Chii chinonzi Vamorolone: Zvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Vamorolone imhando itsva yemishonga yema steroid yakagadzirirwa kurapa Duchenne muscular dystrophy (DMD). Kusiyana nema steroid echinyakare, mushonga uyu unovavarira kupa mabhenefiti ekuvaka tsandanyama uku uchikonzera mashoma migumisiro yakaipa inogona kukanganisa kukura uye hutano hwemapfupa.

Mishonga iyi inomiririra danho rakakosha mberi mukurapa DMD. Inoshanda nekuderedza kuzvimba munyama yetsandanyama uku ichinyanya kunaka pamasisitimu ako echisikigo achienzaniswa nemamwe ma steroid ekare.

Chii chinonzi Vamorolone?

Vamorolone i steroid inoparadzanisa, zvinoreva kuti yakagadzirirwa kuparadzanisa mhedzisiro yakanaka kubva kune yakawanda yeiyo inokuvadza. Iyo ndeyeboka remishonga inonzi corticosteroids, asi yakagadziridzwa zvakanyanya kuti ishande zvakasiyana nema steroid echinyakare seprednisone.

Mishonga iyi inouya semumukanwa wekumiswa waunotora nemuromo. Yakanyatsogadzirirwa kurapa Duchenne muscular dystrophy muvarwere vane makore angangoita 2 okukura.

Funga nezve vamorolone seimwe nzira yakatarwa yekurapa steroid. Kunyange zvazvo ichiri kupa mabhenefiti ekurwisa-kuzvimba anodiwa kubatsira kuchengetedza basa retsandanyama, yakagadzirirwa kudzivisa yakawanda yekukura-kudzora uye mapfupa-anoshaya simba mhedzisiro inoita kuti ma steroid echinyakare ave nematambudziko ekushandiswa kwenguva refu.

Chii chinonzi Vamorolone Chinoshandiswa?

Vamorolone inonyanya kushandiswa kurapa Duchenne muscular dystrophy, mamiriro emagenetic anokonzera kupera simba kwetsandanyama uye kuora. Mamiriro aya anonyanya kukanganisa vakomana uye anowanzo kutanga kuratidza zviratidzo pazera remwana.

Mishonga iyi inobatsira kunonotsa kuora kwetsandanyama uye inogona kuvandudza simba retsandanyama nebasa. Zvinokosha zvikuru nokuti varwere vane DMD vanowanzoda kurapwa kwenguva refu ne steroid, uye vamorolone inopa imwe nzira yakachengeteka yekushandisa kwakawedzerwa.

Chiremba wako angaraira vamorolone kana ma steroid echinyakare akakonzera matambudziko, kana semushonga wekutanga kubatsira kuchengetedza kukura kwemwana wako uye hutano hwemapfupa apo vachiri kupa mabhenefiti ekudzivirira tsandanyama anodiwa pakurapa DMD.

Vamorolone Inoshanda Sei?

Vamorolone inoshanda nekuderedza kuzvimba munyama yetsandanyama, izvo zvinobatsira kunonotsa kukuvadzwa kwetsandanyama kunoitika muDuchenne muscular dystrophy. Inotarisa nzira dzakatarwa mumuviri wako dzinodzora kuzvimba pasina kushandisa zvizere nzira dzinokonzera matambudziko mazhinji e steroid.

Mushonga uyu unoonekwa se steroid yepakati nepakati. Yakasimba zvakakwana kuti ipe mabhenefiti anokosha ekuchengetedza tsandanyama asi inononoka kupfuura ma steroid echinyakare senge prednisone kana zvasvika pakukanganisa kukura, mapfupa, uye mamwe masisitimu emuviri.

Musiyano mukuru ndewekuti vamorolone inosangana sei nemareceptors emuviri wako e steroid. Inosarudza kushandisa mhedzisiro inobatsira yekurwisa-kuzvimba apo ichiita zvishoma pakureceptors zvinodzora kukura, metabolism yemafupa, uye basa re immune.

