Chii chinonzi Sofosbuvir-Velpatasvir-Voxilaprevir: Zvinoshandiswa, Mishonga, Matambudziko, nezvimwe

Sofosbuvir-velpatasvir-voxilaprevir mushonga unosanganisa unoshandiswa kurapa hepatitis C, hutachiona hunokanganisa chiropa chako. Iyi musanganiswa wemishonga mitatu ine simba inoshanda pamwechete kumisa hutachiona hwehepatitis C kubva pakuzviparadzanisa mumuviri wako, ichibatsira chiropa chako kupora uye kudzivirira matambudziko enguva refu.

Kana wakaongororwa uine hepatitis C, unogona kunge uchinzwa wakanyanya nemibvunzo pamusoro pezvokurapa. Mushonga uyu unomiririra imwe yezvokurapa zvinobudirira zviripo nhasi, zvichipa tariro yekupora kwakakwana muzviitiko zvakawanda.

Chii chinonzi Sofosbuvir-Velpatasvir-Voxilaprevir?

Sofosbuvir-velpatasvir-voxilaprevir itafura inosanganisa dose yakagadziriswa ine mishonga mitatu yakasiyana-siyana yeantiviral mupiritsi rimwe. Chikamu chimwe nechimwe chinotarisa hutachiona hwehepatitis C nenzira yakasiyana, ichigadzira nzira yekurapa ine simba.

Mushonga unosanganisa sofosbuvir (nucleotide polymerase inhibitor), velpatasvir (NS5A inhibitor), uye voxilaprevir (NS3/4A protease inhibitor). Funga nezvazvo sekurwisa kwematatu kunoita kuti zvinyanye kuoma kuti hutachiona hupone uye huzviparadzire muhurongwa hwako.

Musanganiswa uyu wakagadzirirwa vanhu vakakundikana kurapwa kwehepatitis C kwapfuura kana vane mamwe marudzi ehutachiona hwehepatitis C hunodzivisa zvinodhaka. Inoonekwa seimwe sarudzo yekurapa yechipiri kana yekununura.

Chii chinoshandiswa Sofosbuvir-Velpatasvir-Voxilaprevir?

Mushonga uyu unorapa hutachiona husingaperi hwehepatitis C muvanhu vakuru vane genotype 1, 2, 3, 4, 5, kana 6 hepatitis C. Zvinonyanya kubatsira kune vanhu avo kurapwa kwavo kwapfuura kusina kushanda kana vakagadzira kuramba kune mamwe mishonga yehepatitis C.

Chiremba wako angakurudzira musanganiswa uyu kana wakamboyedza kurapwa ne sofosbuvir-velpatasvir wega kana mamwe mishonga ye hepatitis C usina kuwana mhinduro ye virologic inogara. Mhinduro ye virologic inogara zvinoreva kuti hutachiona hahuwanikwi muropa rako mumasvondo gumi nemaviri mushure me kupedza kurapwa.

Mishonga iyi inoshandiswawo kune vanhu vane compensated cirrhosis, izvo zvinoreva kuti chiropa chako chine mavanga asi chichiri kushanda zvakanaka. Zvisinei, haikurudzirwi kune vanhu vane matambudziko akakomba echiropa kana decompensated cirrhosis.

Sofosbuvir-Velpatasvir-Voxilaprevir Inoshanda Sei?

Uyu musanganiswa wemishonga unoonekwa sekurapa kwakasimba uye kunobudirira kwe hepatitis C. Chikamu chimwe nechimwe chinovharira hutachiona pazvikamu zvakasiyana zveupenyu hwayo, zvichiita kuti zvisakwanise kuti hutachiona hurambe huchizvitsikirira.

Sofosbuvir inomisa hutachiona kubva pakukopa zvinhu zvayo zve genetic nekudzivisa enzyme inonzi NS5B polymerase. Velpatasvir inodzivirira hutachiona kubva pakuunganidza zvikamu zvitsva nekudzivisa protein ye NS5A. Voxilaprevir inovharira imwe enzyme yakakosha inonzi NS3/4A protease iyo hutachiona hunoda kuti hukure uye huve hutachiona.

