Chii chinonzi Ziconotide: Zvazvinoshandiswa, Mushonga, Mhedzisiro uye Zvimwe

Ziconotide mushonga une simba wekurapa marwadzo unoiswa zvakananga mumvura yakatenderedza musana wako kuburikidza ne pump yakakosha. Iyi vhezheni yekugadzirwa kwekemikari inowanikwa mumagakanje emugungwa inopa tariro kune vanhu vane marwadzo akakomba ekusingaperi apo mamwe marapirwo asina kushanda.

Kusiyana neopioids, ziconotide inoshanda kuburikidza nemaitiro akasiyana zvachose muhurongwa hwako hwetsinga. Yakachengeterwa nyaya dzemarwadzo akaomesesa nekuti inoda kuvhiyiwa kwe pump uye kunyatsoongororwa nemapoka ekurapa akakosha.

Chii chinonzi Ziconotide?

Ziconotide mushonga wekurapa marwadzo usiri weopioid unotevedzera kemikari yechisikigo inowanikwa mumagakanje emugungwa. Vanzvereri vakawana kuti muchetura wegakanje uyu une simba rekudzivisa marwadzo rinogona kubatsira vanhu vanotambura nemarwadzo akakomba ekusingaperi.

Mushonga uyu unouya semhinduro yakajeka, isina ruvara inoiswa zvakananga mumvura yako yecerebrospinal. Mvura iyi inotenderedza uropi hwako nemuzongoza, ichibvumira mushonga kuti ushande chaizvo panofamba zviratidzo zvemarwadzo kuburikidza nehurongwa hwako hwetsinga.

Chinonyanya kuita kuti ziconotide ive yakasiyana ndechokuti haina kukonzera kushivirira, kuvimba, kana kuora mwoyo kwemweya kunowanzoitika nekushandiswa kwenguva refu kweopioid. Zvisinei, inoda sisitimu ye pump yakaiswa kuvhiyiwa kuti ipe mushonga zvakachengeteka uye zvinobudirira.

Chii chinonzi Ziconotide chinoshandiswa?

Ziconotide inorapa marwadzo akakomba ekusingaperi muvanhu vakuru apo mamwe marapirwo emarwadzo asina kupa zororo rakakwana. Chiremba wako angangofunga nezvemushonga uyu kana wakaedza kurapwa kwakawanda pasina kubudirira uye marwadzo ako anokanganisa zvikuru hupenyu hwako hwezuva nezuva.

Mushonga uyu wakabvumidzwa zvakananga kuti utarisire kurwadziwa kwenguva refu kunoda kurapwa nguva dzose, kwenguva refu. Izvi zvinowanzo sanganisira mamiriro ezvinhu akadai se failed back surgery syndrome, complex regional pain syndrome, kana kurwadziwa kwakanyanya kwemitsipa iyo isina kupindura kune mamwe marapirwo.

Usati wafunga nezve ziconotide, vanhu vazhinji vakatoedza akasiyana siyana emishonga yekunwa, physiotherapy, nerve blocks, uye dzimwe nguva kunyange mamwe maturusi anoiswa mumuviri. Ichokwadi kuti ndiyo sarudzo yekupedzisira kana kurapwa kwetsika kukundikana.

Ziconotide Inoshanda Sei?

Ziconotide inodzivisa nzira dzakakosha dze calcium mumutsipa wako dzinotumira zviratidzo zverwadziwa. Funga nezvenzira idzi semagedhi madiki ayo anowanzoita kuti mameseji ekurwadziwa afambe kubva mumuviri wako kuenda kuuropi hwako.

Kana ziconotide yasvika panzira idzi dze calcium, inonyatsovhara magedhi aya, ichidzivirira zviratidzo zverwadziwa kuti zvisasvike muuropi hwako. Izvi zvinoitika padanho remuzongoza wako, ndosaka mushonga uchifanira kupihwa zvakananga mumvura ye cerebrospinal.

Mushonga uyu unoonekwa seune simba rakanyanya nekuti unoshanda pane imwe yenzira dzakakosha dzekutumira kurwadziwa. Kusiyana ne opioids dzinokanganisa maonero ako ehuropi ekurwadziwa, ziconotide inomisa zviratidzo zverwadziwa zvisati zvasvika muuropi hwako.

