Chii chinonzi Ubrogepant: Zvinoshandiswa, Madosi, Zvakaipa uye Zvimwe

Ubrogepant mushonga unopiwa nachiremba wakagadzirirwa kurapa marwadzo emusoro emigraine kana atanga. Iwo wekirasi itsva yemishonga yemigraine inonzi CGRP receptor antagonists, iyo inoshanda nekudzivisa zviratidzo zvekurwadziwa muuropi hwako panguva yekurwisa kwemigraine.

Mushonga uyu unopa tariro kune vanhu vasina kuwana zororo nekutarisirwa kwemigraine yechinyakare. Kusiyana nemimwe mishonga yekare yemigraine, ubrogepant haikonzeri marwadzo emusoro ekudzoka uye inogona kushandiswa kazhinji kana zvichidikanwa.

Chii chinoshandiswa Ubrogepant?

Ubrogepant inorapa kurwisa kwakanyanya kwemigraine muvanhu vakuru, zvinoreva kuti inotorwa kana iwe watove nemarwadzo emusoro emigraine. Mushonga unoshanda kumisa marwadzo emigraine uye zviratidzo zvine chekuita senausea, kunzwa chiedza, uye kunzwa ruzha.

Chiremba wako angakupa ubrogepant kana iwe uine migraine yepakati nepakati kusvika yakanyanya iyo inovhiringidza mabasa ako ezuva nezuva. Zvinonyanya kubatsira vanhu vasingakwanise kutora triptans (imwe kirasi yemishonga yemigraine) nekuda kwemamiriro emoyo kana zvimwe zvehutano.

Mushonga uyu haushandiswe kudzivirira migraine kuti isaitike. Pane kudaro, ndizvo zvinodaidzwa nachiremba kuti "abortive" kurapwa kwaunotora pakutanga kwechiratidzo chemigraine kuti ubatsire kuimisa munzira dzayo.

Ubrogepant Inoshanda Sei?

Ubrogepant inodzivisa CGRP receptors muuropi hwako, izvo zvine chekuita nezviratidzo zvekurwadziwa kwemigraine. CGRP inomirira calcitonin gene-related peptide, protein inova overactive panguva yekurwisa kwemigraine uye inobatsira kurwadziwa kwakanyanya uye zvimwe zviratidzo.

Funga nezve CGRP sechinhu chakakosha chinovhura nzira dzekurwadziwa muuropi hwako panguva yemigraine. Ubrogepant inoita sevhara rinodzivirira pamusoro pekiyi, ichidzivirira CGRP kubva pakukonzera zviratidzo izvozvo zvinorwadza.

Mishonga iyi inoonekwa seyakasimba zvishoma pakurapa migraine. Inotarisa zvakanyanya pane zvinorwadza zvekare asi inogona kunge isina simba nekukurumidza semamwe mishonga yekujekesa. Zvisinei, chiito chayo chaiyo chinowanzoita kuti vanhu vashoma vave nemigumisiro.

Ndingatora sei Ubrogepant?

Tora ubrogepant sezvinorayirwa nachiremba wako, kazhinji semutabheti mumwe chete we50mg kana 100mg paunonzwa migraine ichitanga. Unogona kuitora uine kana usina chikafu, kunyange vamwe vanhu vachiona zviri nyore mudumbu ravo kana vachitora nechisvusvuro chakareruka.

Medza piritsi rose nemvura. Usapwanya, kuputsa, kana kuitsenga, sezvo izvi zvinogona kukanganisa mashandiro emishonga mumuviri wako.

Hezvino zvaunofanira kuziva nezvenguva nekudya usati watora ubrogepant:

• Tora nekukurumidza paunoona zviratidzo zvemigraine zvichitanga
• Unogona kudya zvakajairika usati watora, kunyange chikafu chinorema, chine mafuta chingazvambisa zvishoma mhedzisiro yayo
• Kana migraine yako ikadzoka mushure mekubatsirwa kwekutanga, unogona kutora dose yechipiri mushure memaawa angangoita 2
• Usatore anopfuura 200mg munguva ye24-awa

Kana iwe ukatora ubrogepant nekukurumidza mushure mekutanga kwemigraine yako, inowanzoita zviri nani. Vanhu vazhinji vanoona kuti inonyanya kushanda kana ichitorwa mukati meawa rekutanga yezviratidzo.

