Created at:1/16/2025
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I-Bullous pemphigoid iyisimo sesikhumba esibangelwa ukungasebenzi kahle komzimba lapho kuvela khona amabhabhu amakhulu agcwele amanzi esikhumbeni sakho. Isistimu yakho yokuzikhusela iyahlasela amaprotheni aphilile esikhumbeni sakho, okubangela la mabhabhu abhlungu avame ukuvela ezindaweni ezinjengamakhono, imilenze, nomzimba.
Lesi simo sibathinta kakhulu abadala, ikakhulu labo abaneminyaka engaphezu kwengu-60. Nakuba kungabonakala kukhathaza, i-bullous pemphigoid iyaphatheka ngokunakekelwa komtholampilo okufanele, futhi abantu abaningi bangalawula izimpawu zabo ngokuphumelelayo ngendlela efanele.
Isimpawu esiyinhloko yimabhabhu amakhulu, aqinile avela esikhumbeni sakho. La mabhabhu avame ukuba ubukhulu obungu-1-3 amasentimitha futhi agcwele amanzi acacile, nakuba ngezinye izikhathi angaba namanzi egazi.
Ngaphambi kokuba kuvele amabhabhu, ungase ube nezibonakaliso eziningi zokuqala ezingakusiza ukuthi uqaphele lesi simo ngokushesha:
Amabhabhu ngokwawo anamakha ahlukile awahlukanisa kwamanye amasimo esikhumba. Avame ukuba makhulu, anefomu le-dome, futhi anezingodo ezinzima ezenza kube nzima ukuba aphuleke kalula uma kuqhathaniswa namanye amabhabhu.
Ngokuvamile, uzo bona la mabhabhu emakhonweni, emilenzeni, esifubeni, emuva, nasemathunjini. Avame ukuvela ezindaweni lapho isikhumba sakho siqina khona noma sihlangana nokuqina, njengasezindaweni ezihlangene noma lapho izingubo zicela khona emzimbeni wakho.
Kwezinye izimo, i-bullous pemphigoid ingathinta umlomo wakho, ibangele amabhabhu abhlungu ngaphakathi emathangeni, emagxeni, noma egqokweni. Lokhu kwenzeka cishe ku-10-30% yabantu abanesimo futhi kwenza ukudla noma ukugwinya kube nzima.
Ngokungavamile, ungase uhlushwe yizimpawu ezengeziwe ezifana nokuqeda amandla, ukuthuthumela okuncane, noma ama-lymph nodes avuvukile. Lezi zimpawu zivame ukuvela uma isimo sisakazekile noma ngesikhathi se-flare-ups.
I-Bullous pemphigoid ivela uma uhlelo lwakho lokulwa nezifo luqala ukusebenza kabi futhi luhlasela amaprotheni aphilile esikhunwini sakho. Ngokuqondile, lihlose amaprotheni abizwa nge-BP180 ne-BP230, azihlanganisa izigaba ezahlukene zesikhumba sakho.
Cabanga ngala maprotheni njengolwimi oluhlanganisa izigaba zesikhumba sakho. Uma uhlelo lwakho lokulwa nezifo luwahlasela, izigaba ziyahlukanisana, futhi amanzi agcwalisa isikhala phakathi kwazo, adala lawo mabhula emakhulu ajwayelekile.
Izinto eziningi zingabangela le mpendulo ye-autoimmune, yize imbangela eqondile ingabonakali njalo:
Ubudala buwumsebenzi obalulekile ekuthuthukiseni i-bullous pemphigoid. Uhlelo lwakho lokulwa nezifo luyahlala lushintsha njengoba ukhula, ngezinye izikhathi lube lula ukuhlasela izicubu zakho. Lokhu kuchaza ukuthi isimo sivame kakhulu kubantu abadlula u-60.
Kwezinye izimo ezingavamile, i-bullous pemphigoid ingathuthuka ngaphandle kwanoma iyiphi imbangela ecacile. Ukwakheka kwakho kwe-genetic kungakwenza ube sengozini enkulu, kodwa ngokungafani nezinye izimo ze-autoimmune, ngokuvamile ayidluli ngokushesha emindenini.
