Chii chinonzi Tetrabenazine: Zvayakashandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Tetrabenazine mushonga unopiwa nachiremba unobatsira kudzora kufamba kusingadiwi, kwakanyanya muvanhu vane mamwe mamiriro ekuita zvepfungwa. Inoshanda nekuderedza huwandu hwe dopamine, kemikari yehuropi inokanganisa kufamba, munzvimbo dzakatarwa dzehuropi hwako.

Kana iwe kana mumwe munhu waunoda akanyorerwa mushonga uyu, unogona kuva nemibvunzo pamusoro pekuti unoshanda sei uye zvekutarisira. Gwaro iri richakufambisa iwe kuburikidza nezvose zvaunoda kuziva nezve tetrabenazine mumashoko akajeka, akarurama.

Chii chinonzi Tetrabenazine?

Tetrabenazine ndeyeboka remishonga inonzi vesicular monoamine transporter 2 (VMAT2) inhibitors. Funga nezvayo semushonga unobatsira "kunyaradza" zviratidzo zvekufamba zvakanyanya muuropi hwako.

Mishonga iyi yakagadzirirwa zvakananga kurapa kusagadzikana kwekufamba uko vanhu vanowana kufamba kusingadiwi kwavasingakwanise kudzora. Inoonekwa semushonga wakakosha unoda kutariswa zvakanyanya nevashandi vehutano vanonzwisisa mamiriro ekuita zvepfungwa.

Kusiyana nemimwe mishonga inoshanda mumuviri wako wese, tetrabenazine inotarisa nzira dzakatarwa zvikuru muuropi hwako hunodzora kufamba. Iyi nzira yakatarisa inobatsira kuderedza kufamba kusingadiwi ichideredza migumisiro pane mamwe masisitimu emuviri.

Chii chinonzi Tetrabenazine chinoshandiswa?

Tetrabenazine inonyanya kunyorerwa kurapa chorea ine hukama nechirwere cheHuntington. Chorea inoreva kufamba kusingadiwi, kunotyisa kunogona kukanganisa maoko ako, makumbo, chiso, uye dzimwe nhengo dzemuviri wako.

Chirwere cheHuntington imamiriro ejeneti anokanganisa zvishoma nezvishoma kufamba, kufunga, uye manzwiro. Kufamba kwechorea kunogona kuva kunoshungurudza uye kunokanganisa mabasa ezuva nezuva sekudya, kufamba, kana kutaura zvakajeka.

Chiremba wako anogonawo kufunga nezve tetrabenazine kune mamwe matambudziko ekufamba, kunyangwe izvi zvichizova zvinonzi "off-label" kushandiswa. Mamiriro aya anogona kusanganisira:

• Tardive dyskinesia (kufamba kusingadiwi kunokonzerwa nemishonga yechimwe chirwere chepfungwa)
• Tics muTourette syndrome iyo isina kupindura kune dzimwe nzira dzekurapa
• Mamwe marudzi echorea asina hukama nechirwere cheHuntington
• Zvimwe zviitiko zve dystonia (kusungika kwemhasuru kunokonzera nzvimbo dzisina kujairika)

Mamiriro emunhu mumwe nemumwe akasiyana, uye chiremba wako achanyatsoongorora kana tetrabenazine yakakodzera mamiriro ako chaiwo uye zviratidzo.

Tetrabenazine Inoshanda Sei?

Tetrabenazine inoshanda nekudzivisa kuchengetwa uye kuburitswa kwe dopamine munzvimbo dzakatarwa dzehuropi dzinodzora kufamba. Inoonekwa semushonga wakasimba zvine mwero unoda kugadziriswa kwemadosi zvishoma nezvishoma.

Kuti unzwisise mashandiro ayo, fungidzira dopamine semutumwa anotakura zviratidzo zvekufamba muuropi hwako. Mumamiriro ezvinhu akaita sechirwere cheHuntington, zviratidzo izvi zvinova zvinoshanda zvakanyanya, zvichikonzera kufamba kusingadiwi.