Ndingatora Ubrogepant kwenguva yakareba sei?

Ubrogepant inotorwa chete kana uine migraine, kwete semushonga wezuva nezuva. Nguva imwe neimwe yaunoishandisa, uri kurapa chiitiko chimwe chete chemigraine.

Chiremba wako achasarudza kuti ungashandisa kakawanda sei ubrogepant zvakachengeteka zvichienderana nekuti migraine yako inowanzoitika sei uye zvimwe zvehutano. Vanhu vazhinji vanogona kuishandisa kusvika kune 8 times pamwedzi, asi izvi zvinosiyana zvichienderana nemamiriro ako ega.

Kana iwe ukawana uchida ubrogepant kazhinji, chiremba wako angakurudzira kuwedzera mushonga wekudzivirira migraine kuti uderedze kakawanda kaunowana migraines pakutanga.

Ndezvipi Zvipingamupinyi zveUbrogepant?

Vanhu vazhinji vanotsungirira ubrogepant zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakavimbika pamusoro pekurapa kwako.

Mhedzisiro yakajairika inowanzoita nyoro uye yenguva pfupi:

• Kurwadziwa mudumbu (kunokanganisa vanhu vanenge 4%)
• Kuzara hope kana kuneta
• Muromo wakaoma
• Dizziness
• Kusagadzikana mudumbu

Mhedzisiro iyi yakajairika inowanzoenda mukati memaawa mashoma uye haidi kumisa mushonga. Zvisinei, kana dzikagara kana kuwedzera, zivisa chiremba wako.

Mhedzisiro isingawanzoitiki asi yakakomba inogona kuitika, kunyangwe ichiwanzoitika. Izvi zvinosanganisira mhinduro dzakakomba dzekurwara nemishonga ine zviratidzo zvakaita sekufema kwakaoma, kuzvimba kwechiso chako kana huro, kana kuoma kweganda.

Vamwe vanhu vanowana zvinozivikanwa se "medication overuse headache" kana vakashandisa chero mushonga wemigraine kakawanda. Ichi ndicho chikonzero nei kutevera mirairo yekushandisa yemishonga yachiremba wako yakakosha.

Ndiani Asingafaniri Kutora Ubrogepant?

Ubrogepant haisi yemunhu wese, uye chiremba wako achanyatso funga nezve nhoroondo yako yehutano usati wamupa. Vanhu vane matambudziko akakomba echiropa vanofanira kudzivisa mushonga uyu nekuti miviri yavo haigoni kuugadzirisa zvakanaka.

Haufaniri kutora ubrogepant kana uchishandisa mamwe mamwe mishonga anogona kukanganisa zvine njodzi nayo. Izvi zvinosanganisira mamwe mishonga yekubata mapundu, mamwe maantibiotics, uye mamwe antifungal drugs.

Heano mamiriro apo ubrogepant ingasava yakakodzera:

• Kusagadzikana kwakakomba kwematsvo
• Kusagadzikana kwakakomba kwechiropa
• Kutora mishonga yakasimba yeCYP3A4 inhibitor
• Kuzvitakura kana kuyamwisa (kuchengeteka hakuna kumiswa)
• Nhoroondo yemhinduro dzakakomba dzekurwara nemishonga ku ubrogepant

Chiremba wako achafungawo nezvezvimwe zvinhu zvakaita sezera rako, mamwe mamiriro ehutano, uye mishonga iripo. Vanhu vane makore anopfuura 65 vangangoda madosi mashoma kana kuongororwa pedyo.

Zita reBrand reUbrogepant

Ubrogepant inotengeswa pasi pezita rekuti Ubrelvy. Iri ndiro zita rimwe chete riripo parizvino remushonga uyu muUnited States.

Ubrelvy inowanikwa semapiritsi ekunwa mumuromo mune simba mbiri: 50mg uye 100mg. Chiremba wako achasarudza kuti simba ripi rakanakira maitiro ako chaiwo e migraine uye kuoma kwayo.

