Ukuthi yini i-Choroid Plexus Carcinoma? Izimpawu, Izimbangela, kanye Nokwelashwa

I-Choroid plexus carcinoma iyisigxobo esingavamile sobuchopho esikhula ku-choroid plexus, inyama evelisa i-cerebrospinal fluid ebuchosheni bakho. Leli futhi lisebenza njengophahla oluvikelayo oluzungezile ubuchopho bakho kanye nomgogodla wakho, lugobhoza ngamakhamera akhethekile okuthiwa ama-ventricles.

Nakuba igama lingase lizwakale liyesabekisa, ukuqonda lesi simo kungakusiza uzizwe ulungile futhi unolwazi. Lezi zigxobo azivamile kakhulu, zithinta abantu abangaphansi kuka-1 kwabathathu ubuningi, futhi ziveleka kakhulu kubantwana abancane abangaphansi kweminyaka emi-5.

Ukuthi yini i-Choroid Plexus Carcinoma?

I-Choroid plexus carcinoma iyisigxobo esibi esikhula ezintweni ze-choroid plexus. Cabanga nge-choroid plexus njengezitsha ezincane, ezikhethekile ezingaphakathi kobuchopho bakho ezakha i-cerebrospinal fluid.

Lesi sigxobo siyingxenye yeqembu okuthiwa yi-choroid plexus tumors, ezingaba yi-benign (ezingezona ezimbi) noma ezimbi (ezimbi). Ama-Carcinomas yi-malignant type, okusho ukuthi angakhula ngokushesha futhi asabalale kwezinye izingxenye zobuchopho noma umgogodla.

Isigxobo siyaphazamisa ukukhiqizwa okujwayelekile kwe-fluid kanye nokugeleza, okungabangela ukwakheka kwe-cerebrospinal fluid ebuchosheni. Lesi simo, okuthiwa yi-hydrocephalus, sidalela ukucindezela okukhulu ngaphakathi kwendlu yekhanda futhi sibangela izimpawu eziningi abantu abazibona.

Ziyini Izimpawu ze-Choroid Plexus Carcinoma?

Izimpawu ze-choroid plexus carcinoma zikhula ngoba isigxobo sivala ukopha kwe-fluid okujwayelekile ebuchosheni, sidala ukucindezela. Njengoba lezi zigxobo zithinta kakhulu izingane ezincane kanye nabantwana abancane, izibonakaliso zingase zibe buthakathaka ekuqaleni.

Izimpawu ezivamile ongazibona zihlanganisa:

• Ukuphindaphinda ubukhulu bekhanda kubantwana (macrocephaly)
• Ukugabha okuqhubekayo, ikakhulukazi ekuseni
• Ubuhlungu bekhanda obukhulu obukhula ngokuhamba kwesikhathi
• Ukucasuka okungavamile noma ukushintsha kokuziphatha
• Ubunzima bokuqondana noma ukuhamba
• Izinkinga zobono noma ukushintsha kokunyakaza kwamehlo
• Ukuhlushwa okuvela ngokuzumayo
• Ukulala okukhulu noma ukudinwa

Kubantwana, ungase futhi ubone ama-soft spots ekhanda labo (fontanelles) ephuma ngaphandle noma eba lukhulu. Abanye abantwana bangase babe nobunzima bokuthola ukudla noma babonakale bekhungathekile ngaphandle kwesizathu esicacile.

Izimpawu ezingavamile kodwa ezinzima zingabandakanya ubuthakathaka ohlangothini olulodwa lomzimba, ubunzima bokukhuluma, noma ukushintsha koqapheko. Lezi zimpawu zivame ukuvela kancane kancane ezinyangeni ezimbalwa njengoba isigxobo sikhula futhi ukucindezela kukhula.

Yini ebangela i-Choroid Plexus Carcinoma?

Imbangela eqondile ye-choroid plexus carcinoma ayikaziwa kakhulu, okungase kuzwakale kuyadumaza uma ufuna izimpendulo. Njengezinye izifo eziningi zekhanda, kubonakala sengathi zikhula ekuchithweni okungahleliwe kwe-DNA ye-choroid plexus cells.

Kodwa-ke, abacwaningi baye baqaphela ezinye izinto ezifana ne-genetic ezingase zikhulise ingozi. Ukuhlangana okubaluleke kakhulu kuhilela i-Li-Fraumeni syndrome, isifo esidluliselwa ezizukulwaneni esingavamile esibangelwa ukuguqulwa kwe-TP53 gene. Imindeni enalesi simo inenzuzo enkulu yokuthuthukisa izifo eziningi zekhanda, kufaka phakathi i-choroid plexus carcinomas.

