Chii chinonzi Zavegepant: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Zavegepant mushonga mutsva wekuzora muno wakagadzirirwa kurapa zvakananga kurwadziwa kwemusoro kwemigraine kana kwakatanga. Iwo wekirasi yemishonga inonzi CGRP receptor antagonists, iyo inoshanda nekudzivisa zviratidzo zvekurwadziwa mumucheche wako zvinobatsira kurwisa migraine.

Mishonga iyi inopa tariro kune vanhu vanoda rubatsiro rwekukurumidza kubva kumigraine, kunyanya kana kurapwa kwechinyakare kusingashande zvakanaka kana kukonzera migumisiro isingadiwe. Fomu re nasal spray rinoreva kuti rinogona kutanga kushanda nekukurumidza, kazhinji mukati memaawa maviri ekushandisa.

Chii chinonzi Zavegepant chinoshandiswa?

Zavegepant inobvumidzwa zvakananga kurapa kurwisa kwakanyanya kwemigraine muvanhu vakuru. Izvi zvinoreva kuti yakagadzirirwa kumisa migraine kana yatanga, pane kudzivirira migraine yeramangwana kuti isaitike.

Chiremba wako angakurudzira zavegepant kana iwe uchitambura nekurwadziwa kwemusoro kwemigraine kwepakati kusvika kwakanyanya kunokanganisa mabasa ako emazuva ese. Inogona kubatsira kuderedza kurwadziwa kwakanyanya, kusvotwa, uye kunzwisiswa kune chiedza neruzha izvo zvinowanzoenda nemigraine.

Mishonga iyi inonyanya kubatsira kune vanhu vasingakwanise kutora triptans (imwe kirasi yemishonga ye migraine) nekuda kwemamiriro emoyo kana zvimwe zvehutano. Inogona zvakare kuve sarudzo kana iwe wakaedza mamwe marapirwo eacute migraine pasina kubudirira.

Zavegepant inoshanda sei?

Zavegepant inoshanda nekudzivisa CGRP receptors muuropi hwako nemidzi yeropa. CGRP inomirira calcitonin gene-related peptide, iyo ipuroteni inotamba basa rakakosha mukurwadziwa kwemigraine uye kuzvimba.

Panguva yekurwisa migraine, mazinga eCGRP anowedzera uye anokonzera midzi yeropa mumusoro wako kuti iwedzere uye kuzvimba. Nekudzivisa aya CGRP receptors, zavegepant inobatsira kudzivirira iyi cascade yezviitiko zvinotungamira kurwadziwa kwemigraine.

Mushonga uyu unoonekwa seune simba zvishoma pakurapa migraine. Hauna simba semimwe mishonga inojekeswa, asi inonyanya kutariswa kupfuura zvinorwadza zvakaita se ibuprofen kana acetaminophen.

Ndingatora sei Zavegepant?

Zavegepant inouya semupfuri wemumhino waunoshandisa pakutanga kwezviratidzo zve migraine headache. Madosi akajairika imupfuri mumwe (10 mg) mumumhino mumwe, uye unofanirwa kuishandisa chete kana uine migraine.

Usati washandisa mupfuri, fufunura mhino yako zvinyoro nyoro kuti ubvise chero mucus. Bvisa chivharo, isa muromo mumumhino mumwe, uye dzvanya plunger zvakasimba uchifema zvinyoro nyoro nemumhino dzako. Haufaniri kuitora nechikafu kana mvura.

Hezvino zvaunofanira kuziva nezvenguva uye kugadzirira:

• Shandisa mupfuri pakarepo paunoona zviratidzo zve migraine zvichitanga
• Usadye kana kunwa chero chinhu pakarepo usati kana mushure me kushandisa mupfuri
• Mirira maawa makumi maviri nemana usati washandisa imwe dose
• Chengeta mushonga pakamuri tembiricha, kure nekupisa uye zuva rakananga
• Gadzirira mudziyo wemupfuri usati waushandisa kekutanga nekudzvanya plunger kusvikira waona mhute yakanaka

Mishonga haidi chero zvirambidzo zvakakosha zvekudya, asi kuishandisa mudumbu risina chinhu kunogona kubatsira kuti ishande nekukurumidza. Nguva dzose tevera mirairo chaiyo yachiremba wako, sezvo vachigona kugadzirisa nguva zvichienderana nezvido zvako.