Ndingatora Sei Vamorolone?

Vamorolone inouya semumvuri wemuromo waunotora kamwe pazuva, zviri nani panguva imwe chete zuva rega rega. Unofanira kuitora nechikafu kubatsira kuderedza chero dumbu rinogona kukanganisa uye kuvandudza kunyudzwa.

Usati watora dose yega yega, zunza bhodhoro zvakanaka kuti uve nechokwadi chekuti mushonga wakavhenganiswa zvakanaka. Shandisa syringe yekuyera yakapihwa nemushonga kuyera huwandu chaihwo hwakarairwa nachiremba wako.

Unogona kutora vamorolone nemukaka, mvura, kana muto kana zvichidikanwa kuti zvive nyore. Kuva nechikafu chakareruka kana snack usati watora mushonga kunogona kubatsira kudzivirira chero kusagadzikana mudumbu. Edza kugadzira tsika, senge kuitora nekudya kwemangwanani, kubatsira kuyeuka dose yako yezuva nezuva.

Ndingatora Vamorolone Kwenguva Yakareba Sei?

Vamorolone inowanzo perezverwa semushonga wenguva refu weDuchenne muscular dystrophy. Vanhu vazhinji vanoda kutora mushonga uyu kwemakore, sezvo DMD iri mamiriro anofambira mberi anoda kurapwa nguva dzose.

Chiremba wako achatarisa mhinduro yako kumushonga uye achagadzirisa chirongwa chekurapa sezvinodiwa. Chinangwa ndechekuchengetedza kushanda kwemhasuru uye kunonotsa kufambira mberi kwechirwere uchideredza mhedzisiro.

Kutarisa nguva dzose kuchabatsira kuziva kana vamorolone ichiramba iri sarudzo yakakodzera kwauri. Chiremba wako anogona kugadzirisa muyero kana kufunga nezvesarudzo dzimwe dzekurapa zvichienderana nekuti uri kupindura sei uye chero mhedzisiro yaungave nayo.

Ndezvipi Zvinhu Zvinokonzerwa neVamorolone?

Nepo vamorolone yakagadzirirwa kukonzera mhedzisiro shoma pane ma steroids echinyakare, inogona kuchiri kukonzera zvimwe zvisingadiwi. Vanhu vazhinji vanoshivirira mushonga uyu zvakanaka, asi zvakakosha kuziva zvekutarisa.

Heano mhedzisiro yakajairika yaungave nayo:

• Kusagadzikana mudumbu kana kusvotwa
• Kutemwa nemusoro
• Kuwedzera chido
• Kuchinja kwemafungiro kana kutsamwa
• Kutadza kurara
• Zvirwere zvekufema zvepamusoro

Izvi zvinokonzeresa zvinowanzo kuva zvinyoro uye zvinowanzoita nani muviri wako uchigadzirisa kumushonga.

Zvimwe zvisingawanzoitiki asi zvakanyanya kukomba zvinogona kusanganisira:

• Kuwedzera uremu zvakanyanya
• High blood pressure
• Kuchinja kwemazinga eshuga yeropa
• Kukura kunonoka muvana (kunyangwe zvishoma pane ma steroids echinyakare)
• Kuwedzera njodzi yezvirwere
• Cushingoid features (chiso chakakomberedzwa, kuwedzera uremu mumuviri wepamusoro)

Bata chiremba wako kana ukaona chero shanduko dzinonetsa kana kana mhedzisiro ichikanganisa mabasa ezuva nezuva.

Zvisingawanzoitika asi zvakakomba zvinogona kusanganisira maitiro akanyanya ekuita allergic, shanduko dzakakosha dzemafungiro, kana kubuda ropa risinganzwisisike kana kupwanya. Izvi zvinoda kutariswa kwekurapa nekukurumidza, kunyangwe zvisingawanzoitika nevamorolone.

Ndiani Asingafaniri Kutora Vamorolone?

