Chii chinonzi Pembrolizumab: Zvazvinoshandiswa, Mishonga, Migumisiro Yemuviri, nezvimwe

Pembrolizumab mushonga wekenza unovavarira kubatsira masoja ako emuviri kurwisa masero ekenza zvakanyanya. Inopiwa kuburikidza neIV infusion uye ndeyeboka remishonga inonzi immune checkpoint inhibitors, iyo inoshanda nekubvisa "mabhureki" ayo masero ekenza anoisa pamasoja ako emuviri.

Mishonga iyi yakashandura kurapwa kwekenza kune varwere vazhinji nekushandisa simba remasoja avo emuviri. Kunyange zvazvo iri chishandiso chine simba mukurwisa mhando dzakasiyana dzekenza, kunzwisisa mashandiro ayo uye zvekutarisira zvinogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezvekufamba kwako kwekurapa.

Chii chinonzi Pembrolizumab?

Pembrolizumab iantibody yakagadzirwa murabhoritari iyo inovharisa protein inonzi PD-1 pamasero ako emuviri. Funga nezve PD-1 sechiratidzo che "kumira" chinodzivirira masoja ako emuviri kubva pakurwisa masero ekenza. Nekuvharisa protein iyi, pembrolizumab inobvumira masoja ako emuviri kuziva uye kurwisa kenza zvakanyanya.

Mishonga iyi inozivikanwawo nezita rayo rekutengesa Keytruda. Inoiswa se monoclonal antibody, zvinoreva kuti yakagadzirirwa kunangana neimwe protein mumuviri wako. Kusiyana nechemotherapy yechinyakare iyo inorwisa zvakananga masero anokurumidza kukamukana, pembrolizumab inoshanda nekuvandudza nzira dzako dzekuzvidzivirira dzemuviri.

Pembrolizumab Inoshandiswa Kunei?

Pembrolizumab inorapa mhando dzakawanda dzekenza nekubatsira masoja ako emuviri kushanda zviri nani kurwisa masero ekenza. Chiremba wako angangodaro akakunyora nekuti rudzi rwako rwekenza runopindura zvakanaka kune iyi immunotherapy nzira.

Mhando dzekenza dzakajairika dzinorapwa ne pembrolizumab dzinosanganisira melanoma (kenza yeganda), kenza yemapapu, kenza yemusoro nemutsipa, uye mamwe marudzi ekenza yetsvo. Inoshandiswawo yeHodgkin lymphoma, kenza yeguvhu, uye kenza yedumbu mumamiriro ezvinhu chaiwo. Oncologist wako achasarudza kana rudzi rwako rwekenza uye nhanho zvichikuita munhu akakodzera kurapwa uku.

Zvimwe zvirwere zvisingawanzoitika zvinogona kurapwa ne pembrolizumab zvinosanganisira mhando dzekenza yeropa, kenza yemuromo wechibereko, uye kenza yechibereko. Sarudzo yekushandisa pembrolizumab inowanzoenderana nezvinhu zvakakosha zvemajini mutumor yako, zvakadai sePD-L1 mazinga ekutaura kana microsatellite instability status.

Pembrolizumab Inoshanda Sei?

Pembrolizumab inoshanda nekudzivisa nzira yePD-1, iyo maseru ekenza anoshandisa kuvanza kubva kumuviri wako wekudzivirira chirwere. Kana nzira iyi yakavharwa, maT-cells ako (maseru anorwisa chirwere) anogona kuziva zviri nani uye kurwisa maseru ekenza mumuviri wako wese.

Iri rinotariswa semushonga wekenza une simba zvishoma, asi unoshanda zvakasiyana nekemotheraphy yechinyakare. Panzvimbo yekuuraya zvakananga maseru ekenza, inopa simba muviri wako wekudzivirira chirwere kuti uite basa. Mhedzisiro inogona kugara kwenguva refu nekuti muviri wako wekudzivirira chirwere une

Hamufaniri kuchinja kudya kwenyu musati mapiwa mushonga. Munogona kudya zvakajairika uye kutora mishonga yenyu yenguva dzose kunze kwekunge chiremba wenyu akakuudzai zvimwe. Kugara muchinwa mvura yakawanda musati uye mushure mekurapwa kunogona kubatsira muviri wenyu kuti ugadzirise mushonga wacho zvakanaka.

