Chii chinonzi Infliximab: Zvazvinoshandiswa, Mishonga, Mativi eMuviri uye Zvimwe

Infliximab mushonga une simba unopiwa nachiremba unobatsira kudzikamisa immune system yako painorwisa muviri wako. Inopiwa kuburikidza neIV (intravenous) infusion kuchipatara kana kiriniki, uko nyanzvi dzehutano dzinogona kukutarisa zvakanyanya panguva yekurapa.

Mushonga uyu ndeweboka rinonzi biologics, iro rinogadzirwa kubva kumasero mhenyu pane makemikari. Funga nezve infliximab semubatsiri akatarisana anovharira zviratidzo zvakakosha mu immune system yako zvinokonzera kuzvimba uye kukuvadza tishu.

Chii chinonzi Infliximab chinoshandiswa?

Infliximab inorapa mamiriro akati wandei eautoimmune uko immune system yako inokanganisa kurwisa zvikamu zvine hutano zvemuviri wako. Chiremba wako angakupa mushonga uyu kana dzimwe nzira dzekurapa dzisina kupa rubatsiro rwakakwana kubva kuzviratidzo zvako.

Mushonga uyu wakabvumidzwa neFDA kune mamiriro aya chaiwo:

• Rheumatoid arthritis (kana yakasanganiswa ne methotrexate)
• Chirwere cheCrohn's uye ulcerative colitis
• Ankylosing spondylitis
• Psoriatic arthritis
• Plaque psoriasis

Imwe neimwe yemamiriro aya inosanganisira kuzvimba kusingaperi kunogona kukonzera kurwadziwa kukuru uye kupindira mumabasa emazuva ese. Infliximab inobatsira kuderedza kuzvimba uku, izvo zvinogona kutungamira mukudzora zvirinani zviratidzo uye kuvandudza hupenyu.

Infliximab inoshanda sei?

Infliximab inoshanda nekudzivisa protein inonzi tumor necrosis factor-alpha (TNF-alpha) iyo inoita basa rakakosha mukuzvimba. Kana immune system yako ikagadzira TNF-alpha yakawandisa, inogona kukonzera kuzvimba kunorwadza uye kukuvadza tishu kunoonekwa muzvirwere zveautoimmune.

Nekusungirira kuTNF-alpha uye kudzivirira kuti isashande, infliximab inobatsira kuputsa kutenderera kwekuzvimba. Ichi ndicho chikonzero ichinzi TNF blocker kana TNF inhibitor.

Mushonga uyu unoonekwa semushonga wakasimba, wakanangana nechirwere. Kazhinji unoshandiswa pazvirwere zvepakati nepakati kusvika kune zvakanyanya apo mamwe mishonga asina kushanda zvakakwana. Mhedzisiro yacho inowanzoonekwa mukati memavhiki mashoma kusvika kumwedzi mishoma mushure mekutanga kurapwa.

Ndingatora sei Infliximab?

Infliximab inongopiwa chete seIV infusion munzvimbo yekurapa senge chipatara, kiriniki, kana nzvimbo yekupinza mishonga. Hauzotorere mushonga uyu kumba kana nemuromo.

Maitiro ekupinza mishonga anowanzo tora maawa 2-3, uye iwe uchatariswa nenyanzvi dzehutano mukati mese. Vanhu vazhinji vanogamuchira zvikamu zvavo zvitatu zvekutanga pamavhiki 0, 2, uye 6, wobva waenderera mberi nekupinza mishonga mumasvondo ese 8.

Pamberi pekuiswa kwega kwega, timu yako yehutano ichatarisa zviratidzo zvako zvakakosha uye ichibvunza nezve chero zviratidzo kana kunetseka. Haufaniri kutsanya usati warapwa, asi zvinobatsira kudya chikafu chakareruka uye kuramba uine mvura yakakwana.

Unogona kunzwa wakasununguka kuunza bhuku, piritsi, kana dzimwe mabhuku ekunyaradza sezvo uchagara kwemaawa akati wandei. Vamwe vanhu vanonzwa kuneta mushure mekurapwa, saka funga kuronga kuti mumwe munhu akutyairire kumba.

Ndingatora Infliximab kwenguva yakareba sei?

Kureba kwekurapwa kweinfliximab kunosiyana zvakanyanya zvichienderana nemamiriro ako chaiwo uye kuti unopindura sei kumushonga. Vamwe vanhu vangada kurapwa kwemwedzi yakati wandei, nepo vamwe vachigona kuenderera mberi kwemakore.

Chiremba wako achagara achiongorora kuti mushonga uri kushanda sei uye kana uri kusangana nechero matambudziko. Vachashandisa bvunzo dzeropa, zvidzidzo zvekufungidzira, uye mishumo yako yezviratidzo kuti vaite sarudzo idzi.