Abanye abantu bathuthukisa uhlobo oluqondile lalesi simo oluthinta kuphela indawo eyodwa yomzimba, ngokuvamile kubangelwa ukulimala okuthile noma inqubo yezokwelapha kuleyo ndawo.
Kufanele ubone udokotela ngokushesha uma uthola amabhabhu amakhulu, agcwele amanzi, esihlengeni sakho, ikakhulu uma ehambisana nokukhahlela okukhulu. Ukuxilongwa kwasekuqaleni nokuphathwa kungavimbela izinkinga futhi kukusize uzizwe ukhululekile.
Ungalindi uma ubona amabhabhu amaningi evela ezinsukwini eziningi noma ezemva kwezinsuku. Ngenkathi ezinye izimo zesikhumba zingabonakala zifana, i-bullous pemphigoid idinga ukwelashwa okuqondile okungaphiwa kuphela yisisebenzi sezokunakekelwa kwezempilo.
Funani ukunakekelwa kwezokwelapha okusheshayo uma uhlangabezana nanoma yiziphi lezi zibonakaliso zezexwayiso:
Ngisho noma izimpawu zakho zibonakala zingenamandla, kufanele uzihlolisise. Udokotela wakho angakwahlukanisa i-bullous pemphigoid kwezinye izimo ezibangela amabhabhu futhi aqale ukwelashwa okufanele ngaphambi kokuba isimo sibe sibi.
Uma usuvele uphathwa nge-bullous pemphigoid, xhumana nodokotela wakho uma ubona amabhabhu amasha evela, amabhabhu akhona eba ne-infection, noma uma ukwelashwa kwakho okwamanje kungalawuli izimpawu zakho ngokuphumelelayo.
Ubudala yingqondo enkulu yokuthuthukisa i-bullous pemphigoid. Cishe u-85% wabantu abaxilongwe ngalesi simo baneminyaka engaphezu kwengu-65, futhi ingozi iyakhula kakhulu ngemuva kweminyaka engu-80.
Inkqubo yemvelo yokuguga komzimba wakho ithonya isimiso sakho sokuvikela umzimba nesakhiwo sesikhumba, okwenza abantu abadala babe sengozini yokulimala kwezifo zesikhumba ezizimele njenge-bullous pemphigoid.
Izimo eziningi zezokwelapha zingandisa ingozi yakho yokuthuthukisa i-bullous pemphigoid:
Imithi ethile ingabangela i-bullous pemphigoid, ikakhulukazi uma ubuyiphuza isikhathi eside. Lezi zihlanganisa i-diuretics (amaphilisi amanzi), ama-ACE inhibitors wegazi, amanye ama-antibiotics, kanye nezinye izidakamizwa zokulwa nokuvuvukala.
Izici zokwenyama zingakhuphula nezingozi zakho. Ukwelashwa ngomgqomo wangaphambili, ukushisa okukhulu, noma ukuhlinzwa okukhulu ngezinye izikhathi kungabangela lesimo ezinyangeni noma ngisho neminyaka kamuva. Ukukhanya kwe-UV kanye nokuvuvukala okungamahlalakhona kwesikhumba kungase futhi kudlale indima.
Ngokungafani nezinye izimo ze-autoimmune, i-bullous pemphigoid ayina-genetic component eqinile. Ukuba nelungu lomndeni olunelesimo akuwukhulisi kakhulu ubungozi bakho, yize abanye abantu bangase babe nokuthambekela kwe-genetic ezimweni ze-autoimmune ngokujwayelekile.
Ngokuthakazelisayo, abantu abanezinye izimo zezinzwa, ikakhulukazi lezo ezithinta inkumbulo kanye nokuqonda, banengozi enkulu yokuthuthukisa i-bullous pemphigoid. Abacwaningi basafunda ukuthi kungani lobu buhlobo bukhona.
