Chii chinonzi Hormone Therapy yeCancer yeProstate? Chinangwa, Mhando & Mhedzisiro

Hormone therapy ye prostate cancer mushonga unodzivisa kana kuderedza testosterone nemamwe mahomoni echirume anotsigira kukura kwe prostate cancer. Fungidzira sekudzima mafuta anobatsira maseru ekenza kuti awande uye apararire mumuviri wako.

Nzira iyi inoshanda nekuti maseru ekenza ye prostate anonyanya kuvimba ne testosterone kuti akure uye ararame. Paunoderedza mazinga emahormone aya, unogona kuderedza kana kutokurumidza kenza, kukupa nguva yakawanda uye kazhinji uchivandudza hupenyu hwako.

Chii chinonzi hormone therapy ye prostate cancer?

Hormone therapy mushonga wekenza unotarisa mahomoni anodiwa nekenza yako ye prostate kuti ikure. Inonziwo androgen deprivation therapy (ADT) nekuti inoderedza androgens, ayo ari mahomoni echirume senge testosterone.

Testicles yako uye adrenal glands dzinogadzira mahomoni aya zvakasikwa. Maseru ekenza ye prostate ane receptors akakosha anobata testosterone uye anoishandisa semafuta kuti awande. Nekudzivisa maitiro aya, hormone therapy inogona kunonotsa kukura kwekenza zvakanyanya.

Mushonga uyu hauporesi prostate cancer, asi unogona kuudzora kwemwedzi kana kunyange makore. Varume vazhinji vanorarama hupenyu hwakazara, hunoshingaira vachigamuchira hormone therapy, kunyanya kana yakabatanidzwa nemimwe mishonga.

Nei hormone therapy ye prostate cancer ichiitwa?

Vanachiremba vanokurudzira hormone therapy kana prostate cancer yapararira kupfuura prostate gland kana kana mimwe mishonga isina kukodzera mamiriro ako. Inobatsira zvikuru kune advanced kana metastatic prostate cancer.

Unogona kugamuchira mushonga uyu usati watora radiation therapy kuti udzikise tumor uye uite kuti radiation ive inoshanda. Iyi nzira yekubatanidza, inonzi neoadjuvant therapy, inogona kuvandudza mhedzisiro yako yekurapa.

Dzimwe nguva kurapwa nemahomoni kunoshanda sechibatanidza iwe uchifunga nezvedzimwe sarudzo, kana kana kuvhiyiwa kusingakurudzirwe nekuda kwemakore ako kana mamwe mamiriro ehutano. Chiremba wako achafunga nezve nhanho yekenza yako, hutano hwako hwese, uye zvaunofarira iwe pachako paunenge uchikurudzira nzira iyi.

Ndezvipi zvikamu zvekurapwa nemahomoni ekenza yeprostate?

Nzira dzakasiyana siyana dzinogona kuvharira kana kuderedza mahomoni anodyisa kenza yako yeprostate. Mhando imwe neimwe inoshanda nenzira yakasiyana kuti ibudirire chinangwa chimwe chekufa nenzara maseru ekenza.

Heano mhando huru dzaungafunga nachiremba wako nezve mamiriro ako chaiwo:

• LHRH agonists: Majekiseni emwedzi kana kota inoudza uropi hwako kuti humise chiratidzo chetesticles yako kuti igadzire testosterone
• LHRH antagonists: Majekiseni anobva avharisa kugadzirwa kwemahomoni pasina kutanga kwe testosterone
• Anti-androgens: Mapiritsi anodzivirira testosterone kubva pakunamira kumasero ekenza
• Kuvhiyiwa castration (orchiectomy): Maitiro echigarire anobvisa testicles
• Mishonga mitsva yemahomoni: Mishonga yepamberi senge abiraterone uye enzalutamide inovharisa nzira dzakawanda dzemahomoni

Oncologist wako achasarudza sarudzo yakanakisa zvichienderana nezvinhu zvekenza yako, hutano hwako hwese, uye maitiro ako ekurapa. Varume vazhinji vanotanga nemajekiseni nekuti anogadziriswa uye anoshanda.

