Chii chinonzi Melphalan: Zvazvinoshandiswa, Dosage, Side Effects uye Zvimwe

Melphalan mushonga wechemotherapy unobva muboka remishonga inonzi alkylating agents. Inoshanda nekukanganisa kugona kwemasero ekenza kukura nekuzviparadzanisa, ichibatsira kunonotsa kana kumisa kupararira kwemamwe marudzi ekenza. Chiremba wako anogona kukupa mushonga uyu sechikamu chechirongwa chako chekurapa kenza, kazhinji pamwe chete nemamwe marapirwo.

Chii chinonzi Melphalan?

Melphalan mushonga wechemotherapy unopiwa nachiremba uyo unotarisana nemasero ekenza nekukuvadza DNA yawo. Mushonga uyu wakashandiswa kwemakumi emakore kurapa marudzi akasiyana ekenza yeropa uye inoonekwa sechombo chakakosha mukurapa kenza. Inowanikwa mune fomu remahwendefa ekunwa uye sejojo, kunyangwe tichatarisa vhezheni yekunwa pano.

Mushonga uyu unobva mukirasi inonzi nitrogen mustards, iyo inobva kumakemikari ehondo asi yakagadzirirwa kushandiswa mukurapa. Usarega nhoroondo iyi ichikunetsa - kana ichishandiswa nemazvo pasi pekutariswa kwechiremba, melphalan mushonga unokosha wekurwisa kenza uyo wabatsira varwere vazhinji.

Melphalan Inoshandiswa Kunei?

Melphalan inonyanya kushandiswa kurapa multiple myeloma, rudzi rwekenza yeropa runokanganisa masero eplasma mumapfupa ako. Inorayirwawo kenza yeovari, kunyanya mumatanho epamberi apo mamwe marapirwo asina kubudirira.

Oncologist wako anogona kukurudzira melphalan kune mamiriro akati wandei. Izvi zvinosanganisira kugadzirira kutapurirana kwemapfupa, kurapa kenza yakadzoka mushure memamwe marapirwo, kana sechikamu chechirongwa chekurapa chakasanganiswa. Dzimwe nguva vanachiremba vanoishandisa kune mamwe marudzi ekenza yeropa senge mamwe marudzi e lymphoma, kunyangwe izvi zvisingawanzoitiki.

Mushonga uyu unoshanda zvakanyanya kana masero ekenza achiparadzanisa nekukura. Ichi ndicho chikonzero chiremba wako achanyatso chengeta nguva yako yekurapa kuti uwedzere kushanda uku uchipa masero ako ane hutano nguva yekupora.

Melphalan Inoshanda Sei?

Melphalan inoshanda nekunamatira kuDNA mukati memasero ekenza uye ichivadzivisa kukamukana zvakanaka. Fungidzira sekukanda wrench mumuchina wekutevedzera wesero rekenza - haigoni kugadzira makopi matsva ayo pachayo kana DNA yakakuvadzwa.

Iri rinotariswa semushonga wechemotherapy wakasimba zvishoma, kwete sarudzo yakapfava iripo asi kwete iyo ine hasha zvakanyanya. Inotarisa masero ese anokamukana nekukurumidza, ndosaka ichikanganisa ese masero ekenza nemamwe masero ane hutano anokamukana nekukurumidza, senge ari mumafollicles ako ebvudzi uye nzira yekugaya chikafu.

Mushonga unogara uchishanda mumuviri wako kwemaawa akati wandei mushure mekuutora, uchiramba uchishanda pamasero ekenza panguva ino. Chiropa chako chinopedzisira chaputsa mushonga, ndosaka vanhu vane matambudziko echiropa vachida kugadzirisa dosi.

Ndingatora sei Melphalan?

Tora melphalan sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva mudumbu risina chinhu. Izvi zvinoreva kuitora angangoita awa rimwe usati wadyisa kana maawa maviri mushure mekudya, sezvo chikafu chinogona kukanganisa kuti muviri wako unotora sei mushonga.