Ndingatora Sei Ziconotide?

Ziconotide inopihwa kuburikidza nehurongwa hwepombi yakaiswa kuvhiyiwa iyo inopa mushonga zvakananga mumvura yako yemu spinal. Hauzotore mushonga uyu nemuromo kana kuuzvipinza iwe pachako semamwe mishonga yekurwadziwa.

Pombi inoiswa pasi peganda remudumbu mako panguva yekuvhiya. Chubu chakatetepa chinonzi catheter chinobatanidza pombi kumuzongoza wako, zvichibvumira kuendeswa kwemushonga kwakanyatsojeka.

Chikwata chako cheutano chichaita chirongwa chepombi kuti ipe mishonga yakatarwa panguva dzakatarwa. Pombi inoda kuzadzwa nemushonga mwedzi mishoma yega yega panguva yekushanya kwevarwere vanobuda, uye bhatiri rinowanzo gara makore akati wandei risati ravharwa.

Pamberi pekuiswa kwepombi yechigarire, chiremba wako anogona kuita nguva yekuyedza achishandisa pombi yekunze yenguva pfupi. Kuyedza uku kunobatsira kuziva kana ziconotide ichideredza kurwadziwa kwako zvakanaka uye kana iwe uchigona kutsungirira mhedzisiro yemushonga.

Ndingatora Ziconotide Kwenguva Yakareba Sei?

Ziconotide yakagadzirirwa kushandiswa kwenguva refu mukugadzirisa mamiriro ekurwadziwa kwenguva refu. Paunotanga kurapwa uku, unogona kuramba uchiita izvi zvachose chero zvichipa zororo rinobudirira rekurwadziwa uye iwe uchizvitsungirira zvakanaka.

Kureba kwekurapa kunoenderana nekupindura kwako kwega uye kuti unogadzirisa sei chero mhedzisiro. Vamwe vanhu vanoramba vachirapwa ne ziconotide kwemakore mazhinji, nepo vamwe vachigona kuda kugadzirisa kana kumisa nekuda kwezvinetso kana kuderedzwa kwekubudirira.

Chikwata chako chekurapa chichagara chichitarisa kupindura kwako kumushonga uye kugadzirisa muyero sezvinodiwa. Kugadziriswa uku kunoitika zvishoma nezvishoma pamavhiki kana mwedzi kuti uwane chiyero chakakwana pakati pezororo rekurwadziwa uye mhedzisiro inogoneka.

Ndezvipi Zvipingamupinyi zveZiconotide?

Ziconotide inogona kukonzera mhedzisiro yakakosha, kunyanya ichikanganisa hurongwa hwako hwetsinga uye basa repfungwa. Kunzwisisa izvi zvinogona kukubatsira kushanda nechikwata chako cheutano kuti uzvigadzirise zvinobudirira.

Mhedzisiro yakajairika yaungasangana nayo inosanganisira dzungu, kuvhiringidzika, uye matambudziko nekurangarira kana kufunga zvakajeka. Mhedzisiro iyi inowanzoitika nekuti mushonga unokanganisa hurongwa hwako hwepakati petsinga zvakananga.

Heano mhedzisiro yetsinga uye yepfungwa yaunofanira kuziva nezvayo:

• Kutadza kufema uye kusagadzikana kana uchifamba
• Kuvhiringika uye kuoma kufunga
• Matambudziko ekuyeuka uye kukanganwa
• Kufunga kusinganzwisisiki kana pfungwa dzisinganzwisisiki
• Kurota kana kuona zvinhu zvisipo
• Kuchinja kwemafungiro kusanganisira kuora mwoyo kana kushushikana
• Kutadza kutaura kana kutaura zvisina kujeka
• Kushaya simba kana kuneta

Izvi zvinokanganisa pfungwa zvinogona kuva zvakaoma zvikuru nokuti zvinogona kukanganisa kugona kwako kushanda, kutyaira, kana kuita mabasa ezuva nezuva zvakachengeteka. Chikwata chako chekuchengetedza hutano chichatarisa izvi zvinokanganisa zvakanyanya uye kuchinja mushonga wako kana zvichidikanwa.