Nekurwisa hutachiona panzvimbo nhatu panguva imwe chete, musanganiswa uyu wakaratidza mitengo yekurapa iri pamusoro pe95% mumiedzo yekiriniki. Kurapa kunowanzo bvisa hutachiona mumuviri wako zvachose, zvichibvumira chiropa chako kutanga kupora kubva kumakore ekuputika uye kukuvadzwa.

Ndingatora Sei Sofosbuvir-Velpatasvir-Voxilaprevir?

Tora piritsi rimwe nemuromo kamwe pazuva nechikafu, zviri nani panguva imwe chete zuva rega rega. Piritsi rinofanira kumedzwa rose nemvura uye risatsikwa, kutsengwa, kana kuparadzwa.

Chikafu chakakosha paunotora mushonga uyu nekuti chinobatsira muviri wako kutora mishonga zvakanyanya. Unogona kuitora nechero chikafu kana snack yakakura, asi dzivisa kuitora mudumbu risina chinhu sezvo izvi zvingaderedza kuti mushonga unoshanda sei.

Kana uchitora antacids, dzisiyanise kubva pamushonga wako neanenge maawa 4. Antacids inogona kukanganisa kunyudzwa kwemishonga iyi uye kuita kuti isashande zvakanaka. Izvi zvakafananawo kune zvinowedzera zvine iron, calcium, kana magnesium.

Edza kuisa tsika inoshanda nechikamu chako. Vanhu vazhinji vanoona zvichibatsira kutora mushonga wavo nebhureki kana chisvusvuro, chero chii chinonzwa chichiwirirana netsika yavo yezuva nezuva.

Ndingatora Sofosbuvir-Velpatasvir-Voxilaprevir kwenguva yakareba sei?

Nguva yekurapa yakajairika ndeye vhiki gumi nembiri, zvinoreva kuti uchatora piritsi rimwe zuva rega rega kwemazuva makumi masere nemana. Nguva iyi yakadzidzwa zvakanyanya uye yakaratidzwa kuve yakareba yekurapa inoshanda zvakanyanya kune vanhu vazhinji.

Chiremba wako achatarisa kufambira mberi kwako nemiedzo yeropa panguva yekurapa kuti aone kuti mushonga uri kushanda sei. Miedzo iyi inoyera huwandu hwehutachiona hwehepatitis C muropa rako, uye unofanirwa kuona mazinga achiderera zvakanyanya mukati memavhiki mashoma ekutanga.

Zvakakosha kupedzisa kosi yakazara yemavhiki gumi nembiri kunyangwe ukatanga kunzwa zviri nani kana miedzo yeropa ikaratidza kuti hutachiona hahuwanikwi. Kumisa kurapwa kare kunogona kubvumira hutachiona kudzoka uye zvinogona kukonzera kusadzivirirwa kumishonga.

Mushure mekupedza kurapwa, chiremba wako acharamba achikutarisa nemiedzo yeropa pamavhiki 4, 12, uye 24 kuti asimbise kuti hutachiona hunoramba husingaonekwi. Nguva iyi yekutevera inobatsira kuona kuti wakawana mushonga unogara kwenguva refu.

Ndezvipi Zvakaipa zveSofosbuvir-Velpatasvir-Voxilaprevir?

Vanhu vazhinji vanotsungirira mushonga uyu zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro. Mashoko akanaka ndewekuti mhedzisiro yakakomba haisi yakajairika, uye vanhu vazhinji vanongowana zviratidzo zvakapfava kusvika pakati nepakati zvinovandudzika nekufamba kwenguva.

