Chii chinonzi Nilotinib: Zvazvinoshandiswa, Madosi, Mativi eMuviri uye Zvimwe

Nilotinib mushonga wekenza unovavarira kubatsira kurapa mhando dzekenza dzinokanganisa ropa nekudzivisa mapurotini chaiwo anokurudzira kukura kwemasero ekenza. Mushonga uyu unopiwa nemishonga unokodzera kirasi inonzi tyrosine kinase inhibitors, iyo inoshanda semashandiro emamorekuru chaiwo kuti amise masero ekenza kubva pakukura. Kana iwe kana mumwe munhu waunoda akanyorerwa nilotinib, kunzwisisa mashandiro ayo uye zvaunofanira kutarisira zvinogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezve rwendo urwu rwekurapa.

Chii chinonzi Nilotinib?

Nilotinib mushonga wekenza wemuromo wakagadzirirwa kurapa chronic myeloid leukemia (CML), rudzi rwekenza yeropa inokanganisa masero machena eropa. Funga nezvazvo sekurapa kunovavarira kunoenda kumaseru ekenza apo kazhinji ichisiya masero ane hutano ega. Mushonga uyu unouya semakapsule aunotora nemuromo, zvichiita kuti zvive nyore kupfuura dzimwe nzira zhinji dzekurapa kenza dzinoda kushanya kuchipatara.

Mushonga unoshanda nekudzivisa purotini chaiyo isina kujairika inonzi BCR-ABL iyo inoudza masero ekenza kuti akure uye awande zvisingadzoreki. Nekumisa purotini iyi kubva pakushanda, nilotinib inobatsira muviri wako kuti udzore kutonga pamusoro pekugadzirwa kwemasero eropa. Inoonekwa seyechipiri-chizvarwa tyrosine kinase inhibitor, zvinoreva kuti ndiyo vhezheni yakavandudzwa yemishonga yakafanana yekutanga.

Chii chinonzi Nilotinib chinoshandiswa?

Nilotinib inonyanya kushandiswa kurapa chronic myeloid leukemia (CML) muvanhu vakuru vari muchikamu chechronic kana chikamu chakakurumidza chechirwere. Chiremba wako angakunyora semushonga wekutanga kana uchangobva kuongororwa, kana sesarudzo yechipiri kana mimwe mishonga yeCML isina kushanda zvakanaka kwauri.

Mishonga iyi inobatsira zvikuru kuvanhu vane leukemia yavo yakava nemishonga yekurwisa imatinib, imwe mishonga inowanzo shandiswa kurapa CML. Inoshandiswawo kana varwere vasingakwanise kutora imatinib nekuda kwemigumisiro yayo. Mune dzimwe nguva, vanachiremba vanoraira nilotinib kuvarwere vachangobva kuongororwa vane CML vane zviratidzo zvakakosha zve genetic zvinoratidza kuti vangapindura zviri nani kumishonga iyi pane dzimwe sarudzo.

Nilotinib Inoshanda Sei?

Nilotinib inoshanda nekunangana nechinokonzera chronic myeloid leukemia pamwero wemamorekuru. MuCML, masero ako ane chromosome isina kujairika inogadzira protein isina kukwana inonzi BCR-ABL, iyo inoita sesignal inogara ichibatidzwa ichiudza masero kuti awande nekukurumidza.

Mishonga iyi inovharisa protein isina kukwana kubva pakutumira zviratidzo zvayo zvekukura, zvichibudirira kuisa mabhureki pakugadzirwa kwemasero ekenza. Inoonekwa semushonga wakasimba uye unoshanda zvakanyanya, kazhinji ichiwana izvo vanachiremba vanoti "molecular remission" - zvinoreva kuti kenza haina kuonekwa mumiedzo yeropa. Mushonga uyu unosarudza, zvinoreva kuti unonyanya kunangana nemasero ekenza uine kushoma kukanganisa kumasero ane hutano kana tichienzanisa nechemotherapy yechinyakare.

Ndinofanira Kutora Sei Nilotinib?

Unofanira kutora nilotinib sezvinorairwa nachiremba wako, kazhinji kaviri pazuva maawa anenge gumi nemaviri akaparadzana. Mutemo unonyanya kukosha ndewekutora mudumbu risina chinhu - hapana chikafu kwemaawa anenge 2 usati watora uye awa rimwe mushure meimwe dose. Nguva iyi yakakosha nekuti chikafu chinogona kuwedzera zvakanyanya huwandu hwemishonga inotorwa nemuviri wako, zvichikonzera migumisiro ine njodzi.

