Chii chinonzi Eluxadoline: Zvinoshandiswa, Dosage, Side Effects uye Zvimwe

Eluxadoline mushonga unopiwa nachiremba wakagadzirirwa kurapa irritable bowel syndrome ine manyoka (IBS-D) muvanhu vakuru. Kurapa uku kunoshanda nekugadzirisa kufamba kwematumbo uye nekuderedza kurwadziwa uye kukurumidza kunogona kuita kuti hupenyu hwezuva nezuva huve hunonetsa kuvanhu vane IBS-D.

Kana iwe wanga uchitambudzika nemanyoka anowanzoitika, kurwadziwa mudumbu, uye kusazivikanwa kwemaitiro eIBS, eluxadoline inomiririra nzira itsva yekugadzirisa izvi zvinonetsa. Iyo chikamu chekirasi yemishonga inoshanda zvakananga pane yako intestinal system kubatsira kudzorera basa rematumbo rakajairika.

Chii chinonzi Eluxadoline?

Eluxadoline mushonga une mabasa maviri unotarisa ma receptors akati wandei mumatumbo ako kuti utonge zviratidzo zveIBS-D. Iyo ndeyechikamu chemishonga inonzi mixed opioid receptor modulators, zvinoreva kuti inoshanda munzira dzimwe chete dzinodzora kurwadziwa uye basa rematumbo, asi nenzira yakatarwa.

Kusiyana nemamwe marapirwo ekare eIBS anoshanda mumuviri wako wese, eluxadoline yakagadzirirwa kuita zvakanyanya mudumbu rako. Iyi nzira yakatarwa inobatsira kuderedza mhedzisiro pane dzimwe nhengo dzemuviri wako uchigadzirisa nzira dzemidzi dzinokonzera zviratidzo zveIBS-D.

Mushonga uyu wakagamuchira mvumo yeFDA muna 2015, zvichiita kuti ive imwe yesarudzo itsva iripo yevanhu vane zviratidzo zveIBS-D zvisina kupindura zvakanaka kuchinja kwekudya kana mamwe marapirwo.

Chii chinonzi Eluxadoline chinoshandiswa?

Eluxadoline inonyanya kunyorerwa vanhu vakuru vane irritable bowel syndrome ine manyoka (IBS-D). Iyi mamiriro anokanganisa mamirioni evanhu uye anosanganisira kusanganiswa kwekurwadziwa mudumbu, kurwadziwa, uye kakawanda kusununguka kana mvura stools inogona kukanganisa zvakanyanya hupenyu hwako.

Chiremba wako angangofunga nezve eluxadoline kana uine zvirwere zvekurutsa zvichidzoka pamwe chete nekusagadzikana mudumbu kunotora mwedzi mitanhatu kana kupfuura. Mushonga uyu unobatsira zvikuru vanhu vane zvigaro zvitatu kana kupfuura zvisina kusimba pazuva, zvakabatanidzwa nekuda kwekukurumidza kuenda kuchimbuzi.

Zvakakosha kunzwisisa kuti eluxadoline haishandiswe kune mamwe marudzi eIBS, senge IBS ine constipation (IBS-C) kana akavhenganiswa IBS. Mushonga uyu haunawo kukodzera kurapa kurutsa kwakanyanya kubva kuzvirwere, chepfu yechikafu, kana zvimwe zvikonzero zvenguva pfupi.

Eluxadoline Inoshanda Sei?

Eluxadoline inoshanda nekudyidzana nemhando nhatu dzakasiyana dzeopioid receptors mumugwagwa wako wematumbo, imwe neimwe ichiita basa rakakosha mukudzora basa rematumbo. Izvi zvinoita kuti ive iyo vanachiremba vanoti

Madosi ekutanga anowanzoita 100 mg kaviri pazuva, asi chiremba wako angangokupa mushonga mudiki we 75 mg kaviri pazuva kana uine zvimwe zvinokonzera njodzi. Izvi zvinosanganisira nhoroondo yematambudziko e gallbladder, matambudziko echiropa, kana kana uri kutora mamwe mishonga anogona kukanganisa eluxadoline.

Unofanira kutora dose yega yega nekudya kukuru pane kungodya chikafu chidiki. Izvi zvinoreva kutora mushonga nekudya kwemangwanani uye kudya kwemanheru, kana kudya kwemasikati uye kudya kwemanheru, zvichienderana nehurongwa hwako hwekudya. Chikafu hachifaniri kuve chakakora kana chiremu, asi chinofanira kuve chikafu chakajairika kuti chibatsire muviri wako kugadzirisa mushonga nemazvo.

