Chii chinonzi Reteplase: Zvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe Zvakawanda

Reteplase mushonga une simba unoparadza magwamba eropa unogona kununura hupenyu hwako panguva yekurwisa kwemoyo. Iprotein yakagadzirwa nemajini inoshanda nekunyungudutsa magwamba eropa ane njodzi mumitsipa yako yemoyo, ichibatsira kudzorera kuyerera kweropa kumhasuru dzemoyo wako kana miniti yega yega ichiverengwa.

Mishonga iyi ndeyeboka remishonga inonzi thrombolytics, zvinoreva kuti "vanonyungudutsa magwamba." Funga nezve reteplase sechishandiso chakakosha icho vanachiremba vanoshandisa nekukurumidza kuvhurazve tsinga dzakavharika uye kudzivirira kukuvadzwa kwemoyo kusingaperi.

Chii chinonzi Reteplase?

Reteplase i recombinant tissue plasminogen activator, zvinoreva kuti ndiyo vhezheni yakagadzirwa murabhoritari yeprotein inogadzirwa nemuviri wako pachisikigo kuti iparadze magwamba. Chikamu che "recombinant" chinongoreva kuti masayendisiti akachigadzira vachishandisa tekinoroji yemajini kuti chive chinoshanda zvakanyanya uye chinogara kwenguva refu kupfuura maprotein ako anoparadza magwamba.

Mishonga iyi yakagadzirirwa kushandiswa nekukurumidza muzvipatara panguva yekurwisa kwemoyo kwakanyanya. Haisi chinhu chaungatora kumba kana kushandisa kudzivirira. Pane kudaro, imishonga yekununura iyo zvikwata zvekurapa zvinoshandisa kana ropa remoyo wako ravharika zvakanyanya.

Chii chinonzi Reteplase chinoshandiswa?

Reteplase inonyanya kushandiswa kurapa acute myocardial infarction, iro izwi rekurapa rekurwisa kwemoyo kunokonzerwa negwamba reropa. Kana gwamba rikavhara imwe yemitsipa inopa mhasuru dzemoyo wako, chikamu ichocho chemoyo wako chinotanga kufa nekushaya okisijeni uye zvinovaka muviri.

Mishonga iyi inoshanda zvakanyanya kana ikapiwa mukati memaawa mashoma ekutanga mushure mekutanga zviratidzo zvekurwisa kwemoyo. Vanachiremba vanoshandisa sechikamu cheizvo zvinonzi "reperfusion therapy" - zvakanyanya kumhanyira kudzorera kuyerera kweropa pamberi pekukuvara kusingaperi kunoitika.

Mune dzimwe nguva, vanachiremba vanogona kushandisawo reteplase kurapa pulmonary embolisms yakakura, iyo inova ropa rinotyisa mu mapapu. Zvisinei, izvi hazviwanzoitika uye zvinoda kuongororwa zvakanyatsoenderana nenjodzi nemabhenefiti.

Reteplase Inoshanda Sei?

Reteplase inoshanda nekumisa protein muropa rako rinonzi plasminogen, richirichinja kuita plasmin. Plasmin yakaita semagumbeze ako echisikigo ekucheka fibrin, iyo protein inoumba chimiro chakaita semambure cheropa.

Iri rinotariswa semushonga wakasimba zvikuru nokuti unoshanda nokukurumidza uye nesimba mumuviri wako wose unotenderera ropa. Kusiyana nemamwe ma blood thinners akapfava, reteplase haingodzivisi ropa idzva kuti riumbwe - inonyatso nyungudutsa aripo.

Mushonga unotanga kushanda mukati memaminitsi ekupiwa, uye mhedzisiro yawo inogona kugara kwemaawa akati wandei. Chiito ichi chinokurumidza chakakosha panguva yekurwisa kwemoyo, uko "nguva ndiyo tsandanyama" - zvinoreva kuti nekukurumidza kuyerera kweropa kunodzoreredzwa, ndipo panogona kuponeswa tsandanyama dzemoyo.

Ndingashandisa Sei Reteplase?

Hauchazotori" reteplase iwe pachako - inogara ichipiwa nenyanzvi dzezvekurapa muchipatara kuburikidza nemutsara we intravenous (IV) zvakananga muropa rako. Mushonga uyu unouya seupfu hunosanganiswa nevakashandi vezvipatara kana vanachiremba nemvura yakachena vasati vakupa.

Madosi anowanzoitika anosanganisira majekiseni maviri akasiyana anopiwa maminitsi makumi matatu akaparadzana. Jekiseni rega rega rinopiwa se"bolus," izvo zvinoreva kuti rinomanikidzwa zvakananga mumutsara wako weIV panzvimbo yekudonhedzwa zvishoma nezvishoma nekufamba kwenguva.

