Chii chinonzi Tolcapone: Kushandiswa, Madosi, Matambudziko, nezvimwe

Tolcapone mushonga unopiwa nachiremba unobatsira vanhu vane chirwere cheParkinson kuti vakwanise kudzora zviratidzo zvavo zvakanyanya. Inoshanda pamwe chete nemimwe mishonga yeParkinson kuti ideredze nguva dzekuti zviratidzo zvidzoke pakati pemadosi. Mushonga uyu ndewemukirasi inonzi COMT inhibitors, iyo inobatsira muviri wako kushandisa dopamine zvakanaka.

Chii chinonzi Tolcapone?

Tolcapone mushonga wakagadzirirwa kubatsira vanhu vanorarama nechirwere cheParkinson. Haisi kurapa kwega asi chimwe chinhu chinobatsira kuwedzera kumishonga yako iripo.

Mushonga uyu unoshanda nekudzivisa enzyme inonzi COMT (catechol-O-methyltransferase) iyo inoputsa dopamine muuropi hwako. Nekunonotsa maitiro aya, tolcapone inobatsira kuchengetedza mazinga e dopamine akagadzikana zuva rese. Funga nezvazvo sekubatsira uropi hwako kubata dopamine yaunoda kuti uende zvakanaka uye kudzora zviratidzo zviri nani.

Tolcapone inoonekwa sekurapa kwechipiri, zvinoreva kuti vanachiremba vanowanzoedza dzimwe sarudzo kutanga. Iyi nzira iripo nekuti tolcapone inoda kunyatsoongororwa nekuda kwemigumisiro inogona kuitika yechiveve, iyo yatinokurukura zvakadzama gare gare.

Tolcapone Inoshandiswa Kunei?

Tolcapone inonyanya kunyorerwa vanhu vane chirwere cheParkinson vanowana shanduko dzemota. Shanduko idzi dzinoitika kana mishonga yako yeParkinson ichitanga kuparara isati yasvika dose yako inotevera.

Unogona kuona zviratidzo zvako zvichidzoka kana kuipa panguva idzi dzekuti "off". Zviratidzo zvakajairika zvinosanganisira kuwedzera kudedera, kuoma kwemhasuru, kufamba zvishoma, kana kuoma kwemuviri. Vamwe vanhu vanotsanangura vachinzwa sekunge mishonga yavo inogumira kushanda, ichivasiya vakanzwa vakavharirwa kana kutonhora.

Chiremba wako achafunga nezve tolcapone kana wakatotora carbidopa-levodopa asi uchiri kusangana nenguva idzi dzinonetsa. Chinangwa ndechekuwedzera nguva yako ye "on" paunonzwa zvakanaka uye kuderedza nguva idzo dzinonetsa apo zviratidzo zvinopinda.

Tolcapone Inoshanda Sei?

Tolcapone inoonekwa semushonga wakasimba zvishoma unoshanda nekudzivirira dopamine uropi hwako hunoda. Inovharisa enzyme ye COMT, iyo inowanzoita kuti dopamine nemakemikari ane hukama muropi rwako nemuviri.

Paunotora levodopa (iyo ingredient huru mumishonga yakawanda yeParkinson's), muviri wako unoiita kuti ive dopamine. Zvisinei, enzyme ye COMT inokurumidza kuparadza yakawanda ye dopamine iyi isati yakwanisa kubatsira zviratidzo zvako. Tolcapone inopinda kuti ideredze maitiro aya ekuparadza, ichibvumira dopamine yakawanda kuti irambe iripo kwenguva yakareba.

Maitiro aya anobatsira kupfavisa zvinhu zvakanaka nezvakaipa mukudzora zviratidzo zvako zuva rese. Panzvimbo pekusangana nekuchinja kukuru pakati pekunzwa zvakanaka uye kunzwa zviratidzo, tolcapone inobatsira kugadzira zororo rinowirirana. Mushonga unowanzo kutanga kushanda mukati memazuva mashoma kusvika kumavhiki ekutanga kurapwa.

Ndinofanira Kutora Sei Tolcapone?

Tolcapone inofanira kugara ichitorwa sezvinorairwa nachiremba wako, kazhinji katatu pazuva nemadosi ako e carbidopa-levodopa. Unogona kuitora uine chikafu kana usina, kunyange vamwe vanhu vachiwana kuti kuitora nechikafu chidiki kunobatsira kudzivirira dumbu.

Mushonga uyu unouya muchimiro chepiritsi uye unofanira kumedzwa wese nemvura. Usapwanye, kutsenga, kana kuputsa mahwendefa, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unotorwa nayo. Kana uine dambudziko rekumedza mapiritsi, taura nachiremba wako nezve dzimwe nzira.