Ezinye izifundo zikhomba ukuthi ezinye izifo ze-viral phakathi kokukhulelwa zingase zidlale indima, kodwa lobu buhlobo abubonakali ngokuqinisekile. Izinto ezingaphandle azixhunyaniswanga ngokucacile nalezi zigxobo, futhi azibonakali zibangelwa yilutho abazali abalwenzile noma abangazange balwenze phakathi kokukhulelwa.

Into ebalulekile okumele uyiqonde ukuthi lezi zigxobo zikhula ngokungahleliwe ezimweni eziningi. Azibangelwa izinqumo zokuphila, ukudla, noma ukudalulwa kwemvelo okwakungavinjelwa.

Nini Okufanele Ubone Udokotela Nge-Choroid Plexus Carcinoma?

Kufanele ufuna ukunakekelwa kwezokwelapha ngokushesha uma ubona izimpawu eziqhubekayo ezikhomba ukucindezela okukhulu ebuchosheni, ikakhulukazi kubantwana abancane. Themba intuthuko yakho njengomzali noma umnakekeli.

Xhumana nodokotela wakho ngokushesha uma ubona ubuhlungu bekhanda obukhulu noma obukhulu, ukugabha okuphindaphindayo, ukushintsha kobono, noma ukuhlushwa okusha. Kubantwana, ukukhula kwekhanda okusheshayo, ama-soft spots aphapheme, noma ukushintsha okukhulu ekudleni noma ekuziphatheni kudinga ukulinganiswa okusheshayo.

Ungalindi uma izimpawu zibonakala ziba zimbi ezinsukwini noma emavikeni. Nakuba eziningi zalezi zimpawu zingaba nezizathu ezingathí sina, izigxobo zobuchopho zidinga ukuxilongwa okusheshayo nokwelashwa ukuze kuzuzwe imiphumela emihle.

Uma ingane yakho iye yaxilongwa nge-Li-Fraumeni syndrome noma inemlando womndeni walesi simo, xoxa ngokuhlola okujwayelekile neqembu lakho lezokunakekelwa kwezempilo. Ukutholakala kwangaphambi kwesikhathi kungenza umehluko omkhulu ekuphumeleleni kokwelashwa.

Ziyini Izinto Ezingaba Ingozi Ye-Choroid Plexus Carcinoma?

Izinto ezingaba yingozi ye-choroid plexus carcinoma zimingcono kakhulu, okuveza ukuthi lezi zigxobo zingavamile kangakanani futhi azikwazi ukubikezelwa. Ukuqonda lezi zinto kungakusiza ubeke isimo sakho ngendlela efanele.

Izinto eziyinhloko ezingaba yingozi zihlanganisa:

• Ubudala obukhulu, ikakhulukazi ukuba ngaphansi kweminyaka emi-5
• Ukuba ne-Li-Fraumeni syndrome noma i-TP53 gene mutations
• Umlando womndeni we-Li-Fraumeni syndrome
• Ukudalulwa kwangaphambili kwe-radiation ekhanda (kungavamile kakhulu)

Ubudala yiyona nto ebaluleke kakhulu, ngoba cishe u-70% walezi zigxobo ziveleka kubantwana abangaphansi kweminyaka emi-2. Ingozi iyancipha kakhulu ngemuva kweminyaka emi-5, futhi lezi zigxobo azivamile kakhulu kubantu abadala.

Izinto ze-genetic, nakuba kubalulekile uma zikhona, zibala kuphela ingxenye encane yezimangalo. Abantwana abaningi abathuthukisa i-choroid plexus carcinoma abanazo izinto ezingaba yingozi ezaziwayo, okusho ukuthi lezi zigxobo zivame ukuvela ngokungahleliwe.

Ziyini Izingozi Ezingase Zivele Ngokusebenzisa i-Choroid Plexus Carcinoma?

Izingozi ezivela ku-choroid plexus carcinoma zivelela kakhulu ekucindezeleni okukhulu ebuchosheni nendawo yesigxobo eduze kwezakhiwo ezibalulekile. Ukuqonda lezi zinto kungakusiza ukulungiselela lokho okuzayo.