Medza mahwendefa ese nemvura yakazara - usapwanye, kutsenga, kana kuagura. Kana uine dambudziko rekumedza mapiritsi, taura nechikwata chako chehutano nezve nzira dzinogona kubatsira. Nguva dzose geza maoko ako zvakakwana usati watora mushonga uye mushure mekuutora.

Chiremba wako anogona kunyora melphalan mumakomo, sekutora kwemazuva akati wandei achiteverwa nenguva yekuzorora. Izvi zvinopa masero ako ane hutano nguva yekupora pakati pekurapa. Isa chiratidzo pakarenda yako kana kumisa zviyeuchidzo kuti zvikubatsire kuyeuka chirongwa chako chekupa mishonga.

Chengeta mushonga mumudziyo wawo wekutanga pakamuri tembiricha, kure nekupisa, hunyoro, uye chiedza. Chengeta kure nevana nemhuka, sezvo mishonga yechemotherapy inogona kukuvadza kana ikatorwa netsaona nevamwe.

Ndingatora Melphalan kwenguva yakareba sei?

Kureba kwemushonga we melphalan kunosiyana zvakanyanya zvichienderana nerudzi rwekenza yako, maitiro ako kumushonga, uye chirongwa chako chekurapa. Vamwe vanhu vanoutora kwemwedzi mishoma, asi vamwe vangada kuutora kwegore kana kupfuura.

Oncologist wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa kweropa nguva dzose uye zvidzidzo zve imaging kuti aone kuti kurapwa kuri kushanda sei. Vachatarisawo mhedzisiro inogona kudiwa kumisa kana kugadzirisa muyero wako. Kurapa kunowanzoenderera mberi chero bedzi kuchibatsira kudzora kenza yako uye mhedzisiro yacho ichiramba ichidzoreka.

Usambofa wakamisa kutora melphalan kamwe kamwe kana kuchinja muyero wako usati wataurirana nachiremba wako kutanga. Kunyangwe iwe uchinzwa zviri nani, mushonga unogona kunge uchiri kushanda kuchengetedza maseru ekenza pasi pekutonga. Chikwata chako chehutano chichakutungamira kuburikidza nemaitiro kana nguva yekumisa kurapwa yasvika.

Ndezvipi Zvakaipa zveMelphalan?

Kufanana nemishonga yese ye chemotherapy, melphalan inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoiziva. Mhedzisiro yakajairika inokanganisa kuverenga kweropa rako, hurongwa hwekugaya, uye mazinga ese esimba.

Heano mhedzisiro yaungangosangana nayo panguva yekurapa:

• Kuverenga kwemasero eropa akaderera (kukuita kuti uwedzere kutapukirwa, kubuda ropa, kana kuneta)
• Nausea uye kurutsa, kunyanya mumaawa mashoma ekutora mushonga
• Kurasikirwa nechido uye kurasikirwa uremu
• Diarhea kana kuvharika
• Maronda emuromo kana kuravira kwesimbi
• Kutetepa kana kurasikirwa nebvudzi
• Kuwedzera kuneta kana kusimba

Izvi zvinowanzoitika zvinowanzo dzoreka nekuchengetwa kunotsigira uye zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Mhedzisiro yakakomba inogona kuitika, kunyangwe isingawanzoitiki. Izvi zvinoda kutariswa kwekurapa nekukurumidza uye zvinosanganisira:

• Zviratidzo zvechirwere chakakomba zvakaita sefivha, kutonhora, kana kukosora kusingagumi
• Kubuda ropa kana kupwanyika zvisinganzwisisike
• Muvengu mukuru unokutadzisa kuchengeta chikafu kana mvura pasi
• Kutadza kufema kana kurwadziwa muchipfuva
• Manyoka akakomba ane dehydration
• Kusvava kweganda kana maziso

Bata timu yako yehutano nekukurumidza kana ukaona chero zviratidzo izvi zvakakomba.

Zvimwe zvisingawanzoitiki asi zvakakosha zvinoguma zvichisanganisira njodzi yakawedzerwa yekuvandudza mamwe magomarara makore gare gare uye nyaya dzekubereka. Chiremba wako achakurukura njodzi idzi newe uye achakubatsira kuyera izvi pamwe chete nemabhenefiti ekurapa.

