuchira akawanda cycles ekurapa, ne cycle yega yega inogara mazuva makumi maviri nerimwe uye inosanganisira mazuva mashanu ekutonga chaiko kwemishonga.

Chiremba wako achatarisa kenza yako nguva dzose kuburikidza nemiedzo yeropa, zvidzidzo zvekufungidzira, uye kuongororwa kwemuviri kuti aone kana kurapwa kuri kushanda. Kana kenza yako ichipindura zvakanaka uye uchitsungirira mushonga usina mativi akakomba, unogona kuramba uchirapwa kwemakore akati wandei.

Vamwe varwere vanogona kuwana remission mushure me cycles mashoma, nepo vamwe vangada kurapwa kwenguva refu. Chikwata chako chehutano chichashanda newe kuti uwane chiyero chakakodzera pakati pekurwisa kenza yako nemazvo uye kuchengetedza hupenyu hwako.

Sarudzo dzekurapa dzakanyanya kuita munhu mumwe nemumwe, uye chiremba wako achafunga nezvezvinhu zvakaita sehutano hwako hwese, kupindura kenza, uye chero mativi aunowana paunenge uchisarudza kuti ungaita sei kurapwa kwenguva yakareba sei.

Ndezvipi Zvipingamupinyi zveTagraxofusp-erzs?

Tagraxofusp-erzs inogona kukonzera zvipingamupinyi zvakasiyana, kubva pakureruka kusvika pakukomba, nekuti mushonga unokanganisa kwete maseru ekenza chete asiwo mamwe maseru ane hutano ane CD123 receptors. Kunzwisisa izvi zvinogona kukonzera zvinogona kukubatsira iwe nechikwata chako chehutano kuzvigadzirisa nemazvo.

Zvipingamupinyi zvakajairika zvaungasangana nazvo zvinosanganisira kuneta, kusvotwa, fivha, uye kuzvimba mumaoko ako, makumbo, kana kumeso. Varwere vazhinji vanogadzirawo maitiro eganda, shanduko mumiedzo yekushanda kwechiropa, uye kuverenga ropa kwakaderera kunogona kuwedzera njodzi yako yekutapukirwa kana kubuda ropa.

Zvipingamupinyi Zvakajairika

Heano zvipingamupinyi zvinoitika muvarwere vazhinji vanogamuchira mushonga uyu, kunyangwe kwete munhu wese achazviona zvese:

• Kuneta nekushaya simba zvinogona kukanganisa mabasa ezuva nezuva
• Kusvotwa nekurutsa, izvo zvinowanzoitwa nemishonga inorwisa kusvotwa
• Fivha nekutonhora, kunyanya mushure memadosi mashoma ekutanga
• Kuzvimba (edema) mumaoko, tsoka, makumbo, kana kumeso nekuda kwekuchengetwa kwemvura
• Maitiro eganda anosanganisira rash, kukwenya, kana ganda rakaoma
• Shanduko mumiedzo yekushanda kwechiropa, iyo chiremba wako achazvitarisa zvakanyanya
• Kuverenga maseru eropa akaderera achikanganisa maseru machena eropa, maseru matsvuku eropa, kana maplatelet
• Kurwadziwa nemusoro nekutinhira
• Kurasikirwa nechido uye shanduko yehuremu

Izvi zvipingamupinyi zvakajairika zvinowanzoitwa nekuchengetwa kunotsigira uye mishonga. Chikwata chako chehutano chichashanda newe kuderedza kukanganisa kwavo pahupenyu hwako hwezuva nezuva.

Zvipingamupinyi Zvakakomba

Kunyangwe zvisingawanzoitiki, vamwe varwere vanogona kusangana nezvipingamupinyi zvakakomba zvinoda kutariswa kwekurapa nekukurumidza uye kutariswa kwakanyanya:

• Chirwere chekudonha kwemvura mumidziyo yeropa, chinokonzera mvura kubva mumidziyo yeropa ichipinda munyama dzakapoteredza
• Matambudziko makuru echiropa anogona kuva anotyisa kana asina kurapwa nekukurumidza
• Zvirwere zvakakomba nekuda kwehuwandu hushoma hwemasero machena eropa
• Maitiro makuru ekuita allergic panguva kana nguva pfupi mushure mekuiswa
• Tumor lysis syndrome, uko masero ekenza anoparara nekukurumidza
• Kuchengetwa kwemvura kwakanyanya kunokanganisa basa remoyo kana mapapu
• Hemophagocytic lymphohistiocytosis, maitiro asingawanzoitiki asi akakomba emuviri wekudzivirira chirwere

Chikwata chako chekurapa chichakutarisa zvakanyanya kuti uone izvi zvinokonzera matambudziko uye chichamisa kurapwa kana zvichidikanwa kuchengetedza hutano hwako. Zvizhinji zvezvinhu izvi zvinogadziriswa nekutarisirwa kwakakodzera kwekurapa.