Zvinokanganisa mumuviri zvinogonawo kuitika, kunyange zvazvo kazhinji zvichiwanzowanikwa kudarika zvinokanganisa pfungwa. Unogona kuona kusvotwa, kutemwa nemusoro, kana kuchinja mukuona kwako. Vamwe vanhu vanotaurawo nezve kushaya simba kwemhasuru kana kuzununguka.

Zvinokanganisa zvakakomba asi zvisingawanzoitiki zvinosanganisira maitiro akakomba epfungwa, kusanganisira pfungwa dzekuzvikuvadza kana kuzviuraya. Kana ukaona chero kuchinja kwemafungiro kana pfungwa dzinokunetsa, taura nemupi wako wehutano nekukurumidza.

Ndiani Asingafaniri Kutora Ziconotide?

Ziconotide haina kukodzera munhu wese, uye mamiriro ezvinhu kana mamiriro ezvinhu anoita kuti kurapwa uku kusachengeteka. Chiremba wako achanyatsoongorora nhoroondo yako yezvokurapa usati wafunga nezvesarudzo iyi.

Haufaniri kugamuchira ziconotide kana uine hutachiona hunoshanda, kunyanya hunogona kupararira kumvura yako yemusana. Iyo yakaiswa pombi system inogadzira nzira inogona kubvumira mabhakitiriya kusvika kune yako yepakati tsinga system.

Vanhu vane mamiriro epfungwa anogona kunge vasiri vakanaka vekurapa kweziconotide. Mushonga unogona kuwedzera mamiriro ehutano hwepfungwa aripo kana kukonzera zviratidzo zvitsva zvepfungwa zvinogona kuva njodzi.

Heano mamiriro makuru anowanzo bvisa mumwe munhu kubva mukurapa kweziconotide:

• Zvirwere zvese zviri mumuviri kana zvirwere zvakabatana pedyo nenzvimbo yekuiswa kwechishandiso
• Nhoroondo yezvirwere zvakakomba zvepfungwa zvinosanganisira psychosis kana bipolar disorder
• Zvirwere zvekubuda ropa zvinowedzera njodzi dzekuvhiwa
• Zvirwere zvemoyo zvakakomba zvinoita kuti kuvhiwa kuve nenjodzi
• Kuti une pamuviri kana kuronga kuva nepamuviri
• Kusagadzikana kune ziconotide kana chero zvinhu zvemushonga
• Kusagona kunzwisisa kana kutevedzera zvinodiwa zvekurapa zvakaoma

Chikwata chako chehutano chichafungawo nezve hutano hwako hwese uye tarisiro yehupenyu kana vachiongorora kana ziconotide yakakodzera mamiriro ako.

Mazita emhando yeZiconotide

Ziconotide inowanikwa pasi pezita remhando yePrialt muUnited States nedzimwe nyika zhinji. Iri ndiro fomu rimwe chete rinowanikwa rekutengeserana re ziconotide rekushandiswa kweintrathecal.

Prialt inouya semhinduro isina kusvibiswa yakagadzirirwa zvakananga kuendeswa kuburikidza nemasisitimu emapombi anoiswa. Mushonga unoda kubata kwakakosha uye nzira dzekuchengetera kuchengetedza kushanda kwahwo nekuchengeteka.

Kusiyana nemimwe mishonga yakawanda, ziconotide haina shanduro dzakajairika dziripo. Izvi zvikamu zvishoma nekuda kwekuoma kwekuita uye hunhu hwakakosha hwekurapa.

Zvimwe zvinotsiva Ziconotide

Mishonga yakati wandei yeintrathecal inogona kufungwa kana ziconotide isina kukodzera mamiriro ako. Zvimwe zvinotsiva izvi zvinoshanda kuburikidza nemaitiro akasiyana asi zvakare zvinounzwa zvakananga mumvura yako yemuzongoza.