Vamorolone haikodzeri munhu wese. Chiremba wako achanyatsoongorora kana mushonga uyu wakakodzera iwe kana mwana wako zvichibva munhoroondo yako yekurapa uye mamiriro ako ehutano azvino.

Haufaniri kutora vamorolone kana uine allergic kwairi kana chero zvinhu zvayo. Vanhu vane zvirwere zvakasiyana-siyana zvinogona kudiwa kudzivisa mushonga uyu kusvikira chirwere chichirapwa.

Chiremba wako achashandisa kungwarira kwakanyanya kana uine:

• Zvirwere zveviral, bacterial, kana fungal zviri kushanda
• Mishonga yekudzivirira mwana ichangobva kutorwa kana zvirongwa zvekudzivirira mwana
• Chirwere cheshuga kana matambudziko eshuga yeropa
• Matambudziko emoyo kana BP yakakwira
• Chirwere chechiropa kana itsvo
• Osteoporosis kana matambudziko emapfupa

Vakadzi vane pamuviri kana vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti nachiremba wavo, sezvo paine ruzivo rushoma nezvekuchengeteka kwevamorolone panguva yekuzvitakura.

Mazita eBrand eVamorolone

Vamorolone inowanikwa pasi pezita rebrand Agamree muUnited States. Iri ndiro zita rekutanga rebrand remushonga uyu mumisika yakawanda kwaunobvumidzwa.

Mishonga inogona kuwanikwa pasi pemazita akasiyana ebrand mune dzimwe nyika, asi Agamree ndiro zita rinonyanya kuzivikanwa. Nguva dzose tarisa nemupharmacist wako kuti uve nechokwadi chekuti uri kugamuchira mushonga wakarurama.

Paunenge uchikurukura mushonga uyu nevapi vehutano kana ma pharmacist, unogona kuutaura nezita rayo re generic (vamorolone) kana zita rebrand (Agamree).

Zvimwe zvinotsiva Vamorolone

Mishonga mimwe yakawanda inoshandiswa kurapa Duchenne muscular dystrophy, kunyange vamorolone ichipa mabhenefiti akasiyana se steroid inoparadzanisa. Corticosteroids yechinyakare yakaita se prednisone uye deflazacort ichiri kurairwa zvakajairika.

Prednisone yanga iri kurapwa kwakajairika kweDMD kwemakore mazhinji. Inoshanda pakuchengetedza basa remhasuru asi inogona kukonzera mhedzisiro yakakosha kusanganisira kudzvinyirirwa kwekukura, kurasikirwa kwemapfupa, uye shanduko dzekuzvibata nekushandiswa kwenguva refu.

Deflazacort imwe sarudzo ye steroid inogona kukonzera mhedzisiro shoma pane prednisone, kunyanya maererano nekuwedzera uremu uye shanduko dzekuzvibata. Zvisinei, ichiri kukanganisa kukura uye hutano hwemapfupa nekufamba kwenguva.

Zvimwe zvirwere zveDMD zvinosanganisira eteplirsen, golodirsen, uye casimersen, izvo zvirapi zvemajini zvinoshanda zvakasiyana ne steroids. Izvi zvinongokodzera varwere vane shanduko dzakakosha dzemajini uye vanoshanda nekubatsira maseru kugadzira imwe puroteni ye dystrophin inoshanda.

Ko Vamorolone Zviri Nani Pane Prednisone?

Vamorolone inopa zvakanakira zvakawanda pane prednisone, kunyanya kushandiswa kwenguva refu muDuchenne muscular dystrophy. Bhenefiti huru ndeyekuti vamorolone inokonzera kushoma kukura, hutano hwemapfupa, uye shanduko dzekuzvibata ichiri kupa mhedzisiro yekudzivirira mhasuru.

Zvidzidzo zvakaratidza kuti vamorolone inogona kuchengetedza basa remhasuru zvakafanana ne prednisone asi nemhedzisiro shoma pakureba uye kuwanda kwemapfupa. Izvi zvinoita kuti ive yakakosha kunyanya kuvana vanoda makore ekurapa steroid.

