Yini i-Abaloparatide: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Abaloparatide iyimithi kadokotela esiza ukwakha amathambo aqinile kubantu abanokuqina kwamathambo okukhulu. Isebenza ngokulingisa i-hormone yemvelo emzimbeni wakho evuselela ukwakheka kwamathambo, okwenza kube yigugu ikakhulukazi kulabo abasengozini enkulu yokuphuka kwamathambo.

Lo muthi umelela indlela entsha yokwelapha ukuqina kwamathambo. Ngokungafani neminye imithi yamathambo evimbela ikakhulukazi ukulahleka kwamathambo, i-abaloparatide isiza ngempela umzimba wakho ukuthi wakhe izicubu zamathambo ezintsha, okungakhuthaza ikakhulukazi uma ubhekene namathambo abuthakathaka.

Yini i-Abaloparatide?

I-Abaloparatide iyinguqulo yokwenziwa ye-protein ehlobene ne-parathyroid hormone umzimba wakho oyikhiqiza ngokwemvelo. Ingaphansi kohlobo lwemithi ebizwa ngokuthi ama-ejenti e-anabolic amathambo, okusho ukuthi asiza ukwakha amathambo amasha kunokuvimbela nje ukulahleka kwamathambo.

Umuthi uza njengepeni elizaliswe ngaphambili olilayisha ngaphansi kwesikhumba sakho kanye ngosuku. Yenzelwe ngqo abantu abanokuqina kwamathambo abasengozini enkulu yokuphuka kwamathambo, ikakhulukazi abesifazane abase-postmenopausal kanye namadoda anokulahleka kwamathambo okukhulu.

Udokotela wakho angase ancome i-abaloparatide uma ezinye izindlela zokwelapha ukuqina kwamathambo zingasebenzi kahle noma uma ingozi yakho yokuphuka kwamathambo iphezulu kakhulu. Kuthathwa njengomuthi oqinile ongashintsha kakhulu amandla amathambo ngokuhamba kwesikhathi.

Isetshenziselwani i-Abaloparatide?

I-Abaloparatide isetshenziswa ikakhulukazi ukwelapha ukuqina kwamathambo kubesifazane abase-postmenopausal abasengozini enkulu yokuphuka kwamathambo. Ivunyelwe futhi ukwelapha ukuqina kwamathambo emadodeni anokulahleka kwamathambo okukhulu asengozini eyengeziwe yokuphuka kwamathambo.

Udokotela wakho angase akunikeze lo muthi uma usuvele uhlangabezane nokuphuka kwamathambo ngenxa yokuqina kwamathambo, unezilinganiso eziphansi kakhulu zamathambo, noma ungazange uphendule kahle kwezinye izindlela zokwelapha ukuqina kwamathambo. Kuyasiza ikakhulukazi kubantu amathambo abo asebuthakathaka ngendlela eyingozi.

Umuthi wenzelwe ngqo amacala abucayi e-osteoporosis. Akuyona inketho yokuqala yokwelapha kodwa igcinelwe izimo lapho ukwakha ithambo elisha ngokushesha kubalulekile ekuvikeleni ukuqhekeka okukhulu.

Isebenza Kanjani I-Abaloparatide?

I-Abaloparatide isebenza ngokwenza amangqamuzana amathambo akho abizwa ngokuthi ama-osteoblasts, okuyiwona abhekele ukwakha izicubu zamathambo amasha. Ilingisa isenzo se-parathyroid hormone-related protein, into yemvelo umzimba wakho oyisebenzisela ukulawula ukwakheka kwamathambo.

Uma ujova i-abaloparatide, ikhomba amangqamuzana akho akha amathambo ukuthi asebenze ngokuqhubekayo. Le nqubo isiza ukudala i-matrix yamathambo amasha futhi yandise ukuminyana kwamathambo ngokuhamba kwesikhathi. Cabanga ngayo njengokunika amathambo akho ukukhuthaza kwansuku zonke ukuze azakhele wona aqine.

Lo muthi uthathwa njengonamandla kakhulu mayelana nemiphumela yokwakha amathambo. Ngokungafani neminye imithi ye-osteoporosis ehlisa kakhulu ukulahleka kwamathambo, i-abaloparatide ikhuthaza ngokuqhubekayo ukukhula kwamathambo amasha, okungaholela ekuthuthukisweni okukhulu kwamandla amathambo ezinyangeni ezimbalwa zokuqala ukwelashwa.