Zvisingawanzoitiki asi Zvakakosha Zvinokonzera Matambudziko

Vamwe varwere vanogona kusangana nezvinhu zvisingawanzoitiki zvinokonzera matambudziko, asi zvisingawanzoitiki, zvakakosha kuziva:

• Zvinokanganisa zvakanyanya zvepfungwa zvinosanganisira kuvhiringidzika, kubatwa, kana shanduko mumamiriro epfungwa
• Matambudziko emoyo anosanganisira kurova kwemoyo kusingaite kana mvura yakatenderedza moyo
• Matambudziko akakomba eitsvo anoda dialysis
• Zvirwere zvekuumbwa kweropa zvinogona kukonzera magwamba ane njodzi kana kubuda ropa
• Kusagadzikana kwakanyanya kweelectrolyte kunokanganisa basa remhasuru nemitsipa
• Kuzvimba kwepancreas (pancreatitis) kunokonzera kurwadziwa kwakanyanya mudumbu

Izvi zvisingawanzoitiki zvinoda kutarisirwa kwekurapa nekukurumidza uye zvinogona kukonzera kupinda muchipatara kuti utarise zvakanyanya uye kurapwa.

Ndiani Asingafaniri Kutora Tagraxofusp-erzs?

Tagraxofusp-erzs haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana kurapwa uku kuri kwakachengeteka kwauri. Vanhu vane mamiriro ezvinhu ekurapa kana mamiriro ezvinhu havangave vakakodzera mushonga uyu.

Haufaniri kupihwa mushonga uyu kana muchiziva kuti mune allergy ku tagraxofusp-erzs kana chero chimwe chezvinhu zvayo. Chiremba wenyu achatarisawo hutano hwenyu hwese, kusanganisira basa remoyo, chiropa, uye itsvo, asati akurudzira kurapwa uku.

Varwere vane chirwere chechiropa chakakomba vangasagona kupihwa mushonga uyu zvakachengeteka nekuti unogona kuwedzera matambudziko echiropa. Saizvozvowo, vanhu vane matambudziko emoyo akakomba vangave vari panjodzi yakakura yematambudziko kubva mukuchengetwa kwemvura uye mamwe maitiro emoyo nemitsipa.

Vakadzi vane pamuviri havafaniri kupihwa tagraxofusp-erzs nekuti inogona kukuvadza mwana ari kukura. Kana muri pazera rekubereka vana, chiremba wenyu achakurukura nzira dzinoshanda dzekudzivirira pamuviri dzekushandisa panguva yekurapa uye kwemwedzi yakati wandei mushure meizvozvo.

Zita reBrand reTagraxofusp-erzs

Tagraxofusp-erzs inotengeswa pasi pezita rebrand rekuti Elzonris. Zita rebrand iri rinoshandiswa muUnited States nedzimwe nyika uko mushonga wakabvumirwa kurapa BPDCN.

Pamakagamuchira kurapwa kwenyu, mungawana zita rimwe chete pamarekodhi enyu ekurapa kana magwaro einishuwarenzi. Mazita ese ari maviri anoreva mushonga mumwe chete, saka musavhiringike kana muona mazita akasiyana achishandiswa munzvimbo dzakasiyana.

Elzonris inogadzirwa neStemline Therapeutics uye inowanikwa chete kuburikidza nenzvimbo dzakakosha dzekurapa gomarara nezvipatara zvine ruzivo nerudzi urwu rwekurapa kwakanangana.

Zvimwe zvingashandiswa panzvimbo peTagraxofusp-erzs

Nekuti BPDCN igomarara risingawanzoitiki, pane kurapwa kushoma kunowanikwa. Tagraxofusp-erzs isati yabvumidzwa, vanachiremba vaiwanzoshandisa musanganiswa wemishonga yechemotherapy yakafanana neiyo inoshandiswa kune mamwe magomarara eropa.