Morphine inounzwa intrathecally inoramba iri imwe yezvimwe zvinotsiva zvinowanzoitika ku ziconotide. Kunyangwe iri opioid ine njodzi dzakabatana dzekushivirira uye kuvimba, inogona kunge yakakodzera kune vamwe vanhu, kunyanya avo vane zvimwe zvinhu zvine njodzi yepfungwa.

Dzimwe sarudzo dzinosanganisira intrathecal baclofen kune mamwe marudzi emarwadzo ane hukama ne muscle spasticity, kana kusanganiswa kwemishonga inogona kusanganisira local anesthetics senge bupivacaine.

Heano mamwe maitiro makuru ayo chiremba wako angatarisa:

• Intrathecal morphine yekurapa marwadzo echronic
• Intrathecal baclofen, kunyanya kune spasticity-related pain
• Intrathecal bupivacaine kune mamwe mamiriro emarwadzo ane hukama netsinga
• Kusanganiswa kwekurapa uchishandisa mishonga yakawanda ye intrathecal
• Spinal cord stimulation devices seimwe sarudzo isiri yemishonga
• Dorsal root ganglion stimulation yemaitiro emarwadzo chaiwo

Sarudzo pakati pezvizvi zvinoenderana nemamiriro ako chaiwo emarwadzo, nhoroondo yako yekurapa, uye mhinduro yako pachako kune kurapwa kwakapfuura. Chikwata chako chekurapa marwadzo chichashanda newe kuti chizive sarudzo yakakodzera.

Ko Ziconotide Zviri Nani Kupfuura Intrathecal Morphine?

Kana ziconotide iri nani kupfuura intrathecal morphine zvinoenderana nemamiriro ako pachako uye nhoroondo yekurapa. Mishonga yese ine zvakanakira nezvayakaipira zvinoita kuti ive yakakodzera mamiriro akasiyana.

Ziconotide inopa mukana wakakura wekusakonzera kushivirira, kuvimba nemuviri, kana kuora mwoyo kwekufema semaopioids anoita. Izvi zvinoreva kuti hauzodi madosi akawedzera nekufamba kwenguva, uye hauzove nezviratidzo zvekubvisa kana kurapwa kukavhiringidzwa.

Zvisinei, intrathecal morphine inogona kushivirirwa zviri nani nevamwe vanhu, kunyanya avo vanonzwa kune cognitive effects ye ziconotide. Morphine zvakare ine rekodhi refu rekushandisa uye inowanzozivikanwa kune vanopa hutano.

Sarudzo pakati pemishonga iyi inowanzouya pasi kune yako chaiyo njodzi uye zvinangwa zvekurapa. Kana uine nhoroondo yekushandisa zvinodhaka zvisina kufanira kana zviratidzo zvepfungwa zvinonetsa, chiremba wako angasarudza imwe sarudzo pane imwe.

Mibvunzo Inowanzoitwa Nezve Ziconotide

Ziconotide Yakachengeteka Here Kune Vanhu Vane Chirwere Chemoyo?

Ziconotide inogona kushandiswa muvanhu vane chirwere chemoyo, asi inoda kuongororwa zvakanyanya nechikwata chako chehutano. Mushonga wacho pachake hauna zvakananga mwoyo wako, asi nzira yekuvhiya yekuiswa inotakura njodzi dzemoyo nemitsipa yeropa.

Chiremba wako wemoyo uye timu yekurapa marwadzo vachada kushanda pamwechete kuti vaongorore kana iwe wakakodzera kuvhiyiwa kwekuiswa. Vachafunga nezvezvinhu zvakaita sebasa rako remoyo razvino, zviitiko zvichangoburwa zvecardiac, uye kugadzikana kwemoyo nemitsipa yeropa.

Kana pombi yaiswa uye iwe uchigamuchira ziconotide, mamiriro ako emoyo haafanire kukanganiswa zvakananga nemushonga. Zvisinei, dzimwe mhedzisiro yakaita sedzungu inogona kuwedzera njodzi yako yekuwa, izvo zvingave zvinonetsa kana iwe uchitora mishonga inoderedza ropa.

Ndingaita Sei Kana Ndikashandisa Ziconotide Yakawandisa Netsaona?