Torai mishonga yenyu panguva dzakafanana zuva rese, kazhinji maawa 6 kusvika ku8 ega ega. Iyi nguva yakatsiga inobatsira kuchengetedza mazinga akatsiga emushonga mumuviri wenyu. Kuisa maalarm pafoni kana kushandisa chirongwa chemishonga kunogona kukubatsira kuyeuka mishonga yenyu.

Haufaniri kutora tolcapone nemukaka kana chero chikafu chakakosha. Zvisinei, kuchengetedza nguva dzose dzekudya kunogona kukubatsira kuyeuka kutora mushonga wako uye kunogona kuderedza mukana wekutsamwa mudumbu.

Ndingatora Tolcapone Kwenguva Yakareba Sei?

Tolcapone inowanzoita kurapwa kwenguva refu kwaunozoenderera mberi chero zvichibatsira zviratidzo zvako zveParkinson uye zvisingakonzeri mhedzisiro inonetesa. Vanhu vazhinji vanobatsirwa ne tolcapone vanoiita kwemwedzi kana makore sechikamu chekutungamira kwavo Parkinson's.

Chiremba wako achada kukuona nguva dzose, kunyanya mumwedzi mishoma yekutanga yekurapa. Izvi zvekutarisa zvinosanganisira bvunzo dzeropa kuti uongorore basa rechiropa chako, iro rakakosha pakushandisa kwenguva refu kwakachengeteka. Kana bvunzo dzako dzechiropa dzichiramba dzakajairika uye uri kuona kutonga kwakanaka kwezviratidzo, unogona kuenderera mberi nemushonga usingagumi.

Zvisinei, chiremba wako anogona kugadzirisa chirongwa chako chekurapa kana ukaona mhedzisiro, kana bvunzo dzako dzechiropa dzikava dzisina kujairika, kana mushonga ukamira kushanda. Vamwe vanhu vanowana zvinodiwa zvavo zvichichinja nekufamba kwenguva sezvo Parkinson's ichifambira mberi, ichida nzira dzakasiyana dzemishonga.

Usambomira kutora tolcapone kamwe kamwe usina kutaura nachiremba wako kutanga. Kumira kamwe kamwe kunogona kutungamira mukuvandudzwa kamwe kamwe kwezviratidzo zvako zveParkinson uye zvinogona kukonzera matambudziko akakomba.

Ndezvipi Zvakaipa ZveTolcapone?

Semishonga yese, tolcapone inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoona izvi. Chinhu chakakosha kunzwisisa ndechekuti nepo mhedzisiro ichigona kuitika, vanhu vazhinji vanotsungirira tolcapone zvakanaka kana vakatariswa zvakanaka.

Hezvino zvimwe zvinowanzoitika zvaungawana muviri wako uchigadzirisa tolcapone:

• Kunzwa kusvotwa uye dumbu kusagadzikana
• Manyoka kana zvigaro zvakasununguka
• Kuwedzera kufamba kusingadiwi (dyskinesia)
• Dizziness kana lightheadedness
• Matambudziko ekurara kana zviroto zvakajeka
• Weti yeruvara rweorenji (isina njodzi asi yakajairika)
• Kutemwa nemusoro
• Kuneta kana kunzwa kuneta

Izvi zvinowanzoitika zvinowanzoita zviri nani muviri wako uchijaira mushonga. Kana vakapfuurira kana kuva dambudziko, chiremba wako anogona kugadzirisa dose yako kana kuratidza nzira dzekuvadzora.

Kune zvakare zvimwe zvisingawanzoitiki asi zvakanyanya kukomba zvinokonzeresa zvinoda kutariswa kwechiremba nekukasira. Izvi zvisingawanzoitiki asi zvinokosha zvinokonzeresa zvinosanganisira:

• Matambudziko echiropa (zviratidzo zvinosanganisira kuita yero yeganda kana maziso, weti yakasviba, kuneta kwakanyanya, kana kurwadziwa mudumbu)
• Kutanga kamwe kamwe kwekurara pasina yambiro
• Hallucinations kana kuvhiringidzika
• Manyoka akanyanya asingavandudzi
• Muscle rigidity ine fivha
• Kuchinja mumoyo rhythm

Kutarisa chiropa kunodiwa ne tolcapone kunovapo kunyanya kubata chero matambudziko echiropa kare, vasati vava serious. Ichi ndicho chikonzero nei bvunzo dzeropa dzenguva dzose dzakakosha panguva yekurapa.

Ndiani Asingafaniri Kutora Tolcapone?