Ndingatora Zavegepant kwenguva yakareba sei?

Zavegepant yakagadzirirwa kushandiswa kwenguva pfupi panguva yekurwisa migraine, kwete semushonga wezuva nezuva wekudzivirira. Unofanirwa kui shandisa chete paunenge uchiona migraine inoshanda, uye mhedzisiro yacho inowanzo gara kwenguva yechikamu chekurwadziwa kwemusoro.

Vanhu vazhinji vanowana zororo mukati me2 maawa ekushandisa mupfuri wemumhino, kunyangwe vamwe vachigona kuona kuvandudzwa nekukurumidza. Mhedzisiro yemushonga inogona kugara kusvika maawa makumi maviri nemana, ndosaka uchifanira kumirira zuva rizere usati washandisa imwe dose.

Haufaniri kushandisa zavegepant kanopfuura ka8 pamwedzi. Kana ukaona uchida kurapwa kwemigraine kakawanda kupfuura izvi, zvakakosha kuti ukurukure mishonga yekudzivirira migraine nachiremba wako.

Ndezvipi Zvakaipa ZveZavegepant?

Vanhu vazhinji vanotsungirira zavegepant zvakanaka, asi semishonga yese, inogona kukonzera matambudziko. Ayiwo anowanzoitika anowanzoita akapfava uye ane hukama nenzira yekupa nasal spray.

Heano matambudziko aunonyanya kutarisirwa kusangana nawo:

• Kushanduka kwekureruka mumuromo mako (kazhinji kunotsanangurwa se simbi kana kuvava)
• Kusagadzikana kwemhino kana kutsamwa
• Nausea (kunyangwe izvi zvingave zvichibva kumigraine yako)
• Kutsamwa kwehuro kana muromo wakaoma
• Kuneta kana kurara

Aya matambudziko anowanzoitika anowanzoenda ega mukati memaawa mashoma uye haadi kutariswa kwekurapa kunze kwekunge akava akakomba kana kuramba achiripo.

Matambudziko asingawanzoitiki asi akakomba anogona kuitika, kunyangwe achiwanzoitika. Izvi zvinogona kusanganisira maitiro akakomba ekuita allergic, ayo angakonzera zviratidzo zvakaita sekufema kwakaoma, kuzvimba kwechiso chako kana huro, kana rash yakapararira. Kana iwe ukasangana nechero zviratidzo izvi, tsvaga kutarisirwa kwekurapa nekukurumidza.

Vamwe vanhu vanogonawo kusangana nekutsamwa kwemhino kwakanyanya, kusanganisira kubuda ropa mumhino kana kunzwa kunopfuta kusingavandudzi. Kunyangwe zvisina njodzi, izvi zviratidzo zvinoda hurukuro nemupi wako wehutano.

Ndiani Asingafaniri Kutora Zavegepant?

Zavegepant haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakachengeteka kwauri zvichibva munhoroondo yako yekurapa uye mamiriro ako ehutano azvino.

Haufaniri kushandisa zavegepant kana uine allergic kumushonga kana chero zvawo. Mukuwedzera, hazvikurudzirwi kuvana vari pasi pemakore gumi nemasere, sezvo kuchengeteka uye kushanda hazvina kumiswa muboka rezera iri.

