Chii chinonzi Cinacalcet: Zvinoshandiswa, Dosage, Side Effects uye Zvimwe

Cinacalcet mushonga unopiwa nachiremba unobatsira kudzora mazinga epamusoro ecalcium muropa rako kana ma parathyroid glands ako akanyanya kushanda. Funga nezvazvo semabhureki akapfava ema glands ari kushanda zvakanyanya, achibatsira kudzorera chiyero mukugadzirisa calcium yemuviri wako.

Mushonga uyu unokosha zvikuru kuvanhu vane chirwere cheitsvo chisingaperi kana kenza ye parathyroid vanotambura nekusiyana kwe calcium. Kunzwisisa mashandiro ainoita uye zvaunofanira kutarisira zvinogona kukubatsira kuti unzwe wakavimbika nezvekufamba kwako kwekurapa.

Chii chinonzi Cinacalcet?

Cinacalcet ndeyeboka remishonga inonzi calcimimetics, zvinoreva kuti inotevedzera mhedzisiro ye calcium pamaparathyroid glands ako. Ma parathyroid glands ako ma glands madiki mana mumutsipa mako anodzora mazinga ecalcium muropa rako nemapfupa.

Apo ma glands aya anova akanyanya kushanda, anoburitsa hormone yakawandisa ye parathyroid (PTH), zvichikonzera kuti mazinga ecalcium akwire zvakanyanya. Cinacalcet inonyengerera ma glands aya kuti anofunga kuti pane calcium yakawanda iripo kupfuura iripo, zvichikonzera kuti aderedze kugadzirwa kwavo kwehomoni.

Mushonga uyu unouya semutabhu wemuromo waunotora nemuromo, zvichiita kuti ive sarudzo yakakodzera yekutarisira kwenguva refu kwezvirwere zvine chekuita ne calcium.

Chii chinonzi Cinacalcet chinoshandiswa?

Cinacalcet inorapa mamiriro chaiwo apo muviri wako unogadzira hormone yakawandisa ye parathyroid, zvichikonzera mazinga epamusoro ecalcium. Chiremba wako anogona kuinyora yemamiriro matatu makuru.

Iko kushandiswa kwakajairika ndeye secondary hyperparathyroidism muvanhu vane chirwere cheitsvo chisingaperi vari pa dialysis. Kana itsvo dzako dzisingashande zvakanaka, hadzigone kudzora calcium ne phosphorus nemazvo, zvichikonzera kuti ma parathyroid glands ako ashande nguva yakawanda.

Cinacalcet inobatawo hyperparathyroidism yekutanga kana kuvhiyiwa kusingabviri kana kusina kubudirira. Mamiriro aya anoitika kana imwe kana anopfuura eparathyroid glands yako achigadzira hormone yakawanda pachayo.

Mukuwedzera, mushonga uyu unobatsira kubata hypercalcemia (calcium yakawanda yeropa) muvanhu vane parathyroid carcinoma, rudzi rusingawanzoitiki rwegomarara rinokanganisa parathyroid glands. Muzviitiko izvi, cinacalcet inogona kubatsira kudzora mazinga ecalcium apo mamwe marapirwo anobata gomarara pacharo.

Cinacalcet Inoshanda Sei?

Cinacalcet inoshanda nekubatanidza kune calcium-sensing receptors pane yako parathyroid glands, ichivaita kuti vanyanye kuona calcium muropa rako. Iyi yakawedzera sensitivity inokonzera glands kuti ideredze kugadzirwa kwavo kwe parathyroid hormone, kunyangwe mazinga ecalcium akajairika kana akaderera.

Mushonga uyu unoonekwa seune simba zvishoma uye kazhinji unoratidza mhedzisiro mukati memaawa mashoma ekutora. Zvisinei, zvinogona kutora mavhiki akati wandei kuti uone mabhenefiti akazara sezvo muviri wako uchigadzirisa kune mazinga matsva e hormone.

Runako rwecinacalcet runovanda mukutarisa kwayo. Panzvimbo pokukanganisa muviri wako wose, inonyanya kutarisana ne glands dzine matambudziko, ichibvumira kudzora kwakanyatsojeka kwemazinga ecalcium nemigumisiro mishoma yakapararira.

Ndinofanira Kutora Sei Cinacalcet?

Tora cinacalcet sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva nechikafu kana nguva pfupi yapfuura kudya. Kuitora nechikafu kunobatsira muviri wako kutora mushonga zviri nani uye kunoderedza mukana wekutsamwa mudumbu.

