Chii chinonzi Tavaborole: Kushandiswa, Madosi, Migumisiro Yemativi uye Zvimwe

Tavaborole mushonga we antifungal we topical unovhura zvirwere zvefungus yezvipikiri, kunyanya onychomycosis. Inoshanda zvakasiyana kubva kune dzimwe nzira dzekurapa antifungal nekudzivisa imwe enzyme iyo fungus inoda kuti ipone uye ikure. Uyu mushonga wemishonga unouya semhinduro yakajeka yaunonyora zvakananga kuzvitsoka zvakakanganiswa kamwe pazuva kwemavhiki makumi mana nemasere.

Chii chinonzi Tavaborole?

Tavaborole mushonga we antifungal wemishonga wakagadzirirwa zvakananga zvirwere zvefungus yezvitsoka. Iyo ndeyemukirasi yakasiyana yemishonga ye antifungal inonzi boron-based inhibitors, iyo inoita kuti isiyane kubva kune zvakajairika antifungal kurapwa.

Mushonga unotarisa zvirwere zvefungal padanho re cellular nekukanganisa kugadzirwa kweprotein mumaseru efungal. Iyi nzira inobatsira kubvisa hutachiona ichibvumira tishu yezvipikiri ine hutano kuti ikure zvakare nekufamba kwenguva.

Tavaborole itsva zvishoma kana ichienzaniswa nedzimwe nzira dzekurapa antifungal, yakabvumidzwa neFDA muna 2014. Inopa imwe nzira yevanhu vasina kupindura zvakanaka kune dzimwe nzira dzekurapa antifungal kana vasingade kutora zvinodhaka zvemuromo antifungal.

Chii chinonzi Tavaborole chinoshandiswa?

Tavaborole inorapa onychomycosis, inozivikanwa zvakajairika sefungus yezvitsoka kana chirwere chefungus yezvipikiri. Iyi mamiriro anoita kuti zvipikiri zviwedzere kukora, kushatisa, kuoma, uye dzimwe nguva kurwadza.

Mushonga unoshanda zvakanyanya pazvirwere zvefungus yezvipikiri zvakapfava kusvika pakati nepakati izvo zvisina kupararira kunzvimbo yezvipikiri (nzvimbo iyo kukura kwezvipikiri kunotanga). Inonyanya kushanda kana hutachiona huchikanganisa isingasviki 50% yenzvimbo yezvipikiri.

Chiremba wako angakurudzira tavaborole kana uine zvirwere zvefungus yezvipikiri zvinodzoka kana kana dzimwe nzira dzekurapa topical dzisina kushanda zvakanaka. Inofungidzirwawo kana mishonga ye antifungal yemumuromo isina kukodzera nekuda kwekusangana kwemishonga kana kunetseka kwechiropa.

Tavaborole inoshanda sei?

Tavaborole inoshanda nekudzivisa enzyme inonzi leucyl-tRNA synthetase, iyo masero efungi anoda kugadzira mapuroteni akakosha kuti ararame. Iyi inzira yekurwisa fungal ine simba repakati iyo inonyanya kutarisana nemasero efungi pasina kukanganisa zvakanyanya masero evanhu.

Mushonga unopinda nepakati peplate yezvipikiri kuti usvike panzvimbo yekutapukirwa pasi pechipikiri. Kana yasvika ipapo, inokanganisa kugona kwefungus kuzvibereka nekuzvichengeta, ichibvisa zvishoma nezvishoma hutachiona kwemwedzi yakati wandei.

Kusiyana nemamwe maantifungals akasimba emusystemic, tavaborole inoshanda munzvimbo yekuisa. Iyi nzira yakatarwa inoreva mashoma mativi emuviri wako uchiri kupa kurapwa kunoshanda kunzvimbo yakatapurwa.

Ndingatora sei Tavaborole?

Isa tavaborole kamwe chete pazuva kuzvitsipa zvakachena, zvakaoma, zvichinyanya panguva imwe chete zuva rega rega. Haufanirwe kuitora nechikafu kana mukaka sezvo ichiiswa pamusoro panzvimbo yekumedzwa.

Usati waisa, geza maoko ako netsoka zvakakwana nesipo nemvura, wobva waomesa zvachose. Isa rukoko rutete rwemhinduro pamusoro pechipikiri chose, kusanganisira mubhedha wechipikiri uye pasi pechipikiri kana zvichibvira.

Regai mushonga uome zvachose usati waisa masokisi kana shangu, izvo zvinowanzo tora maminitsi 2-3. Dzivisa kugeza nzvimbo yakabatwa kwemaawa angangoita 6 mushure mekuisa kuti ubvumire kunyudzwa kwakakodzera.