LHRH agonists uye antagonists

Mishonga yeLHRH (luteinizing hormone-releasing hormone) ndiyo inonyanya kushandiswa yekutanga kurapwa kwemahomoni. Vanoshanda nekukanganisa zviratidzo pakati pehuropi hwako netesticles.

Agonists senge leuprolide uye goserelin pakutanga zvinokonzera kukwira kwenguva pfupi mu testosterone vasati vamisa kugadzirwa zvachose. Iyi flare effect inowanzo gara kwemavhiki maviri uye inogona kuwedzera zviratidzo zvako kwenguva pfupi.

Vakakwikwidzi vakaita se degarelix vanosvetuka chikamu chekupisa uye vanobva vangoderedza mazinga e testosterone. Izvi zvinoita kuti zvive zvinobatsira kunyanya kana uine marwadzo emapfupa kana kuvharika kwemugwagwa wemvura inogona kuwedzera nekukwira kwe testosterone.

Mishonga inorwisa androgens

Anti-androgens mapiritsi anovharisa testosterone kubva pakubatanidza kumasero ekenza yeprostate. Zvinhu zvakajairika zvinosanganisira bicalutamide, flutamide, uye nilutamide.

Mishonga iyi inowanzo shandiswa pamwe chete nemishonga yeLHRH kupa yakazara androgen blockade. Iyi musanganiswa inogona kuve inoshanda kupfuura chero kurapwa kwega, kunyangwe zvingawedzera mhedzisiro.

Dzimwe nguva vanachiremba vanonyora anti-androgens vega, kunyanya kune varume vakuru kana avo vanoda kuchengetedza basa repabonde. Zvisinei, nzira iyi inowanzoshanda zvishoma pane kurapa kwemusanganiswa.

Maitiro ekugadzirira kurapwa kwako kwehomoni?

Kugadzirira kurapwa kwehomoni kunosanganisira kugadzirira kwemuviri uye kwemanzwiro. Chikwata chako chehutano chichakutungamira kuburikidza nechinhu chimwe nechimwe kuti uve nechokwadi chekuti unonzwa wakavimbika uye wakaziviswa.

Tangira nekukurukura nhoroondo yako yezvokurapa yakazara ne oncologist wako, kusanganisira chero matambudziko emoyo, chirwere cheshuga, kana nyaya dzemapfupa. Izvi zvinogona kukanganiswa nekurapwa kwehomoni, saka chiremba wako anoda mufananidzo wakazara wehutano hwako.

Funga kuita bvunzo dzekutanga usati watanga kurapwa. Izvi zvinogona kusanganisira kuongororwa kwemapfupa, bvunzo dzemabasa emoyo, uye basa reropa kuyera mazinga ako ehomoni azvino uye zvese zvehutano.

Taura pachena nemumwe wako kana mhuri nezve shanduko dzaungasangana nadzo. Kurapwa kwehomoni kunogona kukanganisa mafungiro ako, mazinga esimba, uye basa repabonde, saka kuva nerutsigiro nekunzwisisa kumba kunoita mutsauko mukuru.

Ndeipi nzira yekurapa kwehomoni?

Nzira yacho inosiyana zvichienderana nerudzi rwekurapa kwehomoni chiremba wako anokurudzira. Kurapa kwakawanda kwakananga uye kunogona kuitwa muhofisi yachiremba wako kana kiriniki yekunze.

Pamusoro pejekiseni, uchaenda kuna chiremba wako mwedzi woga woga, mwedzi mitatu yega yega, kana mwedzi mitanhatu yega yega zvichienderana nemushonga wacho. Jekiseni rinowanzoitwa muruoko rwako, chidya, kana tsandanyama yegaro uye rinotora maminitsi mashoma.

Kana uri kutora mapiritsi, uchatevera chirongwa chezuva nezuva kumba. Chiremba wako achapa mirairo yakajeka pamusoro penguva yekutora, kana kuatora nezvokudya, uye zvekuti uchiitei kana ukakanganwa dose.

