Chii chinonzi Thalidomide: Zvinoshandiswa, Dosages, Side Effects uye Zvimwe

Thalidomide mushonga unopiwa nachiremba uyo uri muboka remishonga inonzi immunomodulators, zvinoreva kuti inobatsira kudzora immune system yako. Pakutanga yakagadzirwa muma1950s sechinhu chinoderedza kushushikana, mushonga uyu wakawana hupenyu hutsva seimwe nzira yekurapa kenza nemamwe mamiriro eimmune. Nhasi, vanachiremba vanonyanya kunyora thalidomide ye multiple myeloma, rudzi rwekenza yeropa, uye inoshandiswawo kune mamwe mamiriro ekuputika kana mamwe marapirwo asina kushanda.

Chii chinonzi Thalidomide?

Thalidomide mushonga une simba unoshanda nekuchinja maitiro eimmune system yako uye nekukanganisa kukura kwemidzi yeropa mitsva. Ndizvo zvinodaidzwa nachiremba kuti immunomodulatory drug, iyo inonyanya kureva kuti inogona kukwidza kana kudzikisa zvikamu zvakasiyana zveimmune mhinduro yako zvichienderana nezvinodiwa nemuviri wako.

Mushonga uyu une nhoroondo yakaoma iyo yakakosha kunzwisisa. Mukupera kwema1950s uye kutanga kwema1960s, thalidomide yakakonzera zvikanganiso zvakakomba zvekuzvarwa kana ichipiwa kuvakadzi vane pamuviri sechinhu chinobatsira kurara. Nguva iyi yakaipa yakatungamira kumitemo yakasimba yekuchengetedza mishonga pasi rese. Nhasi, thalidomide inowanikwa chete kuburikidza nehurongwa hwakanyatso dzorwa hunovimbisa kuti inoshandiswa zvakachengeteka uye zvakakodzera.

Mushonga uyu unouya semacapsules aunotora nemuromo. Inogadzirwa pasi pemirairo yakasimba uye inongogoverwa chete kuburikidza nemakemisi akakosha anobatanidzwa muzvirongwa zvekutarisa kuchengetedzeka.

Chii chinonzi Thalidomide chinoshandiswa?

Thalidomide inorapa mamiriro akakomba akati wandei, nechinangwa chayo chikuru chiri che multiple myeloma, kenza inokanganisa maseru eplasma mumapfupa ako. Chiremba wako angakunyore pamwe chete nemimwe mishonga yekenza kuti ibatsire kudzora chirwere ichi uye kuvandudza hupenyu hwako.

Kunze kwekushanda kurapa kenza, thalidomide inobatsira mukugadzirisa mamiriro akati wandei anokonzeresa kuzvimba. Dzimwe nguva inopiwa kurapa erythema nodosum leprosum, chirwere chinorwadza cheganda chinogona kuitika muvanhu vane maperembudzi. Mushonga uyu unogona kushandiswawo kune dzimwe nzvimbo dzinokonzeresa kuzvimba kana kurapwa kwakajairika kusina kubatsira.

Mune dzimwe nguva, vanachiremba vanogona kufunga kushandisa thalidomide kune mamwe marudzi ekenza yeropa kana mamiriro ane chekuita nekudzivirirwa kwezvirwere. Zvisinei, kushandiswa uku kunoongororwa zvakanyatsonaka zvichienderana nemamiriro ezvinhu, vachiyera mabhenefiti anogona kuwanikwa vachipesana nenjodzi.

Thalidomide Inoshanda Sei?

Thalidomide inoshanda kuburikidza nemaitiro akawanda mumuviri wako, zvichiita kuti isiyane zvakanyanya nemamwe mishonga. Inonyanya kukanganisa immune system yako uye kuumbwa kwemidzi yeropa mitsva, ndosaka ichishanda zvakanaka kune ese ari maviri kenza uye mamiriro anokonzeresa kuzvimba.

Kana zvasvika pakurapa kenza, thalidomide inobatsira nekudzivirira bundu kubva pakugadzira midzi yeropa mitsva yavanoda kuti vakure. Iyi nzira, inonzi angiogenesis, yakafanana nekugura chikafu chebundu. Mushonga uyu unokurudzirawo zvikamu zvakasiyana zve immune system yako kuti izive zviri nani uye kurwisa maseru ekenza.