Medza makapisi ese nemvura yakawanda, uye usambovhura, kupwanya, kana kutsenga. Kana uine dambudziko rekumedza makapisi, taura nachiremba wako nezve dzimwe nzira panzvimbo yekuedza kuagadzirisa iwe pachako. Zvakanakisa kutora mishonga yako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako.

Dzivisa magrapefruit nemuto wemagrapefruit zvachose paunenge uchitora nilotinib, nekuti zvinogona kukanganisa nzira iyo muviri wako unogadzirisa mushonga. Unofanirwawo kungwarira nemimwe michero ye citrus uye kukurukura chero zvinokunetsa zvekudya nechikwata chako chehutano.

Ndingatora Nilotinib Kwenguva Yakareba Sei?

Vanhu vazhinji vane CML vanoda kutora nilotinib kwemakore akati wandei, uye vazhinji vanoenderera mberi vachii tora zvachose sechinhu chinorapwa kwenguva refu. Chiremba wako achatarisa mhinduro yako kuburikidza nekuongororwa kweropa nguva dzose uye biopsy yemuzongoza kuti aone kuti mushonga uri kushanda sei uye kana iwe uchikwanisa kuenderera mberi nehurongwa hwazvino.

Vamwe varwere vanowana remission yakadzama yemamorekuru vanogona kukwanisa kumisa kurapwa pasi pekutariswa kwakanyanya kwechiremba, asi chisarudzo ichi chinoda kuongororwa kwakawanda uye hachikodzeri munhu wese. Chinangwa chinowanzo kuve chekuwana nekuchengetedza remission, iyo inowanzoita kuti urambe uri pamushonga kwenguva refu.

Usambomira kutora nilotinib usati wataurirana nachiremba wako kutanga, kunyangwe uchinzwa zvakanaka. Kumira kamwe kamwe kunogona kubvumira leukemia kudzoka nekukurumidza uye pamwe kuve kwakaoma kurapa.

Ndezvipi Zvakaipa zveNilotinib?

Semishonga yese, nilotinib inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anozviwana. Kunzwisisa zvekutarisa kunogona kukubatsira kubata chero nyaya dzinomuka uye kuziva nguva yekubata chikwata chako chehutano.

Mhedzisiro inowanzoitika yaungasangana nayo inosanganisira kusvotwa, kuneta, kurwadziwa nemusoro, uye nyaya dzekugaya chikafu senzara kana kuvharika. Vanhu vazhinji vanoonawo mabhurashi eganda, kurwadziwa kwemhasuru nemajoini, kana shanduko mukuverenga kwavo kweropa kunooneka mumiyedzo yelabhu yenguva dzose. Mhedzisiro iyi inowanzo manejwa uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Zvimwe zvinokonzeresa zvakanyanya zvinoda kutariswa kwechimbichimbi kwechiremba. Izvi zvinosanganisira zviratidzo zvematambudziko emoyo senge kurwadziwa muchipfuva, kufema nekukurumidza, kana kurova kwemoyo kusingaite zvakanaka. Nilotinib inogona kukanganisa rhythm yemoyo wako, saka chiremba wako achatarisa izvi zvakanyanya ne electrocardiograms (EKGs) nguva dzose. Iwe unofanirwawo kutarisa zviratidzo zvematambudziko echiropa senge kuita yero yeganda kana maziso, weti yakasviba, kana kurwadziwa kwakanyanya mudumbu.

Zvisingawanzoitiki asi zvakanyanya zvinokonzeresa zvinosanganisira kubuda ropa zvakanyanya, zviratidzo zveutachiona nekuda kwehuwandu hushoma hweropa jena, kana zviratidzo zve shuga yeropa yakakwira. Chikwata chako chehutano chichakutarisa nguva dzose kuburikidza nemiedzo yeropa kuti ubate chero shanduko dzinonetesa nekukurumidza.

Ndiani Asingafaniri Kutora Nilotinib?

Vamwe vanhu havafaniri kutora nilotinib nekuda kwengozi yakawedzera yematambudziko akakomba. Kana uine nhoroondo yematambudziko e rhythm yemoyo, kunyanya mamiriro anonzi long QT syndrome, mushonga uyu haugone kuva wakachengeteka kwauri. Vanhu vane chirwere chechiropa chakanyanya kana avo vari kutora mishonga inodyidzana nengozi ne nilotinib vanofanirwawo kuideredza.

