Chii chinonzi Vandetanib: Zvazvinoshandiswa, Mishonga, Migumisiro, nezvimwe

Vandetanib mushonga wekenza unovharira mapurotini akati wandei anobatsira masero ekenza kukura nekupararira. Inonyanya kushandiswa kurapa rudzi rusingawanzoitiki rwekenza yegurokuro inonzi medullary thyroid carcinoma kana kuvhiyiwa kusingagoneki kana kenza yapararira kune dzimwe nhengo dzemuviri.

Mishonga iyi ndeyeboka remishonga inonzi tyrosine kinase inhibitors, iyo inoshanda semagetsi emamorekuru kuti icheke zviratidzo zvinoudza masero ekenza kuti awande. Kunyange zvazvo iri kurapwa kwakakosha, kunzwisisa mashandiro ayo uye zvekutarisira zvinogona kukubatsira kuti unzwe wakagadzirira kana chiremba wako achikurudzira.

Chii chinonzi Vandetanib?

Vandetanib mushonga wekenza unopiwa nachiremba uyo unotarisa mapurotini akati wandei anobatanidzwa mukukura kwemasero ekenza. Ndizvo zvinonzi nachiremba

Mushonga uyu wakabvumirwa zvakananga kuvashandi vane tumor dzisingagoni kubviswa nekuvhiyiwa kana kenza yavo yapararira (yakwira) kune dzimwe nzvimbo dziri kure dzemuviri. Zvinobatsira zvikuru vanhu vane mhando dzinogara nhaka dze medullary thyroid carcinoma inokonzerwa nekuchinja kwemajini.

Dzimwe nguva vanachiremba vanogona kunyora vandetanib kune mamwe marudzi asingawanzoitiki ekenza sechikamu chekuedzwa kwekiriniki kana zvirongwa zvekushandisa tsitsi. Zvisinei, kushandiswa kwayo kwekutanga uye kwakanyatsoongororwa kunoramba kuri mukurapa advanced medullary thyroid carcinoma kana dzimwe nzira dzekurapa dzisina kukodzera.

Vandetanib Inoshanda Sei?

Vandetanib inoshanda nekudzivisa mapuroteni akawanda ayo masero ekenza anoshandisa kukura, kupararira, uye kugadzira midzi yeropa mitsva. Fungidzira sekugadzira zvipingamupinyi mumigwagwa yakawanda iyo masero ekenza anofamba kuti awande uye apararire mumuviri wako.

Mushonga uyu unonyanya kutariswa mapuroteni anonzi RET, VEGFR, uye EGFR, ayo akafanana nemaswitch anoudza masero ekenza kuti akure uye aparadzane. Nekudzivisa maswitch aya, vandetanib inogona kuderedza kana kumisa kufambira mberi kwekenza.

Izvi zvinoonekwa semushonga wekenza une simba rakati rebei. Kunyange zvazvo isina simba seimwe mishonga yekemotheraphy, ichine simba rakakwana rekukanganisa kukura kwekenza zvakanyanya. Nzira yakatarwa zvinoreva kuti inowanzotsungiririka kupfuura chemotherapy yechinyakare, kunyange zvakadaro ichiri kuda kutariswa zvakanaka nechikwata chako chehutano.

Ndingatora Sei Vandetanib?

Tora vandetanib sezvinorayirwa nachiremba wako, kazhinji kamwe pazuva panguva imwe chete zuva rega rega. Unogona kuitora uine kana usina chikafu, asi edza kuenderana nesarudzo yako kuti ubatsire kuchengetedza mazinga akagadzikana mumuviri wako.

Mamedza mahwendefa ese negirazi remvura izere. Usapwanye, kuputsa, kana kuitsenga, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unotorwa nayo. Kana uine dambudziko rekumedza mahwendefa, taura nachiremba wako nezve dzimwe nzira.

Zvakanaka kutora vandetanib mudumbu risina chinhu kana zvichibvira, nekuti chikafu dzimwe nguva chinogona kuderedza kuti muviri wako unotora sei mushonga. Zvisinei, kana uine dambudziko mudumbu, chiremba wako angakurudzira kuutora nechikafu chakareruka kana chidyo.

Dzivisa grapefruit uye muto wegrapefruit paunenge uchitora mushonga uyu, nekuti zvinogona kuwedzera mazinga e vandetanib muropa rako uye zvinogona kukonzera mamwe matambudziko. Zvakare, edza kuutora maawa angangoita 2 usati kana pashure pezvinowedzera calcium kana antacids.

