Iyini i-Lynch Syndrome? Izimpawu, Izimbangela, & Ukwelashwa

I-Lynch syndrome iyisimo sezofuzo esandisa kakhulu amathuba akho okukhula kwezinye izinhlobo zomdlavuza, ikakhulukazi umdlavuza wesisu kanye nomdlavuza we-endometrial. Iyakwaziwa nangokuthi yi-hereditary nonpolyposis colorectal cancer (HNPCC), futhi ithonya abantu abangaba ngu-1 ku-300 emhlabeni jikelele. Nakuba lokhu kungase kuzwakale kukhulu, ukuqonda i-Lynch syndrome kukwenza ukwazi ukuthatha izinyathelo zokuqapha ekuqaleni nokuvimbela.

Iyini i-Lynch Syndrome?

I-Lynch syndrome yisifo sezofuzo esidluliselwa ezizukulwaneni esibangelwa ukuguqulwa kwezinhlobo ze-gene ezivame ukusiza ekulungiseni ukonakala kwe-DNA ezicellini zakho. Uma lezi zinhlobo ze-gene zingasebenzi kahle, ukonakala kwe-DNA kungabuthana, okuholela ekukhuleni komdlavuza. Cabanga ngalezi zinhlobo ze-gene njengesistimu yokulawula ikhwalithi yomzimba wakho yokugcina izicell zisempilweni.

Lesi simo sidluliselwa emindenini ngendlela odokotela abayibiza ngokuthi yi-autosomal dominant pattern. Lokhu kusho ukuthi uma omunye wabazali bakho enesifo se-Lynch syndrome, unethuba elingu-50% lokulisifa. Lesi simo sithinta amadoda nabesifazane ngokulinganayo, nakuba amathuba okukhula komdlavuza angahluka phakathi kwezinhlanga.

Into ebaluleke kakhulu okumele uyicabange ukuthi ukuba ne-Lynch syndrome akusho ukuthi uzokhula umdlavuza. Kusho nje ukuthi amathuba akho aphezulu kunokulinganiselwe, futhi ngokuhlolwa okuqondile nokunakekelwa okuqondile, imidlavuza eminingi ingavikelwa noma itholakale ekuqaleni lapho ilashwa kalula.

Ziyini Izimpawu ze-Lynch Syndrome?

I-Lynch syndrome ngokwayo ayibangeli zimpawu. Kunalokho, ungase uqaphele izimpawu uma futhi kuphela uma umdlavuza ukhula. Ingxenye enzima ukuthi imidlavuza yesigaba sokuqala ivame ukungabangeli zimpawu ezibonakalayo, yingakho ukuhlolwa okuvamile kubaluleke kakhulu kubantu abanesimo.

Uma umdlavuza wesisu ukhula, ungase uhlangabezane nezinguquko emikhumbulweni yakho yokuya esikhumulweni ezihlala isikhathi esingaphezu kwamalanga ambalwa. Lezi zinguquko zingase zibe nzima, kodwa khumbula ukuthi izinguquko eziningi zesikhumulo zinezimbangela ezingelona umdlavuza.

Izimpawu ezivamile okumele uzilindele zihlanganisa:

• Igazi emathunjini akho noma ukuphuma kwegazi emgodini.
• Ukushintsha okuqhubekayo kwemikhuba yomathumbu, kuhlanganise ukweluka noma ukuvimbela.
• Ubuhlungu noma ukugcwala esiswini obungapheli.
• Ukwehla kwesisindo okungachazeki.
• Ukukhathala noma ubuthakathaka obuqhubekayo.
• Amathumbu amancane aqhubeka izinsuku eziningi.

Kubantu besifazane abane-Lynch syndrome, izimpawu zomdlavuza we-endometrial zingase zihlanganise ukuphuma kwegazi okungajwayelekile kwesikhumba, ikakhulukazi ngemuva kokuphela kwesikhathi, ubuhlungu be-pelvic, noma ukukhishwa okungajwayelekile. Lezi zimpawu zidinga ukunakekelwa, nakuba zingase zibonise nezimo eziningi ezingathi sína.