Parizvino, hapana vhezheni ye generic ye ubrogepant iripo, izvo zvinoreva kuti Ubrelvy inowanzoita mari yakawanda kupfuura mishonga yekare ye migraine. Zvisinei, hurongwa hwakawanda hwe inishuwarenzi hunoivhara, uye mugadziri anopa zvirongwa zvekubatsira varwere kune avo vanokodzera.

Zvimwe Zvinhu Zvokutsiva Ubrogepant

Kana ubrogepant isingashande zvakanaka kwauri kana kukonzera mhedzisiro inonetsa, dzimwe nzira dzakawanda dzekurapa migraine dziripo. Chiremba wako anogona kukubatsira kuwana imwe nzira yakanakisa zvichienderana nezvido zvako.

Zvimwe zvinopesana neCGRP receptor zvinosanganisira rimegepant (Nurtec ODT), iyo inonyungudika parurimi rwako, uye zavegepant (Zavzpret), iyo inouya semupfuri wemumhino. Izvi zvinoshanda zvakafanana ne ubrogepant asi zvinogona kukukodzera zviri nani kana uine dambudziko rekumedza mapiritsi.

Mishonga yechinyakare ye migraine inogona kushanda senzira dzimwe dzinosanganisira:

• Triptans senge sumatriptan kana rizatriptan
• NSAIDs senge ibuprofen kana naproxen
• Mishonga yakasanganiswa ine caffeine
• Mishonga inorwisa kusvotwa ye migraine-associated nausea

Vamwe vanhu vanobatsirwawo kubva kune nzira dzisiri dzemishonga senge kushandisa kutonhora kana kupisa, kugara mukamuri rima rakanyarara, kana kushandisa nzira dzekuzorora pamwe chete nemishonga yavo.

Ko Ubrogepant Ari Nani Kudarika Sumatriptan Here?

Ubrogepant na sumatriptan vanoshanda zvakasiyana uye mumwe nemumwe ane zvakanakira zvakasiyana. Sumatriptan, mushonga we triptan, wakashandiswa kwenguva refu uye kazhinji unoshanda nekukurumidza kune migraines yakakomba, asi ubrogepant inogona kuve yakachengeteka kune vanhu vane matambudziko emoyo.

Chinhu chikuru chinobatsira che ubrogepant ndechekuti hachikonzeri kuoma kwemitsipa yeropa sezvinoitwa ne triptans. Izvi zvinoita kuti ive yakachengeteka kune vanhu vane chirwere chemoyo, high blood pressure, kana njodzi yekurohwa vanosakwanisa kutora triptans.

Sumatriptan inowanzoita kuti munhu anzwe kugadzikana nekukurumidza, dzimwe nguva mukati memaminitsi makumi matatu, nepo ubrogepant inowanzo tora awa rimwe kana maviri kuti ishande zvizere. Zvisinei, ubrogepant inogona kukonzera matambudziko mashoma akadai sekusungirirwa pachipfuva kana dzungu iro vamwe vanhu vanowana vaine triptans.

Chiremba wako achafunga nezvehutano hwemoyo wako, kuoma kwemigraine, uye kuti unoda kugadzikana nekukurumidza sei paunenge uchisarudza pakati pemishonga iyi. Vamwe vanhu vanowana imwe ichishanda zviri nani pane imwe, uye zvinogona kutora kuyedza kuti uwane sarudzo yako yakanakisisa.

Mibvunzo Inowanzo Bvunzwa Nezve Ubrogepant

Ubrogepant Yakachengeteka Here Kune High Blood Pressure?

Hongu, ubrogepant inowanzova yakachengeteka kune vanhu vane high blood pressure. Kusiyana nemishonga ye triptan, ubrogepant haikonzeri kuti tsinga dzeropa dzidzikiswe, izvo zvinoita kuti ive sarudzo yakanaka kune vanhu vane matambudziko emoyo.