Kune mamiriro anokonzeresa kuzvimba, thalidomide inoderedza kugadzirwa kwe tumor necrosis factor-alpha, chinhu chinokurudzira kuzvimba mumuviri wako. Funga nezvazvo sekudzikisa vhoriyamu pane mhinduro yekuzvimba kwemuviri wako kana yave yakanyanya hasha.

Iyi inofungidzirwa semushonga une simba une mhedzisiro yakakosha pamasisitimu emuviri wako. Chiremba wako achakutarisa zvakanyanya paunenge uchimushandisa kuti ave nechokwadi chekuti iri kushanda nemazvo uye kuti atarise chero shanduko dzinonetesa.

Ndingashandisa Sei Thalidomide?

Tora thalidomide sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva panguva yekurara negirazi rizere remvura. Kuitora usiku kunobatsira kuderedza zvimwe zvinokonzeresa zvakadai sekurara uye dzungu zvaungasangana nazvo masikati.

Unogona kutora thalidomide uine kana usina chikafu, asi edza kuenderana nesarudzo yako. Kana ukaona kuti inokutsamwisa dumbu rako, kuitora nechikafu chidiki chingabatsira. Dzivisa kupwanya, kutsenga, kana kuvhura makapisi - amedze ese kuti uve nechokwadi chekuti unowana chiyero chakakodzera.

Heano mamwe matungamirirwo akakosha ekutevera paunenge uchitora thalidomide:

• Tora chiyero chako panguva imwe chete manheru ega ega kuti uchengetedze mazinga akagadzikana mumuviri wako
• Usawedzere madosi kana ukapotsa imwe - ingotora chiyero chako chinotevera chakarongeka
• Chengeta mushonga mumudziyo wawo wekutanga kure nekupisa, hunyoro, uye chiedza
• Usambofa wakagovana mushonga wako nevamwe, kunyangwe vaine zviratidzo zvakafanana
• Bata makapisi nekuchenjerera uye geza maoko ako mushure mekuabata

Chiremba wako anogona kukutanga pachiyero chakaderera uye zvishoma nezvishoma achichiwedzera zvichienderana nekuti unopindura sei kurapwa. Iyi nzira yekuchenjerera inobatsira kuderedza mhedzisiro yechipiri uchitsvaga chiyero chinoshanda zvakanyanya kune mamiriro ako.

Ndingatora Thalidomide Kwenguva Yakareba Sei?

Kureba kwekurapa kwe thalidomide kunosiyana zvakanyanya zvichienderana nemamiriro ako chaiwo uye kuti unopindura sei kumushonga. Kune multiple myeloma, unogona kuitora kwemwedzi yakati wandei kusvika kumakore, kazhinji mumakore ane zororo pakati pemwaka wekurapa.

Chiremba wako achagara achiongorora kuti uri kupindura sei kurapwa kuburikidza nemiedzo yeropa, zvidzidzo zvekufungidzira, uye kuongororwa kwemuviri. Aya maonero anobatsira kuona kana uchienderera mberi, kugadzirisa, kana kumisa kurapwa kwako zvichienderana nezvose zvakanakira zvauri kuona uye chero mhedzisiro yaungave nayo.

Kune mamiriro ekuzvimba, nguva yekurapa inogona kunge iri pfupi, dzimwe nguva mwedzi mishoma chete kusvika zviratidzo zvichivandudza. Zvisinei, vamwe vanhu vangada nguva yakareba yekurapa kana mamiriro avo achiita kuti abude kana mushonga wamiswa.

Usambomira kutora thalidomide kamwe kamwe usati wataura nachiremba wako kutanga. Zvichienderana nemamiriro ako, kumira kamwe kamwe kungaita kuti zviratidzo zvako zvidzoke kana kuwedzera. Chikwata chako chekuchengetwa kwehutano chichakubatsira kugadzira chirongwa chekumisa mishonga zvakachengeteka kana nguva yakakodzera yasvika.