Usati wagamuchira reteplase, hauzodi kudya kana kunwa chero chinhu chakakosha, sezvo iri kurapwa kwemamiriro ekukurumidza. Zvisinei, vashandi vezvipatara vanogona kukubvunza nezve zvaungangove wadya uye mishonga kuti vatarise kudyidzana kunogona kuitika kana matambudziko.

Ndingashandisa Reteplase Kwenguva Yakareba Sei?

Kurapa ne reteplase kunopedzwa mukati memaminitsi makumi matatu kusvika awa rimwe. Kusiyana nemishonga yaungatora zuva nezuva kumba, iyi ndiyo kurapa kwenguva pfupi, kwakanyanya kunopiwa chete panguva yechikamu chekukurumidza kwemoyo.

Mushure mekuwana reteplase, iwe unowanzoongororwa zvakanyanya muchipatara kwemaawa makumi maviri nemana kusvika makumi mana nemasere. Panguva ino, vashandi vezvokurapa vachatarisa zviratidzo zvekuti kurapa kwakashanda uye vachatarisa chero matambudziko ekubuda ropa.

Kutevera kurapwa kwako ne reteplase, chiremba wako anogona kunyora mamwe mishonga yekudzivirira moyo kwenguva refu, senge aspirin, beta-blockers, kana ACE inhibitors. Aya mishonga inoenderera mberi inobatsira kudzivirira kurwisa kwemoyo kwemangwana uye kutsigira kupora kwako.

Ndezvipi Zvakaipa zveReteplase?

Njodzi yakanyanya ne reteplase kubuda ropa, sezvo mushonga unokanganisa kugona kweropa rako kuita clot mumuviri wako wese. Izvi zvinogona kubva pakubuda ropa kudiki panzvimbo dzekujekesa kusvika pakubuda ropa kwakanyanya mukati.

Heano mativi akajairika aunogona kusangana nawo panguva kana mushure mekurapa:

• Kubuda ropa panzvimbo yekuiswa IV kana dzimwe nzvimbo dzeburi
• Kukuvadza nyore nyore kupfuura zvakajairika
• Kusvotwa kana kurutsa
• Kuderera kweropa
• Kurova kwemoyo kusingaite
• Fivha kana kutonhora

Izvi zvinokonzeresa zvinowanzo manejwa uye zvinotarisirwa sechikamu chekurapa. Chikwata chako chekurapa chichakutarisa zvakanyanya chero zviratidzo zvematambudziko.

Zvimwe zvakakomba asi zvisingawanzoitiki zvinogona kusanganisira:

• Kubuda ropa kwakanyanya muuropi (intracranial hemorrhage)
• Kubuda ropa kwakakosha mukati mudumbu kana matumbu
• Maitiro eAllergic, kunyangwe izvi zvisingawanzoitiki
• Kudonha kwakanyanya kweropa kunoda kupindira kwekurapa
• Reperfusion injury, uko kuyerera kweropa kwakadzorerwa pakutanga kunokonzera kuzvimba

Kunyange zvazvo matambudziko aya akakomba achinetesa, yeukai kuti reteplase inongoshandiswa chete kana njodzi yekusarapa chirwere chemoyo ichikunda njodzi idzi dzinogona kuitika. Chikwata chenyu chekurapa chine ruzivo rwakawanda rwekubata nemamiriro ezvinhu aya.

Ndiani Asingafaniri Kutora Reteplase?

Reteplase haina kukodzera munhu wese, kunyangwe panguva yekurwisa kwemoyo. Chiremba wenyu achakurumidza kuongorora kana muri munhu akakodzera zvichienderana nenhoroondo yenyu yekurapa uye mamiriro enyu azvino.

Hamufaniri kugamuchira reteplase kana muine chero chimwe chezvinhu izvi:

• Kubuda ropa mukati memuviri kana chirwere chekubuda ropa
• Kuvhiyiwa kukuru munguva pfupi yapfuura mukati memazuva gumi apfuura
• Nhoroondo yekurohwa kana kukuvara kwehuropi mukati memwedzi mitatu yapfuura
• Kukwira kweropa kwakanyanya kusingadzoreki (kupfuura 180/110)
• Tumor yehuropi inozivikanwa kana midzi yeropa isina kujairika muuropi
• Kukuvara kwakanyanya kumusoro munguva pfupi yapfuura

Chiremba wenyu achashandisawo kungwarira kwakanyanya kana muine mamiriro akati wandei anowedzera njodzi yekubuda ropa, kunyangwe asiri zvirambidzo zvakakwana.