Abantu abaningi abane-bullous pemphigoid bangaphatha lesimo labo kahle ngokwelashwa okufanele, kepha ezinye izinkinga zingase zivele uma lesimo lingalawulwa kahle. Ukuqonda lezi zinto kukunceda ubone ukuthi nini kufanele ufune ukunakekelwa okwengeziwe kwezokwelapha.
Izinkinga ezivame kakhulu zihilela amablistere ngokwabo nokuthi athinta kanjani impilo yakho yansuku zonke:
Izinkinga zokudla zingase zenzeke uma i-bullous pemphigoid ithonya umlomo nomphimbo wakho. Amabhabhu abuhlungu angenza ukudla nokuphuza kube nzima, okungenzeka kube yimbangela yokulahlekelwa isisindo, ukuphelelwa amanzi, noma ukungondliwe kahle, ikakhulu kubantu abadala.
Imithi esetshenziswa ukwelapha i-bullous pemphigoid ngezinye izikhathi ingabangela imiphumela emibi, ikakhulukazi uma isetshenziswa isikhathi eside. I-Corticosteroids, evame ukudingeka ekwelapheni, ingathinta ubukhulu lwamathambo akho, amazinga okusanhlamvu kwegazi, kanye nesistimu yakho yokuzikhuza ngokuhamba kwesikhathi.
Kwezinye izikhathi ezingavamile, i-bullous pemphigoid ebanzi ingabangela izinkinga ezinzima kakhulu. Lokhu kuhlanganisa ukulahlekelwa okukhulu kwamanzi ngamabhabhu aphukile, ukungalingani kwama-electrolyte, kanye nokukhuluphala komngcipheko wokutheleleka okukhulu ngenxa yokusebenza okungaphansi kwesikhumba.
Umphumela womzwelo nowengqondo akufanele uhlale ungabonakali. Ukubonakala kwamabhabhu, ukungakhululeki okuqhubekayo, kanye namabala angase abe khona kungathinta ukuzethemba kwakho kanye nekhwalithi yokuphila, ngezinye izikhathi kuholele ekudidekeni noma ekuhlukaniseni komphakathi.
Kwezinye izikhathi ezingavamile, i-bullous pemphigoid ingaba yingozi eyingozi, ikakhulu kubantu abadala noma ababuthakathaka. Lokhu ngokuvamile kwenzeka uma isimo sibanzi, sibe nokutheleleka okukhulu, noma uma kuvela izinkinga ezivela emithini yokwelapha.
Ukuhlola i-bullous pemphigoid kudinga ukuhlanganiswa kokuhlolwa ngamehlo, umlando wezokwelapha, nezivivinyo ezikhethekile. Udokotela wakho uzoqala ngokuhlola ngokucophelela amabhabhu akho bese ebuza ukuthi aqale nini futhi ashintshe kanjani ngokuhamba kwesikhathi.
Ukubonakala nendawo zamabhabhu akho kunikeza izinkomba ezibalulekile, kodwa ezinye izimo zesikhumba zingabonakala zifana, ngakho-ke ukuhlolwa okuqhubekayo kuvame ukudingeka ukuze kutholakale ukuxilongwa okuqinisekile.
Udokotela wakho cishe uzokwenza le mihlola yokuxilonga ukuze aqinisekise i-bullous pemphigoid:
I-biopsy yesikhumba ngokuvamile iwumviwo obaluleke kakhulu. Udokotela wakho uzothatha ingxenye encane yesikhumba ehlanganisa kokubili ibhabhu nesikhumba esijwayelekile esizungezile. Lokhu liqondisa ukubona ingxenye eqondile lapho ukuhlukaniswa kwenzeka khona futhi kuvimbele ezinye izimo zamabhabhu.
Ukuhlolwa kwegazi kungathola ama-antibodies athile abangela i-bullous pemphigoid cishe ku-70-90% yabantu abanesimo. Amazinga aphezulu ama-antibody avame ukuxhumana nesifo esinamandla kakhulu, futhi la mazinga angalandelelwa ukuze kulandelelwe impendulo yokwelashwa.
