Chii chinonzi Valdecoxib: Zvayakashandiswa, Mishonga, Matambudziko, nezvimwe

Valdecoxib yaiva mushonga wemarwadzo waipiwa nachiremba uyo waiva muboka remishonga inonzi COX-2 inhibitors. Mushonga uyu wakagadzirirwa kuderedza marwadzo nekuzvimba ukuwo zvichikonzera matambudziko mudumbu mashoma pane marwadzo echinyakare. Zvisinei, valdecoxib yakabviswa pamusika muna 2005 nekuda kwekunetseka kwakakomba kwekuchengeteka, kunyanya kuwedzera njodzi yekurwadziwa kwemoyo uye sitiroko.

Chii chinonzi Valdecoxib?

Valdecoxib yaiva selective COX-2 inhibitor yaishanda zvakasiyana nemishonga yemarwadzo yakajairika se ibuprofen kana aspirin. Yakagadzirirwa zvakananga kuvharira chete enzyme yeCOX-2, iyo inoita basa rakakosha mumarwadzo nekuzvimba. Iyi nzira yekusarudza yakaitirwa kupa rubatsiro rwemarwadzo runoshanda ukuwo ichideredza njodzi yezvinyorwa mudumbu uye kubuda ropa kunogona kuitika nemishonga isiri-steroidal anti-inflammatory drugs (NSAIDs).

Mushonga uyu wakatengeswa pasi pezita rekuti Bextra uye yaivepo chete nekunyorerwa nachiremba. Yakauya muchimiro chepiritsi uye yaigara ichinyorerwa mamiriro ane marwadzo asingaperi nekuzvimba.

Valdecoxib yaishandiswa kuitei?

Asati abviswa, valdecoxib yaipiwa kurapa mamiriro akati wandei anorwadza. Vanachiremba vakanyanya kuishandisa osteoarthritis, rheumatoid arthritis, uye acute pain management. Mushonga uyu waibatsira zvikuru vanhu vaida rubatsiro rwemarwadzo kwenguva refu asi vakatadza kutsungirira NSAIDs yechinyakare nekuda kwekutsamwa mudumbu.

Vamwe vanachiremba vakanyorawo valdecoxib yekubatsira marwadzo kwenguva pfupi mushure mekuvhiyiwa kwemazino kana kuvhiyiwa kudiki. Mushonga uyu waibatsira zvikuru varwere vaive nenhoroondo yezvinyorwa mudumbu kana kubuda ropa mudumbu, sezvo zvaitendwa kuti yaive nyoro pagadziriro yekugaya.

Valdecoxib yaishanda sei?

Valdecoxib yaishanda nekudzivisa enzyme chaiyo inonzi cyclooxygenase-2 (COX-2). Enzyme iyi ndiyo inogadzira makemikari anonzi prostaglandins, ayo anokonzera kurwadziwa, kuzvimba, uye fivha mumuviri wako. Nekudzivisa COX-2 zvakananga, valdecoxib yakaderedza zviratidzo izvi zvisingafadzi pasina kukanganisa zvakanyanya COX-1, imwe enzyme inobatsira kuchengetedza mudumbu rako.

Maitiro aya ekusarudza akaita kuti valdecoxib ive mushonga wekurwadziwa wakasimba zvishoma. Yaive nesimba kupfuura sarudzo dzisiri dzekutengeserana dzakadai se acetaminophen asi kazhinji isina simba kupfuura mishonga ine simba yekurwadziwa. Mushonga uyu kazhinji waitanga kushanda mukati memaawa mashoma ekutora, nemhedzisiro yepamusoro ichiitika mukati me2-3 maawa.

Valdecoxib Yaifanira Kutora Sei?

Panguva iyo valdecoxib yaivapo, vanachiremba vaiwanzoiraira kuti itorwe kamwe kana kaviri pazuva nezvokudya kana pasina. Kuitora nezvokudya kana mukaka kwaigona kubatsira kuderedza chero kutsamwa kwemudumbu, kunyangwe yakagadzirirwa kuva nyoro pamuviri wekugaya kupfuura maNSAIDs echinyakare.