Mamiriro ezvinhu aya anoda kufunga zvakanyanya:

• Zera rinopfuura makore 75
• Kuvhiyiwa kudiki munguva pfupi yapfuura kana maitiro ekurapa
• Kuzvitakura kana kubereka munguva pfupi yapfuura
• Chirwere chepeptic ulcer chinoshanda
• Chirwere chechiropa kana itsvo chakanyanya
• Kushandiswa munguva pfupi yapfuura kwemishonga inoderedza ropa

Muzviitiko izvi, chiremba wenyu achayerera njodzi nemabhenefiti zvakanyatso, dzimwe nguva achisarudza dzimwe nzira dzekurapa dzakadai sekukanda katheta yemoyo nekukurumidza panzvimbo.

Mazita eReteplase Brand

Reteplase inonyanya kuzivikanwa nezita rayo rebrand Retavase muUnited States. Iyi ndiyo fomu yekutanga yekutengesa yemushonga uyo zvipatara zvinochengeta uye zvinoshandisa kurapa nekukurumidza kurwisa kwemoyo.

Kusiyana nemimwe mishonga ine mazita mazhinji emhando, reteplase yakaramba yakafanana mukuzivikanwa kwayo. Dzimwe nyika dzinogona kushandisa mazita emhando akasiyana, asi chinhu chinoshanda uye kugadzirwa kwacho zvinoramba zvakafanana.

Paunogamuchira mushonga uyu, unogona kuoneka mumarekodhi ako echipatara kana mabhiri se "reteplase" kana "Retavase," zvichienderana nekuti nzvimbo yako yekurapa inonyora sei mishonga.

Zvimwe Zvingashandiswa Panzvimbo peReteplase

Mishonga yakati wandei inobvisa ropa inogona kushandiswa panzvimbo pe reteplase, zvichienderana nemamiriro ako chaiwo uye zviri kuwanikwa kuchipatara chako. Zvimwe zvinowanzo shandiswa zvinosanganisira alteplase (tPA), tenecteplase, uye streptokinase.

Alteplase, inowanzozivikanwa se tPA, ndiyo inogona kunge iri imwe inonyanya kushandiswa. Inoshanda zvakafanana ne reteplase asi inoda nguva yakareba yekupinza uye dosing yakaoma. Zvimwe zvidzidzo zvinoratidza kuti reteplase inogona kuve nyore kupa mumamiriro ekukurumidzira.

Tenecteplase itsva uye inogona kupihwa sejojo rimwe chete panzvimbo yemadosi maviri akasiyana. Zvisinei, haisi kuwanikwa zvakanyanya se reteplase kana alteplase muzvipatara zvakawanda.

Mune zvimwe zviitiko, chiremba wako angakurudzira kupindira kwemuchina panzvimbo yemushonga. Izvi zvinogona kusanganisira emergency cardiac catheterization ine balloon angioplasty, uko vanachiremba vanovhura tsinga yakavharika vachishandisa bhururu diki uye vanowanzoisa stent kuti irambe yakavhurika.

Reteplase iri Nani Kudarika Alteplase?

Zvese reteplase uye alteplase mishonga inobvisa ropa inoshanda zvakanyanya, uye zvidzidzo zvinoratidza kuti zvinoshanda zvakaenzana pakurapa zvirwere zvepfungwa. Sarudzo pakati pavo inowanzoenderana nezvinhu zvinoshanda panzvimbo yekuti imwe iri pachena "iri nani" pane imwe.

Reteplase ine zvimwe zvakanakira mumamiriro ezvinhu ekukurumidzira nekuti inopiwa semajekiseni maviri nekukurumidza panzvimbo pekuenderera mberi kweawa makumi mapfumbamwe sealteplase. Izvi zvinogona kuve nyore kuvashandi vezvokurapa kuti vashandise uye zvinogona kuderedza mukana wekukanganisa kwezvikamu panguva yemamiriro ezvinhu ekukurumidzira.

Zvisinei, alteplase yanga iripo kwenguva refu uye yakadzidzwa zvakanyanya. Vamwe vanachiremba vanonzwa vakasununguka nayo nekuti vane ruzivo rwakawanda vachishandisa. Alteplase inobvumirwawo kurapa sitiroko, nepo reteplase ichinyanya kushandiswa kurwisa kurwisa kwemoyo.

Chinhu chakanyanya kukosha hachisi mushonga chaiwo waunogamuchira, asi nekukurumidza kwaunosvika kuchipatara uye kugamuchira kurapwa. Mishonga yese miviri isarudzo dzakanaka kana ichishandiswa zvakakodzera nemapoka ezvokurapa ane ruzivo.

Mibvunzo Inowanzo Bvunzwa Nezve Reteplase

Reteplase Yakachengeteka Kune Vanhu vane Chirwere cheShuga here?