Kana ukakanganwa dose, usawedzere dose yako inotevera. Ingotora dose yako inotevera yakarongwa nechikafu sezvakajairika. Kutora mishonga yakawanda hakuzoita kuti ishande zviri nani uye inogona kuwedzera njodzi yako yemigumisiro.

Ndingatora Eluxadoline Kwenguva Yakareba Sei?

Kureba kwekurapa kwe eluxadoline kunosiyana kubva kumunhu nemunhu uye kunoenderana nekuti unopindura sei kumushonga uye kuti unoenderana sei nehurongwa hwako hwese hwe IBS. Vanhu vazhinji vanoiita kwemwedzi yakati wandei kusvika kumakore sechikamu chekufambisa kwavo kwenguva refu IBS-D.

Chiremba wako anozoda kutarisa newe mushure memavhiki mashoma ekutanga kuti aone kuti uri kupindura sei kumushonga. Vamwe vanhu vanoona kuvandudzwa kwezviratidzo zvavo mukati mevhiki yekutanga, nepo vamwe vangada mavhiki akati wandei kuti vawane zvizere zvinobatsira.

Nekuti IBS-D inowanzo kuve mamiriro echronic, eluxadoline yakagadzirirwa kushandiswa kwenguva refu pane zororo renguva pfupi. Zvisinei, chiremba wako angangokurudzira zororo renguva nenguva kubva kumushonga kuti aongorore kana zviratidzo zvako zvakavandudzwa zvega kana kana uchiri kuda kurapwa.

Usambomira kutora eluxadoline kamwe kamwe usati wataura nachiremba wako kutanga, kunyanya kana wanga uchii tora kwemwedzi yakati wandei. Kunyange zvazvo isingagadziri mu tsika yechinyakare, kumira kamwe kamwe kungaita kuti zviratidzo zvako zveIBS-D zvidzoke zvakanyanya.

Ndezvipi Zvakaipa ZveEluxadoline?

Kufanana nemishonga yese, eluxadoline inogona kukonzera mhedzisiro, kunyange zvisiri zvese zvinovawana. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye kuziva nguva yekubata chiremba wako.

Mhedzisiro yakajairika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumishonga mumavhiki mashoma ekutanga ekurapa.

Mhedzisiro yakajairika yaungasangana nayo inosanganisira:

• Kuvharika (mhedzisiro inowanzoitika, inokanganisa vanhu vanenge 8%)
• Nausea, iyo inowanzoita nani kana ichitorwa nechikafu
• Kurwadziwa mudumbu kana cramping, kazhinji nyoro kupfuura zviratidzo zvako zveIBS zvepakutanga
• Zvirwere zvepamusoro zvekufema senge dzihwa
• Kurutsa, kunyanya mumazuva mashoma ekutanga ekurapa
• Flatulence kana gasi rakawedzera

Izvi zvinowanzoitika zvinowanzoitika uye zvinowanzoita zvishoma sezvo muviri wako uchijaira mishonga. Vanhu vazhinji vanowana kuti kutora eluxadoline nechikafu chakakwana kunobatsira kuderedza nausea uye dumbu rinogumbuka.

Mhedzisiro yakakomba haisi kazhinji asi inoda kutariswa kwekurapa nekukurumidza:

• Kurwadziwa mudumbu kwakanyanya kusingavandudzi kana kuwedzera
• Pancreatitis (kuzvimba kwepancreas), iyo inokonzera kurwadziwa mudumbu kwakanyanya kunogona kupararira kumusana wako
• Kuvharika kwakanyanya kunogara mazuva anopfuura mashoma
• Sphincter of Oddi spasm, inokonzera kurwadziwa kwakanyanya mudumbu repamusoro
• Zviratidzo zvekuita allergic senge rash, kuoma kufema, kana kuzvimba

Kana uine kurwadziwa kukuru mudumbu, kunyanya kana kwakaperekedzwa nekunzwa kusvotwa, kurutsa, kana fivha, fonera chiremba wako nekukasira. Izvi zvinogona kunge zviri zviratidzo zvepancreatitis, iyo iri dambudziko rakakomba asi risina kujairika rinoda kutarisirwa kwekurapa nekukurumidza.