Maitiro echinyakare echemotherapy anogona kusanganisira musanganiswa wemishonga yakaita se cyclophosphamide, doxorubicin, vincristine, uye prednisone. Zvisinei, kurapwa uku kazhinji hakuna kushanda zvakanaka kurwisa BPDCN uye kunogona kukonzera matambudziko akakomba.

Kune varwere vamwe, kutapurirwa kwemasero emuti kungafungwa, kunyanya kana vakawana remission nekutanga kurapwa. Iyi nzira yakanyanya inosanganisira kutsiva mupfupa wemarwadzo nemasero ane hutano kubva kumupi.

Miedzo yekiriniki inogonawo kupa mukana wekurapa kwechiyero kuri kudzidzwa kweBPDCN. Oncologist wako anogona kukubatsira kuongorora zvese zvingasarudzwa uye kuona nzira yakanakisa yemamiriro ako chaiwo.

Ko Tagraxofusp-erzs Zviri Nani Kupfuura Zvimwe Zvirwere?

Tagraxofusp-erzs inomiririra kufambira mberi kukuru mukurapa BPDCN ichienzaniswa nenzira dzechinyakare dzekemotheraphy. Miedzo yekiriniki yakaratidza kuti iyi terapi yakatarwa inogona kushanda zvakanyanya kupfuura kurapwa kwechinyakare kune varwere vazhinji vane gomarara iri risina kujairika.

Nzira yakatarwa yemushonga inoreva kuti inogona kurwisa masero egomarara zvakanyanya nepo ichikonzera mashoma emhedzisiro yakakomba inobatanidzwa nekemotheraphy yakafara. Izvi zvinogona kutungamira kumigumisiro iri nani uye kuvandudzwa kwemhando yehupenyu kune varwere vazhinji.

Zvisinei,

Chiremba wako achayedza mashandiro echiropa chako usati watanga kurapwa uye achienderera mberi nekutarisa mukati mekurapa kwako kwese. Kana uine matambudziko echiropa akapfava, unogona kunge uchikwanisa kugamuchira mushonga nekuchenjerera uye pamwe nekugadzirisa muyero.

Vanhu vane chirwere chechiropa chakakomba havawanzoita vakwikwidzi vekurapwa uku nekuti njodzi dzinogona kukunda mabhenefiti. Chikwata chako chehutano chichashanda newe kuti uwane nzira yekurapa yakachengeteka uye inoshanda zvakanyanya yemamiriro ako ezvinhu.

Mubvunzo 2. Ndoitei Kana Ndichiwana Zvinhu Zvakaipa Zvikuru?

Kana uine zvinhu zvakaipa zvakanyanya sekufema zvakaoma, kuzvimba kwakanyanya, kurwadziwa kwakanyanya mudumbu, kana shanduko mumamiriro epfungwa, unofanirwa kutsvaga rubatsiro rwekurapa nekukasira. Usamirira kuti uone kana zviratidzo zvichivandudzika zvega.

Bata chikwata chako chehutano nekukasira kana uine fivha, zviratidzo zveutachiona, kubuda ropa kusinganzwisisike kana kupwanya, kana kuneta kwakanyanya kunokutadzisa kuita mabasa ezuva nezuva. Izvi zvinogona kunge zviri zviratidzo zvematambudziko akakomba anoda kurapwa nekukurumidza.

Chikwata chako chekurapa chine ruzivo rwekutarisira zvinhu zvakaipa zvekurapa uku uye chinogona kupa kurapwa kuti ikubatsire kunzwa zviri nani. Vanogona kugadzirisa chirongwa chako chemushonga, kupa rutsigiro rwekutarisira, kana kumbomisa kurapwa kana zvichidikanwa.

Chengeta runyorwa rwenhamba dzekukurumidzira kubva kuchikwata chako chehutano uye ziva chipatara kana nzvimbo yekurapa yekuenda kana uchida kutarisirwa nekukasira kunze kwemaawa emahofisi enguva dzose.

Mubvunzo 3. Ndichaziva sei Kana Kurapwa Kuchishanda?

