

Health Library
October 10, 2025
Question on this topic? Get an instant answer from August.
I-Antiphospholipid syndrome (APS) iyisimo sesistimu yokuzivikela yomzimba lapho isistimu yakho yokuzivikela yomzimba ihlasela ngephutha amaprotheni athile egazini lakho, okwenza kube lula ukuba kube khona ama-clot ayingozi. Cabanga ngayo njengesistimu yakho yomzimba yokwenza ama-clot esebenza ngokweqile lapho ingafanele. Lesi simo sithinta amadoda nabesifazane, nakuba kuvamile kakhulu kubesifazane abaseminyakeni yokuzala, futhi nakuba kuzwakala kuyesabekayo, kuphatheka kakhulu ngokunakekelwa komtholampilo okufanele.
I-Antiphospholipid syndrome kwenzeka lapho isistimu yakho yokuzivikela yomzimba ikhiqiza ama-antibodies ahlose ama-phospholipids namaprotheni abopha kuma-phospholipids egazini lakho. Ama-Phospholipids ayizinto ezibalulekile zokuthi zigcine i-membrane yeselula futhi zidlala indima ebalulekile ekwenzeni ama-clot egazini.
Lapho la ma-antibodies ehlasela, aphula inqubo evamile yokwenza ama-clot egazini lakho. Esikhundleni sokwenza ama-clot kuphela lapho ulimazile, igazi lakho liba lula ukwenza ama-clot ngaphakathi kwezitho zakho zegazi lapho ungawadingi. Lokhu kungabangela izinkinga ezinkulu njengokuqunjelwa, ukuhlaselwa yinhliziyo, noma izinkinga zokukhulelwa.
I-APS ingaba yodwa, ebizwa ngokuthi i-primary antiphospholipid syndrome, noma kanye nezinye izimo zesifo sokuzivikela yomzimba njenge-lupus, okuthiwa yi-secondary antiphospholipid syndrome. Izindaba ezinhle ukuthi ngokwelashwa okufanele, abantu abaningi abane-APS bangaphila impilo evamile, enempilo.
Izimpawu ze-APS zingase zihluke kakhulu ngoba kuncike lapho ama-clot egazini enziwa khona emzimbeni wakho. Abanye abantu bangase bangabi nazimpawu nhlobo kuze kube yilapho i-clot ivela, kanti abanye bangase babe nezibonakaliso ezincane eziya zibuhlungu.
Nawa zimpawu ezivamile ongazihlangabezana nazo:
Kubantu besifazane, izimpawu ezihlobene nokukhulelwa zingafaka ukukhulelwa okuphindaphindayo, ikakhulukazi ekuqedeni kwesibili noma kwesithathu, noma izinkinga njenge-preeclampsia. Lezi zimpawu zenzeka ngoba ama-clot egazini angaphazamisa ukugeleza kwegazi ku-placenta.
Abanye abantu abane-APS bangase babe nezimpawu ezingavamile njengokushintsha kokubona ngokuzumayo, inkulumo ephazamisekile, noma ubuthakathaka ohlangothini olulodwa lomzimba. Nakuba lokhu kungase kukhathaze, khumbula ukuthi akuwona wonke umuntu onale APS ozoba nalezi zimpawu zonke, futhi eziningi zingaphathwa kahle ngokwelashwa.
I-APS ngokuvamile ihlukaniswe izinhlobo ezimbili eziyinhloko kuye kokuthi ivela yodwa noma ngezimo ezinye. Ukuqonda ukuthi yiluphi uhlobo olukhona kuwe kusiza udokotela wakho ukuba enze uhlelo lokwelapha oluphumelelayo kuwe.
I-primary antiphospholipid syndrome ivela lapho une-APS ngaphandle kwanoma yisiphi esinye isifo sokuzivikela yomzimba. Lena yifomu elula kakhulu, lapho izinkinga zokwenza ama-clot egazini ziyikhathazo eliyinhloko. Abantu abaningi abane-primary APS bayaphendula kahle emithi yokuncipha kwegazi.