Ndiani Asingafaniri Kutora Eluxadoline?

Eluxadoline haina kuchengeteka kune vese, uye kune mamiriro akati wandei akakosha uye mamiriro apo chiremba wako haazonyora mushonga uyu. Kuve akatendeseka nezve nhoroondo yako yekurapa kunobatsira kuona kuti unowana kurapwa kwakachengeteka uye kunoshanda.

Haufanire kutora eluxadoline kana uine mamwe mamiriro ekugaya kana chiropa anogona kuita kuti mushonga uyu uve nenjodzi kwauri.

Zvinopesana zvachose zvinosanganisira:

• Hapana gallbladder (cholecystectomy) - izvi zvinowedzera zvakanyanya njodzi yako ye pancreatitis
• Kuzivikanwa kana kufungidzirwa kwekuvharika kwemuviri webiliary
• Sphincter yeOddi kusashanda zvakanaka kana spasm
• Matambudziko akakomba echiropa (hepatic impairment)
• Nhoroondo ye pancreatitis
• Chirwere chakakomba cheitsvo
• Kugara uchinetseka kana kuoma kwakanyanya
• Kuzivikanwa kuvharika kwematumbu

Chiremba wako achavawo akangwarira nezve kunyora eluxadoline kana uine nhoroondo yekushandisa doro zvisina kufanira, sezvo izvi zvinogona kuwedzera njodzi yako ye pancreatitis. Uye zvakare, kana iwe uchitora mamwe mishonga inokanganisa ma enzymes echiropa akafanana anogadzirisa eluxadoline, chiremba wako angasarudza imwe nzira yekurapa.

Zvekufunga zvakakosha zvinoshanda kune:

• Vanhu vane makore anopfuura 65, avo vanogona kunge vachinyanya kunzwisisa kune mhedzisiro
• Avo vane matambudziko echiropa akapfava kusvika pakati nepakati
• Munhu wese ari kutora mishonga inodyidzana ne eluxadoline
• Vanhu vane nhoroondo yekushandisa zvinodhaka zvisina kufanira
• Avo vane pamuviri kana kuyamwisa

Kana wakazvitakura kana kuronga kuzvitakura, kurukurai izvi nachiremba wenyu. Kunyange zvazvo eluxadoline isina kunyatsodzidziswa muvakadzi vane pamuviri, kazhinji haikurudzirwi panguva yekuzvitakura kunze kwekunge zvakanakira zviri pachena kupfuura njodzi.

Mazita eBrand eEluxadoline

Eluxadoline inowanikwa pasi pezita rebrand Viberzi muUnited States. Iri ndiro zita rebrand chete rinowanikwa parizvino, sezvo mushonga uyu uchiri mutsva uye shanduro dzakajairika dzisiri kuwanikwa zvakanyanya.

Kana chiremba wenyu akanyora eluxadoline, vanowanzo nyora mushonga weViberzi, uyo unouya nesimba mbiri: 75 mg uye 100 mg mahwendefa. Ese masimba ari mahwendefa akaita seoval ayo aunotora nemuromo nechikafu.

Kana uri kutsvaga mushonga wako pa pharmacy kana kuukurukura nechikwata chako chehutano, unogona kunzwa mazita ese achishandiswa zvakachinjana. Zvimwe zvirongwa zveinishuwarenzi zvinogona kuisa pasi pezita rakajairika eluxadoline, nepo vamwe vachishandisa zita rebrand Viberzi mumafomu avo.

Zvimwe Zvingashandiswa Panzvimbo peEluxadoline

Kana eluxadoline isiri yako kana isingapi rubatsiro rwakakwana rwezviratidzo, dzimwe nzira dzekurapa dziripo dzekugadzirisa IBS-D. Chiremba wako anogona kukubatsira kuongorora izvi zvimwe zvinhu zvichibva pazviratidzo zvako zvakakosha uye nhoroondo yekurapa.

Zvimwe zvinorayirwa zvemishonga yeIBS-D zvinosanganisira alosetron (Lotronex), iyo yakanyatsogadzirirwa vakadzi vane IBS-D yakakomba, uye rifaximin (Xifaxan), mushonga unorwisa mabhakitiriya unogona kubatsira kugadzirisa mabhakitiriya ako emudumbu. Kune zvakare loperamide (Imodium), sarudzo isingapfuuri-the-counter iyo vanhu vazhinji vanoedza vasati vachinjira kumishonga inorayirwa.