Unogona kudya zvakajairika sezvo uyu uri mushonga wepamusoro, asi dzivisa kuwana mhinduro paganda rine hutano rakakomberedza chipikiri zvakanyanya sezvinobvira. Kana ukawana imwe paganda rakapoteredza, kazhinji haina kukuvadza asi inogona kukonzera kutsamwa kudiki.

Ndingatora Tavaborole kwenguva yakareba sei?

Vanhu vazhinji vanoda kushandisa tavaborole kwemavhiki makumi mana nemasere (anenge gore rimwe) kuti vaone mhedzisiro yakazara. Iyi nguva yekurapa yakawedzerwa inodiwa nekuti zvitsipa zvinokura zvishoma nezvishoma, uye zvinotora nguva kuti chipikiri chine hutano chitsive zvikamu zvakatapukirwa.

Ungatanga kuona kuvandudzika pakuonekwa kwenzara mushure memavhiki makumi maviri nemana, asi zvakakosha kuti uenderere mberi nekurapa kwenguva yakatarwa. Kumira nekukurumidza kunowanzoita kuti hutachiona hudzoke nekuti fungus inogona kunge ichiripo munyama yenzara inoita seyakanaka.

Chiremba wako achatarisa kufambira mberi kwako panguva yekurapa uye anogona kuchinja nguva zvichienderana nekuti nzara dzako dzinopindura sei. Vamwe vanhu vane hutachiona hwakanyanya vangangoda kurapwa kupfuura mavhiki makumi mana nemasere, nepo vamwe vane nyaya dzakapfava vangangona kuona kubviswa kwakakwana nekukurumidza.

Ndezvipi Zvakaipa zveTavaborole?

Vanhu vazhinji vanotsungirira tavaborole zvakanaka, nemigumisiro iri nyoro uye inongogumira kunzvimbo yekushandisa. Migumisiro inowanzoitika inokanganisa ganda nenzara kwaunoshandisa mushonga.

Heano migumisiro yaungasangana nayo, uchiziva kuti yakawanda inguva pfupi uye inogoneka:

• Kutsamwa kweganda kana kutsvuka kutenderedza nzara yakarapiwa
• Kupisa kudiki kana kunzwa kunobaya kana kutanga kushandiswa
• Ganda rakaoma kana kupepuka pedyo nenzvimbo yekushandisa
• Kushanduka kwenguva pfupi kwenzara kana shanduko mumagadzirirwo enzara
• Kuzvimba kudiki kwemunwe kana nyama yakatenderedza

Izvi zviito zvinowanzoita zviri nani sezvo ganda rako rinogadzirisa kumushonga mumavhiki mashoma ekutanga ekurapa.

Migumisiro isingawanzoitiki asi yakakomba inogona kuitika kune vamwe vanhu, kunyangwe izvi zvinokanganisa vashandisi vashoma vanopfuura 1%:

• Kutsamwa kwakanyanya kwemuviri nemavanga akapararira kana kuoma kufema
• Kupisa kunoramba kuripo kana kurwadziwa kunowedzera nekufamba kwenguva
• Zviratidzo zvehutachiona hwehutachiona hwechipiri (kuwedzera kutsvuka, kudziya, pus)
• Kuparadzana kwenzara kubva pamubhedha wenzara (onycholysis)
• Kutsvukisa kweganda kwakanyanya kana ulceration

Kana iwe ukasangana nechero zviito zvakakomba, taura nemupi wako wehutano nekukasira sezvo izvi zvingangoda kumisa mushonga kana kurapwa kwakawedzerwa.

Ndiani Asingafaniri Kutora Tavaborole?

Tavaborole haikodzeri munhu wese, uye mamwe mamiriro anoita kuti zvisakodzere kana kuda matanho chaiwo. Vanhu vane allergy inozivikanwa ku tavaborole kana chero zvimwe zvisingashandi zvinoshandiswa vanofanira kudzivisa mushonga uyu.

Unofanira kukurukura dzimwe nzira nachiremba wako kana uine kukuvadzwa kwakanyanya kwembambo kana zvirwere zvinobatanidza kupfuura 50% yenzvimbo yembambo. Mushonga unoshanda zvakanyanya pazvirwere zvishoma kusvika pakati nepakati uye unogona kusashanda pazviitiko zvepamberi.

Vanhu vane immune systems yakakanganiswa, senge avo vane chirwere cheshuga, HIV, kana kutora mishonga inodzvinyirira immune system, vanogona kuda kuongororwa zvakanyanya panguva yekurapa. Kunyange zvisingatenderwi kushandisa, mamiriro aya anogona kukanganisa kupora uye kuwedzera njodzi dzezvirwere.