Mushonga uyu waishanda zvakanaka kana uchitorwa panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana muropa rako. Varwere vaiudzwa kuti vatore nemvura yakazara uye kudzivisa kurara pasi kwemaminitsi angangoita 30 mushure mekuitora kudzivirira chero kutsamwa kunogona kuitika kune esophagus.

Valdecoxib Yaifanira Kutora Kwenguva Yakareba Sei?

Kureba kwekurapa kwevaldecoxib kwakasiyana zvichienderana nemamiriro ari kurapwa. Kurwadziwa kwakanyanya, senge mushure mebasa remazino, kazhinji yaipihwa kwemazuva mashoma kusvika vhiki. Zvemamiriro akareba searthritis, vamwe varwere vaiitora kwenguva yakareba pasi pekutariswa kwechiremba.

Asi, kunyange vasati vabvisa mushonga uyu, vanachiremba vaive vakangwarira pakunyora valdecoxib kwenguva yakareba. Vaiwongorora varwere nguva dzose kuti vaone mhedzisiro yacho nekushanda kwayo, vachichinja chirongwa chekurapa sezvaidiwa. Chinangwa chaive chekushandisa mushonga wakaderera unoshanda kwenguva pfupi inogoneka.

Ndezvipi Zvaive Zvakaipa ZveValdecoxib?

Valdecoxib yaive nemhedzisiro yakati wandei, kubva pakureruka kusvika kune yakakomba. Kunzwisisa njodzi idzi kwaive kwakakosha kune chero munhu aifunga nezvemushonga uyu, kunyangwe zvakakosha kuyeuka kuti havasi vese vakawana mhedzisiro.

Mhedzisiro inonyanya kunetsa yaive njodzi dzakakomba dzemoyo dzakazopedzisira dzaita kuti mushonga uyu ubviswe mumusika:

• Kuwedzera njodzi yekurwara nemoyo
• Mukana wepamusoro wekurwara ne stroke
• Kuumbwa kweropa
• Kuwedzera kweropa

Njodzi idzi dzemoyo dzakawedzera zvakanyanya muvanhu vaive vaine chirwere chemoyo kana zvinhu zvakawanda zvinokonzera matambudziko emoyo.

Mhedzisiro yakajairika iyo varwere vakawana yaive nyaya dzekugaya chikafu uye kusagadzikana kwakajairika:

• Kurwadziwa mudumbu nekunzwa kusvotwa
• Kutemwa nemusoro nekutenderera
• Kuzvimba mumaoko, tsoka, kana zvitsitsinho
• Kuneta nekupera simba
• Dhayareya kana kuvharika

Mhedzisiro iyi yaigona kudzoreka uye kazhinji yaivandudzika sezvo muviri waigadzirisa kumushonga.

Vamwe varwere vakawanawo maitiro eganda, ayo aigona kubva pakurasika zvishoma kusvika kune mamiriro akakomba seStevens-Johnson syndrome, chirwere cheganda chisingawanzoitiki asi chinogona kuisa hupenyu panjodzi.

Ndiani Aisafanira Kutora Valdecoxib?

Mapoka akati wandei evanhu akakurudzirwa kuti asatore valdecoxib nekuda kwekuwedzera njodzi yematambudziko akakomba. Vanhu vane chirwere chemoyo chinozivikanwa, kusanganisira avo vakamborwara nemoyo kana stroke, kazhinji havana kukodzera mushonga uyu.

Vanhu vane zvirwere zvakasiyana-siyana zvekuzvirwisa vanofanirawo kudzivisa valdecoxib. Izvi zvinosanganisira vanhu vane allergy kune sulfonamides (sulfa drugs) kana avo vakambove nemaitiro ekuzvirwisa kune mamwe maNSAIDs akadai seaspirin kana ibuprofen.