Ndingatora Pembrolizumab kwenguva yakareba sei?

Kureba kwenguva yekurapwa ne pembrolizumab kunosiyana zvakanyanya zvichienderana nerudzi rwenyu rwegomarara uye kuti munopindura sei kumushonga. Vanhu vazhinji vanogamuchira kurapwa kwemwedzi yakati wandei kusvika kumakore maviri, vachipiwa mishonga mazuva ese matatu kusvika kumavhiki matanhatu.

Chiremba wenyu wezve oncology achatarisa kufambira mberi kwenyu nguva dzose kuburikidza nekutarisa, bvunzo dzeropa, uye kuongororwa kwemuviri. Kana gomarara renyu richipindura zvakanaka uye muchigona kurapwa, munogona kuramba muchirapwa kwenguva yakareba inokurudzirwa. Zvisinei, kana mukawana matambudziko akakomba kana gomarara renyu rikafambira mberi, chiremba wenyu anogona kuchinja kana kumisa kurapwa.

Vamwe varwere vanogona kukwanisa kutora zororo rekurapwa kana

Mhedzisiro yakakomba asi isingawanzoitiki inogona kukanganisa nhengo dzakasiyana-siyana kana immune system yako ikava yakanyanya kushanda. Izvi zvinogona kusanganisira kuzvimba kwemapapu (pneumonitis), matambudziko echiropa, matambudziko ethyroid, kana nyaya dzezvikara. Chikwata chako chekurapa chichakutarisa zvakanyanya nemiedzo yeropa nguva dzose uye zvidzidzo zvekuongorora kuti ubate chero matambudziko nekukurumidza.

Mhedzisiro isingawanzoitiki asi yakakomba inogona kusanganisira mhinduro dzakakomba dzine chekuita neimmune dzichikanganisa moyo, uropi, kana dzimwe nhengo. Kunyange zvazvo matambudziko aya asinga wanzwi, anoda kutariswa kwekurapa nekukurumidza. Chikwata chako chehutano chichakudzidzisa zviratidzo zvekuchenjerera zvekuona uye kukupa ruzivo rwekubata kana uine zvinokunetsa zvekukurumidza.

Ndiani Asingafaniri Kutora Pembrolizumab?

Pembrolizumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Vanhu vane mamwe mamiriro eautoimmune vangave vasiri vakwikwidzi vakanaka nekuti mushonga unogona kuwedzera mamiriro avo ari pasi.

Kana uine zvirwere zveautoimmune zvakaita serheumatoid arthritis, lupus, kana inflammatory bowel disease, chiremba wako achayerera njodzi nemabhenefiti zvakanyatso. Unogona kuramba uchikwanisa kugamuchira pembrolizumab, asi uchada kuongororwa zvakanyanya uye pamwe mishonga yekuwedzera yekugadzirisa mamiriro ako eautoimmune.

Vakadzi vane pamuviri havafaniri kugamuchira pembrolizumab sezvo ichikwanisa kukuvadza mwana ari kukura. Kana uri pazera rekubereka vana, uchada kushandisa nzira dzekudzivirira kubata pamuviri panguva yekurapa uye kwemwedzi yakati wandei mushure meiyo yako yekupedzisira dose. Chiremba wako achakurukura sarudzo dzekuronga mhuri uye nguva kana izvi zvichikunetsa.

Vanhu vane chirwere chakakomba cheitsvo kana chiropa vangangoda kugadzirisa dose kana vangave vasiri vakwikwidzi vakakodzera kurapwa. Chiremba wako achaongorora basa rehengo dzako kuburikidza nemiedzo yeropa usati watanga kurapwa uye ucharamba uchiongorora mukati mekutarisirwa kwako.