Ezinye izifo zomdlavuza ezihlotshaniswa ne-Lynch syndrome zingabangela izimpawu ezithile endaweni yazo, njengoba ubuhlungu besisu bomdlavuza wesisu noma ukushintsha kokumisa kwemithambo yomchamo yomdlavuza we-urological. Okubalulekile ukuqaphela ukushintsha okuqhubekayo emzimbeni wakho nokuxoxa ngakho nodokotela wakho.

Iyini Imbangela Ye-Lynch Syndrome?

I-Lynch syndrome ibangelwa yizinguquko ezifuywe ezinjini ezibhekene nokulungisa ukungafani kwe-DNA. Lezi zinjini ngokuvamile zisebenza njengababhali, zibamba futhi zilungise amaphutha avela lapho amaseli akho enza amakhophi e-DNA yawo. Lapho lezi zinjini zingasebenzi kahle, amaphutha aqoqana futhi angabangela umdlavuza.

Isimo sivela ekuhlukaniseni kwenye yezinhlobo eziningi zezinto, kanti ezivamile kakhulu yi-MLH1, i-MSH2, i-MSH6, ne-PMS2. Ngamunye walaba bajini udlala indima ebalulekile ekugcineni ubuqotho bekhwalithi yakho yezakhiwo. Ngokungavamile, ukususwa kwe-EPCAM gene kungabangela i-Lynch syndrome.

Uzuza i-Lynch syndrome komunye wabazali bakho, futhi ilandela iphethini yokudluliselwa komndeni. Lokhu kusho ukuthi udinga ikhophi elilodwa nje lejini eliguqukile ukuze ube nesimo. Uma une-Lynch syndrome, ngamunye wabantwana bakho unethuba elingu-50% lokukudla kuwe.

Kubalulekile ukuqonda ukuthi lezi mutations zikhona kusukela ekuzalweni, kodwa umdlavuza ngokuvamile awuthuthuki kuze kube kamuva ekuphileni. I-mutations idala ukuthambekela kumdlavuza kunokubangela isifo ngokushesha.

Nini Okufanele Ubone Udokotela Nge-Lynch Syndrome?

Kufanele ucabange ngezeluleko ze-genetic kanye nokuhlolwa uma unomlando omkhulu womndeni we-colorectal, i-endometrial, noma ezinye izifo zomdlavuza ezihlobene ne-Lynch syndrome. Umlando "omkhulu" womndeni ngokuvamile usho amalungu amaningi omndeni athintekile yilezi zifo zomdlavuza, ikakhulukazi uma azitholakele eminyakeni emincane.

Isimo esithile esidinga ukunakekelwa kwezokwelapha sihlanganisa ukuba namalungu omndeni amabili noma ngaphezulu ane-Lynch syndrome-associated cancers, amalungu omndeni atholakala ne-colorectal noma i-endometrial cancer ngaphambi kweminyaka engama-50, noma ilungu lomndeni elikhona elikhona elitholakele i-Lynch syndrome.

Uma usuvele uhlushwa izimpawu ezifana nokushintsha okungapheli kwamathumbu, ubuhlungu besisu obungachazeki, noma ukuphuma kwegazi okungajwayelekile, ungalindi. Nakuba lezi zimpawu zinezizathu eziningi ezingaba khona, zifanele ziphenyeke ngokushesha yi-medical evaluation kungakhathaliseki umlando wakho womndeni.

Ngaphezu kwalokho, uma utholakala une-colorectal noma i-endometrial cancer, udokotela wakho angakuncoma ukuhlolwa kwe-tumor ukuze abone ukuthi kubonisa izimpawu ezivumelana ne-Lynch syndrome. Lolu lwazi lungaba lubalulekile kokubili ekwelapheni kwakho nasekulungiseni impilo yomndeni wakho.