Mushonga uyu unonyanya "unodzora vhoriyamu" pazviratidzo izvi zve dopamine zvakanyanya. Izvi zvinoitwa nekudzivirira dopamine kubva pakuchengetwa zvakanaka uye kuburitswa pamagumo etsinga, izvo zvinobatsira kuderedza zviratidzo zvekufamba zvakanyanya.

Mhedzisiro ye tetrabenazine inodzokera shure, zvinoreva kuti kana iwe ukamira kutora mushonga, mazinga ako e dopamine achadzokera zvishoma nezvishoma kune avo ekutanga. Izvi zvakasiyana nemimwe mishonga inokonzera shanduko dzechigarire.

Ndingatora Sei Tetrabenazine?

Tora tetrabenazine sezvakanyorwa nachiremba wako, kazhinji uine chikafu kubatsira kuderedza dumbu. Mushonga uyu unouya muchimiro chepiritsi uye unofanirwa kumedzwa wese nemvura.

Chiremba wako achakutanga padosi yakaderera uye zvishoma nezvishoma kuwedzera pamusoro pemavhiki akati wandei. Iyi nzira inononoka inobatsira muviri wako kugadzirisa kumushonga uye inoderedza njodzi yemigumisiro.

Hezvino zvaunofanira kuziva nezvekutora tetrabenazine nemazvo:

• Torai panguva imwechete zuva rega rega kuti muve nemazinga akagadzikana mumuviri wenyu
• Musapwanye, kutsenga, kana kuputsa mahwendefa
• Torai nechikafu kana mukaka kuti muderedze kutsamwa kwemudumbu
• Kana muchitora kakawanda pazuva, paradzanisai zvikamu zvacho zvakaenzana
• Musamira kuitora kamwe kamwe musati mataura nachiremba wenyu kutanga

Chiremba wenyu achakutarirai zvakanyanya, kunyanya mumwedzi mishoma yekutanga yekurapa. Vanogona kuchinja mushonga wenyu zvichienderana nekuti mushonga uri kushanda sei uye chero mhedzisiro yemunenge muchiita.

Ndingatore Tetrabenazine Kwenguva Yakareba Sei?

Kureba kwekushandisa tetrabenazine kunoenderana nemamiriro enyu chaiwo uye kuti munopindura sei kumushonga. Kwechirwere cheHuntington, kurapwa kunowanzoitika kwenguva refu sezvo iri mamiriro anofambira mberi.

Chiremba wenyu achagara achiongorora kana mushonga uchiri kukubatsirai uye kana mabhenefiti achienderera mberi nekupfuura chero mhedzisiro. Vamwe vanhu vangada kuitora kwemakore mazhinji, nepo vamwe vachigona kuishandisa kwenguva pfupi.

Sarudzo yekuramba kana kumisa kurapwa inofanira kugara ichiitwa nemupi wehutano wenyu. Vachafunga nezvezvinhu zvakaita sekuti mushonga uri kubatsira sei zviratidzo zvenyu, chero mhedzisiro yamuri kusangana nayo, uye shanduko mumamiriro enyu ese.

Kana muchida kumisa kutora tetrabenazine, chiremba wenyu anowanzo deredza muyero wenyu zvishoma nezvishoma pane kuimisa kamwe kamwe. Izvi zvinobatsira kudzivirira chero zvinogona kukonzera kubviswa kana kuwedzera kamwe kamwe kwezviratidzo.

Ndezvipi Zvakaipa zveTetrabenazine?

Semishonga yese, tetrabenazine inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese achizviita. Mhedzisiro inowanzoitika inowanzoita nyoro kusvika pakati nepakati uye inowanzoita nani sezvo muviri wenyu uchigadzirisa kumushonga.

Kunzwisisa zvaunotarisira kunogona kukubatsira kuti unzwe wakagadzirira uye kuziva nguva yekubata chiremba wako. Ngatitarisei mhando dzakasiyana dzezvinokonzeresa zvaungasangana nazvo.

