Kung Ngabe i-Wellbutrin noma i-Lexapro Kungcono? Izimo, Imiphumela Eceleni, Nokusebenza Kahle

Yikuphi okungcono ngokukhathazeka noma ukudangala: i-Wellbutrin noma i-Lexapro? I-Lexapro ngokuvamile ingcono ngokukhathazeka; zombili ziwelapha kahle ukudangala. I-Wellbutrin yandisa amandla kodwa ingase yenze ukukhathazeka kube kubi kwabanye abantu.

Yini umehluko phakathi kwe-Wellbutrin ne-Lexapro?

Ngezinye izikhathi, ukubona umehluko oyinhloko ohlangothini kwenza konke kucace kakhudlwana. Nansi ithebula lokuqhathanisa elisheshayo ukuze siqale, sibheke ku-bupropion vs escitalopram (amagama emithi awavamile ye-Wellbutrin ne-Lexapro).

Isici	I-Wellbutrin (Bupropion)	I-Lexapro (Escitalopram)
Isigaba Sayo Imithi	I-NDRI (Norepinephrine-Dopamine Reuptake Inhibitor)	I-SSRI (Selective Serotonin Reuptake Inhibitor)
Isebenza Kanjani	Yandisa amazinga e-norepinephrine ne-dopamine ebuchosheni.	Yandisa amazinga e-serotonin ebuchosheni.
Izimo Ezamukelwe yi-FDA	Isifo Esikhulu Sokudangala (MDD), Isifo Sokudangala Kwonyaka (SAD), Ukuyeka Ukubhema.	Isifo Esikhulu Sokudangala (MDD), Isifo Esijwayelekile Sokukhathazeka (GAD).
Imiphumela Eceleni Ejwayelekile	Ukungalali, umlomo owomile, ikhanda elibuhlungu, ukuthukuthela, isicanucanu, isiyezi.	Isicanucanu, ukozela, ukujuluka, ukuphazamiseka ngokocansi, umlomo owomile.
Ingozi Yemiphumela Eceleni Ngokocansi	Phansi kakhulu. Ngezinye izikhathi isetshenziselwa ukubuyisela imiphumela yocansi kusuka kwamanye ama-antidepressant.	Engamaphakathi kuya phezulu. Inga bangela ukuncipha kwe-libido, ukubambezeleka kokukhuphuka, nokungasebenzi kahle kwe-erectile.
Umthelela Ekuphathweni Kwesisindo	Ngokuvamile ihlotshaniswa nokuncipha kwesisindo noma ayithinti isisindo.	Ingahambisana nokwanda kwesisindo, ikakhulukazi uma isetshenziswa isikhathi eside.

Zisebenza Kanjani? Umehluko Oyinhloko (I-NDRI vs. I-SSRI)

Umehluko oyisisekelo phakathi kwale mithimithi emibili utholakala endleleni ehlanganisa ngayo nabathumeli bakhemicals bakho, noma ama-neurotransmitters. Ukuqonda lokhu kubalulekile ukuze uqonde ukuthi kungani imiphumela yabo nemiphumela yabo yaseceleni ihlukile kangaka. Leli yinhliziyo yengxabano ye-NDRI vs SSRI.

I-Lexapro: Uchwepheshe we-Serotonin (I-SSRI)

I-Lexapro (escitalopram) ingeyesigaba esivame kakhulu sama-antidepressants: Selective Serotonin Reuptake Inhibitors (SSRIs). Cabanga nge-serotonin njengomlawuli webuchopho bakho wokuthi "uzizwe kahle" nokuthi "uzolile". Ibane indima enkulu emoyeni, ukukhathazeka, ukulala, nemizwa jikelele yenhlalakahle.

I-SSRI isebenza ngokuvimbela ukudonswa kabusha (noma "ukudonswa") kwe-serotonin emithanjeni yobuchopho. Lokhu kushiya i-serotonin eyengeziwe itholakala esikhungweni se-synaptic - isikhala phakathi kwama-neurons - okuyivumela ukuthi idlulise kahle izimpawu ezihlobene nemizwa emihle nokuzola. Lena indlela eqondisiwe egxile kuphela ekwandiseni i-serotonin. Ngokocwaningo olushicilelwe ku-Molecular Brain, le ndlela isebenza kahle kakhulu kuzo zombili izimpawu zokudangala nokukhathazeka umthombo.