Yini Izimbangi Ze-Lynch Syndrome?

Imbangi eyinhloko ye-Lynch syndrome ukuba nomzali onalesi simo, njengoba kuyisifo se-genetic esidluliselwa ezizukulwaneni. Umlando womndeni uhlala ungumqondisi onamandla, ikakhulukazi lapho amalungu amaningi omndeni ethintekile yizifo zomdlavuza ezihlobene ne-Lynch syndrome.

Izindlela eziningi zomlando womndeni zikhuphula amathuba akho okuba ne-Lynch syndrome:

• Izihlobo ezintathu noma ngaphezulu ezinomdlavuza ohambisana ne-Lynch syndrome
• Isizukulwane ezimbili ezilandelayo ezithintekile yilomdlavuza
• Isihlobo esisodwa esaxilongwa ngomdlavuza ngaphambi kweminyaka engama-50
• Umdlavuza omningi oyinhloko kumuntu oyedwa
• I-mutation eaziwayo ye-Lynch syndrome emndenini

Izizwe ezithile zibonisa amazinga aphezulu kancane e-mutations ezithile, kodwa i-Lynch syndrome ithonya abantu bazo zonke izizwe. Isimo asihlukanisi ngokusekelwe ezintweni zokuphila njengokudla noma ukuzivocavoca, nakuba lezi zinto zingathinta ingozi yonke yomdlavuza.

Kubalulekile ukuphawula ukuthi cishe amaphesenti angu-20 abantu abane-Lynch syndrome abanalo umlando wemfula ocacile womdlavuza ohambisanayo. Lokhu kungenzeka lapho i-mutation entsha, lapho umlando wezokwelapha womndeni ungaziwa, noma lapho umdlavuza uqale kodwa awubhalwanga kahle.

Ziyini Izingozi Ezingase Zenzeke Ze-Lynch Syndrome?

Inkinga ephambili ye-Lynch syndrome yingozi enkulu yokuthuthukisa imidlavuza ehlukahlukene phakathi nokuphila kwakho. Ukuqonda lezi zingozi kuzokusiza wena neqembu lakho lokunakekelwa kwezempilo ukwakha uhlelo olufanele lokukhomba nokuvimbela.

Umdlavuza we-colorectal umelela ingozi enkulu kunazo zonke, ngabantu abane-Lynch syndrome abanephungeni lika-20-80% lokuphakama, uma kuqhathaniswa namaphesenti angu-5 kubantu abavamile. Ingozi iyahluka kuye ngokuthi iyiphi i-gene ethintekile, nge-MLH1 ne-MSH2 mutations ngokuvamile ezihamba nezingozi eziphezulu.

Kwabesifazane, umdlavuza we-endometrial ubeka ingozi enkulu, ngama-chances okuphila kusuka ku-15-60%. Lokhu kwenza umdlavuza we-endometrial ube yinto evamile njengomdlavuza we-colorectal kwabesifazane abane-Lynch syndrome. Ingozi yomdlavuza we-ovarian ikhuphukile, nakuba ingakanani.

Eminye imidlavuza ehambisana ne-Lynch syndrome ihlanganisa:

• Umphukane wesisu (ikakhulukazi kubantu abathile)
• Umphukane wesisu esincane
• Umphukane welaphe nezinsimbi zebile
• Umphukane wezinso eziphezulu (inkimbinkimbi ne-ureter)
• Umphukane wobuchopho (owubaluleke kakhulu)
• Umphukane wesikhumba (izinhlayiya ze-sebaceous)

Nakuba lezi zibalo zingase zikwethuse, khumbula ukuthi ukuba sengozini enkulu akusho ukuthi umdlavuza uyaphephela. Abantu abaningi abane-Lynch syndrome abawutholi umdlavuza, futhi labo abawutholayo bavame ukuzuza ekutholeni kwasekuqaleni ngokuhlola.