Zvisinei, unofanira kutaura chiremba wako nezve mamiriro ako eblood pressure uye chero mishonga yaunotora yayo. Dzimwe mishonga yeblood pressure inogona kushanda pamwe chete ne ubrogepant, uye chiremba wako angada kugadzirisa dosing kana kukutarisa zvakanyanya.

Ndoitei Kana Ndikashandisa Ubrogepant Yakawandisa Netsaona?

Kana netsaona ukatora yakawanda kupfuura chiyero chakakurudzirwa che ubrogepant, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukurumidza. Usamirira kuti zviratidzo zviitike, sezvo kuwana gwara kare nguva dzose kuri nani.

Kutora ubrogepant yakawanda kunogona kuwedzera njodzi yako yemigumisiro yakadai sekuona kusvotwa zvakanyanya, dzungu, kana kuneta. Mune zviitiko zvisingawanzoitiki, overdose inogona kukonzera matambudziko akakomba, kunyangwe mushonga uyu uchigamuchirwa zvakanaka kunyangwe pazviyero zvakakwirira.

Chengeta rekodhi yenguva yaunotora mishonga yako kuti udzivise kutora mishonga kaviri netsaona. Kana usina chokwadi kana wakatotora mushonga wako, zviri nani kumirira uone kana migraine yako inovandudzika pane kuisa njodzi yekutora yakawandisa.

Ndoita Sei Kana Ndakakanganwa Kutora Dose yeUbrogepant?

Sezvo ubrogepant ichitorwa chete kana uine migraine, hapana "dose yakarasika" mupfungwa yechinyakare. Unoitora paunoida kurwisa migraine.

Kana wakanganwa kutora ubrogepant apo migraine yako yakatanga uye zvino mava maawa akati wandei gare gare, unogona ichiri kuitora. Mushonga unogona ichiri kupa kumwe kubatsirwa, kunyangwe uchida kushanda zvakanaka kana uchitorwa pakutanga kwechiitiko che migraine.

Usatore mishonga yakawedzerwa kuti "ugadzirise" kusatora kare. Namatira kune dose yakarairwa uye nguva yekutungamira chiremba wako akapa.

Ndingamira Rini Kutora Ubrogepant?

Unogona kumira kutora ubrogepant chero nguva sezvo isiri mushonga wezuva nezuva uyo muviri wako unotsamira pawo. Unongomira kuishandisa pausingachadi kurapwa kwe migraine.

Zvisinei, usati wamira, taura nachiremba wako nezvekuti ubrogepant iri kushanda zvakanaka here kune migraines yako. Kana ichibatsira, kazhinji hapana chikonzero chekurapa kumira kunze kwekunge uri kusangana nemigumisiro inonetsa.

Kana migraines yako ikava isingawanzoitiki kana yakanyanya, unogona zvakasikwa kushandisa ubrogepant kazhinji. Chiremba wako anogona kukubatsira kuona kana uchida mamwe marapirwo kana kana kushandiswa kwenguva pfupi kwe ubrogepant kuchiramba kuri nzira yakanakisisa.

Ndingatora Ubrogepant Nemimwe Mishonga Yekurwadziwa Here?

Unogona kazhinji kutora ubrogepant nemishonga inozivikanwa yekurwadziwa inowanikwa pasina mushonga wakanyorwa sechiremba senge acetaminophen kana ibuprofen, asi gara uchitarisa nachiremba wako kutanga. Vamwe vanhu vanowana kuti kusanganisa marapirwo kunopa zororo riri nani re migraine.

Asi, dzivisa kutora ubrogepant nemimwe mishonga yemigraine yakanyorwa nachiremba yakaita setriptans kunze kwekunge warairwa zvakananga nachiremba wako. Kubatanidza mishonga yakasiyana-siyana yekurapa migraine dzimwe nguva kunogona kuwedzera mhedzisiro kana kuderedza kushanda.

Chenjerera zvikuru pakutora ubrogepant nemishonga inokanganisa chiropa chako, sezvo zvese zvichifanira kugadziriswa nemamwe ma enzymes echiropa. Chiremba wako anogona kuongorora mishonga yako yese kuti ave nechokwadi chekubatanidzwa kwakachengeteka.