Pembrolizumab Zita reBrand

Pembrolizumab inotengeswa pasi pezita rekuti Keytruda, inogadzirwa naMerck & Co. Unogona kunzwa timu yako yehutano ichishandisa rimwe zita zvakachinjana, sezvo vachireva mushonga mumwe chete.

Paunogamuchira kurapwa kwako, vial yemushonga ichanyorwa seKeytruda, uye ndizvo zvaunozoona pamarekodhi ako ekurapa nemapepa einishuwarenzi. Mazita ese ari maviri anoreva chinhu chimwe chete chinoshanda uye fomu.

Zvimwe Zvinotsiva Pembrolizumab

Zvimwe zvakawanda zvinodzora immune checkpoint zvinoshanda zvakafanana ne pembrolizumab, kunyangwe sarudzo yakanakisa ichienderana nerudzi rwako rwekenza uye mamiriro ako ega. Oncologist wako achasarudza sarudzo yakakodzera zvichienderana neuchapupu hwekiriniki uye mamiriro ako chaiwo.

Nivolumab (Opdivo) imwe PD-1 inhibitor inoshanda zvakafanana ne pembrolizumab. Kune mamwe marudzi ekenza, mishonga iyi inoshanda zvakaenzana, nepo kune vamwe, imwe inogona kufarirwa zvichibva pakudzidza kwekutsvaga. Chiremba wako achatsanangura kuti nei vakasarudza pembrolizumab kunyanya kurapwa kwako.

Zvimwe zvingasarudzwa zve immunotherapy zvinosanganisira ipilimumab (Yervoy), iyo inotarisa imwe immune checkpoint inonzi CTLA-4, uye akasiyana PD-L1 inhibitors senge atezolizumab (Tecentriq). Dzimwe nguva mishonga iyi inoshandiswa pamwe chete ne pembrolizumab kuti iwedzere kushanda.

Kurapa kwechinyakare senge chemotherapy, radiation therapy, kana zvinodhaka zvakanangana nekurapa zvinogona zvakare kuve zvimwe zvingasarudzwa kana kushandiswa padivi pe pembrolizumab. Chirongwa chako chekurapa chichagadzirwa zvichienderana nemaitiro ekenza yako, hutano hwako hwese, uye zvinangwa zvako zvekurapa.

Ko Pembrolizumab Ari Nani Pane Nivolumab Here?

Vese pembrolizumab uye nivolumab vanonakidza PD-1 inhibitors vanoshanda nenzira dzakafanana, uye hapana kana imwe iri yakanaka kupfuura imwe. Sarudzo pakati pavo inowanzoenderana nerudzi rwako rwekenza, uchapupu hwekutsvaga hunowanikwa, uye dzimwe nguva zvekufunga zvinoshanda senge dosing schedule.

Pazvimwe zvirwere zvekenza zvakaita se melanoma, mishonga yese iri miviri yakaratidza kushanda zvakafanana mumiedzo yekiriniki. Kune kenza yemapapu, pembrolizumab inogona kufarirwa sekurapa kwekutanga-mutsetse mune dzimwe nzvimbo, nepo nivolumab ichigona kusarudzwa kune vamwe. Chiremba wako weoncologist achavakirira sarudzo yavo parutsva rwekuferefeta rwemamiriro ako chaiwo.

Maitiro ekushanda kwemishonga yese iri miviri akafanana, kunyangwe vamwe varwere vachigona kutsungirira imwe zviri nani pane imwe. Kana iwe ukawana mhedzisiro yakakosha nemushonga mumwe, chiremba wako angangofunga kuchinjira kune mumwe kana zvakakodzera kune rudzi rwako rwekenza.

Mibvunzo Inowanzo Bvunzwa Nezve Pembrolizumab

Pembrolizumab Yakachengeteka Here Kune Vanhu vane Chirwere cheShuga?