Ithonya lengqondo lokukwazi ukuthi une-Lynch syndrome lingase libe inselele. Abanye abantu baye baba novalo ngengozi yomdlavuza noma ubuhlungu ngokudlulisa le simo kubantwana babo. Lezi mizwa iyinhle kakhulu futhi ilungile.

Iyini Indlela Yokuvimbela I-Lynch Syndrome?

Njengoba i-Lynch syndrome iyisimo sezofuzo esidluliselwa ezizukulwaneni, awukwazi ukuvimbela ukuba nale syndrome. Noma kunjalo, ungathatha izinyathelo ezibalulekile zokuvimbela umdlavuza ohambisana nawo noma ukuwubamba emazingeni awo okuqala, asebenza kakhulu.

Ukuhlolwa okuvamile kubonisa ithuluzi lakho elinamandla kakhulu lokuvimbela umdlavuza. Ngokomdlavuza we-colorectal, lokhu kuvame ukusho ukuqala i-colonoscopies eneminyaka engu-20-25 noma iminyaka engu-2-5 ngaphambi kokuthi ilungu lomndeni elincane kakhulu litholakale, noma yikuphi okufika kuqala. Lezi zihlolo zingakwazi ukuthola futhi zisuse ama-polyps angaphambi komdlavuza ngaphambi kokuba abe yimdlavuza.

Kwabesifazane, ukuhlolwa komdlavuza we-endometrial kungafaka i-biopsies ye-endometrial yonyaka eqala eminyakeni engu-30-35. Abesifazane abathile bakhetha ukususwa kwesisu sabo nezibeletho zabo ngemuva kokuphelelisa imindeni yabo, okunganciphisa kakhulu ingozi yomdlavuza.

Ukushintsha indlela yokuphila kungasiza futhi ekuphuculeni ingozi yakho yonke yomdlavuza:

• Gcina ukudla okunempilo okugcwele izithelo, imifino, namanye ama-grain
• Zivocavoca njalo ukuze usekele isimo sakho somzimba
• Gwema ukubhema futhi ubeke umkhawulo ekusetshenzisweni kotshwala
• Gcina isisindo esinempilo
• Cabanga ukuthatha i-aspirin uma udokotela wakho ekuncoma

Ucwaningo oluthile lubonisa ukuthi i-aspirin yansuku zonke inganciphisa ingozi yomdlavuza we-colorectal kubantu abane-Lynch syndrome, yize kufanele ukhulume nodokotela wakho kuqala. Isinqumo sihilela ukulinganisa izinzuzo ezingaba khona nezingozi ezifana nokuphuza igazi.

I-Lynch Syndrome Ihlonishwa Kanjani?

Ukuhlola i-Lynch syndrome kuvame ukubandakanya ukuhlolwa kwe-genetic, kodwa inqubo ivame ukuqala ngokuhlola umlando wakho wezokwelapha nomlando womndeni wakho. Umhlinzeki wakho wezinsizakalo zezempilo uzobheka izindlela ezibonisa ukuthi i-Lynch syndrome ingase ikhona emndenini wakho.

Uma usutholwe unomdlavuza we-colorectal noma i-endometrial, udokotela wakho angase aqhubeke nokuhlola i-tumor tissue yakho ukuze abone izimpawu ezivumelana ne-Lynch syndrome. Lokhu kubandakanya ukuhlola ukungazinzi kwe-microsatellite (MSI) nokuhlola ukubonakaliswa kwe-mismatch repair protein.

Ukuqondisa kwe-genetic kuvame ukuza ngaphambi kokuhlolwa kwe-genetic. Umqondisi we-genetic uzohlola umlando womndeni wakho, achaze inqubo yokuhlolwa, futhi akusize uqonde ukuthi imiphumela ingasho ukuthini ngawe nomndeni wakho. Lesi sinyathelo siqinisekisa ukuthi wenza isinqumo esinolwazi mayelana nokuhlolwa.