Medza mahwendefa ese negirazi remvura izere. Usapwanye, kutsenga, kana kuputsa mahwendefa, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unoburitswa mumuviri wako. Kana uine dambudziko rekumedza mapiritsi, taura nachiremba wako nezveimwe sarudzo.

Chiremba wako anogona kukutanga nemushonga mudiki uye zvishoma nezvishoma kuwedzera huwandu hwemushonga zvichienderana nemigumisiro yebvunzo yeropa rako. Nzira iyi yekuchenjerera inobatsira kuderedza mhedzisiro isingadiwi apo uchitsvaga huwandu hwakakodzera hwezvaunoda.

Edza kutora cinacalcet panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako. Vanhu vazhinji vanoona zvichibatsira kuzvitora nekudya kwemanheru kana chikafu chavo chikuru chezuva.

Ndingatora Cinacalcet Kwenguva Yakareba Sei?

Kureba kwekurapa kwecinacalcet kunoenderana nemamiriro ako ezvinhu uye kuti unopindura sei kumushonga. Vanhu vazhinji vane chirwere cheitsvo chisingaperi kana matambudziko eparathyroid vanoda kurapwa kwenguva refu, kazhinji kwemwedzi kana makore.

Chiremba wako achatarisa mazinga eropa re calcium uye parathyroid hormone nguva dzose kuburikidza nebvunzo dzeropa. Miedzo iyi inobatsira kuona kana mushonga uri kushanda nemazvo uye kana kuchidikanwa kugadzirisa huwandu hwemushonga.

Kune vamwe vanhu vane gomarara reparathyroid, cinacalcet inogona kudiwa zvachose kudzora mazinga e calcium. Zvisinei, kana ukavhiwa zvakanaka hyperparathyroidism yekutanga, unogona kumira mushonga kana basa rako reparathyroid ragadzirika.

Usambomira kutora cinacalcet kamwe kamwe usina kubvunza chiremba wako, sezvo izvi zvinogona kukonzera mazinga ako e calcium kukwira zvakanyanya. Chiremba wako achagadzira chirongwa chakachengeteka chekumisa mushonga kana uye kana zvakakodzera.

Ndezvipi Zvipingamupinyi zveCinacalcet?

Semishonga yese, cinacalcet inogona kukonzera mhedzisiro isingadiwi, kunyange vanhu vazhinji vachizvitsungirira zvakanaka. Kunzwisisa zvekutarisira kunogona kukubatsira kusiyanisa pakati pemhedzisiro yakajairika yekugadzirisa uye zviratidzo zvinoda kutariswa kwechiremba.

Mhedzisiro isingadiwi inowanzoitika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga:

• Kutemwa nemoyo nekutukwa, kunyanya mumavhiki mashoma ekutanga
• Kurasikirwa nechido chekudya kana kunzwa wakazara nekukurumidza
• Kurwadziwa kwemhasuru nekupera simba
• Dizziness kana kunzwa wakaita sedzungu
• Kutemwa nemusoro
• Kuneta kana kunzwa wakaneta zvisingaite

Zviratidzo izvi zvinowanzoita zvishoma nekufamba kwenguva, uye kutora mushonga uyu pamwe chete nechikafu kunogona kubatsira kuderedza kutemwa nemoyo zvakanyanya.

Zvimwe zvinokonzera matambudziko akakomba zvinoda kutariswa kwechiremba nekukasira, kunyangwe zvichiwanzowanikwa:

• Kukakavara kwemhasuru kwakanyanya kana spasms
• Kunzwa kunzwa kana kusanzwa chero chinhu pamuromo pako kana mumunwe wako
• Kurova kwemoyo kusingaite kana kurwadziwa muchipfuva
• Kutapukirwa kana convulsions
• Kuvhiringidzika kwakanyanya kana shanduko dzemafungiro

Zviratidzo izvi zvinogona kuratidza kuti mazinga ako ecalcium akaderera zvakanyanya, mamiriro anonzi hypocalcemia. Ichi ndicho chikonzero nei kuongorora ropa nguva dzose kwakakosha panguva yekurapa.

Vamwe vanhu vanogona kusangana nemigumisiro isingawanzoitiki asi yakakomba inoda kuongororwa kwechiremba nekukasira. Izvi zvinosanganisira maitiro akakomba ekuita allergic ane matambudziko ekufema, kuzvimba kwechiso kana huro, kana kuputika kweganda kwakapararira.