I-secondary antiphospholipid syndrome ivela kanye nezinye izimo zesifo sokuzivikela yomzimba, ikakhulukazi i-systemic lupus erythematosus (SLE noma i-lupus). Cishe u-30-40% wabantu abane-lupus nabo bane-antiphospholipid antibodies. Ezinye izimo ezingaba khona ne-APS zifaka i-rheumatoid arthritis, i-scleroderma, ne-Sjögren's syndrome.
Kukhona futhi uhlobo oluyimfihlo kodwa oluyingozi oluthiwa yi-catastrophic antiphospholipid syndrome (CAPS), oluthinta abantu abangaphansi kuka-1% abane-APS. Ku-CAPS, ama-clot amaningi egazini enziwa ngokushesha emzimbeni wonke, adinga ukwelashwa okusheshayo kwezimo eziphuthumayo. Nakuba lokhu kuzwakala kuyesabekayo, kuyinto engavamile futhi ngokuvamile iyakwelashwa lapho itholakala ngokushesha.
Imbangela eqondile ye-APS ayiqondakali ngokuphelele, kodwa abacwaningi bakholelwa ukuthi ivela ekuhlanganiseni kokuthambekela kwezakhiwo nokuphazamiseka kwemvelo. Isistimu yakho yokuzivikela yomzimba ngokuyisisekelo iyadida futhi iqala ukuhlasela amaprotheni omzimba wakho.
Izici eziningana zingase zifake isandla ekukhuleni kwe-APS:
Kubalulekile ukuqonda ukuthi ukuba nezici zengozi akusho ukuthi uzokhula ngokuqinisekile nge-APS. Abantu abaningi abanezi zici zengozi abakhulumi lesi simo, kanti abanye abangenazo izimbangela ezicacile bayakwenza. Ukuthuthukiswa kwe-APS cishe kudinga isikhathi esifanele sokuthambekela kwezakhiwo nezici zemvelo.
Ngezinye izikhathi, abantu bangaba nama-antiphospholipid antibodies egazini labo ngaphandle kokuba nazimpawu noma ama-clot egazini. Lokhu kuhlukile ekubeni ne-APS ngokwayo, futhi abantu abaningi abanjalo abadingi ukwelashwa.
Kufanele ubheke udokotela ngokushesha uma uhlangabezana nezimpawu ezingase zibonise i-clot egazini, njengoba ukwelashwa okusheshayo kungavimbela izinkinga ezinkulu. Ungalindi ukubona ukuthi izimpawu ziyaphuli yini zodwa.
Funani ukunakekelwa komtholampilo ngokushesha uma uhlangabezana nalokhu:
Kufanele futhi uhlele i-aphoyintimenti nodokotela wakho uma une-pregnancy losses ephindaphindayo, ikakhulukazi uma uke waba nokulahleka kokukhulelwa okubili noma ngaphezulu. Nakuba ukulahleka kokukhulelwa kungaba nezizathu eziningi, ukulahleka kokukhulelwa okuphindaphindayo kungase kubonise i-APS noma enye isimo esiphatheka.
Uma unemlando womndeni wama-clot egazini noma izifo zokuzivikela yomzimba, khuluma lokhu nodokotela wakho. Bangase bancoma ukuhlolwa kwe-APS, ikakhulukazi uma uhlela ukukhulelwa noma uqala ukuphatha ukuzala kwama-hormone, kokubili okungase kukhulise ingozi yokwenza ama-clot.
Izici eziningana zingase zikhulise amathuba akho okukhula nge-APS, nakuba ukuba nalezi zici zengozi akusho ukuthi uzokhula ngalesi simo. Ukuqonda ingozi yakho kusiza wena nodokotela wakho ukuba niqaphele izibonakaliso zokuqala.
Izici zengozi ezibaluleke kakhulu zifaka:
Ezinye izimo zesikhashana zingase zikhulise ingozi yakho yokwenza ama-clot egazini uma une-APS. Lokhu kufaka ukukhulelwa, ukuhlinzwa, ukulala ebethe isikhathi eside, noma ukuthatha ukuphatha ukuzala okune-estrogen noma i-hormone replacement therapy.
Ubudala buyaludlala indima, njengoba ingozi yokukhula nge-APS ikhula ngokwanda kobudala, nakuba ingase ivela kunoma yiliphi iminyaka. Izingane zingase zikhule nge-APS, kodwa kuyinto engavamile kakhulu kunabantu abadala.