Ngezinye izikhathi udokotela wakho angadingeka ukuthi aphikise ezinye izimo ezingabangela amabhabhu afanayo, njenge-pemphigus vulgaris, i-epidermolysis bullosa acquisita, noma i-linear IgA disease. Yilowo nalowo wesimo udinga izindlela zokwelapha ezahlukene.
Inkqubo yokuxilonga ngokuvamile ithatha izinsuku ezimbalwa kuya kwesonto, kuye ngokushesha kokutholakala kwemiphumela yelabhorethri. Ngalesi sikhathi, udokotela wakho angaqala ukwelashwa okuqala ukuze akusize ulawule izimpawu zakho ngenkathi ulinde ukuqinisekiswa.
Ukuphathwa kwe-bullous pemphigoid kugxile ekunciphiseni isimiso sakho sokugcina umzimba siphilile ukuvimbela amabhubhu amasha ukuba angabunjwa futhi usize amanye aqale ukwelapha. Abantu abaningi bayaphendula kahle ekwelapheni, nakuba kungase kudingeke izinsuku ezimbalwa ukubona ukuthuthuka okukhulu.
Udokotela wakho cishe uzoqala nge-corticosteroids yendawo noma emlonyeni, eziyizindlela zokwelapha ezisebenza kakhulu zokuqala zokulawula impendulo ye-autoimmune ebangela i-bullous pemphigoid.
Izindlela zokwelapha ezivamile zihlanganisa:
Nge-bullous pemphigoid ehlala endaweni ethinta izindawo ezincane kuphela, udokotela wakho angase afake ama-steroids amandla endaweni njengokwelapha okuyinhloko. Lezi zingasebenza kakhulu futhi zinama-side effects ambalwa kunokwelapha ngomlomo.
Uma unezibhubhu eziningi, i-corticosteroids emlonyeni idingeka ngokuvamile ekuqaleni. Udokotela wakho ngokuvamile uzoqala ngenani elikhulu ukuze alawule isimo, bese kancane kancane unciphise inani kuya kwelinani elincane elihlala lilawula izimpawu zakho.
Abantu abaningi badinga ukwelashwa okuhlangene, ikakhulukazi ngokuphathwa kwesikhathi eside. Udokotela wakho angase afaka imithi yokucindezela isimiso sokugcina umzimba siphilile ukusiza ukunciphisa inani lama-steroids odinga wona, kunciphisa ama-side effects avela ekusetshenzisweni kwama-steroids isikhathi eside.
Impendulo yekwelapha iyahlukahluka kubantu, kodwa abantu abaningi bayabona ukwakheka kwamathambo amasha kuyeka phakathi kwamasonto angu-2-4 ngokuqala kokwelapha. Ukuphulukiswa okuphelele kwamathambo akhona kungathatha izinyanga eziningi, futhi abanye abantu badinga ukwelashwa okuqhubekayo kokugcina ukuvimbela ukubhebhetheka.
Ezimweni ezingavamile lapho ukwelashwa okujwayelekile kungasebenzi kahle, udokotela wakho angase acabangele ukwelashwa okusha njenge-immunoglobulin ye-intravenous (IVIG) noma i-plasmapheresis, okuhilela ukuhlunga ama-antibodies egazini lakho.
Ukukhathalela ekhaya kudlala indima ebalulekile ekuqondiseni i-bullous pemphigoid kanye nokwelashwa kwakho kwezokwelapha. Ukukhathalela okuhle kwesilonda nokulungiswa kwendlela yokuphila kungasiza ukuvimbela izinkinga futhi kukwenze ukhululeke ngesikhathi sokwelashwa.
Ukukhathalela amathambo akho kahle kubalulekile ukuvimbela ukutheleleka nokukhuthaza ukuphulukisa. Gcina indawo icocekile futhi yomile, futhi gwema imisebenzi engase iholele ekubhebhethekeni kwamathambo ngokushesha.
