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October 10, 2025
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I-Multiple system atrophy (MSA) iyisifo esingavamile sobuchopho esithinta izinhlelo eziningi zomzimba ngesikhathi esisodwa. Kwenzeka lapho amaseli athile ebuchopho aphethe ukunyakaza, ukulinganisela, nemisebenzi yomzimba ezenzakalelayo ehluleka kancane kancane futhi ayeke ukusebenza kahle.
Lesi simo siqhubeka, okusho ukuthi siya sibi ngokuhamba kwesikhathi. Nakuba i-MSA ihlanganyela izinto ezithile ne-Parkinson's disease, ithonya izindawo eziningi zobuchopho ngesikhathi esisodwa futhi ivame ukuqhubeka ngokushesha. Ukuqonda i-MSA kungakusiza ukuthi uqaphele izimpawu zayo futhi wazi ukuthi nini kufanele ufune ukunakekelwa kwezokwelapha.
I-Multiple system atrophy yisifo sobuchopho esonakalayo esithinta ikakhulu abadala abangaphezu kweminyaka engu-50. Igama lichaza ngokuqondile ukuthi kwenzekani - izinhlelo eziningi zomzimba ziyeka ukusebenza kahle ngenxa yomonakalo wamaseli ebuchopho.
Ubuchopho bakho buqukethe amaseli akhethekile akhiqiza iprotheni ebizwa ngokuthi yi-alpha-synuclein. Ku-MSA, le protheni yakha ngokungavamile futhi yonakalisa amaseli aphethe ukunyakaza, ukulinganisela, ukucindezeleka kwegazi, nezinye imisebenzi yomzimba ezenzakalelayo njengokuphefumula nokugaya ukudla.
Kunezinhlobo ezimbili eziyinhloko ze-MSA. Uhlobo lokuqala luthonya ikakhulu ukunyakaza futhi lubizwa ngokuthi yi-MSA-P (i-P imele izici ze-parkinsonian). Uhlobo lwesibili luthonya ikakhulu ukulinganisela nokuxhumanisa futhi lubizwa ngokuthi yi-MSA-C (i-C imele izici ze-cerebellar).
I-MSA ithonya cishe abantu abangu-4 kwabayi-100,000. Nakuba kubhekwa njengokungavamile, ukuthola ukuxilongwa okuqondile kubalulekile ngoba ukwelashwa kungasiza ekulawuleni izimpawu nokuthuthukisa ikhwalithi yokuphila.
I-MSA iza ngezindlela ezimbili eziyinhloko, ngayinye ithonya izingxenye ezahlukene zobuchopho bakho nomzimba. Ukuqonda lezi zinhlobo kusiza odokotela ukuba banikeze ukunakekelwa okuhle futhi kusiza wena ukwazi ukuthi yini okulindelekile.
I-MSA-P (uhlobo lwe-Parkinsonian) ithonya izindawo zobuchopho eziphethe ukunyakaza. Ungase uqaphele ukunyakaza okuhamba kancane, ubunzima bemisipha, ukuzamazama, nobunzima bokulinganisela. Lolu hlobo lungabonakala lufana kakhulu ne-Parkinson's disease emazingeni okuqala.
I-MSA-C (uhlobo lwe-Cerebellar) ilimaza ikakhulu i-cerebellum, indawo yobuchopho ehambisana nokuxhumanisa nokulinganisela. Abantu abalolu hlobo bavame ukuhlupheka ngokuhamba okungazinzile, ubunzima bokwenza izinto ngokuqondile, nezingqinamba zokukhuluma.
Abanye abantu banezici zombili izinhlobo, okwenza ukuxilongwa kube nzima kakhulu. Udokotela wakho uzohlola ngokucophelela izimpawu zakho ezithile ukuze aqonde ukuthi yiluphi uhlobo olukuyo futhi enze uhlelo lokwelapha oluhle kakhulu sesimo sakho.
Izimpawu ze-MSA zivela kancane kancane futhi zingase zihluke kakhulu kumuntu nomuntu. Izimpawu zokuqala zivame ukuba zingezona ezinzima futhi zingase ziphoswe njengokuguga okuvamile noma ezinye izimo.