Kufanele Ngiyithathe Kanjani I-Abaloparatide?

Uzojova i-abaloparatide kanye ngosuku usebenzisa idivayisi yepeni eligcwaliswe ngaphambilini, ngokuvamile ethangeni lakho noma esiswini. Umjovo uya ngaphansi kwesikhumba sakho (subcutaneous), hhayi emsipheni, futhi uzoshintshanisa izindawo zomjovo ukuze uvimbele ukucasuka.

Thatha umjovo wakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho. Abantu abaningi bakuthola kuwusizo ukuwujova ekuseni, kodwa ungakhetha noma yisiphi isikhathi esisebenzela kangcono uhlelo lwakho.

Akudingeki ukuthi uthathe lo muthi ngokudla, kodwa kubalulekile ukuhlala unamanzi kahle futhi ugcine ukudla okwanele kwe-calcium kanye ne-vitamin D ngenkathi usebenzisa i-abaloparatide. Udokotela wakho cishe uzoncoma izithasiselo ze-calcium ne-vitamin D ukusekela inqubo yokwakha amathambo.

Gcina amapeni akho emithi esiqandisini futhi uwavumele afinyelele ezingeni lokushisa legumbi ngaphambi kokujova. Ungalokothi unyakazise ipeni, futhi ngaso sonke isikhathi sebenzisa inaliti entsha ngomjovo ngamunye ukuvimbela ukutheleleka nokuqinisekisa ukulethwa okufanele.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Abaloparatide?

I-Abaloparatide ngokuvamile imiselwe isikhathi esingaphezu kwezinyanga ezingama-24 (iminyaka emi-2) empilweni yakho yonke. Lo mkhawulo ukhona ngoba idatha yokuphepha yesikhathi eside ngaphezu kweminyaka emi-2 ilinganiselwe, futhi imiphumela yokwakha amathambo yomuthi ivelele kakhulu ngalesi sikhathi.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokuskena kobukhulu bamathambo kanye nezinye izivivinyo ngesikhathi sokwelashwa. Abantu abaningi babona ukuthuthuka okukhulu ekuqineni kwamathambo phakathi nezinyanga eziyi-6 kuya kweziyi-12 zokuqala umuthi.

Ngemva kokuqeda inkambo yakho ye-abaloparatide, udokotela wakho cishe uzoncoma ukushintshela emuthini ohlukile we-osteoporosis ukuze ugcine amandla amathambo owatholile. Lokhu kwelashwa okulandelayo kubalulekile ngoba imiphumela yokwakha amathambo ye-abaloparatide ingancipha uma ingalandelwa ukwelashwa okugcina amathambo.

Yiziphi Imiphumela Eceleni ye-Abaloparatide?

Njengayo yonke imithi, i-abaloparatide ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nansi imiphumela emibi ongase uyithole, futhi kuyasiza ukwazi okulindelekile ukuze ukwazi ukuyiphatha ngempumelelo:

• Ukuvuvukala endaweni yokujova - Ububomvu, ukuvuvukala, noma ubuhlungu obuncane lapho ujova khona, ngokuvamile okwesikhashana
• Isicanucanu - Ngokuvamile kulula futhi kungathuthuka ngokuhamba kwesikhathi
• Ukukhathazeka ikhanda - Ngokuvamile kulawuleka ngemithi eqeda ubuhlungu etholakala ngaphandle kwemvume kadokotela
• Isiyezi - Ikakhulukazi uma usukuma ngokushesha
• Ukukhathala - Ukuzizwa ukhathele kakhulu kunokujwayelekile, ikakhulukazi emasontweni ambalwa okuqala
• Ubuhlungu besisu obungaphezulu - Ngokuvamile kulula futhi okwesikhashana

Le miphumela emibi ejwayelekile ngokuvamile iba ngaphansi kokuphazamisa njengoba umzimba wakho ujwayela umuthi, futhi abantu abaningi bayayithola ilawuleka ngokwanele ukuze baqhubeke nokwelashwa.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi ukusabela okukhulu komzimba, isicanucanu esiqhubekayo esihambisana nokuhlanza, noma ubuhlungu obungavamile emathanjeni obungathuthuki.