Zvakakosha kuti usambomira infliximab kamwechete usina kukurukura nachiremba wako kutanga. Kumira kamwechete kunogona kukonzera kuti zviratidzo zvako zvidzoke, dzimwe nguva zvakanyanya kupfuura kare. Chikwata chako chehutano chichagadzira chirongwa chakakodzera mamiriro ako.

Ndezvipi Zvakaipa ZveInfliximab?

Sezvinongoita mishonga yese, infliximab inogona kukonzera matambudziko, kunyangwe kwete munhu wese anoawana. Kunzwisisa zvekutarisa kunokubatsira kuti urambe wakachengeteka uye uwane zvakanyanya kubva mukurapa.

Matambudziko anowanzoitika ayo vanhu vazhinji vanowana anosanganisira:

• Kutemwa nemusoro nekuneta
• Zvirwere zvekufema zvepamusoro senge dzihwa
• Kurwadziwa mudumbu kana kusvotwa
• Maitiro panzvimbo yekuiswa mushonga
• Kurwadziwa kwemhasuru kana majoini

Matambudziko aya anowanzoita nyoro uye anowanzoita nani muviri wako paunojaira mushonga. Zvisinei, iwe unofanirwa kugara uchitaurira chero zviratidzo zvitsva kana kuipa kuchikwata chako chehutano.

Matambudziko akakomba anoda kutariswa kwekurapa nekukasira, kunyangwe asinga wanzani:

• Zviratidzo zvechirwere chakakomba (fivha, kutonhora, kukosora kusingaperi, zviratidzo zvakaita sedzihwa)
• Kuneta kana kusimba kusinganzwisisike
• Kuchinja kweganda kusanganisira kukura kutsva kana maronda
• Kurwadziwa mudumbu kusingaperi kana shanduko mukufamba kwematumbo
• Kufema kwakaoma kana kurwadziwa muchipfuva

Nekuti infliximab inokanganisa immune system yako, unogona kunge uri panjodzi huru yezvirwere. Chiremba wako achakutarisa zvakanyanya uye anogona kukurudzira kudzivirira majekiseni mamwe kana nzvimbo dzakazara panguva yezvipatara zvikuru.

Ndiani Asingafaniri Kutora Infliximab?

Infliximab haina kuchengeteka kune munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Mamwe mamiriro ehutano kana mamiriro anoita kuti mushonga uyu usakodzere kana kuve nenjodzi.

Haufanire kugamuchira infliximab kana uine:

• Zvirwere zvinoshanda, kunyanya tuberculosis kana hepatitis B
• Kukundikana kwemoyo (pakati nepakakomba)
• Kuziva allergy kuinfliximab kana zvikamu zvayo
• Mhando dzakasiyana dzekenza kana nhoroondo ye lymphoma

Chiremba wako achashandisawo kungwarira kwakanyanya kana uine chirwere cheshuga, matambudziko echiropa, kana nhoroondo yezvirwere zvinodzoka. Vanogona kuda kumwe kuyedzwa kana kuongororwa vasati vatanga kurapwa.

Kuzvitakura nekuyamwisa zvinoda kufunga kwakakosha. Kunyange zvazvo infliximab ingashandiswa panguva yekuzvitakura mune dzimwe nguva, zvakakosha kuti ukurukure njodzi nemabhenefiti zvakadzama nechikwata chako chehutano.

Mazita eBrand eInfliximab

Zita rebrand re infliximab ndiRemicade, iyo ndiyo vhezheni yekutanga yemushonga uyu. Unogonawo kusangana ne biosimilar versions, iyo mishonga yakafanana zvikuru inoshanda nenzira imwecheteyo.

Mazita akajairika e biosimilar anosanganisira Inflectra, Renflexis, uye Ixifi. Aya ma biosimilars akaratidzwa kuti anoshanda zvakanyanya uye akachengeteka seRemicade yekutanga, kunyange hazvo inishuwarenzi yako ingasiana pakati pemavhezheni akasiyana.

Chiremba wako nemupharmacist vachashanda pamwechete kuti vaone kuti ndeipi vhezheni iri nani kwauri zvichienderana nekushanda, kuwanikwa, uye kufunga kwemutengo.

Zvimwe Zvinhu Zviri Kutsiva Infliximab

Kana infliximab isiri iyo yakakunakira iwe kana ikamira kushanda nemazvo, dzimwe nzira dzakawanda dzekurapa dziripo. Chiremba wako anogona kukubatsira kuti uongorore izvi zvimwe zvinhu zvichienderana nemamiriro ako chaiwo uye nhoroondo yekurapa.

Mamwe maTNF blockers anosanganisira adalimumab (Humira), etanercept (Enbrel), uye certolizumab (Cimzia). Izvi zvinoshanda zvakafanana ne infliximab asi zvinogona kupiwa semajekiseni aunogona kuita kumba.