Izimpawu zokuqala ezivamile zihlanganisa:
Njengoba i-MSA iqhubeka, ungase ube nezimpawu ezengeziwe. Lezi zingase zihlanganise ubunzima bemisipha, ukuzamazama okuvela ekuphumuleni, ubunzima bokuginya, nezingqinamba zokulawula ubushushu bomzimba.
Abanye abantu nabo bahlupheka ngokuphefumula, ikakhulukazi ngesikhathi sokulala. Ukushintsha ekukhulumeni, njengokukhuluma okuthambile noma okungapheli, kuvamile njengoba isimo siqhubeka.
Izimpawu ezingavamile kodwa ezinzima zingase zihlanganise ukwehla okukhulu kwegazi, ubunzima bokuphefumula, nezingqinamba zokulawula ubushushu bomzimba. Lezi zimpawu zidinga ukunakekelwa kwezokwelapha ngokushesha lapho zenzeka.
Imbangela eqondile ye-MSA ayikaziwa, kodwa abacwaningi baye baqaphela izici ezibalulekile. Isimo libonakala liphuma ekuxubeni kokuthambekela kwezinto eziyizofu nokuthinta kwemvelo.
Inkinga eyinhloko ku-MSA ihilela iprotheni ebizwa ngokuthi yi-alpha-synuclein. Ngokuvamile, le protheni iyasiza amaseli ezinzwa ukusebenza kahle. Ku-MSA, iprotheni iyahlehlisa futhi iqoqana emaseleni ebuchopho, ekugcineni ibubulale.
Izici zezinto eziyizofu zingase zidlale indima, nakuba i-MSA ingalitholi njengezinye izimo. Ososayensi baye bathola ukushintshashintsha okuthile kwezinto eziyizofu okungase kwenze abanye abantu babe sengozini enkulu, kodwa ukuba nalezi zinguquko akusho ukuthi uzophuthuma i-MSA.
Izici zemvelo nazo zifundwa. Abanye abacwaningi bahlola ukuthi ukubhekana nezinto ezinobuthi, ukutheleleka, noma ezinye izinto ezibangela ukuphazamiseka kwemvelo kungase kuhlanganyele ekukhuleni kwe-MSA kubantu abanobungozi ngenxa yezinto eziyizofu.
Ubudala yiyona nto enkulu ezaziwayo yengozi. I-MSA ivame ukuvela kubantu abaneminyaka engu-50 kuya ku-70, iminyaka yokuqala ephakathi icishe ibe yiminyaka engu-60.
Kufanele uxhumane nodokotela wakho uma uqaphela izinkinga eziqhubekayo zokunyakaza, ukulinganisela, noma ukulawula ukucindezeleka kwegazi. Ukubheka ngokushesha kubalulekile ngoba ukuxilongwa okusheshayo kungakhuthaza ukulawulwa kangcono kwezimpawu.
Funani ukunakekelwa kwezokwelapha uma uhlupheka ngokukhungatheka okuvamile uma ukuma, ukuwa okungachazeki, noma ukushintsha okukhulu ekunyakazeni noma ekuxhumaniseni kwakho. Lezi zimpawu zingase zibonise i-MSA noma ezinye izimo ezinzima ezidinga ukubhekwa ngochwepheshe.
Shaya udokotela wakho ngokushesha uma uthola izinkinga ezinkulu zokuphefumula, ukushintsha okukhulu kwegazi, noma ukubi kakhulu kwezimpawu zezinzwa. Lezi zingase zibe izimpawu zezinkinga ezinzima ezidinga ukunakekelwa okusheshayo.
Ungalindi uma ubunzima bokuginya noma ukuphefumula ngesikhathi sokulala. Lezi zimpawu zingaba yingozi futhi zidinga ukubhekwa kwezokwelapha okusheshayo ukuvimbela izinkinga njengokuhlanza noma izinkinga zokuphefumula ezihlobene nokulala.
Izici eziningi zingase zikhulise amathuba akho okukhula kwe-MSA, nakuba ukuba nezinto ezingozi akusho ukuthi uzothola ngokuqinisekile isimo. Ukuqonda lezi zici kungakusiza uhlale uqaphile izimpawu zokuqala.