I-Wellbutrin: I-Duo Enikeza Amandla (I-NDRI)

I-Wellbutrin (bupropion) isephiko elihlukile. Ithathwa njenge "antidepressant engavamile" ngoba ayithinti i-serotonin. Kunalokho, iyinkathi ye-Norepinephrine-Dopamine Reuptake Inhibitor (NDRI).

Isebenza ngokufanayo ne-SSRI kodwa ku-neurotransmitters ezimbili ezihlukene: * I-Norepinephrine: Le chemical ihlotshaniswa nokubukhali, amandla, nokugxilisa ingqondo. * I-Dopamine: Ivame ukubizwa nge-chemical "yomvuzo", i-dopamine ibalulekile ekufiseni, injabulo, nasekugxilisa ingqondo.

Ngokwandisa ukutholakala kwalo mbhangqwana, i-Wellbutrin ngokuvamile inomthelela ovusa amandla noma osheshisayo. Le ndlela ichaza ukuthi kungani ingasiza kakhulu kubantu abahlushwa ukudangala okubonakala ngokukhathala, ukunganaki, nokungakwazi ukuzwa injabulo.

Izimo Ezilapha: Ngaphezu Kokudangala Okukhulu

Ngenkathi zombili zamukelwe ku-Major Depressive Disorder, izindlela zazo ezihlukile ziyenza ilungele uhlu oluhlukile lwezimo, zombili ngokomthetho (ezamukelwe yi-FDA) nangokungemthetho.

Isetshenziselwa Ini i-Wellbutrin?

I-Wellbutrin iza ngezindlela eziningana - zokukhishwa ngokushesha (IR), zokukhishwa okuhlala njalo (SR), nokukhishwa okunwetshiwe (XL) - okuthinta indlela ebanjelwa ngayo nokuthi isetshenziselwa ini.

• Izimo Ezamukelwe yi-FDA:
  • Isifo Esikhulu Sokudangala (MDD)
  • Isifo Sokudangala Kwonyaka (SAD), uhlobo lokudangala oluhlobene nezinguquko zesizini.
  • Ukuyeka Ukubhema (ngaphansi kwegama lokuhweba elithi Zyban).
• Izimo Ezijwayelekile Ezingemthetho:
  • Isifo Sokudangala Nokunganyakazi Kwezingane (ADHD), ngenxa yomthelela wayo ku-dopamine ne-norepinephrine, ezibalulekile ekugxiliseni ingqondo nasekusebenzeni kahle umthombo.
  • Ukudangala Okune-Bipolar (ngokuvamile kuhambisana nesilawuli semizwa).

Ngenkathi abanye bengase babuze nge-Wellbutrin yokukhathazeka, ngokuvamile ayiyona imithi yokuqala. Kwabanye abantu, imiphumela yayo enikela ngamandla ingase yenze ukukhathazeka kube kubi noma ibangela ukuthukuthela.

Isetshenziselwa Ini i-Lexapro?

I-Lexapro iyinketho evame ukusetshenziswa ezimweni lapho ukukhathazeka nokudangala kuhlangene khona.

• Izimo Ezamukelwe yi-FDA:
  • Isifo Esikhulu Sokudangala (MDD)
  • Isifo Esijwayelekile Sokukhathazeka (GAD)
• Izimo Ezijwayelekile Ezingemthetho:
  • Isifo Sokudangala Okunamandla Okungapheli (OCD)
  • Isifo Sokwethuka
  • Isifo Sokuhlukumezeka Ngemva Kobuhlungu Obukhulu (PTSD)
  • Isifo Sokudangala Ngaphambi Kwesikhathi Sesinema (PMDD)

Ukusebenza Kahle: Ingabe Ziyalingana Ekuwelapheni Ukudangala?

Uma kukhulunywa ngokwelapha izimpawu eziyinhloko zokudangala okukhulu, impendulo emfushane ithi yebo. Izifundo ezinkulu ziye zazithola njalo ukuthi i-Wellbutrin ne-Lexapro ziyalingana ekusebenzeni kahle. Ukubuyekeza okukhulu kokusebenza kahle kwama-antidepressant, okwaziwa ngokuthi i-STAR\*D trial, kuthole ukuthi izigaba ezahlukene zama-antidepressant ngokuvamile zisebenza kahle ngokulinganayo, kodwa abantu bayasabela ngendlela ehlukile umthombo.

Ngakho-ke, uma zombili zisebenza, ungenzani ukukhetha? Isinqumo sivame ukuba hhayi ukuthi ziyasebenza yini, kodwa zisebenza kanjani nokuthi yimiphi imiphumela yaseceleni umuntu akulungele ukuyihumusha. Imithi engcono yiyo ehambisana kahle nephrofayili yakho yezimpawu nendlela ophila ngayo.

