Chii chinonzi Telaprevir: Zvazvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Telaprevir mushonga unopesana nemavhairasi wakagadzirirwa kurapa chirwere chechronic hepatitis C virus (HCV). Mushonga uyu ndeweboka remishonga inonzi protease inhibitors, iyo inoshanda nekudzivisa enzyme yakakosha iyo hepatitis C virus inoda kuti iwedzere mumuviri wako.

Nepo telaprevir yaive imwe nguva imwe nzira yekurapa yakakosha, zvakakosha kucherechedza kuti mishonga mitsva, inoshanda zvakanyanya yehepatitis C yakatsiva zvakanyanya mukiriniki. Chiremba wako achabatsira kuona nzira yakanakisa yekurapa mamiriro ako chaiwo.

Chii chinonzi Telaprevir chinoshandiswa?

Telaprevir inonyanya kushandiswa kurapa chronic hepatitis C infection, kunyanya genotype 1 ye virus. Iyi genotype ndiyo imwe yemhando dzakajairika dzehepatitis C dzinoonekwa muUnited States neEurope.

Mushonga uyu unogara uchishandiswa pamwe chete nemimwe mishonga inopesana nemavhairasi, kazhinji peginterferon alfa uye ribavirin. Iyi nzira yekubatanidza inobatsira kuwedzera mikana yekubvisa virus kubva muhurongwa hwako zvachose.

Zvakakosha kunzwisisa kuti telaprevir haishandiswe yega. Iyo hepatitis C virus yakasimba, saka kubatanidza mishonga yakasiyana iyo inoirwisa nenzira dzakasiyana-siyana inokupa mukana wakanakisa wekubudirira kurapwa.

Telaprevir inoshanda sei?

Telaprevir inoshanda nekunangana neprotein chaiyo inonzi NS3/4A protease iyo hepatitis C virus inoshandisa kuzvitsikirira. Funga nezveprotein iyi semapara emagadzirirwo emamorekuru ayo virus inoda kucheka mapuroteni makuru kuita zvidiki, zvinoshanda.

Kana telaprevir ikadzivisa enzyme iyi ye protease, virus haigone kuunganidza zvakanaka makopi matsva ayo. Iyi kukanganiswa muhupenyu hwevirus inobatsira kuderedza huwandu hwevirus muropa rako nekufamba kwenguva.

Telaprevir Inorapa Sei?

Semushonga unopesana nemavhairasi, telaprevir inoonekwa seyakasimba zvishoma. Inoshanda kurwisa hepatitis C, asi inouya nemigumisiro yakawanda inoda kutariswa zvakanyanya nechikwata chako chehutano.

Ndingatora Sei Telaprevir?

Telaprevir inofanira kutorwa sezvakarairwa nachiremba wako, kazhinji katatu pazuva nechikafu. Kuitora nechikafu kwakakosha nekuti kunobatsira muviri wako kutora mushonga zvakanyanya.

Unofanira kuedza kutora dose imwe neimwe maawa 7 kusvika ku9 kuti uchengetedze mazinga akagadzikana emushonga mumuviri wako. Edza kuisa tsika, sekui tora nekudya kwemangwanani, masikati, uye kudya kwemanheru, kuti ikubatsire kuyeuka.

Chikafu chaunodya ne telaprevir hachifanirwe kuve chinhu chakakosha, asi chinofanira kuve nemafuta kuti abatsire kutora. Kudya kana chikafu chikuru chinoshanda zvakanaka. Dzivisa kuitora mudumbu risina chinhu, nekuti izvi zvinogona kuderedza huwandu hwemushonga unonyatso shandiswa nemuviri wako.

Kana uine dambudziko rekumedza mahwendefa, taura nachiremba wako kana muzvinamutsi. Usapwanye kana kuputsa mahwendefa kunze kwekunge wairairwa zvakananga, nekuti izvi zvinogona kukanganisa nzira iyo mushonga unoburitswa mumuviri wako.

Ndingatora Telaprevir Kwenguva Yakareba Sei?

Nguva yekurapa ye telaprevir ndeye vhiki gumi nembiri, kunyangwe izvi zvichigona kusiyana zvichienderana nemamiriro ako chaiwo uye kuti unopindura sei kurapwa. Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa kweropa nguva dzose kuti atevere mazinga evairasi mumuviri wako.

Kunyange kana ukamira kutora telaprevir, ungangodaro ucharamba uchitora mamwe mishonga mukurapa kwako kwemamwe mwedzi. Nguva yekurapa ye hepatitis C inowanzoita kubva kumavhiki makumi maviri nemana kusvika makumi mana nemasere, zvichienderana nezvinhu zvakasiyana.

Zvakakosha kwazvo kupedzisa nzira yese yekurapa, kunyangwe ukatanga kunzwa zviri nani. Kumira kare kunogona kubvumira hutachiona kudzoka uye zvinogona kukonzera kusadzivirirwa kumishonga.

Ndezvipi Zvakaipa ZveTelaprevir?