Ubudala yiyona nto ebaluleke kakhulu yengozi. I-MSA ithonya cishe abadala abangaphezu kweminyaka engu-50 kuphela, ngezimo eziningi ezenzeka phakathi kweminyaka engu-55 no-75. Ubungozi buya bukhula ngokuqhubeka kobudala kuleli banga.
Ubulili budlala indima, ngamadoda anethuba elikhulu lokukhula kwe-MSA kunabesifazane. Noma kunjalo, umehluko mncane, futhi amadoda nabesifazane bobabili bangathinteka.
Ezinye izici zezinto eziyizofu zingase zihlanganyele engozini ye-MSA. Nakuba isimo singalitholi ngokuqondile, ukuba nokushintshashintsha okuthile kwezinto eziyizofu kungase kukwenze ube sengozini enkulu uma ubhekene nezinto ezibangela ukuphazamiseka kwemvelo.
Ukubhekana nemisebenzi noma imvelo kufundwa njengezinto ezingozi ezingaba khona. Abanye abacwaningi bacebisa ukuthi ukubhekana nezinto ezithile ezinobuthi noma ezinye izinto ezibangela ukuphazamiseka kwemvelo kungase kukhulise ubungozi, kodwa lo xhumano alukaqinisiswa ngokuphelele.
I-MSA ingabangela izinkinga eziningi ezinzima njengoba iqhubeka, kodwa ukuqonda lezi zinto ezingaba khona kusiza wena neqembu lakho lokunakekelwa kwezokwelapha ukulungiselela nokuphatha ngokuphumelelayo.
Izinkinga zenhliziyo zihlanganiswe nezinkinga ezivamile nezinzima. Ukwehla okukhulu kwegazi uma ukuma kungabangela ukuwa nokulimala. Abanye abantu nabo bathuthukisa izindlela ezingavamile zenhliziyo noma ezinye izinkinga zenhliziyo.
Izinkinga zokuphefumula zingaba nzima njengoba i-MSA iqhubeka. Ungase uthuthukise i-sleep apnea, lapho ukuphefumula kuyeka okwesikhashana ngesikhathi sokulala, noma ube nobunzima bokuphefumula uma uvukile. Lezi zinkinga zingaba yingozi uma zingalawulwa kahle.
Izinkinga zokugwinya (dysphagia) zingase zikhule, zikhulise ubungozi bokuhlanza noma ukufaka ukudla emaphashini. Lokhu kungabangela i-pneumonia, okuyinkinga enzima edinga ukwelashwa okusheshayo.
Izinkinga zokunyakaza zihlanganisa ukwanda kengozi yokuwa ngenxa yezinkinga zokulinganisela nobuthakathaka bemisipha. Ukuwa kungabangela ukweqa, ukulimala kwekhanda, nezinye izinto ezinzima ezingathinta kakhulu ikhwalithi yokuphila.
Izinkinga ezingavamile kodwa ezinzima zingase zihlanganise ukungasebenzi kahle okukhulu kokulawula komzimba, lapho umzimba wakho ulahlekelwa ukulawula imisebenzi yomzimba eyisisekelo njengokucindezeleka kwegazi, izinga lenhliziyo, nokuphefumula. Izinkinga zesibofu nezisu nazo zingase zibe nzima, ngezinye izikhathi zidinga ukusebenza okuyisikhathi eside.
Ukuxilongwa kwe-MSA kudinga ukubhekwa ngokucophelela ngudokotela wezinzwa oqeqeshwe ngezifo zokunyakaza. Ayikho i-test eyodwa engakwazi ukuxilonga i-MSA ngokuqinisekile, ngakho odokotela basebenzisa ukuxuba kwezindlela.
Udokotela wakho uzoqala ngomlando wezokwelapha onemininingwane kanye nokuhlolwa komzimba. Bazokubuzisa ngezimpawu zakho, lapho zaqala khona, nokuthi ziye zaqhubeka kanjani. Ukuhlolwa komzimba kugxile ekuhlolweni kokunyakaza kwakho, ukulinganisela, imiphumela, nemisebenzi yokulawula komzimba.