Heano mhedzisiro yakajairika yaungasangana nayo panguva yekurapa:

• Kutemwa nemusoro, kunobata vanhu vanenge 1 kubva pa4 vachitora mushonga uyu
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Nyonganyonga, kunyangwe izvi zvichiwanzove zvinyoro uye zvinogoneka
• Manyoka, anowanzoitika mumavhiki mashoma ekutanga ekurapa
• Kutadza kurara kana shanduko mumaitiro ekurara
• Kurwadziwa kwemhasuru kana kusagadzikana kwemuviri wese

Izvi zvinowanzoitika zvinokonzerwa nemishonga zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga. Kana vakava vanokanganisa, taura nachiremba wako nezve nzira dzekuvagadzirisa pane kumisa kurapwa.

Kune zvakare zvimwe zvisingawanzoitiki asi zvakanyanya kukomba zvinokonzerwa nemishonga zvinoda kutariswa kwekurapa nekukasira:

• Kushungurudzika kwakanyanya kana pfungwa dzekuzvikuvadza
• Shanduko dzisingajairiki mumood kana maitiro
• Zviratidzo zvematambudziko echiropa senge kuita yero yeganda kana maziso, weti yakasviba, kana kurwadziwa kwakanyanya mudumbu
• Maitiro akanyanya ekuita allergic anosanganisira rash, kuzvimba, kana kutadza kufema
• Matambudziko emoyo, kunyanya kana uri kutora mamwe mishonga

Kana iwe ukaona chero chimwe chezvinhu izvi zvinokonzerwa nemishonga, taura nemupi wako wehutano nekukasira kana kutsvaga rubatsiro rwekurapa nekukasira. Kunyangwe matambudziko aya asingawanzoitiki, anoda kutariswa nekukurumidza.

Ndiani Asingafaniri Kutora Sofosbuvir-Velpatasvir-Voxilaprevir?

Mushonga uyu hauna kukodzera munhu wese, uye kune mamiriro chaiwo apo chiremba wako achakurudzira dzimwe nzira dzekurapa. Kunzwisisa izvi zvinopesana kunobatsira kuona kuchengeteka kwako panguva yekurapa.

Haufanire kutora mushonga uyu kana uine chirwere chakakomba cheitsvo chinoda dialysis kana kana huwandu hwako hwe glomerular filtration rate huri pasi pe30 mL/min/1.73m². Mushonga unogona kuungana kusvika pamatanho ane njodzi muvanhu vane basa reitsvo rakaderedzwa zvakanyanya.

Vanhu vane cirrhosis yakakomba, zvinoreva kuti chiropa chakatadza zvakanyanya, vanofanirawo kudzivisa musanganiswa uyu. Kana uine zviratidzo zvakaita sekuzvimba kwemvura mudumbu rako, kuvhiringika kubva kumatambudziko echiropa, kana kubuda ropa kubva mumitsipa yakakura, mushonga uyu unogona kunge usina kuchengeteka kwauri.

Mishonga mimwe inogonawo kuita kuti mushonga uyu usakodzere. Heano mishonga inokosha isingashandi zvakanaka nemusanganiswa uyu:

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• Rifampin nemamwe maantibiotics e rifamycin
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• Carbamazepine, phenytoin, nemimwe mishonga yekurapa mafi
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• St. John's wort, imwe herbal supplement
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• Mishonga mimwe yeHIV inosanganisira efavirenz
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• Mishonga mimwe yekurapa fivhiri yemapapu
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Chiremba wako achatarisa mishonga yako yese yazvino uye zvinowedzerwa usati watanga kurapwa kuti aone chero kupindirana kunogona kuitika. Usatanga mishonga mitsva kana zvinowedzerwa panguva yekurapwa usina kuzvikurukura kutanga.

Zita reBrand reSofosbuvir-Velpatasvir-Voxilaprevir

Zita rebrand remushonga uyu musanganiswa ndiVosevi, rinogadzirwa neGilead Sciences. Iri ndiro chete zita rebrand rinowanikwa, sezvo musanganiswa uyu uchiri pasi pekudzivirirwa kwepatent.