Ukuhlolwa kwe-genetic ngokwakho kuhilela ukunikeza isampula legazi noma i-saliva. I-laboratory izohlola i-DNA yakho ukuze ibheke izinguquko ezinhlelweni ezihlobene ne-Lynch syndrome: MLH1, MSH2, MSH6, PMS2, ne-EPCAM.

Imiphumela ivame ukuthatha amasonto ambalwa ukubuyela. Umphumela omuhle usho ukuthi une-mutation ebangela i-Lynch syndrome. Umphumela omubi ungasho ukuthi awunayo i-Lynch syndrome, noma kungasho ukuthi une-mutation yokuhlolwa kwamanje okungayitholi.

Ngesinye isikhathi, ukuhlolwa kwe-genetic kuveza "ukuguquka okungaziwa ukubaluleka kwako." Lokhu kusho ukuthi kutholwe ushintsho lwe-genetic, kodwa ososayensi abaqiniseki ukuthi kubangela yini i-Lynch syndrome. Lezi ziphumo zingadumaza, kodwa zivame ukucaca njengoba kuncishiswa ucwaningo olwengeziwe.

Iyini Ukwelashwa kwe-Lynch Syndrome?

Ukuphathwa kwe-Lynch syndrome kugxila ekunqobeni umdlavuza nokutholakala kwangaphambi kwesikhathi kunokwelapha isimo se-genetic ngokwalo. Njengoba ungakwazi ukushintsha ama-genes akho, umgomo ukunciphisa ingozi yakho yomdlavuza nokuthola noma yimiphi imidlavuza evela ngokushesha ngangokunokwenzeka.

Iqembu lakho lokunakekelwa kwezempilo lizokwakha uhlelo lokukhangisa oluqondene nezidingo zakho ngokususelwa ekuguqukeni kwakho okuthile kwe-genetic kanye nomlando womndeni. Lokhu ngokuvamile kuhlanganisa ukukhangiswa okuvamile nangaphambili kunalokho okusikisela abantu abavamile.

Ukuvimbela umdlavuza we-colorectal, cishe uzodinga i-colonoscopies minyaka yonke noma emibili uqala eminyakeni yakho yobudala eyi-20 noma eyi-30. Ngesikhathi salezi zinqubo, udokotela wakho angasusa ama-polyps angaphambi komdlavuza ngaphambi kokuba abe yimdlavuza. Le ndlela yokwenza ngaphambi kwesikhathi ibonwe ukuthi inciphise kakhulu ingozi yomdlavuza.

Abesifazane abane-Lynch syndrome bavame ukuzuza ekukhangiseni okwengeziwe:

• Ukuhlolwa kwe-endometrial minyaka yonke uqala eminyakeni eyi-30-35
• Ukuhlolwa okuvamile kwe-pelvic kanye ne-transvaginal ultrasounds
• Ukuqondana ngokuhlinzwa okuvimbelayo ngemuva kokuba ukubeletha kuphelile

Abanye abesifazane bakhetha ukususa izitho zabo zokuzala nezinhliziyo (i-hysterectomy ne-oophorectomy) ngemuva kokuba sebeqedile ukubeletha. Lolu hlobo lokuhlinzwa lunganciphisa ingozi yomdlavuza we-endometrial cishe ngamaphesenti ayi-100 futhi kunciphisa kakhulu ingozi yomdlavuza we-ovarian.

Udokotela wakho angase futhi akukhuthaze ukukhangiswa kwezinye izifo ezithinta i-Lynch syndrome, njengokuhlolwa kwe-upper endoscopy yomdlavuza wesisu noma i-urinalysis yomdlavuza we-urinary tract. Izincomo ezithile ziyahlukahluka ngokususelwa emlandweni womndeni wakho kanye nokuguquka kwe-genetic.