Izifundo zokubheka ubuchopho kubalulekile ekuxilongweni. I-MRI scans ingabonisa ukushintsha okufanelekile esakhiweni sobuchopho okusekela ukuxilongwa kwe-MSA. Lezi scans nazo zingasiza ekuqedeni ezinye izimo ezingase zibangele izimpawu ezifanayo.
Izivivinyo zokusebenza kokulawula komzimba zilinganisa ukuthi uhlelo lwakho lwezinzwa lulawula kangcono kanjani imisebenzi yomzimba ezenzakalelayo. Lezi zingase zihlanganise izivivinyo ezilinganisa impendulo yakho yokucindezeleka kwegazi ekumeleni noma izivivinyo zokuphefumula ezibheka izinkinga zokuphefumula ezihlobene nokulala.
Ngezinye izikhathi odokotela basebenzisa ukuhlolwa kwemithi nge-levodopa (imithi ye-Parkinson's) ukusiza ekuhlukaniseni i-MSA ne-Parkinson's disease. Abantu abane-MSA ngokuvamile ababonisi ukuthuthuka okuncane ngale mithi, kanti labo abane-Parkinson's ngokuvamile bayaphendula kahle.
Kwezinye izimo, odokotela bangase bancome izivivinyo ezengeziwe ezikhethekile njenge-DaTscan (ebheka ukusebenza kwe-dopamine ebuchopho) noma ukuhlolwa kokulawula komzimba ukuze bathole isithombe esicacile sesimo sakho.
Nakuba okwamanje ayikho indlela yokwelapha i-MSA, izindlela ezahlukene zokwelapha zingasiza ekulawuleni izimpawu nokuthuthukisa ikhwalithi yokuphila kwakho. Okubalulekile ukusebenza neqembu lezokwelapha elikhethekile ukuze uqonde isimo ngasinye ngokwehlukana.
Izimpawu zokunyakaza zivame ukwelashwa ngemithi efana naleyo esetshenziswa nge-Parkinson's disease. I-Levodopa/carbidopa ingase inikeze izinzuzo ezithile, nakuba impendulo ivame ukulinganiselwa uma iqhathaniswa ne-Parkinson's disease. Udokotela wakho angase azama ezinye izidakamizwa njenge-amantadine noma i-dopamine agonists.
Izinkinga zokucindezeleka kwegazi zidinga ukulawulwa ngokucophelela ngemithi nezindlela zokuphila. I-Fludrocortisone ingasiza ekuqaliseni ukucindezeleka kwegazi, kanti izokisi zokucindezela nokudla usawoti okuningi kungase futhi kunconywe ukuvimbela ukwehla okungozi uma ukuma.
Ukwelashwa komzimba kubalulekile ekuqondeni ukunyakaza nokuvimbela ukuwa. Uchwepheshe wokwelashwa komzimba onolwazi angakufundisa imizamo yokuthuthukisa ukulinganisela, amandla, nokuxhumanisa ngenkathi ekubonisa izindlela ezifanele zokunyakaza nokudlulisela.
Ukwelashwa kokukhuluma kusiza ekuqondeni izinkinga zokukhuluma nokugwinya. Ochwepheshe bokukhuluma bangafundisa amasu okuthuthukisa ukucaca kokukhuluma nezindlela ezifanele zokugwinya ukuvimbela ukufaka ukudla emaphashini.
Ngezingqinamba zokuphefumula, udokotela wakho angase ancome i-CPAP machine ye-sleep apnea noma ezinye izinto zokusekela ukuphefumula. Ezimweni ezinzima, ukusekelwa okukhulu kokuphefumula kungase kudingeke.
Ukusebenza okungalungile kwesibofu ngokuvamile kudinga imithi njenge-oxybutynin yokugwinya okukhulu kwesibofu noma ezinye izindlela zokwelapha kuye ngezimpawu zakho ezithile. Abanye abantu bangase badinge ukufakwa kwesibofu okwesikhashana ukuze baqede ngokuphelele isibovu.
Ukulawula i-MSA ekhaya kuhilela ukwakha indawo ephephile nokusebenzisa amasu akusiza ukuba ugcine ukuzimela ngenkathi uhlala uphephile. Ukushintsha okuncane kungenza umehluko omkhulu ekududuzeni nasekuphepheni kwakho kwansuku zonke.