Nzira dzisiri dzemishonga dzinogona kuwedzera kana dzimwe nguva kutsiva eluxadoline dzinosanganisira:

• Kuchinja kudya kwakadai sekudya kwe low-FODMAP
• Probiotics kutsigira mabhakitiriya emudumbu ane hutano
• Nzira dzekudzora kushushikana dzinosanganisira kurapwa kana kufungisisa
• Kurovedza muviri nguva dzose uye kuchengeta hutano hwekurara
• Zvinowedzerwa zve soluble fiber
• Mishonga yeAntispasmodic yekurwadziwa

Vanhu vazhinji vanowana kuti kusanganisa mishonga nekuchinja mararamiro kunopa mhedzisiro yakanakisa kwenguva refu. Chiremba wako angakurudzira kutanga ne eluxadoline uchiitawo pane zvinokonzera kudya uye nzira dzekudzora kushushikana.

Ko Eluxadoline Zviri Nani Pane Loperamide?

Eluxadoline uye loperamide (Imodium) zvinoshanda zvakasiyana uye zvinoshanda mabasa akasiyana mukurapa IBS-D, saka kuenzanisa hazvina kunanga. Sarudzo yakanakisa inoenderana nezviratidzo zvako zvakananga, kuoma, uye kuti unopindura sei kumushonga wega wega.

Loperamide imushonga unowanikwa pamusoro pe-the-counter uyo unonyanya kuderedza kufamba kwemudumbu kuderedza manyoka. Kazhinji ndiyo yekutanga kurapwa vanhu vanoedza nekuti inowanikwa nyore uye haina kudhura. Zvisinei, inonyanya kutarisa chikamu chemanyoka che IBS-D pasina kutarisana nekurwadziwa mudumbu uye cramping iyo vanhu vazhinji vanowana.

Eluxadoline, kune rumwe rutivi, yakagadzirirwa kutarisa manyoka uye mativi ekurwadziwa mudumbu e IBS-D. Ichi chiito kaviri chinogona kuita kuti chive chinoshanda zvakanyanya kune vanhu vane cramping yakakosha uye kusagadzikana pamwe chete nezviratidzo zvavo zve bowel.

Vanachiremba vazhinji vanokurudzira kuyedza loperamide kutanga, kunyanya kune occasional symptom flares, vasati vaenda kune zvingasarudzwa zvekurapa zvakaita se eluxadoline. Kana loperamide isingapi zororo rakakwana kana kana iwe uchida mishonga yezuva nezuva yekugadzirisa zviratidzo zvako, eluxadoline inogona kunge iri mhinduro iri nani kwenguva refu.

Vamwe vanhu vanowana kuti vanogona kushandisa mishonga yese miviri zvine hungwaru - eluxadoline yekutarisira zuva nezuva uye loperamide yezviratidzo zvinobuda kana mazuva akaoma. Nguva dzose kurukurai nzira iyi nachiremba wenyu musati masanganisa kurapwa.

Mibvunzo Inowanzo Bvunzwa Pamusoro peEluxadoline

Eluxadoline Yakachengeteka Here Kune Vanhu vane Chirwere cheShuga?

Eluxadoline inogona kushandiswa zvakachengeteka nevanhu vane chirwere cheshuga, asi pane zvimwe zvinhu zvakakosha zvekukurukura nachiremba wenyu. Mushonga wacho pachake hauna zvakananga kukanganisa mazinga eshuga yeropa, asi zviratidzo zvekugaya chikafu uye shanduko mumaitiro ematumbo dzimwe nguva zvinogona kukanganisa nzira iyo muviri wenyu unotora nayo zvinovaka muviri nemishonga.

Kana muine chirwere cheshuga, chiremba wenyu achada kukutarisa zvakanyanya paunotanga eluxadoline, kunyanya kana muine chero matambudziko ane chekuita nechirwere chenyu cheshuga anokanganisa hurongwa hwenyu hwekugaya chikafu. Vanhu vane diabetic gastroparesis kana mamwe matambudziko ekugaya chikafu vangangoda kufunga kwakakosha.

Zvakare zvakakosha kucherechedza kuti kutonga kuri nani kweIBS-D kunogona kubatsira kugadzirisa hutano hwenyu hwese, kusanganisira kuita kuti zvive nyore kuchengetedza maitiro ekudya anotsigira manejimendi akanaka echirwere cheshuga.