Misa yekuongorora nguva dzose ichatevera kuti kurapwa kuri kushanda sei uye ichatarisa mativi emuviri. Kushanya uku kunowanzo sanganisira bvunzo dzeropa kuti uongorore mazinga ako etestosterone uye nhamba dzePSA (prostate-specific antigen).

Ungaverenga sei mhedzisiro yako yekurapa mahomoni?

Chiremba wako achaongorora zviratidzo zvakakosha kuti aone kuti kurapwa kwako mahomoni kuri kushanda sei. Zviyero zvakakosha ndizvo zviyero zvako zve testosterone uye PSA.

Kurapa mahomoni kunobudirira kunowanzoita kuti testosterone yako idzikire zvakanyanya, kazhinji iri pasi pe50 ng/dL (vamwe vanachiremba vanovavarira pasi pe20 ng/dL). Izvi zvinonzi castration level, uye zvinowanzoitika mukati memavhiki mashoma ekutanga kurapwa.

Chiyero chako chePSA chinofanirawo kudzikira zvakanyanya, kazhinji kusvika pasi pe4 ng/mL kana kunyange zvishoma. Kuwedzera kwePSA paunenge uri pakurapa mahomoni kungaratidza kuti kenza yako iri kuita resistant kurapwa, izvo zvinoda kugadzirisa nzira yako.

Chiremba wako achaongororawo hutano hwako hwese kuburikidza nebvunzo dzeropa nguva dzose vachiongorora basa rechiropa, mazinga eshuga yeropa, uye cholesterol. Izvi zvinobatsira kubata chero shanduko dzine chekuita nekurapa kare kuitira kuti dzigone kutarisirwa nemazvo.

Ndezvipi zvimwe zvinokonzerwa nekurapa mahomoni?

Kurapa mahomoni kunogona kukonzera mativi akasiyana-siyana nekuti kunoderedza zvakanyanya mazinga ako etestosterone. Kunzwisisa zvekutarisira kunokubatsira kugadzirira uye kubata shanduko idzi nemazvo.

Zvizhinji zvezvinhu zvinokonzerwa nemishonga zvinotanga zvishoma nezvishoma mumavhiki kana mwedzi, uye zvakawanda zvinogona kugadziriswa nemishonga kana kuchinja mararamiro. Chikwata chako chehutano chichashanda newe kuderedza chero zvinhu zvisingafadzi.

Hezvino zvinhu zvakajairika zvaungasangana nazvo:

• Kupisa: Kunzwa kupisa kamwe kamwe nekutukwa, zvakafanana nekumisa kuenda kumwedzi
• Kuneta: Kunzwa kuneta kana kuva nesimba shoma pane zvakajairika
• Kuchinja kwemanzwiro: Kuora mwoyo, kushushikana, kana kunzwa zvakanyanya
• Kuchinja kwezvepabonde: Kuderedzwa kwechido chepabonde uye kusagona kumira
• Kuchinja kwemuviri: Kuwedzera uremu, kurasikirwa kwemhasuru, uye kuwedzera mazamu
• Kutetepa kwemapfupa: Kuwedzera njodzi ye osteoporosis uye mapfupa anotyoka

Zvizhinji zvezvinhu izvi zvinogona kudzoserwa kana iwe ukamisa kurapwa nemahomoni, kunyangwe zvimwe zvinhu zvingatora mwedzi kuti zvivandudze. Chiremba wako anogona kukupa mishonga uye kukukurudzira kuchinja mararamiro kuti akubatsire kugadzirisa zvakawanda zvezvinhu izvi.

Kugadzirisa zvinhu zvakajairika

Kupisa kunokanganisa kusvika ku80% yevarume vari kurapwa nemahomoni, asi nzira dzakawanda dzinogona kupa zororo. Chiremba wako angangokupa mishonga yakaita semishonga yekurwisa kuora mwoyo kana mishonga yekurwisa kubatwa nemusoro iyo inogona kuderedza kakawanda nekukura kwavo.