Ukuvimbela ukuwa kubalulekile ekulungiseni ikhaya lakho. Susa ama-rugs asile, qiniseka ukuthi kukhona ukukhanya okuhle kulo lonke ikhaya lakho, futhi ufake ama-grab bars ezihlanzini. Cabanga ngokusebenzisa isihlalo sokugeza nama-mats angasili ukuvimbela ukuwa ezihlanzini.
Ukulawula ukwehla kwegazi kudinga ukulungiswa kokuphila. Vuka kancane usuka ekuphumuleni noma ekuhlaleni, gcina umzimba wakho unamanzi, futhi ugqoke izokisi zokucindezela uma udokotela wakho ekuncoma. Gcina isihlalo eduze uma ukuma isikhathi eside.
Ukushintsha kokudla kungasiza ngezinkinga zokugwinya. Thatha izicucu ezincane, gwinya kahle, futhi ugweme ukudla okunzima ukugwinya. Ukuhlala uqonde ngesikhathi sodla futhi imizuzu engu-30 ngemuva kwalokho kungavimbela ukufaka ukudla emaphashini.
Ukuhlanzeka kokulala kuba kubalulekile nge-MSA. Sebenzisa i-mattress eqinile, cabanga ngembhedeni yesibhedlela uma ukukhuphuka nokwehla kuya kuba nzima, futhi landela izincomo zokwelapha i-sleep apnea uma kudingeka.
Hlala usebenzile ngaphakathi kwamandla akho ngokwenza imizamo ebushelelezi, ukuhamba, nemisebenzi oyithandayo. Ukunyakaza okuvamile kusiza ekuqondeni amandla emisipha futhi kungathuthukisa isimo sengqondo nokuphila kahle.
Ukulungiselela kahle izivivinyo zakho zezokwelapha kusiza ukuqinisekisa ukuthi uthola izinzuzo eziningi ngesikhathi sakho neqembu lezokwelapha. Ukulungiselela okuhle kuholela ekuxhumaneni kangcono nasekunakekelweni okuphumelelayo.
Gcina idayari yezimpawu okungenani isonto ngaphambi kokuya kwakho kudokotela. Qaphela ukuthi izimpawu zenzeka nini, ukuthi wawenzani, nokuthi zazinzima kangakanani. Lolu lwazi lusiza udokotela wakho ukuqonda izindlela nokulungisa ukwelashwa ngokufanele.
Letha uhlu oluphelele lwemithi, izongezo, namavithamini owathathayo, kufaka phakathi imithamo nesikhathi. Letha futhi noma yimaphi amarekhodi ezokwelapha avela kwabanye odokotela noma imiphumela yokuvivinywa yakamuva udokotela wakho wamanje angase angabi nayo.
Bhala imibuzo yakho ngaphambi kokuya kudokotela ukuze ungakhohlwa izinto ezibalulekile. Beka phambili imibuzo yakho ebaluleke kakhulu uma isikhathi singanele ngesikhathi sokuvakasha.
Cabanga ngokuletha ilungu lomndeni noma umngani ukuze akusize ukukhumbula ulwazi oluxoxwe nokukunikeza ukwesekwa. Bangasiza futhi ekuchazeni izinguquko abazibonile ongasazi.
Lungela ukuxoxa ngendlela izimpawu zakho ezithinta ngayo imisebenzi yakho yansuku zonke. Chaza ngokuqondile ukuthi yini eya kuba nzima futhi yiziphi izindlela ozizamile ukulawula izinkinga.
I-Multiple system atrophy yisimo esinzima kodwa esilawuleka uma uneqembu lezokwelapha elifanele nesistimu yokusekela. Nakuba i-MSA iqhubeka, abantu abaningi baphila impilo ezele iminyaka eminingi ngemuva kokuxilongwa ngokwelashwa okufanele nokunakekelwa.
Ukuxilongwa okusheshayo nokwelashwa kungathuthukisa kakhulu ikhwalithi yokuphila kwakho futhi kusize ekuvimbweni kwezinkinga. Unganqikazi ukufuna ukunakekelwa kwezokwelapha uma uqaphela izimpawu ezikukhathazayo, ikakhulu izinkinga zokunyakaza, ukulinganisela, noma ukucindezeleka kwegazi.