Ndiani Asingafaniri Kutora Cinacalcet?

Cinacalcet haina kukodzera munhu wese, uye mamwe mamiriro anoita kuti ive nenjodzi. Chiremba wako achanyatsoongorora kana mushonga uyu wakachengeteka kune yako chaiyo mamiriro.

Haufanire kutora cinacalcet kana mazinga ako ecalcium eropa akatoderera kana ari pazasi pezvakajairika. Sezvo mushonga uyu uchishanda nekuderedza mazinga ecalcium, kutanga necalcium yakaderera kunogona kutungamira kumatambudziko ane njodzi.

Vanhu vane mamwe mamiriro emoyo vanoda kufunga zvakakosha, sezvo mazinga ecalcium akaderera anogona kukanganisa rhythm yemoyo. Kana uine nhoroondo yeheart arrhythmias, heart failure, kana mamwe mamiriro emoyo, chiremba wako achayerera njodzi nemabhenefiti nekuchenjerera.

Kuzvitakura nekuyamwisa zvinoda kutariswa kwakakosha. Kunyange cinacalcet isina kunyatsodzidziswa zvakanyanya muvakadzi vane pamuviri, zvingasava sarudzo yakanaka panguva yekuzvitakura kunze kwekunge mabhenefiti achipfuura njodzi.

Vana nevechiri kuyaruka vari pasi pemakore gumi nemasere vanofanira kudzivisa cinacalcet kunze kwekunge yakanyorwa zvakananga nachiremba wevana, sezvo kuchengeteka nekushanda hazvina kumiswa mumapoka emakore madiki.

Mazita eCinacalcet Brand

Cinacalcet inowanikwa kazhinji pasi pezita rekuti Sensipar muUnited States. Mune dzimwe nyika, unogona kuiwana ichitengeswa seMimpara.

Mhando dzakajairika dze cinacalcet dzave kuwanikwa mumakore achangopfuura, dzichipa sarudzo dzinodhura dzekurapa kwenguva refu. Aya mafomu akajairika ane chinhu chimwe chete chinoshanda uye anoshanda zvakafanana nemhando dzemazita.

Pharmacy yako inogona kutsiva otomatiki vhezheni yakajairika kunze kwekunge chiremba wako achitaura zvimwe. Kana ukaona chero shanduko mukuona kwako mushure mekutamisa pakati pemhando nemhando dzakajairika, zivisa chiremba wako.

Zvimwe zvinotsiva Cinacalcet

Zvimwe zvinotsiva zviripo zvekugadzirisa mazinga epamusoro e calcium uye overactive parathyroid glands, kunyangwe sarudzo yakanakisa inoenderana nemamiriro ako chaiwo uye hutano hwese.

Kune vanhu vane primary hyperparathyroidism, kuvhiyiwa kubvisa overactive parathyroid gland(s) kazhinji ndiyo kurapwa kunofarirwa kana zvichibvira. Iyi nzira inogona kupa mushonga wechigarire panzvimbo yekuda mishonga inoramba ichienderera mberi.

Mishonga mimwe inogona kushandiswa inosanganisira bisphosphonates senge alendronate kana zoledronic acid, iyo inobatsira kudzivirira calcium kubva pakusiya mapfupa ako. Zvisinei, izvi zvinoshanda zvakasiyana ne cinacalcet uye zvingasava zvakakodzera kune vese.

Kune vanhu vane chronic kidney disease, kugadzirisa kurapwa kwe dialysis uye kubata mazinga e phosphorus kuburikidza nekudya uye phosphate binders dzimwe nguva zvinogona kubatsira kudzora mazinga eparathyroid hormone zvakasikwa.

Mishonga inotevedzera vhitamini D yakaita se calcitriol kana paricalcitol inogona kushandiswa, kunyangwe izvi zvichida kutariswa zvakanyanya nekuti dzimwe nguva dzinogona kuwedzera mazinga e calcium kana zvikasadzora zvakanaka.

Ko Cinacalcet Zviri Nani Pane Paricalcitol?

Cinacalcet ne paricalcitol zvinoshanda nemaitiro akasiyana uye zvinowanzo shandiswa mumamiriro akasiyana, zvichiita kuti kuenzanisa zvakananga kuve kwakaoma. Mishonga yese miviri inobatsira kudzora secondary hyperparathyroidism muvanhu vane chronic kidney disease, asi vanosvika dambudziko iri nenzira dzakasiyana.