Chiremba wako achada kukurukura nhoroondo yako yezvokurapa usati akupa zavegepant, kunyanya kana uine:

• Chirwere chakakomba cheitsvo kana matambudziko echiropa
• Nhoroondo yezvinetso zvakakomba zvemuviri kune mishonga
• Kuzara kwemhino kusingaperi kana kubuda ropa kwemhino kakawanda
• Kuvhiyiwa kwemhino kwemazuva ano kana kukuvara
• Kuzvitakura kana kuronga kutakura

Kana wakazvitakura kana kuyamwisa, kuchengeteka kwezavegepant hakuna kunyatsojeka. Chiremba wako achayerera mabhenefiti anogona kuitika achienzanisa nenjodzi dzinogona kuitika asati akurudzira mushonga uyu.

Zita reBrand reZavegepant

Zavegepant inotengeswa pasi pezita rebrand rekuti Zavzpret muUnited States. Iri ndiro zita rebrand rimwe chete riripo remushonga uyu, sezvo richiri idzva kumusika.

Paunotora mushonga wako, uchaona "Zavzpret" pakupaka uye pakunyora. Mushonga uyu unouya muchishandiso chimwe chete chekushandisa nasal spray chinopa chaizvo 10 mg ye zavegepant pachiyero.

Zvimwe Zvingashandiswa panzvimbo peZavegepant

Kana zavegepant isingashande zvakanaka kwauri kana kukonzera mhedzisiro inonetsa, mamwe marapirwo eacute migraine aripo. Chiremba wako anogona kukubatsira kuwana imwe nzira yakanakisa zvichienderana nezvaunoda uye nhoroondo yako yezvokurapa.

Mamwe maCGRP receptor antagonists anosanganisira rimegepant (Nurtec) uye ubrogepant (Ubrelvy), ayo anotora sematableti emuromo panzvimbo pe nasal sprays. Izvi zvinoshanda zvakafanana ne zavegepant asi zvinogona kushandiswa zviri nani nevanhu vanowana kutsamwa kwemhino.

Mishonga yechinyakare ye migraine inogona kunge iri imwe nzira inosanganisira:

• Triptans senge sumatriptan (Imitrex) kana rizatriptan (Maxalt)
• NSAIDs senge ibuprofen kana naproxen, kazhinji yakasanganiswa necaffeine
• Mishonga yakasanganiswa ine acetaminophen, aspirin, uye caffeine
• Mishonga inorwisa kusvotwa senge metoclopramide kana kusvotwa kwakanyanya

Sarudzo pakati pezvisarudzo izvi zvinoenderana nezvinhu zvakaita sehutano hwemoyo wako, mamwe mishonga yaunotora, uye kuti wakanaka sei kumishonga yakambotaurwa.

Zavegepant Zviri Nani Kudarika Sumatriptan Here?

Zvese zavegepant uye sumatriptan mishonga inoshanda yemigraine, asi inoshanda zvakasiyana uye inogona kunge yakakodzera vanhu vakasiyana. Sarudzo yakanaka inoenderana nehutano hwako pachako uye mhinduro kumishonga.

Zavegepant inopa zvimwe zvakanakira pamusoro pe sumatriptan, kunyanya kune vanhu vane matambudziko emoyo. Kusiyana ne sumatriptan, zavegepant haikonzeri kuoma kwemidzi yeropa, zvichiita kuti ive yakachengeteka kune vanhu vane chirwere chemwoyo, high blood pressure, kana njodzi yekurohwa.

Sumatriptan, zvisinei, yanga iripo kwenguva refu uye ine tsvakurudzo yakawanda inotsigira kushanda kwayo. Inowanikwa mumhando dzakawanda (mapiritsi, majekiseni, nasal sprays) uye kazhinji haina kudhura kupfuura zavegepant.