Nakuba izinkinga ze-APS zingase zibukeke zinzima, abantu abaningi abane ukwelashwa okufanele nokuqapha bangazigwema ngokuphelele. Ikhona ukwazi ukuthi yini okufanele uyibheke futhi usebenze eduze neqembu lakho lokukhathalela impilo.
Izinkinga ezivamile zifaka:
Abanye abantu abane-APS bangase bakhule izinkinga ezingavamile kodwa ezinzima kakhulu. Lokhu kungafaka ama-clot egazini ezindaweni ezingavamile njengobhedu, amehlo, noma ubuchopho, okungase kubangele izimpawu njengokubona izinkinga, ukudideka, noma ukuhlwitha.
Uhlobo oluyimfihlo lwe-APS lungabangela ukwehluleka kwemizimba eminingi, kodwa lokhu kwenzeka kubantu abangaphansi kuka-1% abane-APS. Ngokusetshenziswa kwemithi yanamuhla, ngisho nezinkinga ezinkulu ngokuvamile zingavikeleka noma ziphatheke lapho zitholakala ngokushesha.
Ukuhlola i-APS kudinga ubufakazi bokwenza (njengama-clot egazini noma izinkinga zokukhulelwa) nokuqinisekiswa kwelebhu kwama-antiphospholipid antibodies. Udokotela wakho ngokuvamile uzodinga ukuqinisekisa ukuxilongwa ngokuhlolwa kwegazi okuhle okubili okwenziwe ngesikhathi esingaphezulu kwamasonto angu-12.
Inqubo yokuxilonga ngokuvamile ihlanganisa izinyathelo eziningana. Okokuqala, udokotela wakho uzothatha umlando wezokwelapha ophelele, ebuza nganoma yimaphi ama-clot egazini, izinkinga zokukhulelwa, noma izimpawu ohlangabezana nazo. Bazophinde benze ukuhlolwa komzimba bebheka izibonakaliso zezinkinga zokwenza ama-clot.
Ukuhlolwa kwegazi kuyisisekelo sokuhlola i-APS. Ukuhlolwa okuyinhloko kubheka izinhlobo ezintathu ze-antiphospholipid antibodies: anticardiolipin antibodies, anti-beta-2 glycoprotein I antibodies, ne-lupus anticoagulant. Naphezu kwegama layo, i-lupus anticoagulant empeleni ikhuphula ingozi yokwenza ama-clot kunokuyivimba.
Udokotela wakho angase futhi ahlele ukuhlolwa okwengeziwe ukuze akhiphe ezinye izimo noma abheke izinkinga. Lokhu kungase kuhlanganise izifundo zokwenza izithombe njenge-ultrasounds ukuhlola ama-clot egazini, noma ukuhlolwa ukuhlola umsebenzi wezinso, inhliziyo, noma ubuchopho uma unezimpawu ezithinta lezi zitho.
Ukwelashwa kwe-APS kugxile ekunqobeni ama-clot egazini nokuphatha noma yiziphi izinkinga ezivele sezivela. Izindaba ezinhle ukuthi ngokwelashwa okufanele, abantu abaningi abane-APS bangaphila impilo evamile, esebenzayo ngaphandle kokulinganiselwa okukhulu.
Izindlela zokwelapha eziyinhloko zifaka:
Uhlelo lwakho lokwelapha oluthile luzoxhomeka esimweni sakho somuntu siqu. Uma uke waba nama-clot egazini ngaphambili, cishe uzodinga i-anticoagulation yesikhathi eside. Uma une-APS kodwa awukawabi nama-clot, udokotela wakho angase ancome i-low-dose aspirin njengendlela yokuvikela.
Kubantu besifazane abahlela ukukhulelwa, ukwelashwa ngokuvamile kuhlanganisa ukusetshenziswa kwe-low-dose aspirin ne-heparin injections. Le mithi iphephile ngesikhathi sokukhulelwa futhi inciphisa kakhulu ingozi yezinkinga zokukhulelwa. Udokotela wakho uzokunakekela eduze ngesikhathi sokukhulelwa futhi angase alungise ukwelashwa kwakho njengoba kudingeka.