Zvimwe zvirwere zvakaita kuti valdecoxib isakodzere zvinosanganisira:

• Kukundikana kwakanyanya kwematsvo kana chiropa
• Maronda emudumbu kana kubuda ropa
• Kukundikana kwakanyanya kwemoyo
• Kuvhiyiwa kwemoyo kwemazuva achangopfuura
• Kuzvitakura, kunyanya mune trimester yechitatu

Izvi zvinopesana zvakavapo nekuti valdecoxib inogona kuwedzera zvirwere izvi kana kuita zvine njodzi nezvinetso zvehutano zviripo.

Zita reValdecoxib Brand

Valdecoxib yakatengeswa pasi pezita rekuti Bextra nePfizer, kambani huru yemishonga. Mushonga uyu waivapo muchimiro chepiritsi mumasimba akasiyana-siyana, kazhinji 10mg uye 20mg doses.

Bextra yakatengeswa zvakanyanya seimwe nzira yakachengeteka kune maNSAIDs echinyakare, kunyanya kune vanhu vaida manejimendi ekurwadziwa kwenguva refu. Zvisinei, rudzi urwu rwakabviswa mumusika pasi rose muna 2005 zvichitevera kunetseka kwekuchengeteka kwakaonekwa muzvidzidzo zvekurapa.

Valdecoxib Alternatives

Sezvo valdecoxib isisipo, vanachiremba zvino vanoshandisa mishonga yakasiyana-siyana yezvirwere zvakafanana. Kusarudzwa kweimwe nzira kunoenderana nechinetso chako, nhoroondo yekurapa, uye njodzi.

Kune vanhu vakambotora valdecoxib kurwadziwa kwearthritis, sarudzo dzazvino dzinosanganisira:

• Celecoxib (Celebrex) - imwe COX-2 inhibitor inoramba iripo
• MaNSAIDs echinyakare akadai se ibuprofen kana naproxen
• Zvinobvisa kurwadziwa zvinoshandiswa zvakananga paganda
• Acetaminophen yekurwadziwa kwakapfava kusvika pakati nepakati

Kune avo vanoda rubatsiro rwakanyanya rwekurwadziwa, vanachiremba vanogona kufunga nezvemishonga yekurapa yakadai setramadol kana, muzviitiko zvakakomba, mishonga yeopioid inotariswa zvakanyanya.

Nzira dzisiri dzemishonga dzakawedzerawo kuve dzakakurumbira, kusanganisira kurapwa kwemuviri, acupuncture, uye shanduko dzemaitiro dzinogona kubatsira kubata mamiriro ekurwadziwa kwenguva refu.

Ko Valdecoxib Yakangairi Nani Pane Dzimwe Mishonga Yekurwadziwa?

Valdecoxib yaive nezvose zvakanakira nezvayakaipira zvichienzaniswa nemimwe mishonga yekurwadziwa yaivapo panguva iyoyo. Chakanakira chayo chikuru chaive kuderedzwa kwenjodzi yezvinyorwa mudumbu uye kubuda ropa zvichienzaniswa neNSAIDs yechinyakare senge ibuprofen kana naproxen.

Zvisinei, kubatsirwa uku kwakauya nekutengeserana kwakakosha. Njodzi dzakawedzera dzemoyo dzakapedzisira dzakakunda mabhenefiti emudumbu kune vanhu vazhinji. Zvidzidzo zvakaratidza kuti nepo valdecoxib yaive nyore mudumbu, yaive nenjodzi huru yekurwisa kwemoyo uye sitiroko kupfuura akawanda eNSAIDs echinyakare.

Zvichienzaniswa necelecoxib (Celebrex), imwe COX-2 inhibitor inoramba iripo, valdecoxib yaiita seinotakura njodzi huru dzemoyo. Musiyano uyu mumaprofiles ekuchengetedza wakabatsira kubviswa kwevaldecoxib nepo celecoxib yakaramba iri pamusika ine yambiro dzakagadziridzwa.

Mibvunzo Inowanzo Bvunzwa Nezve Valdecoxib

Ko Valdecoxib Yakachengeteka Kune Vanhu vane Chirwere Chemoyo?