Ukusetshenziswa kwemithi yokuvimbela ukukhula komdlavuza, ikakhulukazi i-aspirin, kuyaqhubeka nokucwaningwa njengendlela yokunciphisa ingozi yomdlavuza kubantu abane-Lynch syndrome. Abanye odokotela base besele beqaphela ukusetshenziswa kwe-aspirin nsuku zonke, nakuba lesi sinqumo kufanele senziwe ngabanye ngokususelwa empilweni yakho jikelele nezici ezingozi.

Ukuzinakekela kanjani nge-Lynch syndrome?

Ukuphila kahle nge-Lynch syndrome kuhilela ukulinganisela ukulinda ngokuqapha nokubukwa kwempilo yakho. Okubalulekile ukuhlala uqaphile ngempilo yakho ngaphandle kokuvumela ukukhathazeka kukuthathe isikhathi sakho sonke.

Namathela esimweni sakho sokuhlolwa njalo. Lezi ziyakuqokela zingase zizwe zingezinhle noma zikubangele ukukhathazeka, kodwa yindlela yakho engcono kakhulu yokulwa nomdlavuza. Cabanga ukuhlela ngezikhathi ezithile ukuze kube yinto ejwayelekile kunokuba kube yimithombo yokucindezeleka.

Gcina indlela yokuphila enempilo esekela impilo yakho jikelele. Gxila ekudleni izithelo, imifino, nokuhlanganiswa kokudla okugcwele ngenkathi ugcina ukudla okucutshunguliwe. Ukuzivocavoca njalo akusizi nje kuphela impilo yakho yomzimba kodwa kungakusiza futhi ukuphatha ukukhathazeka ngengozi yakho yomdlavuza.

Yenza ubudlelwano obuqinile neqembu lakho lokunakekelwa kwezempilo. Thola odokotela abaqonda i-Lynch syndrome futhi bazimisele ukuhlala behlakaniphile ngocwaningo lwakamuva nezincomo. Unganqikazi ukubuza imibuzo noma ufuna imibono yesibili uma kudingeka.

Cabanga ukuxhumana namaqembu wokusekela noma imiphakathi eku-inthanethi yabantu abane-Lynch syndrome. Ukukhuluma nabanye abaqonda isipiliyoni sakho kungakunika ukwesekwa ngokomzwelo nezeluleko eziwusizo zokuphatha lesi simo.

Gcina amarekhodi ezempilo enemininingwane ngawe futhi wabelane ngolwazi olufanele namalungu omndeni. Isipiliyoni sakho ngokuhlolwa kwe-Lynch syndrome nokuphathwa kwalo kungasiza izihlobo ezinawo futhi lesi simo.

Nanake ubekezelele impilo yakho yengqondo. Kuvamile ukuzizwa ufikelwe ukukhathazeka ngengozi yomdlavuza noma unecala ngokuthi mhlawumbe uthumela i-Lynch syndrome kubantwana bakho. Cabanga ngokwelulekwa uma lezi zizwe ziqala ukukukhathaza kakhulu noma zikuphazamisa impilo yakho yansuku zonke.

Kufanele Uzilungiselele Kanjani Ukuya Kulo Dokotela?

Ukulungiselela izivivinyo ezihlobene ne-Lynch syndrome kusiza ukuqinisekisa ukuthi uthola inzuzo enkulu ngesikhathi sakho nabaphakeli bezempilo. Qala ngokuqoqa ulwazi oluphelele ngembali yezokwelapha yomndeni wakho, kufaka phakathi izinhlobo ezithile zomdlavuza, ubudala besikhathi sokutholakala, nanoma yimiphi imiphumela yokuhlolwa kwe-genetic.

Dala umuthi womndeni onemininingwane ehlanganisa izizukulwane ezintathu uma kungenzeka. Qaphela noma imiphi imidlavuza, ikakhulukazi umdlavuza wesisu, umdlavuza wesibalo, umdlavuza we-ovary, isisu, noma eminye imidlavuza ehlobene ne-Lynch syndrome. Faka ubudala besikhathi sokutholakala nokuthi abantu basaphila yini.