Ukuqapha okuvamile kubalulekile kunoma ubani onale APS. Uzodinga ukuhlolwa kwegazi okuvamile ukuhlola umsebenzi wakho wokwenza ama-clot nokuqinisekisa ukuthi imithi yakho isebenza kahle. Udokotela wakho uzophinde abheke noma yiziphi izibonakaliso zezinkinga noma imiphumela emibi yekwelashwa.
Ukuphatha i-APS ekhaya kuhilela ukuthatha imithi yakho ngokuqhubekayo nokwenza izinqumo zokuphila ezisekela impilo yakho yonke. Nakuba ukwelashwa komtholampilo kubalulekile, kunezinto eziningi ongazenza ekhaya ukusiza ukuphatha isimo sakho ngokuphumelelayo.
Ukuhambisana nemithi yilona msebenzi wakho obaluleke kakhulu wokunakekelwa ekhaya. Thatha imithi yakho yokuncipha kwegazi ngokuqondile njengoba kuyalelwe, ngesikhathi esifanayo nsuku zonke. Uma usebenzisa i-warfarin, uzodinga ukuhlolwa kwegazi okuvamile ukuhlola amazinga akho, ngakho gcina zonke i-aphoyintimenti zakho futhi ulandele noma yimiphi imingcele yokudla udokotela wakho ayincoma.
Ukushintsha kwesitayela sempilo kungasiza kakhulu ekuphatheni i-APS yakho:
Qaphela umzimba wakho futhi uqaphele izibonakaliso zezixwayiso zama-clot egazini. Gcina uhlu lwezimpawu okufanele uzibheke, futhi ungangabazi ukuxhumana nodokotela wakho uma uqaphela noma yini ekhathazayo. Kungcono ukuhlola neqembu lakho lokukhathalela impilo kunokungawunaki ama-symptom angase abe yingozi.
Uma uhlela noma yiluphi uhlinzwa noma izinqubo zokwelapha amazinyo, qiniseka ukuthi utshela abahlinzeki bakho bezempilo nge-APS yakho nemithi oyithathayo. Bangase badinge ukulungisa ukwelashwa kwakho okwesikhashana ukunciphisa ingozi yokopha ngesikhathi sezinqubo.
Ukulungiselela i-aphoyintimenti yakho kusiza ukuqinisekisa ukuthi uthola okuningi kakhulu ngesikhathi sakho nodokotela wakho futhi kusiza ukuba banikeze ukunakekelwa okuhle kakhulu okungenzeka. Ukulungiselela okuncane kungenza umehluko omkhulu ekunakekelweni kwakho.
Ngaphambi kwe-aphoyintimenti yakho, buza ulwazi ngezimpawu zakho nomlando wakho wezokwelapha. Bhala phansi ukuthi izimpawu zaqala nini, yini ezenza zibe ngcono noma zibe zimbi, nokuthi zikuthinta kanjani impilo yakho yansuku zonke. Uma uke waba nama-clot egazini noma izinkinga zokukhulelwa, qaphela izinsuku nemininingwane.
Letha uhlu oluphelele lwazo zonke imithi oyithathayo, kufaka phakathi imithi yokuthengwa ngaphandle komthetho, izongezo, nemithi yemifino. Ezinye zalezi zingase zihlangane nemithi yokuncipha kwegazi noma zithinte imiphumela yokuhlola kwakho, ngakho kubalulekile ukuthi udokotela wakho azi ngakho konke oyithathayo.
Lungiselela uhlu lwemibuzo okufanele uyibuze udokotela wakho. Ungase ufune ukwazi ngalokhu:
Uma ubona uchwepheshe okokuqala, cela udokotela wakho oyinhloko ukuba athumele amarekhodi akho ezempilo kusengaphambili. Lokhu kuhlanganisa noma yimiphi imiphumela yokuhlolwa kwegazi edlule, izifundo zokwenza izithombe, noma amarekhodi okwelashwa ahlobene nesimo sakho.