Kwete, valdecoxib yakanga isina kuchengeteka kune vanhu vane chirwere chemoyo, uye ichi chaive chimwe chezvikonzero zvikuru zvakabviswa pamusika. Zvidzidzo zvakaratidza kuti valdecoxib yakawedzera zvakanyanya njodzi yekurwisa kwemoyo uye sitiroko, kunyanya kune vanhu vakanga vatove nematambudziko emoyo kana zvinhu zvine njodzi.

Vanhu vane mamiriro emoyo aripo avo vakatora valdecoxib vaive nemukana wakanyanya wekusangana nezviitiko zvakakomba zve cardiovascular. Njodzi iyi yaive yakakosha zvekuti yakakunda chero mabhenefiti anogona kupa mushonga wekurerutsa kurwadziwa.

Ndoita Sei Kana Ndakashandisa Valdecoxib Yakawandisa Netsaona?

Sezvo valdecoxib isisipo, mamiriro ezvinhu aya haafaniri kuitika nemishonga mitsva. Zvisinei, kana mumwe munhu aiva nemapiritsi ekare e valdecoxib uye netsaona akatora zvakanyanya, vanofanira kunge vakatsvaga rubatsiro rwekurapa nekukasira.

Zviratidzo zvekuwandisa kwe valdecoxib zvinogona kusanganisira kurwadziwa kwakanyanya mudumbu, kusvotwa, kurutsa, kurara, uye mumamiriro ezvinhu akaoma, kuoma kufema kana shanduko mukuziva. Rubatsiro rwekurapa rweEmergency rwaizofanira kuongorora matambudziko akakomba uye kupa kurapwa kwakakodzera.

Ndoita Sei Kana Ndakakanganwa Dose ye Valdecoxib?

Panguva iyo valdecoxib yaivapo, varwere vakakanganwa dose vaiwanzokurudzirwa kuitora pakarepo pavairangarira, kunze kwekunge yave nguva yechikamu chinotevera. Muchiitiko ichocho, vanofanira kusvetuka dose yakakanganwa uye kuramba nechirongwa chavo chekushandisa mishonga.

Varwere vakanyatsochenjedzwa kuti vasambovavarira doses kuti vagadzirise imwe yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yemigumisiro. Kana mumwe munhu aigara achikanganwa doses, vakakurudzirwa kushandisa varongi vepiritsi kana kumisa zviyeuchidzo kuti vabatsire kuchengetedza mazinga emishonga.

Varwere Vaigona Kumira Rini Kutora Valdecoxib?

Asati abviswa, varwere vaiwanzogona kumira kutora valdecoxib zvishoma nezvishoma pasi pekutungamirirwa nachiremba wavo. Kusiyana nemimwe mishonga inoda kutapirwa zvakanyatsonaka, valdecoxib yaigona kumiswa nekukurumidza pasina zviratidzo zvakakomba zvekubviswa.

Zvisinei, varwere vakakurudzirwa kushanda pamwe chete nevapi vehutano kuti vagadzire nzira dzimwe dzokurapa kurwadziwa vasati vamisa mushonga. Izvi zvakaita kuti mamiriro avo ari pasi arambe achitungamirirwa zvakanaka nezvimwe zvingasarudzwa zvakachengeteka.

Pane Zvinetso Zvemutemo Zvine Chokuita neValdecoxib Here?

Hongu, paive nematambudziko makuru emutemo akapoteredza valdecoxib mushure mekubviswa kwayo mumusika. Varwere vazhinji vakawana kurwisa kwemoyo kana sitiroko vachitora mushonga vakaisa mhosva kuna Pfizer, vachiti kambani yakatadza kunyevera zvakakwana nezve njodzi dzemoyo nemidziyo yeropa.

Nyaya idzi dzemutemo dzakaguma nekugadziriswa kukuru uye dzakaratidza kukosha kwekuongorora kwakakwana kwekuchengetedza uye kutaurirana pachena nezve njodzi dzemishonga. Mamiriro e valdecoxib akabatsira kune zvinodiwa zvakasimba zvekuongorora kuchengetedzwa kwemoyo nemidziyo yeropa yemishonga mitsva inorwisa kuzvimba.