Nawa amasu abalulekile okunakekela ekhaya:
Ukuqondisa ukukhahlela kuvame ukuba omunye wemisebenzi enzima kakhulu yokuphila ne-bullous pemphigoid. Ama-compress abandayo anganika impumuzo yesikhashana, futhi ukugcina iinzipho zakho zimfushane kusiza ukuvimbela ukulimala ngokukracula.
Ukudla kwakho kungadlala indima yokusekela ekuphulukiseni kwakho. Ukudla ukudla okunamaprotheni amaningi kusiza isikhumba sakho siphulukise, kuyilapho ukuhlala unamanzi okuhle kusekela impilo yonke yesikhumba. Uma unemathambo emlonyeni, ukudla okuthambile, okubandayo kuvame ukuba kulula.
Qaphela izimpawu zokutheleleka eduze kwamafinyila akho, njengokwanda kokubomvu, ukushisa, ukukhula, noma ithusi. Xhumana nodokotela wakho ngokushesha uma ubona lezi zimpawu, njengoba ukutheleleka kunganciphisa ukuphulukisa futhi kubangele izinkinga.
Ukuzivocavoca okuthambile, njengoba kukhuthazwa, kungasiza ekuqondiseni impilo yakho jikelele nengqondo ngesikhathi sokwelashwa. Noma kunjalo, gwema imisebenzi ebangela ukukhishwa okukhulu kwesikhumba noma ukusulela ezindaweni zesikhumba ezibuhlungu.
Gcina idayari yezimpawu ukuze uqaphele intuthuko yakho futhi ubone noma yiziphi izindlela eziqhumayo. Lolu lwazi lungaba lubalulekile eqenjini lakho lokunakekelwa kwezempilo ekulungiseni uhlelo lwakho lokwelapha.
Ukulungiselela isikhathi sakho sokuhlangana kusiza ukuqinisekisa ukuthi uthola ukuxilongwa okuchane kakhulu nehlelo lokwelapha eliphumelelayo. Letha uhlu oluphelele lwemithi yakho yamanje, kufaka phakathi izithasiselo ezithengiswayo, njengoba ezinye zingase zibangele noma zenzima i-bullous pemphigoid.
Bhala ngokucophelela izimpawu zakho ngaphambi kokuvakashela kwakho. Qaphela ukuthi amafinyila avele nini okokuqala, indlela ashintshile ngayo, nokuthi yini eyenza kube ngcono noma kubi. Izithombe zingasiza, ikakhulukazi uma amafinyila akho ashintshile kusukela uqalise ukubhuka isikhathi sokuhlangana.
Lungiselela lolu lwazi ngodokotela wakho:
Bhala imibuzo ethile ofuna ukuyibuza, njengokuthi yini okufanele uyilindele ekwelapheni, imiphumela emibi yemithi, nokuthi unganakekela kanjani amafinyila akho ekhaya. Unganqikazi ukubuza noma yini ekukhathazayo.
Uma kungenzeka, letha ilungu lomndeni noma umngani wakho lapho uya khona. Bangakusiza ukuba ukhumbule ulwazi olubalulekile futhi bakunike ukwesekwa, ikakhulu uma uzizwa ucindezelekile ngalokho okubhekene nakho.
Lungela ukuxoxa ngekhwalithi yokuphila kwakho ngokwethembeka. Tshela udokotela wakho ukuthi lesi simo siyakuthinta kanjani ukulala kwakho, imisebenzi yansuku zonke, nokuthula kwakho kwengqondo. Lolu lwazi luyabasiza ukuthi baqonde ngokugcwele ithonya lesimo sakho.
Buza ngokunakekelwa okulandelayo nokuthi yiziphi izimpawu okumele zikwenze ucingo ngaphambi kokubonisana kwakho okulandelayo. Ukuqonda ukuthi nini kufanele ufuna ukunakekelwa okusheshayo kungavimbela izinkinga futhi kukunikeze ukuthula kwengqondo.