Vosevi inouya semapiritsi akavharwa nefirimu, piritsi rega rega riine 400 mg ye sofosbuvir, 100 mg ye velpatasvir, uye 100 mg ye voxilaprevir. Mapiritsi acho akatsvukaguru uye akaumbwa neovha aine

Kune vanhu vasina kumbobvira varapwa, sofosbuvir-velpatasvir (Epclusa) kazhinji ndiyo yekutanga kurapa. Iyi musanganiswa wemishonga miviri inoshanda kune vanhu vazhinji vane hepatitis C uye ine kushoma kwekudyidzana kwemishonga pane musanganiswa wemishonga mitatu.

Dzimwe nzira dzinosanganisira glecaprevir-pibrentasvir (Mavyret), iyo imwe musanganiswa unoshanda zvakanyanya unoshanda zvakanaka kune varwere vasina kurapwa uye vamwe vakakundikana kurapwa kwakamboitwa. Musanganiswa uyu zvakare une nguva pfupi yekurapa kune vamwe varwere.

Kune vanhu vane ma genotypes chaiwo kana mapatani ekudzivirira, vanachiremba vanogona kufunga nezvemisanganiswa yekare senge sofosbuvir ine ribavirin, kunyangwe izvi zvisingawanzo shandiswa nhasi nekuda kwehuwandu hwekupora hwakaderera uye mativi akawanda.

Nyanzvi yako yehepatitis C ichafunga nezvezvinhu zvakaita se genotype yako yevirusi, hutano hwechiropa, basa reitsvo, mamwe mishonga, uye inishuwarenzi yekuvhara kana uchisarudza nzira yakanakisa yekurapa iwe.

Ko Sofosbuvir-Velpatasvir-Voxilaprevir Zviri Nani Pane Sofosbuvir-Velpatasvir?

Sofosbuvir-velpatasvir-voxilaprevir hazvifanirwe kunzi

Asi, musanganiswa wemishonga mitatu une mukana mukuru wekudyidzana kwemishonga nemigumisiro yakaipa kana ichienzaniswa neiyo mhando yemishonga miviri. Inodhurawo zvakanyanya uye inogona kunge iine zvinodiwa zvakasiyana zveinishuwarenzi.

Chiremba wako achasarudza musanganiswa unokupa mukana wakanaka wekurapa uchideredza njodzi nemigumisiro yakaipa zvichienderana nemamiriro ako ega.

Mibvunzo Inowanzo Bvunzwa Nezve Sofosbuvir-Velpatasvir-Voxilaprevir

Sofosbuvir-Velpatasvir-Voxilaprevir Yakachengeteka Kune Vanhu vane Chirwere cheShuga Here?

Hongu, mushonga uyu unowanzo chengeteka kune vanhu vane chirwere cheshuga, uye kuva nechirwere cheshuga hakukudzivisi kutora mushonga uyu wehepatitis C. Zvisinei, chiremba wako achada kukutarisa zvakanyanya panguva yekurapa.

Vamwe vanhu vane chirwere cheshuga vanogona kusangana nekuchinja kudiki mumazinga eshuga yeropa panguva yekurapa hepatitis C, kunyange izvi zvichiwanzogoneka. Ramba uchitarisa glucose yeropa rako sezvinokurudzirwa nechikwata chako chekuchengeta chirwere cheshuga uye unoshuma chero maitiro asingawanzo kuona kuchiremba wako.

Kana iwe uchitora mishonga yechirwere cheshuga, kazhinji hapana hukama hukuru nemusanganiswa uyu wehepatitis C, asi chiremba wako achatarisa mishonga yako yese kuti ave nechokwadi chekuchengeteka.

Ndingaita Sei Kana Ndikangoerekana Ndatora Sofosbuvir-Velpatasvir-Voxilaprevir Yakawandisa?