Non-TNF biologics senge rituximab, tocilizumab, kana abatacept inotarisa zvikamu zvakasiyana zve immune system. Zvinodhaka zvechinyakare zvinogadzirisa chirwere senge methotrexate, sulfasalazine, kana hydroxychloroquine zvinogonawo kuva sarudzo.

Sarudzo inoenderana nezvinhu zvakaita sekuongororwa kwako chaiko, kurapwa kwakapfuura, zvaunofarira mararamiro, uye kuti muviri wako unopindura sei kumishonga yakasiyana.

Infliximab iri nani pane Adalimumab here?

Zvese zviri zviviri infliximab ne adalimumab zvinoshanda zvakanaka se TNF blockers, asi zvine zvakanakira zvakasiyana zvichienderana nemamiriro ako. Hapana kana chimwe chacho chiri nani pane chimwe.

Infliximab inopiwa se IV infusion mumasvondo masere ega ega, izvo zvinoreva kushoma kwemishonga asi zvinoda kushanya kuchipatara. Adalimumab imishonga yekuzviisa iwe pachako inopiwa vhiki rega rega kumba, ichipa nyore asi mishonga inowanzoitika.

Vamwe vanhu vanopindura zviri nani kumushonga mumwe pane mumwe, uye izvi hazvigone kufanotaurwa. Chiremba wako angasarudza imwe zvichienderana nemamiriro ako chaiwo, mararamiro, inishuwarenzi, kana nhoroondo yekurapa yapfuura.

Mishonga yese ine kushanda kwakafanana uye mhedzisiro. Sarudzo inowanzobva pakusarudza kwemunhu pachake nezvekushanya kuchipatara kana majekiseni epamba.

Mibvunzo Inowanzo Bvunzwa Nezve Infliximab

Q1. Infliximab Yakachengeteka Kune Vanhu vane Chirwere cheShuga here?

Infliximab inogona kushandiswa kune vanhu vane chirwere cheshuga, asi inoda kuongororwa kwakawanda uye matanho ekuchengetedza. Sezvo chirwere cheshuga chinogona kukanganisa immune system yako nekupora, chiremba wako achakutarisa zvakanyanya zviratidzo zvehutachiona.

Unoda bvunzo dzeropa nguva dzose kuti uongorore mazinga eshuga yeropa rako uye hutano hwese. Zvakakosha kuchengetedza kutonga kwakanaka kweshuga yeropa paunenge uchitora infliximab, sezvo izvi zvichibatsira immune system yako kushanda zvakanaka sezvinobvira.

Q2. Ndingaita Sei Kana Ndikawana Infliximab Yakawandisa netsaona?

Sezvo infliximab ichipiwa munzvimbo yekurapa, overdoses netsaona hazviwanzoitiki. Nyanzvi dzehutano dzinonyatsoverenga uye kuongorora muyero wako panguva ye infusion yega yega.

Kana iwe uchinetseka nezvekugamuchira muyero usiri iwo, usazeze kubvunza timu yako yehutano kuti iongorore ruzivo rwako uye muyero usati watanga kurapwa. Vanofanira kugara vachitarisa kuzivikanwa kwako uye kuongorora chirongwa chako chekurapa newe.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose ye Infliximab?

Kana ukakundikana kuwana infusion yakarongwa, taura nachiremba wako nekukurumidza sezvinobvira kuti urongezve. Usaedze kutsiva mushonga wakarasika nekugamuchira mushonga wakawanda gare gare.

Chiremba wako achasarudza nzira yakanakisisa yekukudzosera panzira nechirongwa chako chekurapa. Izvi zvinogona kureva kugadzirisa nguva yako inotevera yekupa mushonga kana kuongorora zvakare chirongwa chako chekurapa.

Q4. Ndingamira Rini Kutora Infliximab?

Sarudzo yekumisa infliximab inofanira kugara ichiitwa nekurairwa nachiremba wako. Vamwe vanhu vanogona kumira mushure mekuwana remission yenguva refu, nepo vamwe vachigona kuda kurapwa kwenguva refu.

Chiremba wako achafunga nezvezvinhu zvakaita sekuti mamiriro ako akadzorwa sei, wakagara kwenguva yakareba sei wakagadzikana, uye njodzi yako yekutadza. Vanogona kuderedza zvishoma nezvishoma muyero wako kana kuwedzera nguva pakati pe infusions vasati vamira zvachose.

Q5. Ndingawana Majekiseni Ndiri Kutora Infliximab Here?

Majekiseni mazhinji akachengeteka uchiita infliximab, asi majekiseni mhenyu anofanira kudziviswa. Chiremba wako achaongorora majekiseni aungade uye nguva yekuaagamuchira.

Zvinowanzo kurudzirwa kugadziridza majekiseni ako usati watanga kurapwa kweinfliximab. Majekiseni akajairika sejekiseni reflu uye jekiseni renyumonia akakosha zvakanyanya sezvo infliximab inogona kuwedzera njodzi yako yekutapukirwa.