Khumbula ukuthi i-MSA ithonya wonke umuntu ngokuhlukile, futhi okuhlangenwe nakho kwakho kungase kuhluke kakhulu kwalokho abanye abakuchazayo. Gxila ekusebenzeni neqembu lakho lezokwelapha ukuze uqonde izimpawu zakho ezithile futhi ugcine ukuzimela kwakho ngangokunokwenzeka.
Ukusekelwa komndeni, abangane, namaqembu okusekela i-MSA kungaba yigugu. Abantu abaningi bathola ukuthi ukuxhumana nabanye abaqonda isimo kunikeza ukwesekwa ngokomzwelo nezeluleko ezisebenzayo ngezinselele zansuku zonke.
Ukuqhubeka kwe-MSA kuyahluka kakhulu kumuntu nomuntu, kodwa abantu abaningi baphila iminyaka engu-6-10 ngemuva kokuxilongwa. Abanye abantu bane-progression ehamba kancane futhi bangaphila isikhathi eside, kanti abanye bangase babe nezinguquko eziqhubeka ngokushesha. Ikhwalithi yokuphila nokulawulwa kwezimpawu ngokuvamile kubaluleke kakhulu kunokulindela ukuphila, futhi abantu abaningi baqhubeka bejabulela imisebenzi enengqondo nobuhlobo kulo lonke uhambo lwabo ne-MSA.
I-MSA ayilitholi ngokuqondile njengezinye izifo zezinto eziyizofu, ngakho-ke ngokuvamile ayihambeli emindenini. Noma kunjalo, abacwaningi bathole ukuthi ukushintshashintsha okuthile kwezinto eziyizofu kungase kwenze abanye abantu babe sengozini enkulu yokukhula kwe-MSA uma bebhekene nezinto ezibangela ukuphazamiseka kwemvelo. Ukuba nelungu lomndeni eline-MSA akukhuphuli kakhulu ubungozi bakho bokukhula kwesimo.
Okwamanje, ayikho indlela ezaziwayo yokuvimbela i-MSA ngoba asiqondi ngokuphelele ukuthi iyini imbangela yayo. Njengoba ubudala buyona nto ebaluleke kakhulu yengozi futhi isimo libonakala liphuma ekuxubeni okunzima kwezinto eziyizofu nezici zemvelo, amasu okuvimbela awaziwa kahle. Ukuqondisa impilo ngokuvamile ngokwenza imizamo, ukudla okunempilo, nokugwema izinto ezinobuthi ezaziwayo kungase kube lumnandi ngempilo yengqondo ngokuvamile, kodwa la masu awakaqinisekiswa ukuthi avimbela i-MSA ngokuqondile.
Nakuba i-MSA ne-Parkinson's disease zihlanganyela izimpawu ezifanayo, ziyizimo ezihlukile. I-MSA ngokuvamile iqhubeka ngokushesha futhi ithonya izinhlelo eziningi zomzimba ngesikhathi esisodwa, kufaka phakathi ukulawula ukucindezeleka kwegazi, ukuphefumula, nokusebenza kwesibofu. Abantu abane-MSA ngokuvamile abaphenduli kahle emithini ye-levodopa, evame ukusiza abantu abane-Parkinson's disease. I-MSA futhi ivame ukubangela izinkinga ezinkulu zokulinganisela nokusebenza okungalungile kokulawula komzimba uma iqhathaniswa ne-Parkinson's disease.
Uma uhlupheka ngezimpawu ezikukhathazayo, cinga ngokuya kudokotela wakho wokuqala. Bangahlola izimpawu zakho futhi bakuncome kudokotela wezinzwa uma kudingeka. Ungazami ukuzixilonga, njengoba izimo eziningi zingabangela izimpawu ezifanayo. Gcina ulwazi lwezimpawu zakho, lapho zenzeka khona, nendlela ezithinta ngayo imisebenzi yakho yansuku zonke. Ukubhekwa okusheshayo kubalulekile ngoba ukuxilongwa okufanele nokwelashwa kungasiza ekulawuleni izimpawu nokuthuthukisa ikhwalithi yokuphila kwakho.
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