Chii chinonzi Mitotane: Zvinoshandiswa, Mishonga, Migumisiro uye Zvimwe

Mitotane mushonga wakakosha unoshandiswa kurapa adrenocortical carcinoma, rudzi rwekenza rusingawanzoitiki asi rwakakomba runokanganisa adrenal glands. Kana iwe kana mumwe munhu waunoda akanyorerwa mushonga uyu, ungangove uri kubata nemanzwiro akaoma uye mibvunzo pamusoro pezvirikumberi.

Iri rinorwisa kenza rine simba rinoshanda nekunanga maseru ekenza mu adrenal cortex ukuwo richibatsira kubata nezviratidzo kana kenza isingakwanise kubviswa zvachose. Kunyange zvazvo mitotane ichida kutariswa zvakanyanya uye inogona kukonzera migumisiro, chishandiso chakakosha chakabatsira vanhu vazhinji kubata neichi chimiro chakaoma.

Chii chinonzi Mitotane?

Mitotane mushonga wemuromo wechemotherapy uyo uri muboka remishonga inonzi adrenolytic agents. Inonyanya kunanga rutivi rwekunze rwe adrenal glands yako, inonzi adrenal cortex, uko marudzi akati wandei ekenza anogona kukura.

Adrenal glands yako inogara pamusoro pemapapu ako uye inogadzira mahomoni akakosha se cortisol uye aldosterone. Kana kenza ikakura mumaglands aya, mitotane inogona kubatsira nekunanga maseru ekenza uye kuderedza kugadzirwa kwemahomoni akawandisa ayo anowanzoitika nerudzi urwu rwetumor.

Mushonga uyu wave uchishandiswa kwemakumi emakore uye unoramba uri mumwe wemishonga inoshanda zvikuru iripo ye adrenocortical carcinoma. Kunyange zvazvo ichionekwa semushonga wakasimba unoda kutariswa zvakanyanya, varwere vazhinji vakawana kuti inobatsira mukubata nemamiriro avo.

Chii chinonzi Mitotane chinoshandiswa?

Mitotane inonyanya kunyorerwa kurapa adrenocortical carcinoma, kenza isingawanzoitiki inokanganisa vanhu vanenge 1-2 pamamiriyoni gore rega rega. Chiremba wako angakurudzira mushonga uyu mumamiriro maviri makuru.

Kutanga, mitotane inogona kushandiswa mushure mekuvhiyiwa kubvisa bundu re adrenal, kunyangwe kuvhiyiwa kuchioneka kubudirira. Iyi nzira, inonzi adjuvant therapy, inobatsira kuderedza njodzi yekuti kenza idzoke nekunangana nemaseru ekenza asara anogona kunge ari madiki zvakanyanya kuti aonekwe.

Chechipiri, mushonga uyu unogona kubatsira kubata advanced adrenocortical carcinoma kana kenza yapararira kune dzimwe nhengo dzemuviri kana isingakwanise kubviswa zvachose nekuvhiyiwa. Muzviitiko izvi, mitotane inogona kubatsira kunonotsa kukura kwekenza uye kuderedza zviratidzo zvinokonzerwa nekugadzirwa kwakanyanya kwehomoni.

Vamwe vanachiremba vanonyorawo mitotane yeCushing's syndrome kana ichikonzerwa nematumo e adrenal. Ichi chimiro chinoitika kana muviri wako uchigadzira cortisol yakawandisa, zvichikonzera zviratidzo zvakaita sekuwedzera uremu, high blood pressure, uye shanduko dzemood.

Mitotane Inoshanda Sei?

Mitotane inoshanda nekunanga uye kuparadza maseru mu adrenal cortex, ese ari maviri maseru ekenza uye akajairika munzvimbo iyi. Funga nezvayo semushonga une chido chakakosha kune adrenal tissue, zvichimugonesa kuisa pfungwa dzake pazvinodiwa zvakanyanya.

Mishonga inovhiringidza kugadzirwa kwe steroid mahomoni mugland yako ye adrenal, kusanganisira cortisol uye aldosterone. Iyi chiito kaviri inobatsira kurwisa maseru ekenza uku ichideredzawo mazinga ehomoni akawandisa ayo anowanzo kukonzera zviratidzo zvinonetsa muvarwere vane adrenal tumors.