Ndingatora Vandetanib Kwenguva Yakareba Sei?

Unowanzoenderera mberi uchitora vandetanib chero bedzi ichidzora kenza yako uye uchigona kuigamuchira zvakanaka. Izvi zvinowanzoita kuti utore kwenguva refu, dzimwe nguva kwemwedzi kana kunyange makore, zvichienderana nekuti kenza yako inopindura sei.

Chiremba wako achatarisa kupindura kwako kuburikidza nekuongorora nguva dzose uye bvunzo dzeropa, kazhinji mwedzi mishoma yega yega. Kana kenza ikamira kupindura kumushonga kana kana ukaona matambudziko akakomba, chiremba wako anogona kugadzirisa dose kana kufunga kuchinja kune imwe kurapwa.

Kureba kwekurapa kunosiyana zvakanyanya kubva kumunhu nemunhu. Vamwe vanhu vanoi tora kwemakore akati wandei vaine mhedzisiro yakanaka, nepo vamwe vachigona kumira nekukurumidza nekuda kwematambudziko kana kufambira mberi kwekenza. Chikwata chako chehutano chichashanda newe kuti uwane chiyero chakakodzera pakati pekudzora kenza yako uye kuchengetedza hupenyu hwako.

Ndezvipi Zvakaipa Zve Vandetanib?

Semishonga yese yekenza, vandetanib inogona kukonzera matambudziko, kunyangwe kwete munhu wese anoawana. Matambudziko mazhinji anogona kugadziriswa nekuchengetwa kwakakodzera kwekurapa uye kuongorora.

Heano matambudziko anowanzoitika aunogona kusangana nawo:

• Manyoka, inobata vanhu vanenge 60% vachitora mushonga uyu
• Mavanga paganda kana mapundu akafanana neakne pachiso chako nemuviri wepamusoro
• High blood pressure inoda kutarisa nguva dzose
• Nausea uye kuderedzwa kwechido chekudya
• Kuneta uye kushaya simba
• Kutemwa nemusoro
• Kuchinja muzvipikiri zvako zveminwe nezvigunwe

Izvi zvinowanzoitika zvinowanzoitika zvinyoro kusvika pakati nepakati uye zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga. Chiremba wako anogona kunyora mishonga yekubatsira kubata zviratidzo zvakaita semanyoka uye nausea.

Zvimwe zvinokuvadza asi zvisingawanzoitiki zvinosanganisira shanduko yerhythm yemoyo, kuita kweganda kwakanyanya, uye matambudziko echiropa. Chiremba wako achakutarisa zvakanyanya nemiedzo yeropa yenguva dzose uye kutarisa rhythm yemoyo kuti ubate chero nyaya dzakakomba pakutanga.

Kazhinji, vamwe vanhu vanogona kusangana nematambudziko akakomba emapapu, kubuda ropa kwakanyanya, kana mamiriro anonzi tumor lysis syndrome uko maseru ekenza anoparara nekukurumidza. Kunyange izvi zvisingawanzoitiki, zvakakosha kuzivisa chero zviratidzo zvisingawanzoitiki kuchikwata chako chehutano nekukasira.

Ndiani Asingafaniri Kutora Vandetanib?

Vandetanib haikodzeri munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wainyora. Vanhu vane mamwe mamiriro emoyo, kunyanya avo vane nhoroondo ye rhythm yemoyo isina kujairika, vangave vasiri vakanaka kumushonga uyu.

Haufaniri kutora vandetanib kana wakazvitakura kana kuyamwisa, sezvo inogona kukuvadza mwana asati aberekwa kana mucheche anoyamwisa. Vakadzi vane makore ekubereka vana vanofanirwa kushandisa nzira yekudzivirira kubata pamuviri panguva yekurapa uye kwemwedzi yakati wandei mushure mekumisa mushonga.

Vanhu vane matambudziko akakomba echiropa kana itsvo vangangoda kugadzirisa dosi kana vangave vasingakwanise kutora mushonga uyu zvakachengeteka. Chiremba wako achaongorora chiropa chako nebasa reitsvo usati watanga kurapwa uye achavatarisa nguva dzose.

Kana uine nhoroondo yezvirwere zvinobuda ropa, kuvhiyiwa kwemazuva ano, kana uri kutora mishonga inotetesa ropa, chiremba wako achafanira kuyera zvakanaka njodzi nemabhenefiti. Uyezve, vanhu vane mamwe mamiriro ejeneti anokanganisa rhythm yemoyo vangave vasina kukodzera.