Telaprevir inogona kukonzera zvakawanda zvakaipa, uye zvakakosha kuziva zvekutarisira kuitira kuti ushande nechikwata chako chehutano kuti uzvitarise zvakanaka. Vanhu vazhinji vanowana zvimwe zvakaipa, asi vazhinji vanozviwana zvichigoneka nerutsigiro rwakakodzera.

Zvakajairika zvakaipa zvaungasangana nazvo zvinosanganisira:

• Mavanga paganda, anogona kubva pakureruka kusvika pakukara
• Kuneta uye kunzwa kuneta kupfuura zvakajairika
• Nausea uye kugumbuka kwemudumbu
• Musoro
• Kukwenya kana kusagadzikana
• Kuchinja mukuravira
• Dhayareya

Izvi zvakajairika zvakaipa zvinowanzoitika kwenguva pfupi uye zvinogona kuvandudzika sezvo muviri wako uchigadzirisa kumushonga. Chikwata chako chehutano chinogona kupa nzira dzekubatsira kutarisira zviratidzo izvi.

Kune zvakare zvimwe zvakakomba zvakaipa zvinoda kutariswa kwekurapa nekukurumidza, kunyangwe zvisingawanzoitiki:

• Zvakakomba zveganda, kusanganisira Stevens-Johnson syndrome kana toxic epidermal necrolysis
• Severe anemia (yakaderera tsvuku yeropa)
• Zviratidzo zvematambudziko echiropa, senge kuita yero yeganda kana maziso
• Kutadza kufema kana kurwadziwa muchipfuva
• Kuchinja kwakanyanya kwemafungiro kana kuora mwoyo

Kana iwe ukasangana nechero ipi zvayo yezvakaipa izvi, taura nachiremba wako nekukurumidza kana kutsvaga rubatsiro rwekurapa rwekusununguka. Kuchengeteka kwako ndiko kutanga, uye izvi zvinogumbura, kunyangwe zvisingawanzoitiki, zvinoda kutariswa nekukurumidza.

Ndiani Asingafaniri Kutora Telaprevir?

Telaprevir haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Kune mamiriro akati wandei apo mushonga uyu unofanirwa kudziviswa kana kushandiswa nekuchenjerera kwakanyanya.

Haufanire kutora telaprevir kana uine mamwe mamiriro ekurapa kana kutora mishonga yakatarwa:

• Kurwara zvakanyanya kwechiropa kana cirrhosis (kuoma kwechiropa kwakanyanya)
• Kuzvitakura kana kuronga kuzvitakura
• Kuyamwisa
• Nhoroondo yekushungurudzika kwakanyanya kana pfungwa dzekuzviuraya
• Zvimwe zvirwere zvemoyo
• Kutora mishonga inoshanda zvinotyisa ne telaprevir

Uyezve, telaprevir inogona kushanda nemimwe mishonga yakawanda, kusanganisira mamwe akajairika semamwe ma blood thinners, mishonga yemoyo, uye mishonga yekubata. Nguva dzose paunopa chiremba wako runyorwa rwakakwana rwemishonga yese, zvinowedzera, uye zvigadzirwa zvechirimwa zvauri kutora.

Zera rinogonawo kuva chinhu. Vanhu vakuru vanogona kunge vachinyanya kunzwa kune mhedzisiro uye vanogona kuda kuongororwa kakawanda panguva yekurapa.

Mazita eTelaprevir Brand

Telaprevir inowanikwa pasi pezita rekuti Incivek muUnited States. Zvisinei, zvakakosha kuziva kuti mushonga uyu hauchanyanya kutengeswa nemugadziri kubva muna 2014.

Sarudzo yekumisa kutengesa yakaitwa nekuti mishonga mitsva, inoshanda zvakanyanya yehepatitis C yakawanikwa iine mhedzisiro shoma uye mitengo yekurapa iri nani. Chiremba wako anogona kukurudzira izvi zvingasarudzwa zvitsva panzvimbo.

Telaprevir Zvimwe Zvingasarudzwa

Mishonga mitsva yehepatitis C yakatsiva telaprevir zvakanyanya mukurapa kwekiriniki. Izvi zvingasarudzwa zvinowanzoita kuti zviite zviri nani nemhedzisiro shoma uye nguva pfupi yekurapa.

Zvingasarudzwa zvekutanga zvinogona kufungwa nachiremba wako zvinosanganisira:

• Sofosbuvir-based regimens (seHarvoni kana Epclusa)
• Glecaprevir/pibrentasvir combinations (seMavyret)
• Velpatasvir-containing treatments
• Zvimwe zvakananga-zviito zveantiviral (DAA) musanganiswa

Mishonga mitsva iyi inowanzo kurapa hepatitis C mumavhiki 8 kusvika ku12 nemitengo yekurapa iri pamusoro pe95%. Ivo zvakare vanowanzoita mhedzisiro shoma kana ichienzaniswa nemaitiro ekare aibatanidza telaprevir.