Bhala phansi imibuzo yakho kusengaphambili. Ungase ufune ukubuza ngezinhlelo zokuhlola, ukuguqulwa kwesitayela sempilo, izinto zokucubungula umndeni, noma yiziphi izimpawu ezifanele zikhuthaze ukunakekelwa kwezokwelapha ngokushesha. Ukuba nemibuzo ebhalwe phansi kuqinisekisa ukuthi ngeke ukhohlwe ngezihloko ezibalulekile ngesikhathi sokuya kudokotela.

Letha uhlu oluphelele lwemithi yakho yangamanje, kufaka phakathi izithasiselo ezingaphezu kokuthengwa ngaphandle kwesikripthi. Eminye imithi noma izithasiselo zingase zihlangane nemithi noma zithinte ingozi yomdlavuza, ngakho-ke udokotela wakho udinga isithombe esiphelele.

Uma ubona udokotela omusha, letha amakhophi anoma yimiphi imiphumela yokuhlolwa kwe-genetic yangaphambili, imibiko ye-pathology evela kunoma yimiphi imidlavuza noma i-biopsies, kanye nemiphumela yokuhlolwa kokuhlola. Lolu lwazi lusiza udokotela wakho omusha ukuqonda umlando wakho nokwenza izincomo ezifanele.

Cabanga ngokuletha umngane othembekile noma ilungu lomndeni emihlanganweni ebalulekile. Bangakusiza ukuba ukhumbule ulwazi oluxoxiwe futhi banikeze ukwesekwa ngokomzwelo ngesikhathi sokuqala ukuxoxa okucindezelayo.

Zilungisele ngokomzwelo ngaphambi kokubhekana nodokotela. Kuvamile ukuzizwa unesizungu uma uxoxa ngengozi yomdlavuza noma imiphumela yokuhlolwa. Cabanga ngezindlela zokubhekana nezimo ezikusebenzelayo kangcono, kungaba ukuphefumula okujulile, ukukhuluma okuhle ngawe, noma ukuhlela okuthile okujabulisayo ngemva kokubhekana nodokotela.

Iyini into ebaluleke kakhulu ngo-Lynch Syndrome?

I-Lynch syndrome iyisimo se-genetic esilawuleka esidinga ukunakekelwa okuphila konke kodwa akudingeki ukuthi ichaze impilo yakho. Nakuba iyakwandisa ingozi yakho yomdlavuza, ukutholakala kwangaphambi kwesikhathi nezindlela zokuvimbela kuye kwabonakala kusebenza kakhulu ekunciphiseni leyo ngozi nokwenza imiphumela ibe ngcono.

Into ebaluleke kakhulu ongayenza ukuba uzibophelele ekubhekeni okuvamile. Lezi zivivinyo zingabamba izinguquko ezingaphambi komdlavuza noma umdlavuza wokuqala lapho kulula khona ukwelapha. Abantu abaningi abane-Lynch syndrome baphila impilo egcwele, enempilo ngaphandle kokuthuthukisa umdlavuza.

Ulwazi yigunya uma kuziwa ku-Lynch syndrome. Ukuqonda isimo sakho kukwenza ukwazi ukuthatha izinqumo ezinolwazi mayelana nokubheka, izinqumo zokuphila, nohlelo lwentsha. Kusiza futhi ukuba umelele ukunakekelwa okufanele kwezokwelapha futhi uhlale usesikhathini ngezinguquko ezintsha ekwelapheni nasekuvimbeleni.

Khumbula ukuthi ukuba ne-Lynch syndrome kuchaphazela umndeni wakho wonke. Ukwabelana ngolwazi mayelana nokuxilongwa kwakho kungasiza izihlobo ukuthi zithathe izinqumo ezinolwazi mayelana nokuhlolwa kwe-genetic nokubheka umdlavuza. Le ndlela egxile emndenini yokuphatha i-Lynch syndrome ivame ukubangela imiphumela engcono kubo bonke.