Vakadzi vane pamuviri uye vanoyamwisa vanofanira kushandisa tavaborole chete kana mabhenefiti achipfuura njodzi dzinogona kuitika. Data shoma iripo pakuita kwayo kuchengeteka panguva yekuzvitakura, saka chiremba wako achanyatso kuyera mamiriro ako chaiwo.

Zita reBrand reTavaborole

Tavaborole inotengeswa pasi pezita rebrand Kerydin muUnited States. Iri ndiro chete brand inobvumidzwa neFDA ine tavaborole seactive ingredient.

Kerydin inogadzirwa neAnacor Pharmaceuticals (zvino chikamu chePfizer) uye inouya semhinduro ye5% topical mubhodhoro rine bhurashi rekuisa. Iyo brand name formulation ndiyo yakadzidzwa mumiedzo yekiriniki uye yakabvumidzwa kurapa fungus yechitsitsinho.

Mhando dzegeneric dze tavaborole hadzisati dzichiwanzowanikwa, saka mazhinji mapepa achazadzwa nezita rebrand Kerydin. Inishuwarenzi yako inogona kusiyana yemishonga yezita rebrand, saka tarisa nemupi wako nezve sarudzo dzekuvhara.

Zvimwe Zvinhu zveTavaborole

Kurapa kwakawanda kwakasiyana kunowanikwa kune fungus yechitsitsinho kana tavaborole isingakodzere kana isingashande kwauri. Izvi zvinosanganisira mamwe maantifungals epamusoro, mishonga yemuromo, uye kurapwa kweprocedural.

Dzimwe nzira dzemishonga inorwisa fungal dzinosanganisira ciclopirox (Penlac), efinaconazole (Jublia), uye amorolfine (isipo muUS). Izvi zvinoshanda nemaitiro akasiyana uye zvinogona kushanda kana tavaborole isingashandi.

Mishonga yekurwisa fungal yemuromo yakaita se terbinafine (Lamisil) kana itraconazole (Sporanox) ndiyo mhinduro dzine simba rekuti zvirwere zvakanyanya. Zvisinei, zvinotakura njodzi huru dzemigumisiro uye kusangana kwemishonga zvichienzaniswa nemishonga yepamusoro.

Kurapa kutsva kunosanganisira laser therapy, photodynamic therapy, uye kubviswa kwezvipikiri zvekushanda mumamiriro ezvinhu akakomba. Chiremba wako anogona kubatsira kuona kuti ndeipi imwe nzira ingashanda zvakanaka zvichienderana nehutachiona hwako chaihwo uye mamiriro ehutano.

Ko Tavaborole Zviri Nani Pane Ciclopirox?

Ose ari maviri tavaborole uye ciclopirox mishonga inoshanda yekurwisa fungal, asi anoshanda nemaitiro akasiyana uye ane zvakanakira zvakasiyana. Tavaborole inogona kushanda zvakanyanya kune vamwe vanhu nekuda kwechiito chayo chakasiyana chekuvhara enzyme.

Zvidzidzo zvekiriniki zvinoratidza kuti tavaborole inowana mitengo yekuporeswa yakazara yeanenge 6-9% ichienzaniswa neiyo ciclopirox's 5-8% rate. Kunyange zvazvo musiyano uyu uchioneka muduku, maitiro matsva ekuita a tavaborole anogona kushanda zviri nani kune zvirwere zvinodzivisa mishonga yekurwisa fungal yechinyakare.

Ciclopirox inoda kushandiswa zuva nezuva nekubviswa kwevhiki nevhiki uchishandisa doro rinokwesha, nepo tavaborole iine nzira iri nyore yekushandisa kamwe pazuva. Vamwe vanhu vanosarudza chirongwa chiri nyore chekushandisa tavaborole uye havana hanya nenguva refu yekurapa.

Sarudzo pakati pemishonga iyi inowanzoenderana nerudzi rwako rwefungal, mhinduro dzakapfuura dzekurapa, uye zvaunofarira. Chiremba wako anogona kubatsira kuona kuti ndeipi sarudzo inopa mukana wakanaka wekubudirira kune yako chaiyo kesi.

Mibvunzo Inowanzo Bvunzwa Nezve Tavaborole

Ko Tavaborole Yakachengeteka Here Kune Chirwere cheShuga?

Tavaborole inogona kushandiswa zvakachengeteka nevakawanda vane chirwere cheshuga, asi inoda kutariswa zvakanyanya uye kutarisirwa kwetsoka. Chirwere cheshuga chinogona kunonotsa kupora uye kuwedzera njodzi dzekutapukirwa, saka chiremba wako achada kutevera kufambira mberi kwako zvakanyanya.