Izvi zvinoonekwa semushonga une simba nekuti unogona kukanganisa zvakanyanya basa rako re adrenal. Nepo iyi nzira yakatarwa ndiyo inoita kuti mitotane ishande kurwisa adrenal cancer, zvinorevawo kuti iwe uchada hormone replacement therapy kuti uchengetedze mabasa akajairika emuviri.

Mishonga inovaka mumaseru ako emafuta nekufamba kwenguva, izvo zvinoreva kuti inoenderera mberi ichishanda kunyangwe iwe ukamira kuitora. Iyi hunhu inobatsira kuchengetedza mhedzisiro yayo yekurwisa kenza asi zvinorevawo kuti mhedzisiro inogona kuramba ichiripo kwemavhiki kana mwedzi mushure mekurapa kunopera.

Ndingatora Sei Mitotane?

Mitotane inofanira kutorwa sezvakanyorwa nachiremba wako weoncologist, kazhinji kutanga nedosi yakaderera inowedzera zvishoma nezvishoma nekufamba kwenguva. Chiremba wako achanyatso tarisa mazinga eropa rako uye achagadzirisa dosi kuti awane chiyero chakakodzera pakati pekubudirira uye mhedzisiro inogoneka.

Tora mitotane uine chikafu, zviri nani nezvikafu zvine mafuta, sezvo izvi zvichibatsira muviri wako kutora mushonga zvakanyanya. Varwere vazhinji vanoona zvichibatsira kutora mushonga panguva imwe chete zuva rega rega kuti vachengetedze mazinga akagadzikana mumuviri wavo.

Vanhu vazhinji vanotanga ne2-6 gramu pazuva, yakakamurwa kuita 3-4 dosi mukati mezuva. Chiremba wako angawedzera izvi zvishoma nezvishoma, dzimwe nguva kusvika 8-10 gramu zuva nezuva, zvichienderana nekuti unotsungirira sei mushonga uye mazinga eropa rako.

Zvakakosha kuti urambe wakanyatsogadzirwa mvura uchitora mitotane uye kudzivisa doro, sezvo zvese zviri zviviri zvinogona kukanganisa maitiro emuviri wako kumushonga. Chikwata chako chehutano chichapa gwara rakajeka nezve chero chikafu kana mamwe mishonga yekudzivisa.

Ndingatora Mitotane Kwenguva Yakareba Sei?

Kureba kwekurapa mitotane kunosiyana zvakanyanya zvichienderana nemamiriro ako chaiwo uye maitiro ako kumushonga. Vamwe varwere vanoi tora kwemwedzi yakati wandei, nepo vamwe vachigona kuida kwemakore.

Kana iwe uchitora mitotane mushure mekuvhiyiwa kudzivirira kudzoka kwekenza, kurapwa kunowanzoenderera mberi kwemakore 2-5, chero iwe uchitsungirira zvakanaka uye mazinga eropa rako achiramba akakodzera. Chiremba wako achagara achiongorora kana kuenderera mberi nekurapa kuchibatsira kune yako chaiyo kesi.

Kune advanced adrenocortical carcinoma, kurapwa kazhinji kunoenderera chero bedzi mushonga uchibatsira kudzora kenza uye iwe uchigadzirisa mhedzisiro zvakanaka. Chikwata chako chehutano chichatarisa kufambira mberi kwako kuburikidza nekuongorora nguva dzose uye bvunzo dzeropa.

Usambomira kutora mitotane kamwechete usina kutanga wataurirana nachiremba wako. Nekuti mushonga unogara mumuviri wako kwemavhiki kana mwedzi, kurapwa kwako kwehomoni uye chirongwa chekutarisa zvinogona kuda kugadziriswa kunyangwe iwe ukamira kuutora.

Ndezvipi Zvazvinokonzera Mitotane?