Kuti utarisire hutano hwemapfupa, chiremba wako anogona kukukurudzira calcium uye vitamin D supplements, pamwe nekurovedza muviri kunosanganisira kutakura uremu. Vamwe varume vanoda mishonga inonzi bisphosphonates kudzivirira kurasikirwa kwemapfupa.

Kuchengetedza mhasuru uye kugadzirisa kuwedzera uremu kunoda kurovedza muviri nguva dzose uye kutarisisa kudya kwako. Kushanda nemunyanzvi wezvekudya uye muviri kunogona kukubatsira kugadzira chirongwa chinogara chichikodzera mazinga ako esimba uye kugona.

Ndezvipi zvinhu zvinokonzerwa nekushandisa mahomoni kwenguva refu?

Kurapa kwenguva refu nemahomoni kunogona kukonzera shanduko huru mumuviri wako, kunyanya kana ukaramba uchirapwa kwemakore akati wandei. Kunzwisisa izvi zvinogona kuitika kunokubatsira kuti uite sarudzo dzine ruzivo nezvekuchengetwa kwako.

Utano hwemoyo hunova kunetseka kukuru nekushandiswa kwemahomoni kwenguva yakareba. Dzimwe ongororo dzinoratidza njodzi yakawedzerwa yezvirwere zvepfungwa uye sitiroko, kunyanya varume vane matambudziko emoyo aripo.

Kukora kwemapfupa kunowanzoita kudzikira nekufamba kwenguva, zvichikonzera osteoporosis uye kuwedzera njodzi yekutyoka. Chiremba wako achazvitarisa zvakanyanya uye anogona kukurudzira kurapwa kwekudzivirira kana kukora kwemapfupa ako kuchidzika zvakanyanya.

Shanduko dzekuziva, dzimwe nguva dzinonzi "brain fog," dzinogona kuitika nekushandiswa kwenguva refu. Izvi zvinogona kusanganisira matambudziko ekuyeuka, kuoma kufunga, kana kufunga zvishoma nezvishoma. Izvi zvinokonzeresa zvinowanzoita zvinyoro asi zvinogona kukanganisa hupenyu hwako hwezuva nezuva.

Kurapa nemahomoni kunoshanda sei kenza yeprostate?

Kurapa nemahomoni kunoshanda zvakanyanya pakudzora kenza yeprostate, kunyanya kana kenza yapararira kupfuura prostate gland. Varume vazhinji vanoona kuvandudzwa kukuru mumazinga avo ePSA uye zviratidzo mukati memwedzi mishoma yekutanga.

Kenza yeprostate yakakura, kurapa nemahomoni kunogona kudzora chirwere kwemwedzi 18 kusvika kumakore akati wandei. Vamwe varume vanopindura kwenguva refu, nepo vamwe vachigona kukudziridza kuramba nekukurumidza.

Kana yakasanganiswa nekumwe kurapwa senge radiation therapy, kurapa nemahomoni kunogona kuvandudza zvakanyanya mazinga ekupona uye mhando yehupenyu. Iyi nzira yakasanganiswa yave yakajairika yekuchengetwa kwemarudzi mazhinji ekenza yeprostate yakakura.

Mhinduro yako yega yega inoenderana nezvinhu zvakaita sekurwisa kwekenza yako, yakapararira sei, uye hutano hwako hwese. Oncologist wako achatarisa kufambira mberi kwako zvakanyanya uye achagadzirisa chirongwa chako chekurapa sezvinodiwa.

Kurapa nemahomoni kungamira rini kushanda?

Pakupedzisira, kenza zhinji yegland ye prostate inokura kusadzivirirwa kurapa kwehomoni, mamiriro anonzi castration-resistant prostate cancer (CRPC). Izvi hazvirevi kuti kurapwa kwakundikana zvachose, asi kuti kenza yakawana nzira dzekukura pasinei nekuderera kwe testosterone levels.