Imibuzo Evame Ukubuzwa Ngo-Lynch Syndrome

Ingabe i-Lynch syndrome ingadlulela izizukulwane?

I-Lynch syndrome aliqali ukuthi aliwugqibi izizukulwane, kodwa lingabonakala liwugqiba. Njengoba kuyisimo esibangelwa yi-gene edominayo, umntwana ngamunye womzali othe xakeke unethuba elingu-50% lokuba alizuze. Ngezinye izikhathi abantu bazuza i-mutation kodwa abazuze umdlavuza, okwenza kubonakale sengathi isimo siliqabule. Ngaphezu kwalokho, umdlavuza ungase ungahlolwa kahle noma ungarekhodwa ezizukulwaneni ezingaphambili, okwenza kubonakale sengathi izizukulwane ziqatshelwe.

Ubunyani bekulingwa kwe-gene ku-Lynch syndrome bungakanani?

Ukuhlolwa kwe-gene ku-Lynch syndrome kunenkambo enkulu uma kutholakala i-mutation eyaziwayo ebangela isifo. Noma kunjalo, ukuhlolwa okungabi namphumela akuhlali kusho ukuthi awunayo i-Lynch syndrome. Ukuhlolwa kwamanje kungase kuphuthe ezinye i-mutation, noma ungase ube ne-mutation ku-gene engakavulwa. Yingakho ukwelulekwa kwe-gene kubaluleke kakhulu ngaphambi nangemva kokuhlolwa.

Ingabe abantwana bami kufanele bahlolwe i-Lynch syndrome?

Ochwepheshe abaningi bancoma ukulinda kuze kube yilapho abantwana befinyelele eminyakeni engu-18 ubudala ngaphambi kokuhlolwa kwe-gene, ngaphandle uma kunesizathu esithile sezokwelapha sokuhlola ngaphambi kwesikhathi. Lokhu kuvumela abantu abadala abasebancane ukuba benze izinqumo zabo siqu eziqondisiwe mayelana nokuhlolwa. Noma kunjalo, uma une-Lynch syndrome, abantwana bakho kufanele baqaphele umlando womndeni futhi bacabangele ukuhlolwa ngaphambi kokuba bafinyelele ebudaleni lapho ukuhlolwa kuvame ukuqala khona.

Ingabe ukuba ne-Lynch syndrome kuchaphazela insimbi yokuphila?

E-United States, i-Genetic Information Nondiscrimination Act (GINA) iyalela ukungabandlululwa kwezempilo nokusebenza ngokusekelwe kolwazi lwe-gene. Noma kunjalo, i-GINA ayihlanganisi insimbi yokuphila, insimbi yokukhubazeka, noma insimbi yokunakekelwa kwesikhathi eside. Abanye abantu bakhetha ukuthola lezi zinhlobo zensimbi ngaphambi kokuhlolwa kwe-gene. Kubalulekile ukuxhumana nomxhumanisi we-gene mayelana nemiphumela engase ibe khona.

Ingabe ukushintsha indlela yokuphila kunganciphisa ingozi yomdlavuza uma ngine-Lynch syndrome?

Nakuba ungakwazi ukususa ingozi yakho eyenyuke kakhulu yomdlavuza ngokushintsha indlela yokuphila kuphela, imikhuba enempilo ingasiza ekunciphiseni ingozi yakho iyonke. Ukuzivocavoca njalo, ukudla okunamaqabunga nemifino, ukugcina isisindo esinempilo, ukugwema ukubhema, nokulinganisela utshwala konke kungase kube nomthelela emiphumeleni yempilo engcono. Ucwaningo oluthile lubonisa ukuthi i-aspirin ingasiza ekunciphiseni umdlavuza we-colorectal kubantu abane-Lynch syndrome, kodwa lokhu kufanele kuxoxwe nodokotela wakho kuqala.