Izingozi eziqondile zihlanganisa:

• I-Hydrocephalus edinga ukopha okuhlinzwayo
• Izinkinga zobono noma ubuthakathaka ngenxa yokucindezela emithanjeni yobono
• Ukulibaziseka kokukhula kubantwana abancane
• Izifo zokuhlasela ezingase ziqhubeke ngemuva kokwelashwa
• Ubuthakathaka noma ukuqina ngenxa yokucindezela ezindaweni zemoto
• Ukulahlekelwa ukuzwa ngenxa yokucindezela emizileni yokuzuma

Izingozi zesikhathi eside zingabandakanya imiphumela yokuqonda, ikakhulukazi kubantwana abancane abanawobuchopho obulokhu buthuthuka. Abanye abantwana bangase babe nobunzima bokufunda, izinkinga zememori, noma ukulibaziseka ekufinyeleleni izigaba zokukhula.

Izingozi ezihlobene nokwelashwa nazo ziyakwazi, kufaka phakathi imiphumela evela ekuhlinzweni, i-chemotherapy, noma i-radiation therapy. Kodwa-ke, iqembu lakho lezokwelapha lizozama ngokucophelela ukunciphisa lezi zingozi ngenkathi liwelapha isigxobo ngokuphumelelayo.

Ukuthi yini i-Choroid Plexus Carcinoma?

Ukuthola i-choroid plexus carcinoma kuhilela izinyathelo eziningi, kuqale ngomlando wezokwelapha ophelele kanye nokuhlolwa komzimba. Udokotela wakho uzobuza ngezimpawu futhi angase enze ukuhlolwa kwe-neurological ukuze ahlole izinto eziphindaphindayo, ukuqondana, kanye nomsebenzi wobuchopho.

Ithuluzi elibaluleke kakhulu lokuthola i-diagnosis yi-magnetic resonance imaging (MRI) yobuchopho. Le scan eningiliziwe ingabonisa ubukhulu besigxobo, indawo, kanye nobuhlobo nezakhiwo zobuchopho ezizungezile. I-MRI iyasiza futhi ekubeni i-hydrocephalus kanye nokulungiselela izindlela zokwelapha.

I-Computed tomography (CT) scan ingase isetshenziswe ekuqaleni, ikakhulukazi ezimweni eziphuthumayo, kodwa i-MRI inikeza ulwazi olunemininingwane eminingi. Udokotela wakho angase futhi ayalele i-MRI yomgogodla ukuze ahlole ukuthi isigxobo sisabalale yini.

I-diagnosis eqinisekisiwe idinga isampula yenyama, evame ukutholakala ngesikhathi sokuhlinzwa ukususa isigxobo. I-pathologist ihlola le nyama ngaphansi kwesikhombi ukuze iqinisekise i-diagnosis futhi ibone izici ezikhethekile zesigxobo.

Ukuhlolwa okwengeziwe kungabandakanya ukuhlolwa kwe-genetic ukuze kufunwe i-Li-Fraumeni syndrome, ikakhulukazi uma kunomlando womndeni wekhanda. Ukuhlaziywa kwe-cerebrospinal fluid kungase futhi kwenziwe ukuze kufunwe izicubu zesigxobo.

Ukwelashwa kwe-Choroid Plexus Carcinoma?

Ukwelashwa kwe-choroid plexus carcinoma kuvame ukubandakanya indlela yeqembu, ukuhlanganisa ukuhlinzwa, i-chemotherapy, kanye ngezinye izikhathi i-radiation therapy. Uhlelo oluthile luxhomeke ebudaleni bengane yakho, ubukhulu nendawo yesigxobo, nokuthi sisabalale yini.

Ukuhlinzwa kuvame ukuba yisinyathelo sokuqala, sihlose ukususa ingxenye enkulu yesigxobo ngangokunokwenzeka. Ukususwa okuphelele kunikeza ithuba elihle kakhulu lokuphulukisa, nakuba lokhu kungekho njalo okungenzeka ngenxa yendawo yesigxobo eduze kwezakhiwo ezibalulekile zobuchopho.

I-Chemotherapy ilandela ukuhlinzwa ezimweni eziningi, isebenzisa imithi ehlose izicubu zekhanda emzimbeni wonke. Imithi ethile nesikhathi sokuqhubeka kuxhomeke ezintweni ezifana nobudala bengane yakho nokuthi kungakanani isigxobo esisusiwe ngesikhathi sokuhlinzwa.