Kana iwe ukangoerekana watora piritsi rimwe chete pazuva, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira kuti uwane gwara. Kunyange zvazvo paine ruzivo rushoma pamusoro pekuwandisa nemusanganiswa uyu chaiwo, kutora madosi ekuwedzera kunogona kuwedzera njodzi yako yemigumisiro yakaipa.

Usaedze kutsiva dose yekuwedzera nekusvetuka dose yako inotevera yakarongwa. Pane kudaro, ramba uchiita nehurongwa hwako hwekuisa madosi sezvakarairwa nemupi wako wehutano.

Kana iwe ukashaya simba mushure mekutora mushonga wekuwedzera, tsvaga rubatsiro rwekurapa nekukasira. Uya nebhodhoro remushonga newe kuitira kuti vanopa hutano vagone kuona chaizvo zvawakatora uye zvakawanda sei.

Ndingaita Sei Kana Ndakanganwa Dose yeSofosbuvir-Velpatasvir-Voxilaprevir?

Kana muchiyeuka mukati meawa gumi nemasere mushure me dose yamakanganwa, itorai nekukurumidza sezvinobvira pamwe chete nechikafu. Zvadaro rambai muchitevera chirongwa chenyu chemazuva ose zuva rinotevera. Izvi zvinobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wenyu.

Kana zvapfuura maawa gumi nemasere kubva pa dose yamakanganwa, regai dose yamakanganwa uye torai dose yenyu inotevera panguva yakajairika. Musaite madosi maviri panguva imwe chete kuti muzadze dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yenyu yemigumisiro.

Edzai kuderedza madosi akakanganwa nekuisa maalarm pafoni kana kushandisa chirongwa chemapiritsi. Kana muchikanganwa madosi kakawanda, taurai nachiremba wenyu nezve nzira dzekukubatsirai kuyeuka mushonga wenyu.

Ndingamira Rini Kutora Sofosbuvir-Velpatasvir-Voxilaprevir?

Munofanira kungomira kutora mushonga uyu mushure mekupedza kosi yose yevhiki gumi nembiri sezvakanyorwa nachiremba wenyu. Kumira kare, kunyangwe mukanzwa zviri nani kana bvunzo dzeropa dzichiratidza kuvandudzwa, zvinogona kubvumira hutachiona kudzoka uye zvinogona kukudziridza kuramba.

Chiremba wenyu achakuudzai kana zvakachengeteka kumira zvichienderana nekupindura kwenyu kurapwa uye kupedzwa kwekosi yose. Kunyangwe migumisiro ichinetsa, shandai nechikwata chenyu chehutano kuti muvatarise pane kumisa kurapwa.

Mushure mekupedza kurapwa, chiremba wenyu acharamba achikutarisa nemiedzo yeropa kuti ave nechokwadi chekuti hutachiona hunoramba husingaonekwe. Iyi nguva yekutevera yakakosha pakusimbisa kuti makawana mushonga unogara kwenguva refu.

Ndinganwa Doro Here Ndichitora Sofosbuvir-Velpatasvir-Voxilaprevir?

Munofanira kudzivisa doro zvachose muchitora mushonga uyu uye zvakanaka kwemwedzi yakati wandei mushure mekurapwa. Doro rinogona kukanganisa kugona kwechiropa chenyu kupora uye rinogona kuderedza kushanda kwemishonga yenyu yehepatitis C.

Sezvo hepatitis C yatokonzera kuzvimba muchiropa chako, kuwedzera doro kunowedzera kushushikana pachiviri ichi chakakosha. Chiropa chako chinoda simba raro rose rakatarisana nekupora uye kugadzirisa mishonga nemazvo.

Kana uri kunetseka nekushandisa doro, taura nachiremba wako nezve zviwanikwa zvekutsigira. Kurapa hepatitis C nekubudirira kunopa chiropa chako mukana wakanaka wekupora, asi izvi zvinoda kubvisa mamwe masosi ekukuvara senge doro.