Cinacalcet inoderedza zvakananga kugadzirwa kwe parathyroid hormone uye inowanzo deredza mazinga e calcium. Paricalcitol, analog ye vhitamini D, inobatsira kudzora calcium uye phosphorus balance asi dzimwe nguva inogona kuwedzera mazinga e calcium.

Vanachiremba vazhinji vanosarudza cinacalcet kana mazinga e calcium akatokwira kana kana kurapwa kwe vhitamini D kwaimbove kusina kubudirira. Paricalcitol inogona kusarudzwa kana mazinga e calcium akajairika kana akaderera, kana kana kushomeka kwe vhitamini D kuri chinhu chakakosha.

Vamwe vanhu vanogona kubatsirwa nekushandisa mishonga yese miviri pamwe chete pasi pekutariswa kwechiremba. Chiremba wako achafunga nezve lab values dzako, zviratidzo, uye hutano hwese paanenge achisarudza nzira inoshanda zvakanyanya kwauri.

Mibvunzo Inowanzo bvunzwa Nezve Cinacalcet

Ko Cinacalcet Yakachengeteka Kuvanhu vane Chirwere Chemoyo?

Cinacalcet inoda kungwarira zvakanyanya muvanhu vane chirwere chemoyo nekuti mazinga e calcium akaderera anogona kukanganisa rhythm yemoyo uye kushanda. Chiremba wako achatarisa hutano hwemoyo wako zvakanyanya kana uine mamiriro emoyo aripo.

Vanhu vane heart failure, irregular heartbeats, kana mamwe mamiriro emoyo akakomba vangangoda kutariswa kakawanda uye pamwe madosi akaderera. Mushonga hausiwo usina njodzi, asi unoda kutariswa kwechiremba zvakanyanya.

Gara uchizivisa chiremba wako nezve chero matambudziko emoyo usati watanga cinacalcet, uye shuma chero kurwadziwa kutsva muchipfuva, irregular heartbeat, kana matambudziko ekufema nekukasira.

Ndingaita Sei Kana Ndakatora Cinacalcet Yakawandisa Netsaona?

Kana ukatora cinacalcet yakawanda kupfuura yakanyorwa, fonera chiremba wako kana nzvimbo inobatsira kana uine chepfu nekukasika. Kutora yakawanda kunogona kukonzera kuti mazinga ako e calcium adzikire zvakanyanya, zvichikonzera zviratidzo zvakakomba.

Tarisa zviratidzo zve calcium yakaderera zvakaita sema cramp emhasuru, kunzwa kunzwa muromo mako, kunzwa kusina simba mumunwe wako, kana kuvhiringika. Zviratidzo izvi zvinogona kukura mukati memaawa ekutora mushonga wakawanda.

Usaedze ku

Chiremba wako angatarisa kumisa mushonga kana mamiriro ako ari nani zvakanyanya, sekutevera kubudirira kwekuvhiyiwa kweparathyroid kana kutamiswa kweitsvo. Zvisinei, sarudzo iyi inoda kunyatso tarisa mazinga ako ecalcium neparathyroid hormone.

Usambomira kutora cinacalcet kamwe kamwe, sezvo izvi zvinogona kukonzera mazinga ako ecalcium kukwira zvakanyanya. Chiremba wako achagadzira chirongwa chekuderera zvishoma nezvishoma kana kumisa kwakakodzera, achibvumira muviri wako kuti uchinje zvakachengeteka.

Ndingatora Zvinhu Zvekutsigira Calcium ndiri paCinacalcet here?

Kana iwe uchikwanisa kutora zvinowedzera calcium uchiri pa cinacalcet zvinoenderana nemazinga ako ecalcium nemamiriro ako ezvokurapa. Vamwe vanhu vangada zvinowedzera calcium kudzivirira mazinga kubva pakuderera zvakanyanya, nepo vamwe vachifanira kuzvirega zvachose.

Chiremba wako achatarisa mazinga ako eropa calcium nguva dzose uye achakurudzira kana zvinowedzera zvichidikanwa. Vanogona zvakare kukurudzira mhando dzakasiyana dzezvinowedzera calcium kana nguva dzakatarwa kuti vawedzere kunyudzwa.

Usambotanga kana kumisa zvinowedzera calcium wega uchitora cinacalcet. Kubatana pakati pemishonga iyi nezvinowedzera kunoda kutarisirwa kwekurapa kwakanyatsojeka kuchengetedza mazinga ecalcium akachengeteka.