Mitotane inogona kukonzera zvakasiyana-siyana zvinokonzerwa nekuti inokanganisa basa rakajairika remaadrenal glands ako, asi kunzwisisa zvekutarisira kunogona kukubatsira kugadzirira uye kuzvigadzirisa nemazvo. Zvizhinji zvezvazvinokonzeresa zvine chekuita nekukanganisa kwemushonga pakugadzirwa kwehomoni uye nehurongwa hwako hwetsinga.

Hezvino zvinowanzoitika zvaungasangana nazvo:

• Nyaya dzekugaya chikafu: Kusvotwa, kurutsa, manyoka, uye kurasikirwa nechido zvinowanzoitika, kunyanya kana uchitanga kurapwa kana kuwedzera zviyero
• Zviratidzo zvepfungwa: Dizziness, kuvhiringidzika, kuneta, uye matambudziko ekubatana anogona kuitika sezvo mushonga unokanganisa hurongwa hwako hwetsinga
• Adrenal insufficiency: Iwe uchada kurapwa kwehomoni nekuti mitotane inoderedza kugadzirwa kwako kwehomoni yechisikigo
• Kuchinja kweganda: Kuputika kweganda, flushing, kana kuwedzera kunzwisiswa kune zuva zvinogona kukura
• Kuneta kwese: Varwere vazhinji vanonzwa kuneta uye kusimba, kunyanya mumavhiki mashoma ekutanga ekurapa

Izvi zvinowanzoitika zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga uye kurapwa kwako kwehomoni kunovandudzwa. Chikwata chako chehutano chichashanda pedyo newe kuti ugadzirise izvi zvinokonzeresa.

Zvimwe zvisingawanzoitiki asi zvakakomba zvinokonzeresa zvinoda kutariswa kwekurapa nekukasira. Kunyange izvi zvichiitika muzvikamu zvidiki zvevarwere, zvakakosha kuzviziva:

• Zviratidzo zvakakomba zvepfungwa: Kuvhiringidzika kukuru, matambudziko ekuyeuka, kana kuoma kwemaitiro kunokanganisa mabasa ezuva nezuva
• Dambudziko re adrenal: Kusava nesimba kukuru, kusvotwa, kurutsa, uye kudzikira kweropa kunogona kuva nenjodzi kuhupenyu pasina kurapwa nekukurumidza
• Matambudziko echiropa: Kuwedzera kweiyo liver enzymes, kuita yero yeganda kana maziso, kana kurwadziwa kwakanyanya mudumbu
• Maitiro akakomba ekuita allergic: Kuoma kufema, kuputika kwakanyanya, kana kuzvimba kwechiso nehuro

Chiremba wako achakutarisa zvakanyanya kuburikidza nekuongororwa kweropa nguva dzose uye kuongororwa kuti ubate chero shanduko dzinonetsa nekukurumidza. Mazhinji emigumisiro inogona kubatwa nerutsigiro rwakakodzera uye kugadzirisa kuronga kwako kurapwa.

Ndiani Asingafanire Kutora Mitotane?

Mitotane haikodzeri munhu wese, uye chiremba wako achanyatsoongorora kana iri sarudzo yakakodzera yemamiriro ako chaiwo. Mamwe mamiriro ehutano nemamiriro anoita kuti mushonga uyu usachengeteke kana kushanda zvishoma.

Haufanire kutora mitotane kana iwe uchiziva allergy kumushonga kana chero zvawo zvinosanganiswa. Vanhu vane chirwere chechiropa chakakomba vangangodaro vasingakwanise kugadzirisa mushonga zvakachengeteka, sezvo mitotane inogona kuwedzera kushushikana kwechiropa.

Kuzvitakura kunopa zvinhu zvakakosha nekuti mitotane inogona kukuvadza mwana ari kukura. Vakadzi vane pamuviri kana kuronga kuva nepamuviri vanofanira kukurukura dzimwe nzira dzekurapa nechikwata chavo chehutano. Varume nevakadzi vanofanira kushandisa nzira dzekudzivirira kubata pamuviri vachitora mushonga uyu.

Kana iwe uchiyamwisa, mitotane inogona kupfuura mumukaka wemazamu uye inogona kukuvadza mwana wako. Chiremba wako achakurukura njodzi nemabhenefiti uye akubatsire kusarudza nzira yakachengeteka kwauri nemwana wako.