Haufaniri kutora nilotinib kana wakazvitakura kana kuyamwisa, sezvo ichigona kukuvadza mwana wako. Vakadzi vane makore ekubereka vanoda kushandisa nzira dzekudzivirira kubata pamuviri panguva yekurapa uye kwenguva yakati mushure mekumisa mushonga. Varume vari kutora nilotinib vanofanirwawo kushandisa nzira dzekudzivirira kubata pamuviri kudzivirira pamuviri muvadyidzani vavo.

Vanhu vane mamiriro akati wandei emagenetic anokanganisa maitiro emiviri yavo emishonga, chirwere chakanyanya cheitsvo, kana avo vakaita maitiro ekugadzirisa kune mishonga yakafanana vangave vasiri vakanaka vekurapa kwe nilotinib.

Nilotinib Zita reBrand

Nilotinib inotengeswa pasi pezita rebrand Tasigna, inogadzirwa neNovartis. Iyi ndiyo fomu yakajairika yaunosangana nayo, kunyangwe shanduro dzakajairika dzinogona kuwanikwa mune dzimwe nzvimbo. Mushonga uyu unouya muchimiro chekapsule chine simba rakasiyana, kazhinji 150 mg uye 200 mg.

Paunozadza mushonga wako, ita shuwa kuti mushonga unokupa rudzi rwakakodzera kana vhezheni yakabvumirwa yegeneric sezvakatsanangurwa nachiremba wako. Mafomula akasiyana anogona kuva nemitengo yakasiyana yekutora, saka kuenderana kwakakosha kuchengetedza mazinga eropa akagadzikana.

Zvimwe Zvinotsiva Nilotinib

Mishonga yakati wandei inogona kurapa leukemia ye chronic myeloid kana nilotinib isingakukodzere. Imatinib (Gleevec) inowanzo sarudzwa yekutanga yeCML ichangobva kuongororwa uye inoramba ichishanda zvakanyanya kune varwere vazhinji. Dasatinib (Sprycel) imwe sarudzo yechizvarwa chechipiri inoshanda zvakafanana ne nilotinib asi inogona kushivirirwa zviri nani nevamwe vanhu.

Sarudzo itsva dzinosanganisira bosutinib (Bosulif) uye ponatinib (Iclusig), iyo inogona kushandiswa kana mamwe marapirwo asina kushanda kana kana kenza yakagadzira maitiro akakosha ekudzivisa. Chiremba wako achafunga nezvezvinhu zvakaita sehutano hwako hwese, mamwe mishonga yaunotora, uye kuti leukemia yako inopindura sei kuti aone imwe nzira yakanakisisa.

Sarudzo pakati pemishonga iyi inowanzoenderana nemamiriro ako ega, kusanganisira kushivirira kwemigumisiro, hutano hwemoyo, uye hunhu hwemajini e leukemia yako.

Nilotinib Ari Nani Kudarika Imatinib Here?

Nilotinib uye imatinib zvose zvinorapa zvakanaka zveCML, asi imwe neimwe ine simba rakasiyana. Nilotinib inowanzoita simba uye inogona kukubatsira kuti uwane kuregererwa kwakadzama nekukurumidza kupfuura imatinib. Zvimwe zvidzidzo zvinoratidza kuti vanhu vanotora nilotinib vanogona kusvika kumakore ekuregererwa kwemamorekuru nekukurumidza.

Zvisinei,

Chiremba wako achafunga nezvezvinhu zvakaita semakore ako, hutano hwako hwese, kushanda kwemoyo, uye zvaunofarira iwe pachako paunenge uchisarudza pakati pemishonga iyi. Zvese zviri zviviri zvinoshanda zvakanyanya pakudzora CML, saka sarudzo yakanakisa ndiyo inoshanda zvakanaka kune mamiriro ako chaiwo.

Mibvunzo Inowanzo Bvunzwa Nezve Nilotinib

Nilotinib Yakachengeteka Here Kune Vanhu vane Chirwere Chemoyo?

Nilotinib inoda kufungwa zvakanyanya kana uine chirwere chemoyo, sezvo ichikwanisa kukanganisa rhythm yemoyo uye zvinogona kuwedzera mamwe mamiriro emoyo. Chiremba wako anogona kuraira electrocardiogram (EKG) usati watanga kurapwa uye achatarisa kushanda kwemoyo wako nguva dzose panguva yekurapa.