Ndezvipi Zvakaipa ZveThalidomide?

Thalidomide inogona kukonzera mativi akati wandei, kubva pakureruka kusvika pakukomba. Kunzwisisa zvekutarisira kunokubatsira kuziva kana uchifanira kutaurirana nemupi wako wehutano uye kana mativi akashata achigoneka kumba.

Mativi akajairika aunogona kusangana nawo anosanganisira kurara, dzungu, uye kuneta. Izvi zvinowanzoonekwa paunotanga kutora mushonga uye zvinowanzoita nani muviri wako paunojaira. Kutora mushonga wako panguva yekurara kunogona kubatsira kuderedza kukanganisa kwekurara pamabasa ako ezuva nezuva.

Heano mativi anowanzoitika vanhu vanosangana nawo:

• Kurara uye kuneta zvinogona kutora kusvika zuva rinotevera
• Dzungu, kunyanya kana uchimuka nekukurumidza
• Kuvharika, izvo zvinowanzoitwa nekuchinja kudya
• Muromo wakaoma neganda
• Nausea kana dumbu rinogumbuka
• Kushaya simba kwemhasuru kana kurwadziwa kwemajoini
• Musoro

Vamwe vanhu vanogona kusangana nemativi anokanganisa anoda kutariswa kwekurapa nekukurumidza. Izvi zvinosanganisira peripheral neuropathy, iyo inokonzera kunzwa, kupera simba, kana kurwadziwa mumaoko ako netsoka. Kukuvadzwa kwetsinga uku dzimwe nguva kunogona kuva kusingaperi, saka zvakakosha kuti utaure chero manzwiro asingawanzoitiki kuchiremba wako nekukurumidza.

Mativi akakomba anoda kutariswa kwekurapa nekukurumidza anosanganisira:

• Zviratidzo zvemaropa akavharika zvakaita sekufema kamwe kamwe, kurwadziwa muchipfuwa, kana kuzvimba kwemakumbo
• Kubuda ropa kusinganzwisisike kana kupwanya
• Zviratidzo zvehutachiona zvakaita sefivha, kutonhora, kana kurwadziwa kwehuro kunoramba kuripo
• Kuita kweganda kwakanyanya kana rash
• Kurova kwemoyo kusingaenderane kana kurwadziwa muchipfuwa
• Dizziness yakanyanya kana kufenda
• Kuchinja kwemanzwiro kana kuora mwoyo

Matambudziko asingawanzoitiki asi akakomba anogona kusanganisira kudonha kwakanyanya kwemasero eropa, izvo zvinokanganisa kugona kwemuviri wako kurwisa hutachiona uye kudzora kubuda ropa. Chiremba wako achatarisa ropa rako nguva dzose kuti abate shanduko idzi pakutanga.

Ndiani Asingafaniri Kutora Thalidomide?

Thalidomide haina kumbokodzera vakadzi vane pamuviri nekuda kwemigumisiro yayo yakakomba ye teratogenic, zvinoreva kuti inogona kukonzera zvikanganiso zvakakomba zvekuzvarwa. Vakadzi vezera rekubereka vana vanofanira kushandisa nzira dzekudzivirira pamuviri dzakavimbika uye kuita bvunzo dzepamuviri nguva dzose vachitora mushonga uyu.

Vanhu vane mamwe mamiriro ezvinhu havafaniri kutora thalidomide kana vachida kuongororwa kwakakosha kana kurapwa kuchidikanwa. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akupa mushonga uyu.

Haufaniri kutora thalidomide kana uine:

• Kuziva allergy kune thalidomide kana mishonga yakafanana
• Pamuviri kana zvirongwa zvekuva nepamuviri
• Kusagona kutevedzera matanho ekudzivirira pamuviri anodiwa
• Severe peripheral neuropathy
• Mamwe marudzi ezvirwere zvemtima
• Hutachiona hwakakomba hunoshanda

Kungwarira kwakakosha kunodiwa kana uine nhoroondo yemagwamba eropa, matambudziko emoyo, chirwere cheitsvo, kana matambudziko echiropa. Chiremba wako angangoda kugadzirisa muyero wako kana kukutarisa zvakanyanya kana uine mamiriro aya.