Zviratidzo zvekuti hormone therapy ingave iri kurasikirwa nekushanda zvinosanganisira kuwedzera kwe PSA levels, zviratidzo zvitsva zvakaita se kurwadziwa kwemapfupa, kana bvunzo dzekuona dzichiratidza kukura kwekenza. Izvi zvinowanzoitika zvishoma nezvishoma pamusoro pemwedzi kana makore.

Kana kusadzivirirwa kukakura, chiremba wako ane dzimwe nzira itsva dzekurapa dziripo. Izvi zvinosanganisira mishonga yepamusoro yehomoni yakaita se abiraterone uye enzalutamide, chemotherapy, immunotherapy, kana kurapwa kutsva kwakatarwa.

Kukura kwekusadzivirirwa hakurevi kuti mamiriro ako haana tariro. Varume vazhinji vanoramba vachirarama zvakanaka nekutarisirwa kunoshanda kwekenza ye prostate inodzivirira castration, kazhinji kwemakore mushure mekunge hormone therapy isisashande.

Ko hormone therapy yakakunakira here?

Sarudzo yekutanga hormone therapy inoenderana nezvinhu zvakawanda zvakakosha kumamiriro ako. Oncologist wako achafunga nezvechiyero chekenza yako, hutano hwese, zera, uye zvaunofarira wega paunenge uchiita zvinokurudzirwa.

Hormone therapy inonyanya kubatsira varume vane kenza yepamusoro kana metastatic prostate cancer, kana avo vanoiwana pamwe chete ne radiation therapy. Inogona kunge isiri sarudzo yakanaka yekutanga yekenza yematanho ekutanga inogona kuporeswa nekuvhiyiwa kana radiation chete.

Zvinangwa zvako zvehupenyu zvinokosha zvakanyanya musarudzo iyi. Vamwe varume vanokoshesa kudzora kenza yavo zvisinei nemigumisiro, nepo vamwe vachisarudza kuchengetedza hupenyu hwavo hwazvino sezvinobvira.

Tora nguva yekukurukura zvese zvaunogona kusarudza nechikwata chako chehutano, kusanganisira mabhenefiti anogona kuitika, njodzi, uye dzimwe nzira. Kuwana imwe pfungwa kunogona kukubatsira kuti unzwe wakavimbika musarudzo yako.

Kurarama zvakanaka panguva ye hormone therapy

Varume vazhinji vanobudirira kurarama hupenyu hunoshingaira, hunogutsa vachigamuchira mushonga wemahomoni. Chinhu chikuru ndechokuva nechido chekugadzirisa matambudziko uye kuchengetedza hutano hwako hwese.

Kurovedza muviri nguva dzose kunova kwakakosha panguva yekurapa mahomoni. Kunyange mabasa akareruka sekufamba anogona kubatsira kuchengetedza tsandanyama, simba remapfupa, uye mazinga esimba ukuwo achivandudza manzwiro ako.

Kudya chikafu chakaringana chine calcium yakawanda, vhitamini D, uye mapuroteni kunotsigira hutano hwemapfupa ako uye kunobatsira kugadzirisa shanduko yehuremu. Funga nezvekushanda nemunhu akanyoreswa wezvekudya anonzwisisa zvinodiwa zvekudya zvevarwere vane gomarara.

Ramba wakabatana nenetiweki yako yekutsigira, ingave mhuri, shamwari, kana mapoka ekutsigira gomarara. Varume vazhinji vanozviwana zvichibatsira kutaura nevamwe vakapfuura nezviitiko zvakafanana.

Ndingatarisirwa kuona chiremba riini panguva yekurapa mahomoni?

Kugadzwa kwekuongorora nguva dzose kwakakosha panguva yekurapa mahomoni, asi iwe unofanirwawo kubata timu yako yehutano kana ukaona chero zviratidzo zvinonetsa pakati pekushanya.

Fonera chiremba wako nekukasira kana ukaona kurwadziwa muchipfuva, kufema kwakanyanya, zviratidzo zvemaropa, kana pfungwa dzekuzvikuvadza. Izvi zvinogona kuratidza matambudziko akakomba anoda kutariswa nekukasira.