Kana uine chirwere chemoyo chinyoro, unogona kukwanisa kutora nilotinib nekutarisa pedyo uye pamwe nekugadzirisa dosi. Zvisinei, vanhu vane matambudziko akakomba erhythm yemoyo kana kurwisa kwemoyo kwemazuva ano vangada mamwe marapirwo. Chiremba wako wemoyo uye chiremba wekenza vachashanda pamwechete kuti vaone nzira yakachengeteka yemamiriro ako ezvinhu.

Ndoita Sei Kana Ndikatora Nilotinib Yakawandisa Netsaona?

Kana netsaona ukatora nilotinib yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira, kunyangwe ukanzwa zvakanaka. Kutora zvakawanda kunogona kukonzera mhedzisiro yakakomba, kusanganisira shanduko dzinotyisa mu rhythm yemoyo, kusvotwa kwakanyanya uye kurutsa, kana kusagadzikana kwemagariro eropa.

Usamirira kuti uone kana zviratidzo zvichivapo - tsvaga rubatsiro rwekurapa nekukasira. Uya nebhodhoro remushonga newe kuimba yekukurumidzira kuti vapi vehutano vazive chaizvo zvawakatora uye zvakawanda sei. Munguva yemberi, funga kushandisa murongi wepiritsi kana kumisa zviyeuchidzo zvefoni kubatsira kudzivirira overdoses netsaona.

Ndoita Sei Kana Ndikarasikirwa neDosi yeNilotinib?

Kana ukakanganwa kutora mushonga we nilotinib, utore paunorangarira, asi chete kana zvapfuura maawa asingasviki 6 kubva panguva yako yakatarwa yekutora mushonga. Kana maawa anopfuura 6 apfuura, siya mushonga wawakanganwa wotora mushonga wako unotevera panguva yakajairika. Usambofa wakatora mishonga miviri panguva imwe chete kuti ugadzirise mushonga wawakanganwa.

Edza kuchengetedza zvinodiwa zvekudya mudumbu risina chinhu kunyangwe kana uri kutora mushonga wenguva pfupi - usadya chikafu kwemaawa 2 usati watora mushonga uye awa 1 mushure mekutora mushonga. Kana uchikanganwa kutora mishonga kakawanda, taura nachiremba wako nezve nzira dzekukubatsira kurangarira, senge maapplication e smartphone kana kubatanidza mishonga kune maitiro ezuva nezuva.

Ndingamira Rini Kutora Nilotinib?

Sarudzo yekumisa nilotinib yakaoma uye inofanirwa kuitwa chete nekutungamirirwa nachiremba wako. Vanhu vazhinji vane CML vanofanirwa kuramba vachitora mushonga kwenguva isingagumi kuti varambe vaine leukemia mukuregerera. Zvisinei, vamwe varwere vanowana kuregererwa kwemamorekuru kwakadzama vangave vakakodzera kuyedzwa kwekuregererwa kusina kurapwa.

Miedzo iyi inosanganisira kumisa mushonga uchiongorora zvakanyanya zviratidzo zvekenza ichidzoka. Vanhu vanenge 40-50% chete vanoedza izvi vanoramba vari mukuregerera vasina kurapwa. Chiremba wako achafunga nezvezvinhu zvakaita sekuti wava nenguva yakareba sei mukuregerera, mazinga ako ekupindura emamorekuru, uye hutano hwako hwese paunenge uchifunga kana izvi zvichigona kuve sarudzo kwauri.

Ndingatora Mamwe Mishonga Ndiri paNilotinib Here?

Mishonga yakawanda inogona kushamwaridzana ne nilotinib, saka zvakakosha kuti uudze chiremba wako nezvezvose zvauri kutora, kusanganisira mishonga yekurapa, mishonga isingatengwe, zvinowedzera, uye mishonga yemakwenzi. Dzimwe kushamwaridzana kunogona kuva kwengozi, nepo vamwe vangada kugadzirisa dosi kana kuwedzera kuongorora.

Mishonga inokanganisa rhythm yemoyo inonyanya kunetsa kana yakasanganiswa ne nilotinib. Mamwe maantibiotics, antifungals, uye mishonga yemoyo zvinogona kudiwa kuti zvisadziviswa kana kushandiswa nekuchenjerera kukuru. Chiremba wako nemupharmacist vanogona kukubatsira kufamba nekudyidzana uku zvakachengeteka uye kukurudzira dzimwe nzira kana zvichidikanwa.