Chiremba wako achatarisa mhinduro yako kune tagraxofusp-erzs kuburikidza nekuongororwa kweropa nguva dzose, kuongororwa kwemuviri, uye zvidzidzo zvekufungidzira. Unogona kutanga kuona kuvandudzwa muzviratidzo zvakaita sekuneta, maronda paganda, kana ma lymph nodes akazvimba mukati memavhiki mashoma ekutanga ekurapa.

Miedzo yeropa icharatidza shanduko mumaseru ekenza uye nhamba yeropa rose, nepo zvidzidzo zvekuongorora zvakadai seCT scans kana PET scans zvinogona kuratidza kana tumor dziri kudzikira. Chiremba wako achatsanangura zvinoratidzwa nemiedzo iyi uye zvinoreva chii chirongwa chako chekurapa.

Vamwe varwere vanogona kunzwa vachirwara pakutanga sezvo maseru avo ekenza achiparadzwa, izvo zvinogona kuwedzera zvimwe zvinokonzeresa kwenguva pfupi. Izvi hazvirevi kuti kurapwa hakushandi, asi timu yako yehutano ichakubatsira kunzwisisa zvaunotarisira.

Mhinduro yekurapa inogona kusiyana zvakanyanya pakati pevarwere, uye zvinogona kutora akati wandei matenderedzwa usati iwe nachiremba wako vagona kuongorora zvizere kuti mushonga uri kushanda sei kwauri.

Q4. Ndingaramba ndichiita mabasa angu enguva dzose panguva yekurapa here?

Varwere vazhinji vanogona kuramba vachiita zvimwe zviitiko zvenguva dzose panguva yekurapa, kunyangwe iwe uchizofanira kugadzirisa zvichienderana nekuti unonzwa sei uye nemigumisiro yako. Kuneta kwakajairika, saka ungangoda kuzorora zvakanyanya kupfuura zvakajairika uye kumhanyisa zviitiko zvako.

Unofanira kudzivisa nzvimbo dzakazara uye vanhu vanorwara nekuti mushonga uyu unogona kuderedza nhamba yako yeropa chena, zvichiita kuti ugone kutapukirwa nezvirwere. Chikwata chako chehutano chichapa nhungamiro dzakakosha nezvekuti zvakachengeteka riini kuva nevamwe.

Kurovedza muviri zvishoma senge kufamba kunogona kubatsira kana uchinzwa uchikwanisa, asi dzivisa zviitiko zvakanyanya zvinogona kuwedzera njodzi yako yekukuvara, kunyanya kana nhamba yako yeplatelet yakaderera. Kushambira mumadziva eruzhinji kunofanira kudziviswa nekuda kwenjodzi yekutapukirwa.

Taura nechikwata chako chehutano nezvebasa rako, zvirongwa zvekufamba, uye zvimwe zviitiko. Vanogona kukubatsira kuita zvisarudzo zvine ruzivo nezvekuti chii chakachengeteka uye chakakodzera panguva yako yekurapa.

Q5. Ndingada kugara muchipatara panguva yekurapa here?

Vanhu vazhinji vanogamuchira tagraxofusp-erzs sekurapwa kwekunze, zvinoreva kuti unogona kuenda kumba pazuva rimwechete mushure mekuiswa kwega kwega. Zvisinei, kurapwa kwako kwekutanga kuchada kutariswa zvakanyanya, uye unogona kuda kugara panzvimbo yekurapa kwemaawa akati wandei mushure mekuiswa kwega kwega.

Vamwe varwere vanogona kuda kupinda muchipatara, kunyanya kana vakawana matambudziko akakomba akadai se capillary leak syndrome kana matambudziko akakomba echiropa. Chikwata chako chehutano chichasarudza nzvimbo yakachengeteka yekurapwa kwako zvichienderana nezvinhu zvako zverisiko.

Kana iwe uchigara kure nenzvimbo yekurapa, chiremba wako angakurudzira kugara pedyo panguva yekurapwa kwako kuti ugone kuwana rubatsiro nekukurumidza kana zvichidikanwa. Nzvimbo zhinji dzekenza dzinogona kupa ruzivo nezve nzvimbo dzekugara dzevarwere nemhuri.

Chikwata chako chekurapa chichakurukura chirongwa chekutarisa newe uye kukubatsira kunzwisisa zvekutarisira panguva uye mushure mechikamu chega chega chekurapa. Vachapawo mirairo yakajeka yekuti ungatsvaga riini kutariswa kwekurapa nekukurumidza.