Ziconotide overdose haina kujairika nekuti mushonga unotumirwa kuburikidza nehurongwa hwepombi hwakarongwa zvakanyatsonaka. Zvisinei, kana iwe uchifungidzira kusashanda zvakanaka kwepombi kana kuona kuwedzera kwakanyanya kwemhedzisiro, tsvaga rubatsiro rwekurapa nekukurumidza.

Zviratidzo zvekuwandisa kweziconotide zvinogona kusanganisira kuvhiringidzika kwakanyanya, dzungu rakanyanya, kurasikirwa kwechizvarwa, kana shanduko dzakanyanya mumamiriro ako epfungwa. Zviratidzo izvi zvinogona kuratidza kuti mushonga wakawandisa uri kutumirwa kuhutano hwako hwetsinga.

Kana iwe ukaona zviratidzo zvinonetsa, taura nemupi wako wehutano nekukurumidza kana kuenda kukamuri rekukurumidzira riri pedyo. Uya neruzivo nezve zvirongwa zvako zvepombi uye zvichangoburwa zvekuzadzazve mishonga kuti ubatsire vashandi vezvokurapa kunzwisisa mamiriro ako nekukurumidza.

Ndingaita Sei Kana Ndikakanganwa Dose yeZiconotide?

Haugoni "kushaya mushonga" weziconotide munzira yechinyakare nekuti inotumirwa nguva dzose kuburikidza nehurongwa hwako hwakaiswa pombi. Pombi yakarongwa kutumira mushonga panguva dzakatarwa pasina kubatanidzwa kwako zvakananga.

Kana uine hanya nekuti pombi yako haishande zvakanaka kana uchiwana kurwadziwa kwakanyanya, taura nemupi wako wehutano. Vanogona kutarisa mashandiro epombi yako nemazinga emishonga kuti vaone kuti zvese zviri kushanda sezvakarongwa.

Usambofa wakaedza kugadzirisa marongero epombi yako iwe pachako kana kuyedza kutsiva zviyero zvaunofunga kuti wakashaya. Nyanzvi dzehutano dzakadzidziswa chete ndidzo dzinofanira kuchinja hurongwa hwako hwekuendesa ziconotide.

Ndingamira Rini Kutora Ziconotide?

Kumisa ziconotide kunofanirwa kuitwa nguva dzose pasi pekutariswa kwechiremba, kunyangwe isingakonzeri kuvimba kwemuviri semaopioids anoita. Chikwata chako chehutano chichakubatsira kuona kana uye rinhi kumisa kwakakodzera.

Unogona kufunga kumisa ziconotide kana uri kuwana mhedzisiro isingashiviriki isingavandudzike nekugadzirisa muyero, kana mushonga usingachapi rubatsiro rwakakwana rwerwadziwa, kana kana mamiriro ako ari nani zvakanyanya.

Maitiro ekumisa ziconotide anowanzo sanganisira kuderedza zvishoma nezvishoma muyero nekufamba kwenguva pane kumira kamwe kamwe. Izvi zvinobatsira kuderedza chero kurwadziwa kunogona kudzoka uye zvinobvumira muviri wako kuti uchinje kuchinja.

Ndingatyaira Here Ndichitora Ziconotide?

Kutyaira uchitora ziconotide kazhinji hakukurudzirwi, kunyanya paunotanga kurapwa kana mushure mekuita gadziriso yemuyero. Mushonga uyu unowanzoita dzungu, kuvhiringika, uye kukanganiswa kwekuziva kunogona kukanganisa zvakanyanya kugona kwako kutyaira zvakachengeteka.

Mupi wako wehutano achatarisa mhinduro yako pachako kumushonga uye achakubatsira kusarudza kuti rinhi, kana zvichibvira, zvichava zvakachengeteka kwauri kuti utangezve kutyaira. Sarudzo iyi inoenderana nezvinhu zvakaita sedosi yako, mhedzisiro, uye kushanda kwepfungwa kwese.

Vanhu vazhinji vanotora ziconotide vanofanira kuvimba nemamwe maitiro ekufambisa. Funga kuronga nhengo dzemhuri, shamwari, kana masevhisi ekufambisa kuti akubatsire kusvika kumisangano uye kubata mabasa ezuva nezuva zvakachengeteka.