Ndoitei Kana Ndikatora Eluxadoline Yakawandisa Netsaona?

Kana netsaona mukatora eluxadoline yakawanda kupfuura yakarairwa, taura nachiremba wenyu kana nzvimbo yekudzora muchetura nekukasira, kunyangwe mukasanzwa zviratidzo pakarepo. Kutora eluxadoline yakawanda kunogona kuwedzera njodzi yezvipingamupinyi zvakakomba, kunyanya kuvharika kwakanyanya kana kurwadziwa mudumbu.

Musaedze ku

Kana uine marwadzo akanyanya mudumbu, kutadza kufema, kana zvimwe zviratidzo zvakakomba mushure mekunwa mishonga yakawandisa, tsvaga rubatsiro rwekurapa nekukurumidza. Uya nebhodhoro remushonga newe kuitira kuti nyanzvi dzekurapa dzizive chaizvo zvawakatora uye zvawakatora zvakadii.

Ndingaita sei kana ndikakanganwa dose yeEluxadoline?

Kana ukakanganwa dose yeeluxadoline, inwe paunorangarira, asi chete kana uchikwanisa kuitora nechikafu. Kana yava nguva yekutora dose yako inotevera, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chekushandisa mishonga.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yezvinetso zvisina kufanira pasina kupa mamwe mabhenefiti. Eluxadoline inoshanda zvakanyanya kana ichitorwa nguva dzose, asi kukanganwa dose dzimwe nguva hakuzokukuvadzi kana kukanganisa zvakanyanya kurapwa kwako.

Kana iwe uchikanganwa madosi kazhinji, funga kumisa zviyeuchidzo zvefoni kana kushandisa murongi wepiritsi kuti akubatsire kuti urambe uri munzira. Kushandisa mishonga nguva dzose kunobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wako kuti utonge zviratidzo zvakanaka.

Ndingamira rini kutora Eluxadoline?

Sarudzo yekumira kutora eluxadoline inofanira kugara ichiitwa mukubvunzana nachiremba wako pane wega. Sezvo IBS-D inowanzoita mamiriro echronic, vanhu vazhinji vanoda kurapwa kwenguva refu kuti vachengetedze kutonga kwezviratidzo.

Chiremba wako angangofunga kumisa kana kuderedza eluxadoline kana zviratidzo zvako zvave zvichidzora zvakanaka kwenguva yakareba, kana ukaita shanduko huru dzemararamiro dziri kutonga IBS-D yako, kana kana uri kusangana nezvinetso zvisina kufanira zvinopfuura mabhenefiti.

Vamwe vanhu vanowana kuti vanogona kutora zororo kubva kueluxadoline munguva iyo zviratidzo zvavo zveIBS-D zviri zvishoma. Zvisinei, izvi zvinofanira kurongwa nemupi wako wehutano kuti ave nechokwadi chekuti une nzira dziripo kana zviratidzo zvikadzoka.

Kana muchida kumisa eluxadoline, chiremba wenyu anowanzo kuraira kuderedza zvishoma nezvishoma pane kumisa kamwechete, kunyanya kana makanga muchiitora kwemwedzi yakawanda. Izvi zvinobatsira kudzivirira kudzoka kamwechete kwezviratidzo zvingave zvakanyanya kupfuura IBS-D yenyu yekutanga.

Ndinganwa Doro Ndichiri Kutora Eluxadoline?

Zvinowanzo kurairwa kudzivisa kana kuderedza zvakanyanya doro muchitora eluxadoline, kunyanya kana muine nhoroondo yematambudziko ane chekuita nedoro. Doro rinogona kuwedzera njodzi yenyu yekuwana pancreatitis, iyo yatove mhedzisiro isingawanzoitiki asi yakakomba yeeluxadoline.

Kana mukasarudza kunwa doro dzimwe nguva, kurukurai izvi nachiremba wenyu kutanga. Vanogona kukubatsirai kunzwisisa njodzi dzenyu dzega uye kupa gwara pamiganhu yakachengeteka. Vanhu vane nhoroondo yekushandisa doro zvisina kufanira vanofanira kudzivisa zvachose doro vachitora eluxadoline.

Rangarirai kuti doro rinogonawo kukonzera zviratidzo zveIBS-D muvanhu vazhinji, saka kuderedza kunwa doro kungangobatsira kuvandudza kutonga kwenyu kwezviratidzo pamusoro pezvinhu zvekuchengetedza mishonga.