I-Bullous pemphigoid iyisimo esiphatheka kahle sesikhumba esibangelwa yi-autoimmune esithinta ikakhulu abadala. Nakuba amabhabhu amakhulu angabonakala esesabekayo, abantu abaningi bayaphendula kahle ekwelapheni futhi bangazuza ukulawulwa okuhle kwezimpawu zabo ngokunakekelwa komtholampilo okufanele.
Ukuxilongwa kwasekuqaleni nokwelashwa kubalulekile ukuze kuzuzwe imiphumela emihle. Uma ubona amabhabhu amakhulu, ahlala njalo esikhumbeni sakho, ikakhulukazi ngokukhahlela okukhulu, ungangabazi ukuya kudokotela ngokushesha.
Lesi simo sidinga ukulawulwa komtholampilo oluqhubekayo, kodwa ngendlela yokwelapha efanele, abantu abaningi bangagcina bekulukhwalithi oluhle lokuphila. Iqembu lakho lokunakekelwa kwezempilo lizohlangana nawe ukuthola uhlelo lokwelapha oluphumelelayo ngenkathi kunciphisa imiphumela emibi.
Khumbula ukuthi i-bullous pemphigoid ayithwali, futhi ngokunakekelwa okufanele, izinkinga zivame ukuvinjelwa. Hlala uxhumene nabaphakeli bakho bezempilo, landela uhlelo lwakho lokwelapha ngokuqhubekayo, futhi ungangabazi ukuxhumana nabo uma unokukhathazeka ngesimo sakho.
Cha, i-bullous pemphigoid aliwuhlaseleli nhlobo. Iyisimo sesistimu yokuzivikela yomzimba lapho i-immune system yakho ihlasela khona isikhumba sakho, hhayi ukutheleleka okungadluliselwa kwabanye. Awukwazi ukuyithola komunye umuntu, futhi awukwazi ukuyinikeza amalungu omndeni noma abangane ngokuthinta.
I-bullous pemphigoid ngokuvamile ihlala iminyaka eyi-1-5 ngokwelashwa, nakuba lokhu kuhluka kakhulu phakathi kwabantu. Abanye abantu bafinyelela ekubuyiselweni ngaphakathi kwezinyanga, kanti abanye badinga ukwelashwa okuqhubekayo iminyaka eminingi. Cishe amaphesenti angu-30-50 abantu ababona ukubuyiselwa okuphelele ngaphakathi kweminyaka engu-2-3 beqale ukwelashwa.
Nakuba kungekho ukwelashwa okuhlala njalo kwe-bullous pemphigoid, abantu abaningi bafinyelela ekubuyiselweni isikhathi eside lapho bengenawo amabhubhu asebenzayo futhi abadingi ukwelashwa. Abanye abantu abazange babe nokuqhuma okunye ngemuva kwesikhathi sabo sokwelashwa sokuqala, kanti abanye bangadinga ukwelashwa okuqhubekayo ukuvimbela ukubuyela.
Awekho ukudla okuthile okufanele ukugweme nge-bullous pemphigoid, njengoba ukudla ngokuvamile kungabangeli ukuqhuma. Kodwa-ke, uma unemibhubhu emlonyeni, ungase uthole ukudla okunoshukela, okunomsoco, noma okunembobo kungabi nhlanhla. Gxila ekudleni ukudla okulinganiselayo okunamaprotheni amaningi ukuze usekele ukululama kwesikhumba.
Ukucindezeleka kungase kubangele ukuqhuma kwe-bullous pemphigoid noma kwenze izimpawu ezikhona zibe zimbi, njengoba ukucindezeleka kuchaphazela i-immune system yakho. Nakuba ukucindezeleka kudwa kungabangeli lesimo, ukuphatha ukucindezeleka ngezindlela zokupumula, ukulala okwanele, nokusekelwa ngokomzwelo kungaba usizo ohlelweni lwakho lokwelashwa oluphelele.