Chiremba wako achafunga nezvezvinhu zvakaita se genotype yako chaiyo ye hepatitis C, chero kurapwa kwawakambove nako, mamwe mamiriro ezvinhu ekurapa, uye mikana yekudyidzana kwemishonga paanenge achisarudza kurapwa kwakanakisa kwauri.

Ko Telaprevir Zviri Nani Pane Sofosbuvir?

Kurapwa kunobva paSofosbuvir kunowanzoonekwa sekupfuura telaprevir pakurapa hepatitis C. Maitiro matsva e sofosbuvir anopa zvakawanda zvakanakira zvinoita kuti ive sarudzo inosarudzwa kune vazhinji varwere.

Kurapwa kunobva paSofosbuvir kazhinji kune mitengo yepamusoro yekupora, kazhinji inodarika 95% ichienzaniswa nemitengo yakaderera yekubudirira ye telaprevir. Ivo zvakare vanowanzoita kuti vave nemigumisiro mishoma uye vanoda nguva shoma yekurapa, kazhinji 8 kusvika ku12 mavhiki panzvimbo yemakosi marefu anodiwa ne telaprevir.

Uye zvakare, sofosbuvir inoshanda pamagenotype akawanda e hepatitis C, zvichiita kuti ive yakawanda kupfuura telaprevir, iyo inonyanya kutariswa genotype 1. Ichi ndicho chikonzero chiremba vazhinji zvino vanokurudzira sofosbuvir-based regimens sekurapa kwemutsara wekutanga.

Mibvunzo Inowanzo Bvunzwa Nezve Telaprevir

Ko Telaprevir Yakachengeteka Here Kune Vanhu vane Chirwere cheItsvo?

Telaprevir inogona kushandiswa muvanhu vane chirwere cheitsvo chinyoro kusvika pakati nepakati, asi inoda kunyatsoongororwa uye kugadzirisa muyero. Chiremba wako achada kuongorora kushanda kweitsvo dzako kuburikidza nemiedzo yeropa usati watanga kurapwa.

Kana uine chirwere cheitsvo chakakomba kana uri pa dialysis, telaprevir ingasava sarudzo yakanakisa kwauri. Chikwata chako chehutano chingangokurudzira dzimwe nzira dzekurapa hepatitis C dzakachengeteka kune vanhu vane matambudziko eitsvo akakwirira.

Ndoita Sei Kana Ndikashandisa Telaprevir Yakawandisa Netsaona?

Kana ukatora telaprevir yakawanda netsaona kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora chepfu nekukasira. Usamirira kuti uone kana zviratidzo zvichikura, sezvo kuwana zano rekurapa nekukurumidza kwakakosha.

Kutora telaprevir yakawanda zvakanyanya kunogona kuwedzera njodzi yako yezvinetso zvakakomba, kunyanya kuita ganda rakakomba kana matambudziko echiropa. Murapi wako wezvehutano angangoda kukutarisa zvakanyanya uye anogona kukurudzira kurapwa kwakakosha kubatsira muviri wako kugadzirisa mushonga wakawandisa.

Ndingaita Sei Kana Ndakanganwa Dose yeTelaprevir?

Kana ukakanganwa dose ye telaprevir, itore pakarepo paunoyeuka, asi chete kana iri mukati me4 maawa enguva yako yakarongwa. Kana maawa anopfuura 4 apfuura, siya dose yakakanganwa uye tora dose yako inotevera panguva yakajairika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinetso. Edza kumisa tsika kana kumisa zviyeuchidzo kuti zvikubatsire kuyeuka madosi ako, sezvo kupa madosi nguva dzose kwakakosha kubudirira kwekurapa.

Ndingamira Rini Kutora Telaprevir?

Unofanira kungomira kutora telaprevir kana chiremba wako akuudza, kazhinji mushure mekupedza yako yakarongwa 12-vhiki kosi. Kumira kare kunogona kubvumira hutachiona hwehepatitis C kudzoka uye zvinogona kukudziridza kuramba mushonga.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongororwa kweropa nguva dzose kuti aone mazinga ehutachiona hwako. Kunyangwe kana izvi zviedzo zvikaratidza kuti hutachiona hahuonekwe, zvakakosha kupedzisa kosi yakazara yekurapa kuti uve nechokwadi chekuwana mukana wakanaka wekurapa zvachose.

Ndinganwa Doro Ndiri Kutora Telaprevir?

Unofanira kudzivisa doro zvachose uchitora telaprevir nemimwe mishonga yehepatitis C. Doro rinogona kuwedzera kukuvadza chiropa uye kukanganisa kushanda kwekurapa kwako.

Sezvo uri kurapa hepatitis C, iyo yatove inokanganisa chiropa chako, kuwedzera doro kumusanganiswa kunogona kukonzera kumwe kushushikana pane nhengo iyi yakakosha. Chiropa chako chinoda rutsigiro rwese rwaanogona kuwana panguva yekurapa kuti apore uye apore zvakanaka.