Tolcapone haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Kune mamiriro akati wandei akakosha uko tolcapone inofanira kudziviswa kana kushandiswa nekuchenjerera kwakanyanya.

Vanhu vane chirwere chechiropa kana nhoroondo yematambudziko echiropa havafaniri kutora tolcapone. Izvi zvinosanganisira avo vane hepatitis, cirrhosis, kana yakakwira chiropa enzymes kubva kune chero chikonzero. Mushonga unogona kukonzera kuwedzera chiropa basa, zvichiita kuti isakodzere vanhu vane mamiriro echiropa aripo.

Unofanirawo kudzivisa tolcapone kana wakambove ne allergic reaction kwairi munguva yakapfuura kana kana uri kutora mishonga yakati wandei inosangana nenzira ine njodzi nayo. MAO inhibitors, rudzi rwe antidepressant, inogona kukonzera kusangana kwakakomba ne tolcapone.

Zvimwe zvinhu zvinogona kukanganisa kana tolcapone yakakunakira zvinosanganisira:

• Kutadza kwakanyanya kwematsvo
• Nhoroondo ye rhabdomyolysis (kuputsika kwemhasuru)
• Kushandisa doro zvakanyanya
• Kuzvitakura kana kuyamwisa
• Mamwe mamiriro emoyo
• Nhoroondo ye neuroleptic malignant syndrome

Chiremba wako achayerera zvinhu izvi zvakanyatsonaka uye anogona kukurudzira mamwe marapirwo kana tolcapone isina kukunakira mamiriro ako chaiwo.

Mazita eTolcapone Brand

Tolcapone inowanikwa pasi pezita rekuti Tasmar munyika zhinji, kusanganisira United States. Iri ndiro rudzi rwe tolcapone runonyanya kunyorerwa iwe rwaunosangana naro kumafemu.

Mhando dzegeneric dze tolcapone dzinogonawo kuwanikwa, zvichienderana nenzvimbo yako uye inishuwarenzi. Mishonga yegeneric ine chinhu chimwe chete chinoshanda uye inoshanda zvakanyanya semhando dzemazita, kazhinji nemutengo wakaderera.

Nguva dzose bvunza chiremba wako wemishonga kana uine mibvunzo pamusoro peiyo vhezheni yaunogamuchira. Kunyangwe iwe ukawana zita rekuti Tasmar kana generic tolcapone, kushanda kwemushonga uye kuchengeteka kwakafanana.

Tolcapone Alternatives

Kana tolcapone isina kukunakira kana isingapi kutonga kwakakwana kwezviratidzo, mishonga yakati wandei inogona kubatsira kubata Parkinson's motor fluctuations. Chiremba wako anogona kukurukura sarudzo idzi zvichienderana nezvido zvako chaiwo uye nhoroondo yekurapa.

Entacapone imwe COMT inhibitor inoshanda nenzira imwechete se tolcapone asi haidi kuongororwa kwechiropa. Inowanzoonekwa yekutanga nekuda kwekuvimbika kwayo kuri nani, kunyangwe ingangoda kutora kakawanda zuva rese.

Zvimwe zvingasarudzwa zvekugadzirisa kuchinja kwemotokari zvinosanganisira:

• Dopamine agonists (semuenzaniso pramipexole kana ropinirole)
• MAO-B inhibitors (semuenzaniso selegiline kana rasagiline)
• Amantadine yekugadzirisa dyskinesia
• Extended-release formulations ye carbidopa-levodopa
• Apomorphine injections yenguva dzakakomba dzekudzima

Chiremba wako achafunga nezvezvinhu zvakaita semaitiro ako ezviratidzo, mamwe mishonga yaunotora, uye hutano hwako hwese paanokurudzira zvimwe zvingasarudzwa. Dzimwe nguva musanganiswa wemishonga yakasiyana unoshanda zvirinani pane chero imwe sarudzo.

Ko Tolcapone Zviri Nani Pane Entacapone?

Ose ari maviri tolcapone uye entacapone ndiCOMT inhibitors anogona kubata zvinobudirira kuchinja kwemotokari yeParkinson, asi vane misiyano yakakosha inoita kuti imwe neimwe ive yakakodzera mamiriro akasiyana.

Tolcapone inowanzoonekwa seyakasimba uye inogara kwenguva refu kupfuura entacapone. Inotorwa katatu pazuva ichienzaniswa nekudiwa kweentacapone kwekushandisa nemadosi ese ecarbidopa-levodopa. Zvimwe zvidzidzo zvinoratidza kuti tolcapone inogona kupa kutonga kuri nani kwezviratidzo kune vanhu vane kuchinja kwakanyanya kwemotokari.