Into ebaluleke kakhulu okumele uyiqonde nge-APS ukuthi nakuba kuyisimo esinzima, kuphatheka kakhulu lapho kuphathwa kahle. Abantu abaningi abane-APS abamukela ukwelashwa okufanele bangalindela ukuphila impilo evamile, enempilo ngaphandle kokulinganiselwa okuncane.
Ukuqaphela nokwelashwa okusheshayo kubalulekile ekuvinjeni izinkinga. Uma unezimpawu ezingase zibonise ama-clot egazini noma uma unezici zengozi ze-APS, ungangabazi ukuxoxa nazo udokotela wakho. Ukuhlolwa kwegazi kungathola kalula ama-antibodies abangela i-APS, futhi ukwelashwa kungaqala ngokushesha uma kudingeka.
Khumbula ukuthi ukuba ne-APS akusho ukuthi uqondiswe ukuba ube nama-clot egazini noma ezinye izinkinga. Ngokunakekelwa komtholampilo okufanele, ukuhambisana nemithi, kanye nezindlela zokuphila ezempilo, ungaphatha lesi simo ngokuphumelelayo. Abantu abaningi abane-APS bayaqhubeka beba nokukhulelwa okuphumelelayo, imisebenzi esebenzayo, nempilo ezele.
Hlala uxhumene neqembu lakho lokukhathalela impilo futhi ungesabi ukubuza imibuzo noma ukukhuluma ngezinkinga. Ukuhlanganyela kwakho okusebenzayo ekunakekelweni kwakho kuyinye yezinto ezibaluleke kakhulu ekuphatheni i-APS ngokuphumelelayo.
Okwamanje, ayikho imithi yokwelapha i-APS, kodwa ingaphathwa kahle kakhulu ngemithi nokushintsha kwesitayela sempilo. Abantu abaningi abane-APS abamukela ukwelashwa okufanele bangavimba ama-clot egazini futhi baphile impilo evamile. Abacwaningi baqhubeka becwaninga izindlela zokwelapha ezintsha ezingase zinikeze imiphumela engcono nakakhulu esikhathini esizayo.
Lokhu kuncike esimweni sakho somuntu siqu. Uma uke waba nama-clot egazini, cishe uzodinga i-anticoagulation yesikhathi eside ukuvimbela ama-clot esikhathi esizayo. Uma une-APS kodwa awukawabi nama-clot, udokotela wakho angase ancome i-low-dose aspirin noma ukuqapha ngaphandle kwemithi yokuncipha kwegazi. Uhlelo lwakho lokwelapha lungase lushintshe ngokuhamba kwesikhathi kuye ezicini zakho zengozi nendlela oyiphendula ngayo ekwelapheni.
Yebo, abesifazane abaningi abane-APS baba nokukhulelwa okuphumelelayo ngokunakekelwa komtholampilo okufanele. Ukwelashwa ngesikhathi sokukhulelwa ngokuvamile kuhlanganisa i-low-dose aspirin ne-heparin injections, eziphephile kokubili umama nomntwana. Uzodinga ukuqapha eduze ngesikhathi sokukhulelwa, kodwa abesifazane abaningi abane-APS bangakwazi ukuthwala izingane zabo kuze kube sekupheleni.
I-APS ingase ibe khona emindenini, kodwa ayidluliselwa ngqo njengezinye izimo zezakhiwo. Ungase uzuze ama-gene akwenza ube sengozini enkulu yokukhula nge-APS, kodwa ukuba nelungu lomndeni eline-APS akusho ukuthi uzokhula ngayo. Uma unemlando womndeni we-APS noma ama-clot egazini, xoxa lokhu nodokotela wakho ukuze uthole ukuhlolwa okufanele.
Nakuba ukuhlupheka kungayibangeli ngokuqondile i-APS, kungase kukhulise ingozi yakho yokwenza ama-clot egazini ngokuthinta isistimu yakho yokuzivikela yomzimba nokukhuphula ukuvuvukala. Ukuphatha ukuhlupheka ngezindlela zokupumula, ukuvivinya umzimba okuvamile, nokulala okwanele kungaba usizo empilweni yakho yonke futhi kungase kusize ukunciphisa ingozi yakho yokwenza ama-clot.
6Mpeople
Get clear medical guidance
on symptoms, medications, and lab reports.