Pembrolizumab inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga, asi inoda kunyatsoongororwa nekuti mushonga unogona dzimwe nguva kukanganisa mazinga eshuga yeropa. Chikwata chako chekutungamira chirwere cheshuga chichashanda pedyo nechikwata chako cheoncology kuti chive nechokwadi chekuti shuga yako yeropa inoramba ichidzorwa zvakanaka panguva yekurapa.

Muzviitiko zvisingawanzoitiki, pembrolizumab inogona kukonzera rudzi rwe1 rwechirwere cheshuga kuti chigadzirwe, kunyangwe muvanhu vasina kumbove nechirwere cheshuga kare. Chikwata chako chehutano chichatarisa mazinga ako eshuga yeropa nguva dzose uye chichatarisa zviratidzo zvakaita sekuwedzera nyota, kuwanda kwemvura, kana kurasikirwa uremu kusingatsanangurike.

Ndingaita Sei Kana Ndikakanganwa Dose yePembrolizumab?

Kana iwe ukakanganwa infusion ye pembrolizumab yakarongwa, taura nechikwata chako cheoncology nekukurumidza sezvinobvira kuti urongezve. Sezvo mushonga uyu uchipiwa pane chirongwa chaiwo, zvakakosha kuchengetedza nguva inoenderana kuti uwane mhedzisiro yakanaka.

Chiremba wako achasarudza nzira yakanakisa yekudzoka panzira nechirongwa chako chekurapa. Muzviitiko zvakawanda, iwe uchangogamuchira dose yako inotevera nekukurumidza sezvainogona kurongwa, uye wobva wenderera mberi nechirongwa chako chetsika kubva ipapo.

Ndingaita Sei Kana Ndikawana Mhedzisiro Yakakomba?

Kana uine matambudziko akakomba akadai sekufema zvakaoma, kurwadziwa muchipfuva, manyoka akakomba, kana kuneta kusinganzwisisike, taura nechikwata chako chehutano nekukasira kana kuenda kukamuri yekukurumidzira. Izvi zvinogona kunge zviri zviratidzo zvematambudziko akakomba ane hukama neimmune anoda kutariswa nekukurumidza.

Chikwata chako cheoncology chichakupa gwara rakajeka pamusoro pezviratidzo zvinoda kutariswa kwekurapa nekukasira uye ruzivo rwekukurumidzira. Matambudziko mazhinji anogona kubatwa zvakanaka kana akabatwa nekukurumidza, saka usazeze kubata kana uine hanya.

Ndingamira Rini Kutora Pembrolizumab?

Sarudzo yekumisa kurapwa kwe pembrolizumab inoenderana nezvinhu zvakati wandei, kusanganisira kuti kenza yako iri kupindura sei, matambudziko auri kusangana nawo, uye hutano hwako hwese. Oncologist yako ichaita sarudzo iyi zvichibva pakutarisa nguva dzose uye kuongorora.

Vamwe varwere vanopedzisa nzira yavo yekurapa yakarongwa uye vanogona kumira mushure mekuwana mhedzisiro yakanaka. Vamwe vangangoda kumira nekukurumidza nekuda kwematambudziko kana kufambira mberi kwekenza. Chiremba wako achakurukura nguva uye zvikonzero zvekumisa kurapwa pachine nguva kuitira kuti ugadzirire chikamu chinotevera chekutarisirwa kwako.

Ndingatora Mamwe Mishonga Ndiri paPembrolizumab Here?

Unogona kuenderera mberi uchitora mishonga yako yakajairika uchigamuchira pembrolizumab, asi zvakakosha kuti uzivise chikwata chako cheoncology nezvezvose zvauri kutora. Mamwe mishonga, kunyanya zvinodzvinyirira immune system, zvinogona kuda kugadziriswa kana kutariswa zvakanyanya.

Nguva dzose bvunza nechikwata chako chehutano usati watanga chero mishonga mitsva, kusanganisira mishonga inotengeswa pasina mushonga, zvinowedzera, kana mishonga yemakwenzi. Vanogona kukupa zano pamusoro pechero hukama hunogona kuitika uye kuona kuti kurapwa kwako kunoramba kuri kwakachengeteka uye kunobudirira.