Ndiani Asingafaniri Kutora Melphalan?

Melphalan haikodzeri munhu wese, uye chiremba wako achanyatsoongorora kana zvakakukodzera. Vanhu vane immune systems dzakakomba kana mamwe mamiriro aripo vangangoda mamwe marapirwo.

Haufanire kutora melphalan kana uine allergic kwairi kana uine maitiro akakomba kumishonga yakafanana yechemotherapy. Vanhu vane zvirwere zvinoshanda, zvisingadzoreki vanofanirwa kumirira kusvikira chirwere chacho charapwa vasati vatanga mushonga uyu.

Kungwarira kwakakosha kunodiwa kana uine chirwere cheitsvo kana chiropa, sezvo nhengo idzi dzichibatsira kugadzirisa mushonga. Chiremba wako angangoda kugadzirisa muyero wako kana kukutarisa zvakanyanya kana uine mamiriro aya.

Vakadzi vane pamuviri kana vanoyamwisa havafaniri kutora melphalan, sezvo ichikwanisa kukuvadza mwana ari kukura. Kana uri pazera rekubereka, uchada kushandisa nzira yekudzivirira kubata pamuviri panguva yekurapa uye kwenguva yakati gare gare.

Melphalan Mazita eBrand

Melphalan inowanikwa pasi pezita remhando yeAlkeran muchimiro chepiritsi. Unogona zvakare kuinzwa ichinzi nezita rayo re generic, melphalan, iyo ndiyo imwechete inoshanda zvisinei nemugadziri.

Mhando inojekeswa ine zita rekuti Evomela, asi izvi zvinopiwa muzvipatara kana makiriniki panzvimbo yekutorwa kumba. Kambani yako yemishonga inogona kupa zvese zita remhando kana vhezheni yechinyakare, zvichienderana nekavharo yako yeinishuwarenzi uye zviri kuwanikwa.

Zvimwe Zvinotsiva Melphalan

Mishonga yakati wandei yekemotherapu inogona kurapa mhando dzakafanana dzekenza, kunyangwe sarudzo yakanakisa ichienderana nemamiriro ako chaiwo. Zvimwe zvinotsiva zvinowanzoitika zvinosanganisira cyclophosphamide, bendamustine, uye marapirwo matsva akatarisirwa seborzomib kana lenalidomide.

Kune multiple myeloma, chiremba wako angangofunga nezve mishonga yeimmunomodulatory senge thalidomide kana pomalidomide. Kurapa kutsva kunosanganisira CAR-T cell therapy uye monoclonal antibodies, kunyangwe izvi zvinowanzo chengeterwa mamiriro chaiwo.

Sarudzo yechimwe chinhu inotsamira pazvinhu zvakaita serudzi rwako rwekenza, kurapwa kwakapfuura, hutano hwese, uye kuti wakatakura sei mamwe mishonga. Oncologist wako achashanda newe kuti uwane sarudzo yakakodzera kana melphalan isina kukodzera.

Melphalan Yakanyanya Here Pane Cyclophosphamide?

Kuenzanisa melphalan uye cyclophosphamide hakuna kunanga nekuti vanowanzo shandiswa kune mamiriro akasiyana kana kunyange pamwechete mukurapa kwakabatanidzwa. Ose ari maviri maajenti ealkylating anoshanda zvakafanana, asi ane simba rakasiyana uye maprofiles emhedzisiro.

Melphalan inowanzoita inonyanya kushanda kune mamwe mhando dzekenza yeropa senge multiple myeloma, nepo cyclophosphamide ichiwanzofarirwa kune tumarara twakasimba uye mamwe ma lymphomas. Cyclophosphamide inowanzoita kuti muviri usanzwe kusvotwa asi inogona kuve nemhedzisiro yakawanda pachibereko.

Chiremba wako anosarudza pakati pemishonga iyi zvichienderana nerudzi rwako rwekenza, nhanho, kurapwa kwakapfuura, uye hutano hwese. Dzimwe nguva anoshandiswa pamwechete mumaitiro ekubatanidza kuti awedzere kushanda uku achibata mhedzisiro.