Zvimwe zvirwere zvinoda kungwarira kwakanyanya kana uchifunga nezvekurapa mitotane. Vanhu vane chirwere chakakomba cheitsvo, zvirwere zvinoshanda, kana matambudziko makuru ehutano hwepfungwa vangangoda nzira dzekurapa dzakachinjwa kana kuongororwa kwakawedzerwa.

Mazita eMitotane Brand

Mitotane inowanikwa pasi pezita remhando yeLysodren munyika zhinji, kusanganisira United States. Iyi ndiyo fomu inonyanya kunyorerwa yemishonga uye yakashandiswa zvakachengeteka kwemakumi emakore.

Mune dzimwe nzvimbo, unogona kuwana mitotane ichiwanika pasi pemazita akasiyana emhando kana semashanduro ejeneric. Zvisinei, nekuti mushonga uyu unoda kuyera uye kuongorora zvakanyatsonaka, zvakakosha kuti urambe uine zita rimwe chete remhando kana fomu kunze kwekunge chiremba wako achibvumira kuchinja.

Pharmacy yako inofanira kugara ichipa zita rimwe chete remhando kana vhezheni yejeneric kuti ive nechokwadi chekuenderana mukurapa kwako. Kana ukaona misiyano mukuonekwa kwemushonga wako, tarisa nemu pharmacist wako kana mupi wehutano usati wautora.

Mitotane Zvimwe Zvinhu

Nepo mitotane ichiramba iri kurapwa kukuru kweadrenocortical carcinoma, dzimwe sarudzo dzinogona kufungwa zvichienderana nemamiriro ako chaiwo uye kuti unotsungirira sei mitotane.

Kune varwere vasingakwanise kutsungirira mitotane kana vasingapinduri zvakanaka kwairi, mamwe mishonga yekemotherapu yakaita seetoposide, doxorubicin, cisplatin, kana streptozocin inogona kushandiswa yoga kana pamwe chete. Zvimwe zvinhu izvi zvinoshanda zvakasiyana ne mitotane asi zvinogona kubatsira kurwisa gomarara re adrenal.

Mishonga mitsva yakatarwa uye mishonga yeimmunotherapy iri kudzidzwa yeadrenocortical carcinoma, kunyangwe izvi zvinowanzo kuwanikwa kuburikidza nekuedzwa kwekiriniki kana mamiriro chaiwo. Oncologist wako anogona kukurukura kana chero imwe yesarudzo idzi itsva ingave yakakodzera kune yako kesi.

Pakugadzirisa zviratidzo zvine chekuita nemahomoni, mishonga yakaita seketoconazole, metyrapone, kana etomidate inogona kubatsira kuderedza kugadzirwa kwemahomoni akawandisa pasina kurwisa maseru ekenza zvakananga. Izvi zvinogona kushandiswa pamwe chete kana panzvimbo pemitotane mune dzimwe nguva.

Ko Mitotane Zviri Nani Kupfuura Zvimwe Zvirwere zveAdrenal Cancer?

Mitotane inoonekwa seyakajairika kurapwa kweadrenocortical carcinoma nekuti ndiyo mushonga wakanyanya kudzidzwa wekenza iyi isingawanzoitiki. Makumi emakore ekutsvagurudza akaratidza kuti inogona kubatsira kuwedzera kupona uye kuvandudza hupenyu hwevanhu vazhinji.

Kusiyana nemimwe mishonga yekemotherapu inokanganisa maseru mumuviri wako wese, mitotane inonyanya kutarisana nenyama ye adrenal, zvichiita kuti ive inoshanda zvakanyanya kumakenza e adrenal. Iyi nzira yakatarwa inowanzoita kuti ive inoshanda kupfuura mishonga yakajairika yekemotherapu yerudzi urwu rwekenza.

Zvisinei,

Varwere vazhinji vane chirwere cheshuga vanobudirira kutora mitotane vachichengetedza kutonga kwakanaka kweshuga yeropa. Chinhu chakakosha ndeyekutaurirana pachena nevanachiremba vako veoncologist uye timu yako yekutarisira chirwere cheshuga kuti uve nechokwadi chekutarisirwa kwakabatana.