Zvisinei, prednisone yakashandiswa kwemakumi emakore uye ine tsvakurudzo yakawanda inotsigira kushanda kwayo. Izvo zvakare zvinowanikwa zvakanyanya uye kazhinji zvakachipa pane vamorolone. Chiremba wako achafunga nezvezvinhu zvakaita sezera rako, chinzvimbo chekukura, kupindura kurapwa kwapfuura, uye inishuwarenzi paachisarudza pakati pezvisarudzo izvi.

Mibvunzo Inowanzo Bvunzwa Nezve Vamorolone

Q1. Ko Vamorolone Yakachengeteka Here Kune Matambudziko Emoyo?

Vamorolone inogona kushandiswa muvanhu vane matambudziko emoyo, asi zvinoda kunyatso tarisa. Sezvo DMD inowanzo kukanganisa moyo pamwe chete nemhasuru dzemumuviri, chiremba wako achada kuenzanisa mabhenefiti ekuchengetedza mhasuru nemhedzisiro ipi neipi inogona kuitika pamoyo.

Mishonga iyi inogona kukonzera kuwedzera kudiki kweropa mune vamwe varwere, izvo zvinogona kunetsa kana iwe watove nematambudziko emoyo. Chiremba wako anogona kutarisa ropa rako uye basa remoyo zvakanyanya kana uine matambudziko emoyo.

Q2. Ndingaita Sei Kana Ndakashandisa Vamorolone Yakawandisa Netsaona?

Kana iwe netsaona ukatora yakawanda kupfuura chiyero chakatemwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Usavhunduka, asi tsvaga mazano ekurapa nekukurumidza kuti uone kana imwe yekutarisa kana kurapwa kuchidikanwa.

Kutora vamorolone yakawanda kunogona kuwedzera njodzi yemhedzisiro, kunyanya iyo ine chekuita ne steroid yakawandisa senge ropa rakakwira, shanduko dzemafungiro, kana kukwira kweshuga yeropa. Mupi wako wehutano anogona kuda kukutarisa zvakanyanya mumazuva mashoma anotevera.

Q3. Ndingaita Sei Kana Ndakakanganwa Dose yeVamorolone?

Kana iwe ukakanganwa dose, itore nekukasira paunorangarira, kunze kwekunge yava nguva yechiyero chako chinotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chese.

Usambofa wakatora zviyero zviviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Kana iwe uchikanganwa zviyero kazhinji, funga kuseta zviyeuchidzo zvefoni kana kutora mushonga panguva imwe chete nebasa rezuva nezuva senge kudya kwemangwanani.

Q4. Ndingamira Rini Kutora Vamorolone?

Haufanire kumira kutora vamorolone kamwechete usina kubvunza chiremba wako. Kufanana nemamwe ma steroids, mushonga uyu unogona kudikanwa kuti udzikiswe zvishoma nezvishoma kuti udzivise zviratidzo zvekubviswa.

Chiremba wako achasarudza kuti ungachinja sei kana kumisa vamorolone zvichienderana nekufambira mberi kweDMD yako, mhedzisiro, uye hutano hwako hwese. Sarudzo yekumisa kurapwa inogara ichiitwa pamwe chete pakati pako nechikwata chako chehutano.

Mubvunzo 5. Vamorolone Inogona Kukanganisa Majekiseni?

Vamorolone inogona kukanganisa mhinduro yemasoja emuviri wako kumajekiseni, kunyangwe zvishoma pane ma steroids echinyakare. Unofanira kudzivisa majekiseni mhenyu paunenge uchitora mushonga uyu, sezvo angangokonzera hutachiona.

Majekiseni asina simba (semajekiseni eflu) anowanzo chengeteka, asi anogona kushanda zvishoma paunenge uchitora vamorolone. Nguva dzose zivisa chiremba wako nezve chero majekiseni akarongwa kuti vakwanise kukupa zano panguva yakanakisisa uye nzira yekusvika.