Zvisinei, entacapone ine kuchengeteka kwakakosha nekuti haidi kuongororwa kwechiropa. Izvi zvinoita kuti ive sarudzo yekutanga inofarirwa yevazhinji vanachiremba nevarwere. Entacapone inowanzoedzwa kutanga, uye tolcapone inochengeterwa vanhu vasingawani zororo rakakwana kubva kuentacapone.

Sarudzo pakati pemishonga iyi inoenderana nemamiriro ako ega, kuoma kwezviratidzo, uye kushivirira kwekuda kuongorora. Chiremba wako achakubatsira kuyera mabhenefiti nenjodzi dzesarudzo imwe neimwe zvichienderana nezvido zvako chaizvo.

Mibvunzo Inowanzo Bvunzwa Nezve Tolcapone

Ko Tolcapone Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Tolcapone inogona kushandiswa nevanhu vane chirwere chemoyo, asi zvinoda kunyatso tarisa uye kufunga nezve mamiriro ako chaiwo emoyo. Mushonga uyu dzimwe nguva unogona kukonzera shanduko mumoyo kana ropa, saka chiremba wako achatarisa hutano hwemoyo wako asati wanyora mushonga uyu.

Kana uine chirwere chemoyo, chiremba wako angangokutanga pamwero wakaderera uye achakutarisa zvakanyanya mumavhiki mashoma ekutanga ekurapa. Vachashandawo pamwe chete nachiremba wako wemoyo kuti vaone kuti tolcapone haizokanganisi mishonga yako yemoyo kana kuwedzera zviratidzo zvako zvecardiac.

Ndingaita Sei Kana Ndakashandisa Zvakanyanya Tolcapone Netsaona?

Kana netsaona ukatora tolcapone yakawandisa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira, kunyangwe usina kunzwa kusvotwa. Kutora zvakanyanya kunogona kuwedzera njodzi yako yezvinhu zvisingadiwi, kunyanya kusvotwa, kurutsa, uye kuwedzera kufamba kusingadiwi.

Usayedze kuzviita kuti urutse kunze kwekunge wakanzi nevanachiremba. Chengeta rekodhi rekuti wakatora mushonga wakawanda sei uye paakauita, sezvo ruzivo urwu ruchabatsira vanopa hutano kuti vaone nzira yakanakisa yekutora. Mazhinji ekuwandisa kweTolcapone anogona kubatwa nekuchengetedza, asi kuongororwa kwekurapa kwakakosha.

Ndingaita Sei Kana Ndikakanganwa Dose yeTolcapone?

Kana ukakanganwa dose ye tolcapone, itore paunorangarira, kunze kwekunge yava nguva ye dose yako inotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nehurongwa hwako hwekurapa.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinhu zvisingadiwi. Kana iwe uchikanganwa madosi kazhinji, funga kushandisa chirongwa chemushonga kana kuseta zviyeuchidzo zvefoni kuti zvikubatsire kuchengetedza nguva yemishonga.

Ndingamira Rini Kutora Tolcapone?

Unofanira kungomira kutora tolcapone pasi pekutariswa kwachiremba wako. Sarudzo yekumisa kazhinji inoenderana nezvinhu zvakati wandei, kusanganisira kuti mushonga uri kudzora sei zviratidzo zvako, kana uri kusangana nemigumisiro, uye mhedzisiro yebasa rechiropa chako.

Chiremba wako anowanzo kuderedza muyero wako zvishoma nezvishoma pane kuumisa kamwechete. Iyi nzira inobatsira kudzivirira kudzoka kamwechete kwezviratidzo zvakakomba zveParkinson uye inoderedza njodzi yematambudziko. Maitiro ekuderedza anowanzo tora mazuva akati wandei kusvika kumavhiki, zvichienderana nemamiriro ako ega.

Ndinganwa Doro Ndiri Kutora Tolcapone Here?

Zvakanakisa kudzivisa doro uchitora tolcapone, kunyanya mumwedzi mishoma yekutanga yekurapa. Doro rinogona kuwedzera njodzi yematambudziko echiropa, izvo zvatove dambudziko ne tolcapone. Uyezve, doro rinogona kuwedzera mamwe mativi emigumisiro senge dzungu uye kurara.

Kana ukasarudza kunwa dzimwe nguva, zvidzore kumari shoma uye taura izvi nachiremba wako kutanga. Vanogona kuda kuongorora basa rechiropa chako zvakanyanya kana ukashandisa doro nguva dzose. Usambofa wakashandisa doro senzira yekugadzirisa zviratidzo zveParkinson, sezvo zvichigona kuita kuti mamiriro ako aende mberi nekufamba kwenguva.