Ndingaita Sei Kana Ndakatora Mitotane Yakawanda Netsaona?

Kana netsaona ukatora mitotane yakawanda kupfuura yakarairwa, taura nemupi wako wehutano kana nzvimbo yekudzora muchetura nekukasira. Kutora mitotane yakawanda kunogona kuwedzera njodzi yako yezvinetso zvakakomba, kunyanya zviratidzo zvepfungwa uye kusvotwa kwakanyanya.

Usaedze kutsiva mushonga wakawedzerwa nekusvetuka mushonga wako unotevera wakarongwa. Pane kudaro, tevera gwara remupi wako wehutano rekuti ungaita sei nechirongwa chako chekushandisa mushonga nguva dzose.

Zviratidzo zvekuwandisa mitotane zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, kuvhiringidzika, matambudziko ekubatana, kana kurara kunoshamisa. Kana ukaona chero zviratidzo izvi mushure mekutora mushonga wakawedzerwa, tsvaga rubatsiro rwekurapa nekukurumidza.

Ndingaita Sei Kana Ndikakanganwa Dose yeMitotane?

Kana ukakanganwa dose ye mitotane, itore nekukasira paunorangarira, kunze kwekunge yava nguva yekutora dose yako inotevera yakarongwa. Muchiitiko ichocho, svetuka dose yakakanganwa uye uenderere mberi nechirongwa chako chekushandisa mushonga nguva dzose.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinetso. Nekuti mitotane inogara mumuviri wako kwenguva refu, kukanganwa dose dzimwe nguva hakuwanzo kuve nedambudziko kupfuura nemimwe mishonga.

Kana iwe uchikanganwa madosi kazhinji, funga kumisa zviyeuchidzo zvefoni kana kushandisa chirongwa chemushonga kuti zvikubatsire kuti urambe uri munzira. Kushandisa mushonga nguva dzose kunobatsira kuchengetedza mazinga eropa akagadzikana uye kuwedzera kushanda kwemushonga.

Ndingamira Rini Kutora Mitotane?

Sarudzo yekumisa mitotane inofanira kugara ichiitwa mukubvunzana nevanachiremba vako veoncologist zvichibva pakupindura kwako kurapwa, zvinetso, uye hutano hwese. Usambofa wakamira kutora mitotane wega, kunyangwe uchinzwa zviri nani.

Chiremba wako achagara achiongorora kana kuenderera mberi nemitotane kuchibatsira kuburikidza nekufungidzira zvidzidzo, bvunzo dzeropa, uye kuongorora zviratidzo zvako. Kana kenza ichidzoreka zvakanaka uye uri kusangana nemigumisiro yakakura, chiremba wako angangofunga kumisa kana kuderedza muyero.

Nekuti mitotane inogara mumuviri wako kwemavhiki kana mwedzi mushure mekumisa, unozoda kuenderera mberi nekuongororwa uye kurapwa kwehomoni kunyangwe mushure mekumisa mushonga. Chikwata chako chehutano chichagadzira chirongwa chekuchinja kubva kumushonga zvakachengeteka.

Ndingafamba here ndichitora Mitotane?

Unogona kufamba uchitora mitotane, asi zvinoda kuronga kwakawanda uye matanho ekuchengetedza. Nguva dzose takura mishonga yako mumidziyo yavo yepakutanga uye uuye nezvimwe zvekushandisa kana paine kunonoka kufamba.

Nekuti uchange uchitora kurapwa kwehomoni pamwe chete nemitotane, ita shuwa kuti une zvakakwana zvemishonga yako yese yerwendo rwese pamwe nemazuva mashoma ekuwedzera. Funga kutakura tsamba kubva kuchiremba wako ichitsanangura mamiriro ako ekurapa nemishonga.

Kana uri kuenda kune imwe nzvimbo yenguva, taura nemupi wako wehutano nezvekuti ungachinja sei chirongwa chako chekushandisa. Zvakare kuchenjera kutsvaga nzvimbo dzekurapa kwauri kuenda kana iwe uchida kutarisirwa kwekurapa uri kure nemba.