Bata timu yako yehutano mukati memazuva mashoma kana ukaona kupisa kwakanyanya kunokanganisa kurara, kurwadziwa kwemapfupa kusingatsananguriki, shanduko dzakakosha dzemanzwiro, kana chero matambudziko anokunetsa.

Usazeze kubata nekubvunza mibvunzo pamusoro pekurapa kwako, kunyangwe zvichioneka zvidiki. Chikwata chako chehutano chiripo kuti chikutsigire mukati merwendo rwako rwekurapa.

Mibvunzo inowanzo bvunzwa nezvekurapa mahomoni egomarara re prostate

Mubvunzo 1: Kurapa mahomoni chemotherapy here?

Aihwa, mushonga wemahomoni hausi chemotherapy. Kunyange zvose zviri kurapwa kwekenza, zvinoshanda zvakasiyana. Mushonga wemahomoni unonyanya kuvharidzira kana kuderedza mahomoni echirume anokurudzira kukura kwekenza yeprostate, nepo chemotherapy ichishandisa mishonga inorwisa zvakananga masero anokurumidza kukamukana mumuviri wako wose. Mushonga wemahomoni kazhinji une mhedzisiro shoma uye yakasiyana kana ichienzaniswa nechemotherapy.

Mubvunzo 2: Ndingamira mushonga wemahomoni kana mhedzisiro yacho yava kuoma?

Unogona kukurukura kumisa kana kutora zororo kubva kumushonga wemahomoni nenyanzvi yako yezvokurapa kana mhedzisiro yacho ikakanganisa zvakanyanya hupenyu hwako. Vamwe vanachiremba vanokurudzira mushonga wemahomoni wenguva nenguva, kwaunotora zororo rakarongeka kuti testosterone yako ipore kwenguva pfupi. Zvisinei, kumisa kurapwa kungabvumira kenza yako kukura, saka sarudzo iyi inoda kufunga zvakanyanya nezve mabhenefiti vachipesana nenjodzi.

Mubvunzo 3: Mushonga wemahomoni uchakanganisa kugona kwangu kuva nevana here?

Mushonga wemahomoni kazhinji unoita kuti varume vasabereke vachiri kurapwa nekuti unoderedza zvakanyanya testosterone uye unomisa kugadzirwa kwemumbe. Kana uchifarira kuva nevana mune ramangwana, taura nachiremba wako nezve kubhanga sperm usati watanga kurapwa. Kubereka kunogona kudzoka mushure mekumisa mushonga wemahomoni, asi izvi hazvivimbiswi, kunyanya mushure mekurapwa kwenguva refu.

Mubvunzo 4: Ndichada kugara pamushonga wemahomoni kwenguva yakareba sei?

Kureba kunosiyana zvakanyanya zvichienderana nemamiriro ako chaiwo. Vamwe varume vanogamuchira mushonga wemahomoni kwemwedzi mishoma vasati vaita radiation, nepo vamwe vane kenza yakakura vachigona kuenderera mberi kwemakore kana zvisingaperi. Nyanzvi yako yezvokurapa ichaongorora nguva dzose kana kuenderera mberi nekurapwa kuchipa mabhenefiti akawanda kupfuura njodzi. Chinangwa ndechekudzora kenza yako uchichengetedza mhando yehupenyu hwakanakisisa.

Mubvunzo 5: Ndingaita maekisesa zvakajairika ndiri pamushonga wemahomoni here?

Hongu, kurovedza muviri kunokurudzirwa panguva yekurapa mahomoni uye kunogona kubatsira kudzora mativi mazhinji. Ungangoda kugadzirisa maitiro ako nekuda kwekuneta kana shanduko dzemhasuru, asi kuramba uchishingaira kunobatsira kuchengetedza kuwanda kwemapfupa, huwandu hwemhasuru, uye hutano hwepfungwa. Shanda nechikwata chako chehutano kuti ugadzire chirongwa chekurovedza muviri chakachengeteka uye chakakodzera chiyero chako chekufitinesi chazvino uye chero mamwe mamiriro ehutano aunogona kunge uine.