Imiphumela Eceleni: Isicelo Esibalulekile Kubantu Abaningi

Lokhu mhlawumbe kuyingxenye ebaluleke kakhulu yengxoxo ye-Wellbutrin vs Lexapro kubantu abaningi. Amaphrofayili emiphumela yaseceleni lapho le mithimithi emibili ihlukana kakhulu khona.

Imiphumela Eceleni Ehlangene

Okokuqala, ake sibheke izinto ezifanayo. Zombili imithi ingabangela: * Umlomo owomile * Isicanucanu (ikakhulukazi uma uqala ukuyisebenzisa) * Ukungalali * Ikhanda elibuhlungu * Isiyezi

Le miphumela yaseceleni ngokuvamile ayinakho, futhi ivame ukuncipha njengoba umzimba wakho ujwayela imithi ezontweni ezimbalwa.

Umehluko Oyinhloko #1: Imiphumela Eceleni Ngokocansi

Lena yinto enkulu eyenza umehluko. * Imiphumela Eceleni Ye-Lexapro: Njengamanye ama-SSRI, i-Lexapro inengozi eyaziwa kahle yokubangela ukuphazamiseka ngokocansi. Lokhu kungabandakanya ukuncipha kwe-libido (ukuncipha kokufisa ucansi), ukubambezeleka kokukhuphuka kwabesilisa, nokuzikhandla noma ukungakwazi ukufinyelela i-orgasm kwabesilisa nabesifazane. Kwabanye, le miphumela yaseceleni ibalulekile kangangokuthi iyabenza bayeke ukwelashwa. * Imiphumela Eceleni Ye-Wellbutrin Ngokocansi: I-Wellbutrin yaziwa ngokuba nokuvela okuphansi kakhulu kwemiphumela yaseceleni ngokocansi. Ngoba ayithinti i-serotonin, igwema izinkinga ezijwayelekile zama-SSRI. Eqinisweni, ngezinye izikhathi ihlinzekwa kanye ne-SSRI ngqo ukuze ibuyisele imiphumela yocansi.

Umehluko Oyinhloko #2: Izinguquko Zesisindo

Izinkathazo mayelana nesisindo zingaba isithiyo esibalulekile sokuqala noma sokuqhubeka nokwelashwa kwe-antidepressant. * Ukukhuluphala Kwesisindo Nge-Lexapro: Noma kungekhona wonke umuntu okuyibonayo, ukukhuluphala nge-Lexapro kuyinto eyenzeka, ikakhulukazi lapho kusetshenziswa izinyanga eziyisithupha noma ngaphezulu. Isizathu esiqondile asiqondakali ngokuphelele kodwa singase sihlobane nemiphumela ye-serotonin ekufiseni nasekuhanjweni komzimba. * Ukuncipha Kwesisindo Nge-Wellbutrin: Ngokuphambene, ukuncipha kwesisindo nge-Wellbutrin kuyimiphumela yaseceleni evame kakhulu. Izimpahla zayo ezikhuthazayo zingakhuphula kancane ukuhanjiswa komzimba futhi zicindezele ukufisa, okuyenza ibe yindlela ekhethwayo kulabo abakhathazekile ngokukhuluphala.

Imiphumela Eceleni Ebucayi & Isixwayiso Sebhokisi

Kubalulekile ukwazi ngemiphumela yaseceleni eyenzeka kancane, kodwa ebucayi. * Isixwayiso Sebhokisi Le-FDA: Zombili i-Wellbutrin ne-Lexapro ziphethe isixwayiso esibucayi kakhulu se-FDA sokwandisa ingozi yokucabanga nokuziphatha kokuzibulala ezinganeni, intsha, nabantu abadala abancane (ngaphansi kweminyaka engu-25). Kubalulekile ukubona noma yiziphi izinguquko zemvelo, ikakhulukazi lapho uqala imithi noma ushintsha isilinganiso. * Imiphumela Eceleni Ye-Wellbutrin (Eqondile): Ingozi enkulu ehlukile kwe-Wellbutrin yile yokwandisa ingozi yokuzamazama. Le ngozi incike kusilinganiso futhi iphakeme kulabo abanenkathi yokuzamazama noma izinkinga zokudla njenge-anorexia noma i-bulimia. * Imiphumela Eceleni Ye-Lexapro (Eqondile): Ingozi engavamile kodwa ebucayi nge-Lexapro yile ye-serotonin syndrome, isimo esibangelwa amazinga aphezulu kakhulu e-serotonin. Kungenzeka ukuthi yenzeke lapho i-Lexapro ihlanganiswa nezinye izinto eziphinde zikhuphule i-serotonin (njengemithi ethile ye-migraine noma i-St. John's Wort). Izimpawu zibandakanya ukuthukuthela, ukudideka, isivinini senhliziyo esheshayo, nokuqina kwemisipha.