Zera rinogona zvakare kuve chinhu mukuziva kana thalidomide yakakodzera kwauri. Vakuru vakuru vanogona kunge vachinyanya kukanganiswa nemigumisiro uye vangangoda madosi akaderera kana kuongororwa kakawanda.

Mazita eThalidomide Brand

Thalidomide inowanikwa pasi pemazita akawanda emhando, neThalomid ndiyo fomu inonyanya kunyorerwa muUnited States. Iyi vhezheni yezita remhando inogadzirwa neCelgene Corporation uye ndiyo fomu iyo vanachiremba vazhinji vanojairana nayo pakunyorera.

Mamwe mazita emhando anosanganisira Contergan mune dzimwe misika yepasi rose, kunyangwe kuwanikwa kuchisiyana nenyika. Iyo generic vhezheni ye thalidomide inogonawo kuwanikwa, asi ichiri pasi pekutonga kwakafanana kwekuvharidzirwa sezita remhando vhezheni.

Zvisinei nekuti ndeipi mhando kana generic vhezheni yaunowana, zvigadzirwa zvese zve thalidomide zvinopihwa kuburikidza neakakosha mapurogiramu emakemikari anovimbisa kubata kwakakodzera uye kuongorora murwere. Murapi wako wemishonga achapa ruzivo rwakadzama nezve fomu yako chaiyo uye chero zvinodiwa zvakasiyana zvekuchengetera kana kubata.

Zvimwe Zvinhu Zviri Panzvimbo peThalidomide

Zvimwe zvinhu zviri panzvimbo pe thalidomide zviripo, zvichienderana nemamiriro ako chaiwo uye zvaunoda kurapwa. Kune multiple myeloma, chiremba wako angangofunga lenalidomide (Revlimid) kana pomalidomide (Pomalyst), izvo zviri zvinodhaka zvine hukama mukirasi imwechete yemishonga asi zvinogona kuve nezvimwe zvakasiyana zvekukanganisa.

Zvimwe zvingasarudzwa zvekutapwa kwe multiple myeloma zvinosanganisira proteasome inhibitors senge bortezomib (Velcade) kana carfilzomib (Kyprolis). Izvi zvinoshanda kuburikidza nemaitiro akasiyana pane thalidomide uye zvinogona kunge zvakakodzera kune yako chaiyo mamiriro.

Kune mamiriro ekuzvimba, zvimwe zvingasarudzwa zvinogona kusanganisira corticosteroids, mamwe mishonga yekudzivirira immune, kana kurapwa kwakatarwa kwezvinhu zvipenyu. Sarudzo inoenderana nekuongororwa kwako chaiko, mhinduro dzakapfuura dzekurapa, uye hutano hwako hwese.

Chiremba wako achakubatsira kuyera mabhenefiti nenjodzi dzechisarudzo chega chega kuti uwane kurapwa kwakakodzera kwemamiriro ako ega. Dzimwe nguva musanganiswa wemishonga yakasiyana unoshanda zvirinani pane chero mushonga mumwechete uri wega.

Thalidomide iri Nani Pane Lenalidomide Here?

Kufananidza thalidomide ne lenalidomide hakusi nyore nekuti mishonga yese miviri ine zvainobatsira nezvazvakaipa. Lenalidomide inowanzo sarudzwa kune varwere vazhinji nekuti inowanzoita kuti pave nezvinetso zvishoma, kunyanya neuropathy yechipimo uye kurara.

Thalidomide inogona kushanda zvakanyanya kune mamwe marudzi e multiple myeloma, kunyanya kana ichishandiswa pamwe chete nemimwe mishonga. Zvisinei, lenalidomide inowanzotsungirirwa zviri nani uye inobvumira vanhu kuti vachengetedze hupenyu hwakanaka panguva yekurapa.

Sarudzo pakati pemishonga iyi inoenderana nezvinhu zvakawanda zvinosanganisira maitiro ako chaiwo ekenza, kurapwa kwakapfuura, mamwe mamiriro ehutano, uye zvaunofarira. Chiremba wako weoncologist achafunga nezve mufananidzo wako wekurapa wakazara paanokurudzira kuti imwe mishonga yakakodzera kwauri.