Zita reBrand reVandetanib

Vandetanib inotengeswa pasi pezita rebrand Caprelsa. Iri ndiro zita rebrand chete rinowanikwa remushonga uyu, sezvo uchigadzirwa nemakambani eAstraZeneca.

Unogona kuona mazita ese ari maviri achishandiswa zvakatsinhirana mumabhuku ekurapa uye zvirongwa. Kunyangwe mushonga wako uchiti "vandetanib" kana "Caprelsa," imushonga mumwe chete une chinhu chimwe chete chinoshanda uye mhedzisiro imwe chete.

Mishonga yakajairika ye vandetanib haisati yawanikwa zvakanyanya munyika zhinji, saka vanhu vazhinji vanogamuchira zita rebrand Caprelsa. Inishuwarenzi yako uye pharmacy ndiyo ichasarudza kuti ndeipi vhezheni yaunogamuchira, kunyangwe mushonga wacho uchiramba wakafanana.

Zvimwe Zvinogona Kushandiswa Pane Vandetanib

Kana vandetanib isina kukodzera iwe kana ikamira kushanda zvakanaka, pane dzimwe nzira dzekurapa dzinowanikwa dzekurapa medullary thyroid carcinoma. Chiremba wako achafunga nezve mamiriro ako chaiwo paanokurudzira dzimwe nzira.

Cabozantinib imwe nzira yekurapa inotarwa inoshanda zvakafanana ne vandetanib uye inowanzo shandiswa seimwe nzira. Inotarisa mamwe mapuroteni akafanana asi inogona kushanda zvirinani kune vamwe vanhu kana kuve nemhedzisiro yakasiyana.

Dzimwe nzira dzinosanganisira mishonga yechinyakare yekemotherapy, radiation therapy, kana kutora chikamu mumiedzo yekiriniki yekuyedza nzira itsva dzekurapa. Imwe nzira yakanakisa inoenderana nezvinhu zvakaita sehutano hwako hwese, kuti gomarara rako rakapindura sei kurapwa kwakapfuura, uye zvaunofarira.

Dzimwe nguva vanachiremba vangakurudzira kusanganiswa kwemishonga kana kuronga kuzorora kubva kumishonga kuti muviri wako upore usati waedza imwe nzira. Chinhu chakakosha kushanda pamwe chete nechikwata chako cheoncology kuti uwane chirongwa chekurapa chinoshanda zvakanyanya kumamiriro ako chaiwo.

Ko Vandetanib Ari Nani Kudarika Cabozantinib?

Vose vandetanib na cabozantinib mishonga inoshanda yekurapa medullary thyroid carcinoma, asi hapana anokunda zvakajeka anoshanda zviri nani kune vese. Sarudzo pakati pavo inowanzoenderana nemamiriro ako ega uye maitiro ako kumushonga wega wega.

Zvidzidzo zvinoratidza kuti cabozantinib inogona kushanda zvishoma kuderedza bundu uye kunonotsa kufambira mberi kwekenza, asi inogonawo kukonzera mhedzisiro yakakomba kune vamwe vanhu. Vandetanib inowanzo shivirirwa zviri nani nevakawanda varwere, kunyanya maererano nemhedzisiro yekugaya.

Chiremba wako achafunga nezvezvinhu zvakaita sehutano hwako hwese, mimwe mishonga yaunotora, uye mhando yako chaiyo yekenza yegurokuro paunenge uchisarudza pakati pezvisarudzo izvi. Vamwe vanhu vanoita zviri nani nemushonga mumwe pane mumwe, uye hazvigoneke nguva dzose kufanotaura kuti ndechipi chichashanda zvakanyanya kwauri.

Mashoko akanaka ndewekuti kuva nezvose zviripo zvinokupa iwe nachiremba wako kuchinjika mukuronga kurapa. Kana imwe isingashande zvakanaka kana kukonzera mhedzisiro inonetsa, unogona kazhinji kuchinjira kune imwe.

Mibvunzo Inowanzo Bvunzwa Nezve Vandetanib

Ko Vandetanib Akachengeteka Kune Vanhu vane Chirwere Chemoyo?

Vandetanib inoda kungwarira kwakakosha kune vanhu vane mamiriro emoyo nekuti inogona kukanganisa rhythm yemoyo. Chiremba wako achaita electrocardiogram (EKG) asati atanga kurapwa uye achatarisa moyo wako nguva dzose mukati mekurapa.

Kana uine nhoroondo yematambudziko emoyo, kutadza kwemoyo, kana mamwe mamiriro akakomba emoyo, chiremba wako achanyatso kuyera njodzi nemabhenefiti. Unogona kuda kuongororwa kakawanda kana mushonga wakaderera kuti uve nechokwadi chekuchengeteka kwako.