Mibvunzo Inowanzo Bvunzwa Nezve Melphalan

Mubvunzo 1. Melphalan Yakachengeteka Here Kune Vanhu vane Chirwere cheItsvo?

Melphalan inogona kushandiswa muvanhu vane chirwere cheitsvo, asi zvinoda kunyatso tariswa uye kazhinji kugadzirisa mushonga. Itsvo dzako dzinobatsira kubvisa mushonga mumuviri wako, saka kushanda kwetsvo kwakaderera kunogona kukonzera mazinga emishonga akakwira uye mhedzisiro yakawanda.

Chiremba wako achaita bvunzo dzeropa nguva dzose kuti aongorore kushanda kwetsvo dzako uye kugadzirisa mushonga wako zvinoenderana. Vanogona zvakare kupatsanura mishonga yako zvakasiyana kana kukurudzira imwe rubatsiro rwekuchengetedza itsvo dzako panguva yekurapa.

Q2. Ndingaita Sei Kana Ndakatora Melphalan Yakawanda Netsaona?

Kana netsaona ukatora melphalan yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira, kunyangwe ukanzwa zvakanaka. Kutora zvakanyanya kunogona kukonzera mhedzisiro yakakomba, kunyanya kudonha kunotyisa muhuwandu hwemasero eropa.

Usamirira kuti zviratidzo zviitike usati watsvaga rubatsiro. Chikwata chako chehutano chingada kukutarisa zvakanyanya kana kupa rubatsiro rwekuchengetedza kudzivirira matambudziko. Chengeta bhodhoro remushonga newe paunofona kuti ugone kupa ruzivo rwechokwadi nezve zvawatora.

Q3. Ndingaita Sei Kana Ndikakanganwa Kutora Mushonga weMelphalan?

Kana ukakanganwa kutora mushonga we melphalan, taura nechikwata chako chehutano kuti uwane gwara pane kuyedza kuzvisarudzira iwe pachako. Nzira yakanakisa inoenderana nekuti unoyeuka riini mushonga wakakanganwa uye chirongwa chako chekurapa.

Kazhinji, usawedzere mishonga kana kutora imwe mishonga kuti ugadzirise mushonga wakakanganwa. Chiremba wako anogona kugadzirisa chirongwa chako kana kupa mirairo chaiyo zvichienderana nechirongwa chako chekurapa uye nguva yakapfuura kubva pamushonga wakakanganwa.

Q4. Ndingamira Rini Kutora Melphalan?

Unofanirwa kungomira kutora melphalan kana chiremba wako akuudza kuti zvakachengeteka kuita kudaro. Sarudzo iyi inobva pakuti kurapa kuri kushanda sei, mhedzisiro yako, uye zvinangwa zvako zvekutanga zvekutariswa.

Chiremba wako wezve gomarara achashandisa bvunzo dzeropa, zvidzidzo zvema imaging, uye bvunzo dzemuviri kuti aone kuti rinhi zvakakodzera kumisa kurapwa. Dzimwe nguva kurapwa kunoenderera mberi kunyangwe iwe uchinzwa zviri nani, sezvo mushonga ungave uchiri kudzora maseru egomarara asiri kukonzera zviratidzo zvakadaro.

Q5. Ndinganwe Doro Ndiri Kutora Melphalan Here?

Kazhinji zvakanakisa kudzivisa doro uchitora melphalan, sezvo zvese zviri zviviri zvinogona kukanganisa chiropa chako uye zvinogona kuwedzera mhedzisiro. Doro rinogonawo kukanganisa immune system yako, iyo yatove yakakanganiswa ne chemotherapy.

Kana iwe uchingonwa doro dzimwe nguva, kurukura izvi nechikwata chako chehutano. Vanogona kupa gwara rakagadzirirwa iwe zvichienderana nehutano hwako hwese, basa rechiropa, uye mhinduro yekurapa. Vamwe vanhu vanogona kukwanisa kuva nezvidiki zvidiki dzimwe nguva, nepo vamwe vachifanira kudzivisa doro zvachose.