Mutengo uye inishuwarenzi inogonawo kukanganisa sarudzo, sezvo mishonga iyi inogona kudhura. Chikwata chako chehutano chichashanda newe kuti uwane kurapwa kunoshanda zvakanyanya kunowanikwawo mumamiriro ako emari.

Mibvunzo Inowanzo Bvunzwa Nezve Thalidomide

Thalidomide Yakachengeteka Here Kune Zvirwere Zvemoyo?

Thalidomide inoda kufungwa zvakanyanya kana uine chirwere chemoyo nekuti inogona kuwedzera njodzi yeropa uye inogona kukanganisa rhythm yemoyo. Chiremba wako wecardiologist uye oncologist vachada kushanda pamwe chete kuti vaone kana zvakanakira zvichipfuura njodzi mumamiriro ako chaiwo.

Kana iwe ukatora thalidomide uine chirwere chemoyo, uchada kuongororwa kakawanda kusanganisira maEKG enguva dzose uye bvunzo dzeropa. Chiremba wako anogonawo kuraira zvinoderedza ropa kuti dzipfungaire njodzi, kunyangwe izvi zvichiwedzera kuoma kuronga kwako kurapwa.

Ndoita Sei Kana Ndikatora Thalidomide Yakawandisa Netsaona?

Kana ukatora thalidomide yakawanda kupfuura yakanyorwa netsaona, fonera chiremba wako kana nzvimbo inobata chepfu nekukasira, kunyangwe ukaita kunge wakanaka. Kutora yakawanda kunogona kukonzera kurara zvakanyanya, kuvhiringidzika, uye zvimwe zvinokanganisa zvakakomba zvingasazviratidza pakarepo.

Usaedze kuzviita kuti urutse kunze kwekunge wakanzi zvakananga nachiremba. Chengeta bhodhoro remushonga newe paunenge uchitsvaga rubatsiro rwekurapa kuti vashandi vehutano vazive chaizvo zvawakatora uye yakawanda sei.

Ndingaita Sei Kana Ndikakanganwa Dose yeThalidomide?

Kana ukakanganwa dose ye thalidomide, itore paunorangarira, asi chete kana iri mukati me12 maawa enguva yako yakarongwa. Kana maawa anopfuura 12 apfuura, siya dose yakakanganwa uye tora dose yako inotevera yakarongwa panguva yakajairika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvipingamupinyi zvakakomba. Kana uchikanganwa madosi kazhinji, funga kuisa zviyeuchidzo zvefoni kana kushandisa murongi wemapiritsi kuti akubatsire kuti urambe uri munzira.

Ndingamira Rini Kutora Thalidomide?

Unofanirwa kungomira kutora thalidomide kana chiremba wako achiona kuti zvakachengeteka uye zvakakodzera kuita kudaro. Sarudzo iyi yakavakirwa pakuti mamiriro ako ari kupindura sei kurapwa, zvipingamupinyi zvauri kusangana nazvo, uye hutano hwako hwese.

Pakurapa kenza, kumira nekukurumidza kungabvumira chirwere kuti chifambire mberi. Kune mamiriro ekuzvimba, kumira kamwe kamwe kungakonzera kuti zviratidzo zvidzoke. Chiremba wako achakubatsira kugadzira chirongwa chekumisa kurapwa zvakachengeteka kana nguva yakwana.

Ndinganwa Doro Ndiri Kutora Thalidomide Here?

Zvakanakisa kudzivisa doro uchitora thalidomide nekuti zvese zvinogona kukonzera kurara uye dzungu. Kuzvibatanidza kunogona kuwedzera zvakanyanya izvi zvinokanganisa uye kuwedzera njodzi yako yekuwa kana tsaona.

Kana ukasarudza kunwa doro dzimwe nguva, ita zvishoma uye chenjerera zvakanyanya mabasa anoda kungwarira. Nguva dzose kurukura kushandiswa kwedoro nachiremba wako, sezvo vachigona kuva nezvavanokurudzira zvakavakirwa pamamiriro ako ega uye mamwe mishonga yaunotora.