Hezvino maitiro avanoenzaniswa maererano nezvinhu zvinoshanda:

• Kukurumidza kwekuita: Sumatriptan injections inoshanda nekukurumidza, nepo zavegepant nasal spray uye sumatriptan nasal spray inoshanda pamwero wakafanana
• Kuchengeteka kwemoyo: Zavegepant yakachengeteka kune vanhu vane matambudziko emoyo
• Mhedzisiro: Zavegepant inowanzoita mhedzisiro shoma
• Mutengo: Sumatriptan inowanzoita mari shoma, kunyanya muchimiro che generic
• Kureruka: Zvese zvinopa nasal spray sarudzo yevanhu vasingakwanise kumedza mapiritsi panguva ye migraines

Chiremba wako achafunga nezve nhoroondo yako yekurapa, mhinduro dzakapfuura dzemishonga, uye njodzi dzemunhu mumwe nemumwe paanokubatsira kusarudza pakati pemishonga iyi.

Mibvunzo Inowanzo Bvunzwa Nezve Zavegepant

Zavegepant Yakachengeteka Here Kune Chirwere Chemoyo?

Hongu, zavegepant inowanzofungidzirwa kuti yakachengeteka kune vanhu vane chirwere chemoyo kana ichienzaniswa nemimwe mishonga yakawanda yemigraine. Kusiyana ne triptans, zavegepant haiite kuti tsinga dzeropa dzidzike, izvo zvinoreva kuti haawedzere njodzi yekurwisa kwemoyo kana sitiroko.

Izvi zvinoita kuti ive sarudzo yakanaka kune vanhu vane coronary artery disease, high blood pressure, kana matambudziko emoyo akamboitika. Zvisinei, unofanira kukurukura hutano hwemoyo wako nachiremba wako usati watanga chero mushonga mutsva wemigraine.

Ndoita Sei Kana Ndikashandisa Zvakawandisa Zavegepant Netsaona?

Kana netsaona ukashandisa zvinopfuura chiyero chimwe che zavegepant mukati meawa makumi maviri nemana, usavhunduka, asi zviite kuti uzvitarise kuti uone kana paine mhedzisiro yakawedzera. Bata chiremba wako kana nzvimbo yekudzora chepfu kuti uwane gwara, kunyanya kana uine kusvotwa kwakanyanya, dzungu, kana zviratidzo zvisingawanzoitiki.

Mhedzisiro inogona kuitika yekutora zvakanyanya ingave shanduro dzakawedzerwa dzemhedzisiro yakajairika, senge shanduko dzakasimba dzekuravira kana kutsamwa kwemhino. Kunyange zvazvo mhedzisiro yakakomba yekupfuurisa isingaiti, zviri nani nguva dzose kutsvaga mazano ekurapa kana uchizengurira.

Ndoita Sei Kana Ndikakanganwa Chiyero cheZavegepant?

Sezvo zavegepant ichishandiswa chete kana uine migraine, hapana chirongwa chekushandisa nguva dzose che

Vamwe vanhu vanowana marwadzo avo emusoro achideredza kuwanda kana kuoma nekufamba kwenguva, zvichideredza kudiwa kwavo kwekurapa kwakanyanya senge zavegepant. Vamwe vanogona kuchinjira kumushonga wakasiyana uyo unoshanda zviri nani kwavari. Nguva dzose kurukurai chero shanduko mumaitiro ako emarwadzo emusoro kana zvaunoda kurapwa nemupi wako wehutano.

Ndingashandisa Zavegepant Nemimwe Mishonga Yemarwadzo Emusoro Here?

Zavegepant inogona kushandiswa pamwe chete nemimwe mishonga yemarwadzo emusoro, asi nguva uye musanganiswa zvinokosha. Hau faniri kuishandisa nemimwe mishonga yekurapa marwadzo emusoro panguva imwe chete, sezvo izvi zvinogona kuwedzera njodzi yemigumisiro isingadiwi pasina kupa mamwe mabhenefiti.

Zvisinei, kazhinji zvakachengeteka kushandisa zavegepant kana uri kutora mishonga yekudzivirira marwadzo emusoro zuva nezuva senge topiramate, propranolol, kana CGRP preventive injections. Chiremba wako achatarisa mishonga yako yese kuti ave nechokwadi chekuti hapana kusangana uye kuti chirongwa chako chekurapa chinoita musoro wako.