Zvinokonzeresa Zvakajairika

Izvi zvinokonzeresa zvinoitika muvanhu vazhinji vanotora tetrabenazine uye zvinowanzogoneka:

• Kuzara kana kuneta (kunzwa kuneta kupfuura zvakajairika)
• Kuora mwoyo kana shanduko dzemafungiro
• Kusagadzikana kana kushushikana
• Kutadza kurara (kusarara)
• Kusvotwa kana dumbu rinogumbuka
• Dizziness, kunyanya kana uchimira
• Kutadza kuisa pfungwa

Mazhinji emhedzisiro iyi anooneka zvakanyanya paunotanga kutora mushonga kana kana mushonga wako wakawedzerwa. Vanowanzova vashoma sezvo muviri wako uchigadzirisa kurapwa.

Zvinokonzeresa Zvakakomba

Nepo zvisingawanzoitiki, zvimwe zvinokonzeresa zvinoda kutariswa kwechiremba nekukasira. Bata chiremba wako nekukasira kana iwe ukaona:

• Kuora mwoyo kwakanyanya kana pfungwa dzekuzviuraya
• Kutadza kumedza kana kufema
• Fivha yakanyanya ine kuoma kwemhasuru
• Kurova kwemoyo kusingaenderane kana kurwadziwa muchipfuva
• Kusagadzikana kwakanyanya kana kufara
• Kusagadzikana kwemhasuru kusingadzoreki pachiso chako kana muviri

Izvi zvinokonzeresa zvakakomba hazviwanzoitiki, asi zvakakosha kuzviziva uye kutsvaga rubatsiro rwekurapa nekukasira kana zvikaitika.

Zvinokonzeresa Zvisingawanzoitiki

Vamwe vanhu vanogona kusangana nemhedzisiro isingawanzoitiki iyo ichiri kuda kutariswa:

• Neuroleptic malignant syndrome (mamiriro asingawanzoitiki asi akakomba ane fivha yakanyanya, kuoma kwemhasuru, uye kuvhiringidzika)
• Yakawedzerwa QT interval (shanduko yerhythm yemoyo inoonekwa paEKG)
• Kudonha kwakanyanya kweropa
• Parkinsonism (kudedera, kuoma, uye kufamba zvishoma nezvishoma)
• Akathisia (kusagadzikana kwakanyanya uye kuda kufamba nguva dzose)

Chiremba wako achakutarisa iwe kuti uone mhedzisiro iyi isingawanzoitika asi yakakomba, kunyanya munguva yekutanga yekurapa.

Ndiani Asingafaniri Kutora Tetrabenazine?

Tetrabenazine haina kukodzera munhu wese, uye mamiriro akati wandei kana mamiriro anoita kuti isachengeteke kushandisa. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akurudzira mushonga uyu.

Haufaniri kutora tetrabenazine kana uine kuora mwoyo kwakanyanya kana uine pfungwa dzekuzviuraya. Mushonga uyu unogona kuwedzera kuora mwoyo, saka zvakakosha kugadzirisa chero matambudziko ehutano hwepfungwa usati watanga kurapwa.

Zvimwe zvinopesana zvinosanganisira:

• Kuora mwoyo kusina kurapwa kana kusina kurapwa zvakakwana
• Pfungwa dzekuzviuraya dziripo kana kuyedza kuzviuraya nguva pfupi yapfuura
• Kutora monoamine oxidase inhibitors (MAOIs) kana wakambovatora mukati memazuva gumi nemana apfuura
• Matambudziko akakomba echiropa
• Kuziva allergy kune tetrabenazine kana zvikamu zvayo

Mamiriro akati wandei anoda kungwarira kwakanyanya uye kutariswa kwepedyo kana iwe uchitora tetrabenazine:

• Nhoroondo yekuora mwoyo kana mamwe mamiriro ehutano hwepfungwa
• Matambudziko emoyo kana rhythm isina kujairika yemoyo
• Chirwere chechiropa
• Matambudziko eitsvo
• Chirwere chaParkinson
• Kutambudzika kumedza

Nguva dzose udza chiremba wako nezvemamiriro ako ese ekurapa, kusanganisira chero nhoroondo yenyaya dzehutano hwepfungwa, kunyangwe dzichiratidzika kunge dzisina hukama nedambudziko rako rekufamba.

Mazita eTetrabenazine Brand

Tetrabenazine inowanikwa pasi pezita rekuti Xenazine muUnited States. Iyi ndiyo fomu inonyanya kurairwa yemushonga.