I-Radiation therapy ingase icelwe kubantwana abadala, ngokuvamile labo abangaphezu kweminyaka emi-3 ubudala, ikakhulukazi uma isigxobo singakwazanga ukususwa ngokuphelele. Kodwa-ke, i-radiation ivame ukugwenywa kubantwana abancane kakhulu ngenxa yemiphumela engase ibe khona ebuchosheni obuthuthukayo.

Uma i-hydrocephalus ikhona, ingane yakho ingase idinge i-shunt, idivayisi encane ephuma i-cerebrospinal fluid engaphezulu ebuchosheni kwenye ingxenye yomzimba. Le nqubo inganikeza ukukhululeka okusheshayo ezimpawu ezibangelwa ukucindezela okukhulu ebuchosheni.

Ukuthi Ungayiphatha Kanjani Ukunakekelwa Kwasekhaya Phakathi Kokwelashwa?

Ukuphatha ukunakekelwa kwasekhaya phakathi kokwelashwa kudinga ukuzeka kade umsindo, ukuhleleka, kanye nokuqondana okuqinile neqembu lakho lezokwelapha. Ukudala indawo yokusekela kungasiza ingane yakho ukuba ibhekane nezinselele zokwelashwa.

Gxila ekuqondeni izinto ezijwayelekile ngangokunokwenzeka ngenkathi uqina uma imiphumela yokwelashwa iphazamisa. Gcina ulandelela izimpawu, imithi, nanoma yikuphi ukushintsha okuqaphelayo, njengoba lolu lwazi lusiza iqembu lakho lezokunakekelwa kwezempilo ukulungisa ukwelashwa njengoba kudingeka.

Ukudla kuba yinto ebalulekile ngesikhathi sokwelashwa. Sebenza nodokotela wokudla ukuqinisekisa ukuthi ingane yakho ithola ama-calories anele kanye nezondlo, ngisho noma isisindo sibuthakathaka. Ukudla okuncane, okuvamile kuvame ukusebenza kangcono kunokudla okukhulu.

Qaphela izimpawu zokutheleleka, ezifana nokuqhuma, ukudinwa okungavamile, noma ukushintsha kokuziphatha, njengoba i-chemotherapy ingase iyanciphise i-immune system. Xhumana neqembu lakho lezokwelapha ngokushesha uma ubona izimpawu ezinkulu.

Ungakhohlwa ukunakekela wena kanye namanye amalungu omndeni phakathi nalesi sikhathi esinzima. Yamukela usizo lwabangani nomndeni, futhi cabanga ngokuxhumana namaqembu okusekela noma izinsizakalo zokwelulekwa.

Ukuthi Ungazilungiselela Kanjani Imihlangano Yakho Nodokotela?

Ukulungiselela imihlangano yezokwelapha kungakusiza ukuba wenze okuningi ngesikhathi sakho neqembu lezokunakekelwa kwezempilo futhi uqinisekise ukuthi imibuzo ebalulekile iphendulwa. Qala ngokubhala zonke izimpawu ozibonile, kufaka phakathi ukuthi zaqala nini nokuthi zishintshe kanjani.

Letha uhlu lwemithi yonke, izithasiselo, kanye nokwelashwa ingane yakho elikwamukelayo njengamanje. Faka izilinganiso nesikhathi, njengoba lolu lwazi lusiza odokotela ukugwema ukusebenzisana okungase kube yingozi.

Lungiselela imibuzo yakho kusengaphambili, ugxile ezinkingeni ezibaluleke kakhulu kuqala. Cabanga ukubuza ngezinketho zokwelashwa, imiphumela okulindelekile, imiphumela engase ibe khona, kanye nendlela yokuphatha izimpawu ekhaya.

Letha ilungu lomndeni othembekile noma umngani emihlanganweni uma kungenzeka. Bangasiza ukukhumbula ulwazi oluxoxwe futhi banikeze ukusekela ngokomzwelo phakathi kokuxoxa okuyinselele.

Unganqikazi ukucela ulwazi olubhaliwe noma izinsiza mayelana nesimo sengane yakho. Imindeni eminingi ikuthola kuwusizo ukurekhoda izingxenye ezibalulekile zengxoxo (ngemvume) ukuze ibuyekeze kamuva.

Iyini Into Ebaluleke Kakhulu Mayelana ne-Choroid Plexus Carcinoma?

I-Choroid plexus carcinoma iyisigxobo esingavamile kodwa esinzima sobuchopho esithinta kakhulu abantwana abancane. Nakuba i-diagnosis ingase izwakale iyadumaza, ukuthuthuka kokwelashwa kuye kwathuthukisa kakhulu imiphumela eminingi yabantwana abanesimo.