Vanhu vane chirwere cheshuga vanofanira kuongorora tsoka dzavo zuva rega rega kuti vaone chero zviratidzo zvekutsamwa kana kutapukirwa kwechipiri vachishandisa tavaborole. Kudzora shuga yeropa zvakanaka kunobatsira kuvandudza kupora uye kunoderedza njodzi yematambudziko panguva yekurapa.

Mupi wako wehutano angakurudzira kuongororwa kakawanda kuti ave nechokwadi chekuti mushonga haukonzere kutsamwa kwakanyanya kana kuviga zviratidzo zvemamwe matambudziko etsoka anowanzoitika muvanhu vane chirwere cheshuga.

Ndoita Sei Kana Ndikashandisa Tavaborole Yakawandisa Netsaona?

Kana ukashandisa tavaborole yakawandisa, usavhunduka - izvi zvinowanzoita matambudziko akakomba sezvo iri mushonga wepamusoro. Bvisa chero mhinduro yakawandisa netishu yakachena uye dzivisa kushandisa zvakawanda kusvika panguva yako inotevera yakarongwa.

Kushandisa zvakanyanya hakuzoite kuti mushonga ushande nekukurumidza uye unogona kuwedzera kutsamwa kweganda munzvimbo inobatwa. Kana ukaona kuwedzera kupisa, kutsvuka, kana kutsamwa, unogona kugeza nzvimbo yacho zvinyoro-nyoro nemvura inotonhorera.

Ramba uchiita chirongwa chako chekushandisa nguva dzose zuva rinotevera, uchishandisa chete huwandu hunokurudzirwa. Kana kutsamwa kuchiramba kuripo kana kuwedzera, taura nemupi wako wehutano kuti uwane gwara rekuti uenderere mberi nekurapa here.

Ndoita Sei Kana Ndikakanganwa Dose yeTavaborole?

Kana ukakanganwa dose, shandisa tavaborole pakarepo paunoyeuka, kunze kwekunge yava nguva yekushandisa kwako kunotevera kwakarongwa. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chese.

Usawedzere madose nekuisa mushonga wakawanda kuti ugadzirise kushandisa kwakakanganwa. Izvi hazvizokurumidze kupora uye zvinogona kuwedzera njodzi yekutsamwa kweganda.

Edza tsika yekushandisa mushonga nguva dzose, zvichida uchishandisa mushonga panguva imwechete zuva rega rega, kubatsira kuyeuka mishonga. Kugadza chirangaridzo pafoni kunogona kubatsira panguva yekurapa kwenguva refu.

Ndingamira Rini Kutora Tavaborole?

Unofanira kuramba uchishandisa tavaborole kwenguva yakarairwa, kazhinji vhiki makumi mana nemasere, kunyangwe zvipikiri zvako zvikatanga kutaridzika zviri nani kare. Kumira nekukurumidza kazhinji kunotungamira kukudzoka kwehutachiona nekuti fungus inogona kuramba iri munyama yezvipikiri inoita seyakanaka.

Chiremba wako achaongorora kufambira mberi kwako panguva yekushanya kwekutevera uye achasarudza kana zvakachengeteka kumira kurapwa. Kuchenesa zvipikiri zvakakwana, uko chipikiri chose chinoita sechakanaka uye chakajairika, ndicho chinangwa usati wamisa.

Mushure mekumisa tavaborole, ramba uchishandisa kuchengeta tsoka dzakanaka uye kutarisira zvipikiri kudzivirira kutapukirwa zvakare. Chiremba wako anogona kukurudzira kuongororwa nguva nenguva kuti ave nechokwadi chekuti hutachiona hahudzoki.

Ndingapfeka Polish Yezvipikiri Ndingachishandisa Tavaborole?

Zvinowanzoita zviri nani kudzivisa polish yezvipikiri uchishandisa tavaborole, sezvo ichigona kukanganisa kugona kwemushonga kupinda muchipikiri uye kusvika kuhutachiona. Polish yezvipikiri inoitawo kuti zvive zvakaoma kutarisa kufambira mberi kwako kwekurapa.

Kana uchifanira kupfeka polish yezvipikiri pazviitiko zvakakosha, ibvise zvachose usati waisa tavaborole yako inotevera uye mirira angangoita maawa makumi maviri nemana mushure mekuisa mushonga usati waisa polish zvakare.

Tarisa pahutano hwechipikiri panguva yekurapa pane chitarisiko - yeuka kuti zvipikiri zvine hutano, zvakajeka ndizvo chinangwa chikuru rwendo rwako rwekurapa rwevhiki makumi mana nemasere.