Kune zvakare mushonga mutsva, une hukama unonzi deutetrabenazine, uyo unotengeswa pasi pezita rekuti Austedo. Iyi ishanduro yakagadziridzwa ye tetrabenazine inogona kuve nezvimwe zvakanakira maererano nekugara uchishandisa uye mhedzisiro.

Chiremba wako achasarudza kuti imhando ipi yemushonga yakakodzera mamiriro ako chaiwo. Mishonga yese iri miviri inoshanda zvakafanana, asi panogona kuva nemusiyano wemazuva aunofanira kuitora uye mhedzisiro yayo.

Nguva dzose shandisa zita chairo uye fomu iro chiremba wako anokuraira, sezvo kuchinja pakati pemhando dzakasiyana kunofanirwa kuitwa chete pasi pekutariswa kwechiremba.

Zvimwe Zvinhu Zvokutsiva Tetrabenazine

Kana tetrabenazine isingakukodzere kana isingashande zvakanaka, chiremba wako angatarisa dzimwe nzira dzokurapa. Kusarudzwa kwechimwe chinhu chokutsiva kunoenderana nemamiriro ako chaiwo uye zviratidzo.

Kune Huntington's disease chorea, zvimwe zvingasanganisira:

• Deutetrabenazine (Austedo) - mushonga mutsva, wakafanana
• Mishonga yeAntipsychotic yakaita sehaloperidol kana olanzapine
• Benzodiazepines yekuzvidya mwoyo uye zvimwe zviratidzo zvemaitiro
• Mishonga inodzivirira kubatwa nemoyo yakaita sevalproic acid

Kune zvimwe zvirwere zvemaitiro, chiremba wako angatarisa:

• Botulinum toxin injections yematambudziko emhasuru emunharaunda
• Deep brain stimulation kune mamwe mamiriro
• Zvimwe zvinodzivirira dopamine
• Physical therapy uye occupational therapy

Nzira yakanakisisa yokurapa inowanzobatanidza mishonga nemamwe marapirwo akaita sephysical therapy, speech therapy, kana counseling kuti itarisane nezvinhu zvakasiyana-siyana zvematambudziko emaitiro.

Tetrabenazine iri nani pane Deutetrabenazine here?

Tetrabenazine ne deutetrabenazine mishonga inoshanda pakurapa matambudziko emaitiro, asi vane misiyano yakakosha inogona kuita kuti imwe ikukodzere kupfuura imwe.

Deutetrabenazine (Austedo) imushonga mutsva wakagadzirirwa kuvandudza tetrabenazine. Zvakanakira zvikuru zve deutetrabenazine zvinosanganisira:

• Kushandisa mushonga kashoma (kazhinji kaviri pazuva panzvimbo petatu pazuva)
• Mazinga anozivikanwa zvakanyanya mumuviri wako
• Zvichida matambudziko mashoma
• Kudyidzana kushoma nezvimwe zvinhu zvemajini zvinokanganisa metabolism yemishonga

Zvisinei, tetrabenazine yakashandiswa kwenguva refu uye ine tsvakurudzo yakawanda shure kwayo. Vamwe vanhu vanogona kupindura zviri nani kumushonga mumwe pane mumwe, uye mari inogonawo kutamba basa mukusarudza.

Chiremba wako achafunga nezvezvinhu zvakaita sezviratidzo zvako zvakananga, mimwe mishonga yaunotora, purogiramu yako yezuva nezuva, uye inishuwarenzi paachisarudza kuti imushonga upi wakanakira iwe. Hapana mushonga wakakwana - kusarudza kunoenderana nemamiriro ako ega.

Mibvunzo Inowanzo Bvunzwa Nezve Tetrabenazine

Tetrabenazine Yakachengeteka Kune Vanhu Vane Chirwere Chemoyo Here?

Tetrabenazine inoda kufungwa zvakanyanya kana uine matambudziko emoyo. Mushonga unogona kukanganisa rhythm yemoyo wako, kunyanya chimwe chinhu chinonzi QT interval paEKG.

Usati watanga tetrabenazine, chiremba wako anogona kuraira EKG kuti aongorore rhythm yemoyo wako. Kana uine mamwe mamiriro emoyo kana kutora mishonga inokanganisa rhythm yemoyo, unogona kuda kuongororwa kakawanda kana imwe nzira yekurapa.