Hongu, reteplase inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga panguva yekurwisa kwemoyo. Kuva nechirwere cheshuga hakukudzivise kugamuchira mushonga uyu unoponesa hupenyu, kunyangwe zvichikuisa panjodzi yakakura yekurwisa kwemoyo pakutanga.

Zvisinei, kana uine diabetic retinopathy (kukuvadzwa kwemaziso kubva kushuga), chiremba wako achada kungwarira zvakanyanya sezvo mamiriro aya anogona kuwedzera njodzi yako yeropa mumaziso. Vachayerera njodzi iyi vachipesana nenjodzi iri pedyo yekurwisa kwemoyo wako.

Mazinga ako eshuga yeropa achatariswa zvakanyanya panguva uye mushure mekurapwa, sezvo kushushikana kwekurwisa kwemoyo uye kupinda muchipatara kunogona kukanganisa manejimendi ako eshuga.

Ndingaita Sei Kana Ndikashandisa Reteplase Yakawandisa Netsaona?

Hauzozove uri munzvimbo yekushandisa reteplase yakawandisa netsaona sezvo ichingopiwa nevashandi vezvokurapa munzvimbo dzechipatara dzakadzorwa. Mushonga uyu unouya muzvikamu zvakayerwa, uye vashandi vakadzidziswa vanobata kugadzirira kwese uye kutungamira.

Kana vashandi vezvipatara vakapa reteplase yakawandisa netsaona, vane mitemo yekugadzirisa mamiriro ezvinhu aya. Chinhu chikuru chavanofanira kunetseka nacho ndiko kuwedzera njodzi yekubuda ropa, iyo yavanogona kutarisa uye kurapa kana zvichidikanwa.

Uyu ndiwo mumwe wemabhenefiti ekugamuchira reteplase muchipatara - unowana rubatsiro rwekurapa nekukasira kana chero matambudziko akamuka kubva mukurapa.

Ndoita Sei Kana Ndikakanganwa Dose yeReteplase?

Mubvunzo uyu haushande zvakanyanya kune reteplase sezvo iri kurapwa kamwe chete kwemamiriro ekukurumidzira kunopiwa muchipatara. Hauzotori madhizi akarongeka kumba aunogona kukanganwa.

Kurapa kwe reteplase kwakajairika kunosanganisira majekiseni maviri anopiwa maminitsi makumi matatu akasiyana. Kana nekuda kwechimwe chikonzero jekiseni rechipiri rakanonoka, timu yako yezvokurapa ichasarudza nzira yakanakisisa yekuita zvichienderana nekupindura kwako kune dose yekutanga uye mamiriro ako ese.

Mushure mekunge kurapwa kwako kwe reteplase kwapera, ungangotanga pamishonga mimwe yekudzivirira moyo unogara uripo. Mishonga iyoyo ichava nehurongwa hwayo hwekuisa iyo chiremba wako achakutsanangurira.

Ndingamira Rini Kutora Reteplase?

Kurapa kweReteplase kunopedzwa otomatiki mukati meawa imwe chete yekutanga. Uyu hausi mushonga waunoramba uchitora kana uchida kusarudza kuti ungamira rini - ndiko kupindira kwenguva pfupi kwemamiriro ekukurumidzira.

Mushure mekuwana reteplase, kutariswa kwako kuchachinjira pakupora uye kudzivirira moyo kwenguva refu. Chiremba wako achanyora mishonga mimwe yaungada kutora kwemwedzi kana kunyange makore kudzivirira kurwisa kwemoyo kwemunguva yemberi.

Mhedzisiro ye reteplase pachayo inopera mukati meawa, asi mabhenefiti ekudzosa kuyerera kweropa kumhasuru dzemoyo wako anogona kugara hupenyu hwese kana iwe ukatevera mazano echiremba wako ekuchengetedzwa kunoenderera mberi.

Ndingatyaira Mushure meKugamuchira Reteplase Here?

Aiwa, hamungakwanisi kutyaira kwemazuva akati wandei mushure mekuwana reteplase. Muchaiswa muchipatara kuti muongororwe mushure mekurapwa, uye kunyangwe mushure mekubuda muchipatara, muchada nguva yekupora kubva pakurwara kwemoyo kwenyu.

Chiremba wenyu achakuzivisai kana zvakachengeteka kutangazve kutyaira, izvo zvinowanzoenderana nekupora kwenyu kwese, chero maitiro amakaitwa, uye kuti moyo wenyu unoshanda sei. Sarudzo iyi inowanzoitwa panguva yekugadzwa kunotevera vhiki kana maviri mushure mekuiswa muchipatara.

Munguva yekupora kwenyu, muchada kuronga kuti nhengo dzemhuri kana shamwari dzikubatsire mukufambisa kuenda kumisangano yekurapa nezvimwe zviitiko zvinodiwa.