Mishonga inogona kukonzera mamiriro anonzi QT kuwedzera, izvo zvinokanganisa sisitimu yemagetsi yemoyo. Kunyange izvi zvichigoneka nekutarisa kwakakodzera, ndosaka kuongororwa kwenguva dzose kwemoyo kuchikosha zvakanyanya panguva yekurapa.

Ndoita Sei Kana Ndakatora Vandetanib Yakawandisa Netsaona?

Kana netsaona ukatora vandetanib yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Usamirira kuti uone kana zviratidzo zvichikura, sezvo kupindira kwekutanga kwakakosha nemishonga yekenza.

Zviratidzo zve overdose zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, manyoka, kana shanduko mumoyo. Kana ukaona chero zviratidzo izvi mushure mekutora mishonga yakawandisa, tsvaga rubatsiro rwekurapa nekukasira.

Kuti udzivise overdose netsaona, shandisa chirongwa chemapiritsi kana kumisa zviyeuchidzo pafoni yako. Chengeta mishonga mumudziyo wayo wekutanga uine mavara akajeka, uye usambotora madosi ekuwedzera kuti ugadzirise ayo akapotswa.

Ndoita Sei Kana Ndikakanganwa Dose yeVandetanib?

Kana ukakanganwa dose ye vandetanib, itore nekukasira paunorangarira, asi chete kana paine maawa anopfuura gumi nemaviri kusvika kune yako inotevera dose yakarongwa. Kana paine maawa asingasviki gumi nemaviri kusvika kune yako inotevera dose, tsika dose yakapotswa uye uenderere mberi nechirongwa chako chese.

Usambotora madosi maviri panguva imwe chete kuti ugadzirise dose yakapotswa, sezvo izvi zvinogona kuwedzera njodzi yako yemigumisiro yakakomba. Zviri nani kupotsa dose imwe pane kuwedzera uye zvinogona kukonzera kukuvadza.

Funga nezve kumisa zviyeuchidzo zvemazuva ese pafoni yako kana kushandisa chirongwa chemapiritsi kuti zvikubatsire kurangarira madosi ako. Kuenderana kwakakosha pakuchengetedza mazinga akagadzikana emishonga mumuviri wako.

Ndingamira Rini Kutora Vandetanib?

Unofanira kungomira kutora vandetanib kana chiremba wako akuudza kuti zvakakodzera kuita kudaro. Sarudzo iyi inowanzoenderana nekuti mushonga uri kudzora sei kenza yako uye kuti uri kutsungirira sei mhedzisiro yese.

Chiremba wako achagara achiongorora mhinduro yako kumushonga kuburikidza nekuongorora uye bvunzo dzeropa. Kana kenza ikafambira mberi pasinei nemushonga, kana kana ukaona mhedzisiro yakakomba isingakwanise kudzora, chiremba wako anogona kukurudzira kumisa mushonga.

Usambomira kutora vandetanib wega, kunyangwe uchinzwa zviri nani kana uchiona mhedzisiro. Kumira kamwe kamwe kunogona kubvumira kenza kukura nekukurumidza. Nguva dzose kurukura chero zvinokunetsa nezvekupfuurira kurapwa nechikwata chako chehutano kutanga.

Ndingatora Mimwe Mishonga Ndichiri paVandetanib?

Mishonga mimwe inogona kuita pamwe chete nevandetanib, saka zvakakosha kuti uudze chiremba wako nezve mishonga yese, zvinowedzera, uye zvigadzirwa zvemiti zvauri kutora. Izvi zvinosanganisira zvinodhaka zvinotengeswa pasina mushonga, mavitamini, uye kunyange maherbal teas anoita seasingakuvadzi.

Mishonga inokanganisa rhythm yemoyo yakakosha zvikuru kukurukura, sezvo kuibatanidza nevandetanib kunogona kuwedzera njodzi yekuchinja kwengozi yemoyo. Zvinoderedza ropa, mamwe maantibayoti, uye mamwe mishonga yekurwisa fungal anogonawo kuita pamwe chete nevandetanib.

Chiremba wako anogona kuda kugadzirisa zviyero, kukutarisa zvakanyanya, kana kukurudzira mamwe mishonga kudzivirira kupindirana kunogona kuva nengozi. Nguva dzose tarisa nechikwata chako chehutano usati watanga chero mishonga mitsva kana zvinowedzera uchitora vandetanib.