Ukuqaphela kwangaphambi kwesikhathi kwezimpawu kanye nokunakekelwa kwezokwelapha okusheshayo kubalulekile ukuze kuzuzwe imiphumela emihle kakhulu. Ukuhlanganiswa kokwelashwa, i-chemotherapy, kanye nokunakekelwa okusekela kunikeza ithemba emindenini eminingi ebhekene naleli lungiselelo.

Khumbula ukuthi isimo sangane ngayinye sihlukile, futhi iqembu lakho lezokwelapha lizozama nawe ukwakha uhlelo lokwelashwa olufanele kakhulu. Unganqikazi ukubuza imibuzo, ufuna imibono yesibili, noma ucele ukusekelwa okwengeziwe uma ukudinga.

Nakuba uhambo oluzayo lungase lube yinselele, awulwi ludwa. Ama-centers wokwelashwa kwezifo zekhanda kubantwana anamaqembu akhethekile anamava ekwelapheni lezi zigxobo ezingevamile nokusekela imindeni kuwo wonke inqubo.

Imibuzo Evamile Ebuzwayo Mayelana ne-Choroid Plexus Carcinoma

Q.1 Ingakanani i-choroid plexus carcinoma?

I-Choroid plexus carcinoma ayivamile kakhulu, ithonya abantu abangaphansi kuka-1 kwabathathu ubuningi. Ibala ingxenye engaphansi kuka-1% yazo zonke izigxobo zobuchopho kanye cishe u-2-5% yezigxobo zobuchopho zabantwana. Izimo eziningi ziveleka kubantwana abangaphansi kweminyaka emi-5, ngokwanda okukhulu kubantwana abangaphansi kweminyaka emi-2 ubudala.

Q.2 Iyini izinga lokuphila le-choroid plexus carcinoma?

Izinga lokuphila liyahluka kakhulu ngokuya ngezinto ezifana nobudala bengane, ukwanda kokususa okuhlinzwayo, kanye nokuphendula ekwelapheni. Ngokuvamile, izinga lokuphila leminyaka emi-5 liphakathi kuka-40-70%, ngemiphumela emihle uma isigxobo singasuswa ngokuphelele ngokuhlinzwa. Abantwana abaxilongwe ebudaleni obukhulu kanye nalabo abanawo amasigxobo asuswe ngokuphelele bavame ukuba nemiphumela emihle.

Q.3 Ingabe i-choroid plexus carcinoma ingasabalala kwezinye izingxenye zomzimba?

I-Choroid plexus carcinoma ingasabalala ngaphakathi kwesistimu yezinzwa eziyinhloko ngemizila ye-cerebrospinal fluid, okungase kuthinte ezinye izingxenye zobuchopho noma umgogodla. Kodwa-ke, ukusabalala ngaphandle kwesistimu yezinzwa kwezinye izitho kuyinto engavamile kakhulu. Yingakho odokotela bavame ukuhlola umgogodla nge-MRI futhi bangase bahlaziye i-cerebrospinal fluid ngesikhathi sokuthola i-diagnosis.

Q.4 Ingane yami iyoba nemiphumela yesikhathi eside ngemuva kokwelashwa?

Imiphumela yesikhathi eside ixhomeke ezintweni eziningi kufaka phakathi indawo yesigxobo, ubukhulu bokuthuthukiswa kokwelashwa, nobudala bengane ngesikhathi sokuthola i-diagnosis. Abanye abantwana baba nezinqubo zokuqonda, ubunzima bokufunda, noma ukulibaziseka kokukhula, kanti abanye baphila ngokuphelele. Ukulandelela okujwayelekile nochwepheshe kusiza ukulandelela ukuthuthuka nokwenza ukusebenzisana kwangaphambi kwesikhathi uma kudingeka.

Q.5 Ingabe i-choroid plexus carcinoma iyefa?

Izimo eziningi ze-choroid plexus carcinoma ziveleka ngokungahleliwe futhi azidluliselwa ezizukulwaneni. Kodwa-ke, cishe u-10-15% yezimangalo zihlangene ne-Li-Fraumeni syndrome, i-hereditary cancer predisposition syndrome ebangelwa yi-TP53 gene mutations. Uma ingane yakho ixilongwe ngalesi sigxobo, ukwelulekwa kwe-genetic kungase kucelelwe ukuhlola ingozi yomndeni.