Ungakwazi Ukuthatha i-Wellbutrin ne-Lexapro Ndawonye?

Kungase kubonakale kungahambisani, kodwa impendulo ithi yebo. Ukunikeza i-Lexapro ne-Wellbutrin ndawonye kuyindlela evamile futhi ephumelelayo eyaziwa njengokwelapha ukukhula.

Udokotela angase ancoma le nhlanganisela ngezizathu ezimbalwa: 1. Ukuthuthukisa Ukusebenza Kahle: Uma i-Lexapro yodwa ingayixazululi ngokuphelele izimpawu zokudangala, ukwengeza i-Wellbutrin kungase kunikeze ukwengeza ngokugxila ezindleleni ze-dopamine ne-norepinephrine. Lokhu kungasiza kakhulu ekulweni nokukhathala okuhlala njalo noma ukuntuleka kokufisa. 2. Ukubuyisela Imiphumela Eceleni: Uma isiguli siphumelela nge-Lexapro kodwa sihlushwa imiphumela yaseceleni ngokocansi, ukukhathala, noma ukukhuluphala, udokotela angase engeze isilinganiso esincane se-Wellbutrin ukusiza ukunciphisa lezi zinkinga.

Le nhlanganisela kufanele kuphela yenziwe ngaphansi kokuqondisa okungaphezulu komunye ochwepheshe wezempilo ongabheka imiphumela yaseceleni futhi alungise izilinganiso ngokufanele.

Ukwenza Isinqumo: Yikuphi Okungaba Kuhle Kuwe?

Isinqumo sokugcina sisekuwe nodokotela wakho, kodwa nansi isifinyezo ukuze kusize ukwengamela leyo ngxoxo. Khumbula, ukushintsha kusuka ku-lexapro kuya ku-wellbutrin (noma okuphambene) kuhlale kuyindlela uma ukhetho lokuqala lungalungile.

Cabanga nge-Lexapro Uma…

• Uhlushwa ukudangala okukhulu nokukhathazeka. I-Lexapro yamukelwe yi-FDA yi-Generalized Anxiety Disorder futhi ngokuvamile iyasebenza kakhulu ekunikezeni umuzwa wokuzola.
• Unaluzwelo kwimithi "enika amandla" kakhulu futhi ukhathazeke ngokuthukuthela noma ukungalali okungase kube khona.
• Ukudangala kwakho kuhilela izimpawu zokucasuka, ukubuyekezwa, noma ukucabanga okunamandla okungapheli.

Cabanga nge-Wellbutrin Uma…

• Ukudangala kwakho kubonakala ngamandla aphansi, ukukhathala, ukulala kakhulu, nokuntuleka kokufisa.
• Ukhathazeke kakhulu nge-wellbutrin sexual side effects noma lexapro weight gain okungase kube khona.
• Uphinde uzama ukuyeka ukubhema.
• Awukaze uphumelele nama-SSRI esikhathini esidlule.

Izwi Lokugcina

Uhambo lokuthola imithi efanele yempilo yengqondo luyohluka kumuntu ngamunye. Emqhudelwaneni we-Wellbutrin vs Lexapro, akukho mngeneli jikelele - kunalokho okungcono kakhulu kuwe.

Umlayezo oyinhloko yilokhu: I-Lexapro iyi-SSRI egxile ku-serotonin okuyithuluzi elinamandla elwa nokudangala nokukhathazeka, kodwa iveza ingozi ephakeme yemiphumela yaseceleni ngokocansi nokukhuluphala. I-Wellbutrin yi-NDRI egxile ku-dopamine ne-norepinephrine engase ibe namandla kakhulu futhi inganele kancane ukubangela le miphumela yaseceleni, kodwa inengozi yokuzamazama futhi ingase ingalungele labo abakhathazeka kakhulu.

Sebenzisa lolu lwazi hhayi ukuze uzilaphe, kodwa ukuze ube nengxoxo enolwazi kangcono, enokwethenjwa, nenenzuzo nodokotela wakho. Ngokubambisana, ningahlola izinzuzo nezingekho futhi nenze uhlelo lokwelashwa oluzokusiza uzizwe njengowakho futhi.