Vanhu vane chirwere chemoyo dzimwe nguva vanogona kutora tetrabenazine zvakachengeteka, asi zvinoda kubatana pedyo pakati pechiremba wako weuropi uye cardiologist kuti ave nechokwadi chekuti moyo wako unogara uine hutano panguva yekurapa.

Ndingaita Sei Kana Ndikatora Tetrabenazine Yakawandisa Netsaona?

Kana iwe ukatora tetrabenazine yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira, kunyangwe ukanzwa zvakanaka. Kudhakwa kunogona kukonzera matambudziko akakomba ayo angasaoneka pakarepo.

Zviratidzo zve tetrabenazine yakawandisa zvinogona kusanganisira kurara zvakanyanya, kuvhiringidzika, kuoma kufema, kuoma kwemhasuru, kana kurasikirwa nekuziva. Kana ukaona chero zviratidzo izvi, tsvaga rubatsiro rwekurapa nekukurumidza.

Kudzivirira overdoses netsaona, chengeta mushonga wako mumudziyo wawo wekutanga, gadza zviyeuchidzo zvekuti unozvitora riini, uye usambofa wakawedzera madosi kana ukakanganwa imwe. Funga kushandisa chirongwa chemapiritsi kana uchitora mishonga yakawanda.

Ndoita Sei Kana Ndikakanganwa Dose yeTetrabenazine?

Kana ukakanganwa dose ye tetrabenazine, itore paunorangarira, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, siya dose yakakanganwa uye tora dose yako inotevera panguva yakajairika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemigumisiro. Kana iwe uchikanganwa madosi nguva dzose, taura nachiremba wako nezve nzira dzekukubatsira kurangarira, senge kugadzira maalarm efoni kana kushandisa app yekuyeuchidza mishonga.

Kana ukakanganwa madosi nguva dzose, zviratidzo zvako zvinogona kuwedzera, saka zvakakosha kuwana maitiro anokushandira. Vamwe vanhu vanoona zvichibatsira kutora mishonga yavo panguva imwe chete nezvimwe zviitiko zvemazuva ese, senge zvekudya.

Ndingamira Rini Kutora Tetrabenazine?

Sarudzo yekumira kutora tetrabenazine inofanira kugara ichiitwa nachiremba wako. Usamira kuitora kamwe kamwe wega, sezvo izvi zvinogona kukonzera zviratidzo zvako kudzoka nekukurumidza kana kutowedzera zvishoma.

Chiremba wako anogona kukurudzira kumira kana kuderedza tetrabenazine kana migumisiro ikava inonetsa zvakanyanya, kana mamiriro ako akachinja, kana kana mamwe marapirwo akava akakodzera mamiriro ako.

Panguva yekumira, chiremba wako anowanzo deredza dose yako zvishoma nezvishoma kwemavhiki akati wandei. Izvi zvinobatsira kuderedza chero migumisiro yekubvisa uye inobvumira muviri wako kuti ugadzirise zvishoma nezvishoma kushanda usina mushonga.

Ndinganwa Doro Ndiri Kutora Tetrabenazine Here?

Zvakanaka kudzivisa doro paunenge uchitora tetrabenazine, sezvo zvese zviri zviviri zvinogona kukonzera kurara uye kukanganisa kubatana kwako. Kuzvibatanidza kunogona kuwedzera mhedzisiro iyi uye kukonzera kuti unzwe wakanyanya kudzikama kupfuura zvakajairika.

Doro rinogonawo kuwedzera kuora mwoyo, izvo zvatove dambudziko ne tetrabenazine. Kana ukasarudza kunwa dzimwe nguva, taura nachiremba wako nezvehuwandu hupi hunogona kuva hwakachengeteka kwauri, uye usambofa wakanwa kana uchinzwa uine kuora mwoyo kana kuchinja kwemafungiro.

Teerera kuti doro rinokukanganisa sei paunenge uri pamushonga uyu, sezvo unogona kuona kuti unonyanya kunzwa kune mhedzisiro yaro kupfuura zvaive zvisati zvaitika usati watanga kurapwa.