Abanye abantu bangase babe namazinga e-calcium aphakeme egazini labo, yingakho udokotela wakho ezoqapha amazinga akho e-calcium ngokuhlolwa kwegazi okuvamile. Izimpawu ze-calcium ephezulu zifaka phakathi ukoma ngokweqile, ukuvama ukuchama, noma ukudideka.

Ubani Ongafanele Athathwe I-Abaloparatide?

I-Abaloparatide ayifanele wonke umuntu, futhi kunezimo eziningana ezibalulekile lapho lo muthi kufanele ugwenywe khona. Udokotela wakho uzoqapha ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwunika.

Akufanele uthathe i-abaloparatide uma unomlando womdlavuza wamathambo, eminye imidlavuza esabalale emathanjeni, noma amazinga aphakeme angachazeki e-alkaline phosphatase. Lo muthi awunconyelwe uma uke wathola ukwelashwa ngemisebe okubandakanya amathambo akho.

Abantu abanezifo ezinzima zezinso, amazinga aphezulu e-calcium egazini labo, noma umlando wamatshe ezinso kufanele basebenzise lo muthi ngokucophelela okukhulu noma bawugweme ngokuphelele. Abesifazane abakhulelwe noma abancelisa ngamabele akufanele basebenzise i-abaloparatide, njengoba imiphumela yayo ezinganeni ezisakhulayo ingaziwa.

Uma unesifo sePaget samathambo, uke wathola ukwelashwa ngemithi ethile yamathambo eminye iminyaka engaphezu kwemibili, noma unomlando wezinhlungu zamathambo ezingachazeki, udokotela wakho uzodinga ukuhlola ngokucophelela ukuthi i-abaloparatide ilungele yini wena.

Amagama Omkhiqizo we-Abaloparatide

I-Abaloparatide itholakala ngaphansi kwegama lomkhiqizo elithi Tymlos e-United States. Leli yigama eliyinhloko lomkhiqizo ozohlangana nalo lapho udokotela wakho ekunikeza lo muthi.

Umuthi uza njengepeni eligcwaliswe ngaphambili eliqukethe imithamo eminingi. Ipeni ngalinye lenzelwe ukusetshenziswa kalula kanye nokulinganisa okulungile, okwenza ukuzijova nsuku zonke kube lula kubantu abaningi.

Njalo sebenzisa umkhiqizo onqunywe udokotela wakho, njengoba amafomula ahlukene angase abe nezici ezihlukene kancane noma izidingo zokulinganisa.

Ezinye Izindlela ze-Abaloparatide

Uma i-abaloparatide ingakulungele, imithi eminingi ehlukile ye-osteoporosis iyatholakala. Ukukhetha kuncike esimweni sakho esithile, umlando wezokwelapha, nokuthi i-osteoporosis yakho inkulu kangakanani.

I-Teriparatide ngomunye umuthi wokwakha amathambo osebenza ngendlela efana ne-abaloparatide kodwa sekuyisikhathi eside itholakala. Inikezwa futhi njengomjovo wansuku zonke futhi inokuphumelela okufanayo ekwakheni ukuminyana kwamathambo.

Kubantu abathanda imithi yomlomo, ama-bisphosphonates afana ne-alendronate noma i-risedronate angasiza ekuvikeleni ukulahleka kwamathambo, nakuba engawakhi amathambo amasha njenge-abaloparatide. Lezi zivame ukusetshenziswa njengokwelashwa kokugcinwa ngemva kokuqeda inkambo yomuthi wokwakha amathambo.

I-Denosumab ngumjovo onikezwa njalo ezinyangeni eziyisithupha ovimbela ngempumelelo ukulahleka kwamathambo futhi unciphise ingozi yokuphuka. Ilusizo ikakhulukazi kubantu abangakwazi ukubekezelela imijovo yansuku zonke noma imithi yomlomo.

Ingabe i-Abaloparatide ingcono kune-Teriparatide?

Kokubili i-abaloparatide ne-teriparatide ziyimithi esebenza kahle yokwakha amathambo, futhi ukukhetha phakathi kwazo kuvame ukuncika ezintweni zomuntu ngamunye kanye nokuhlola kukadokotela wakho izidingo zakho ezithile.

Ucwaningo luphakamisa ukuthi i-abaloparatide ingase ibangele ukukhuphuka okuncane emazingeni e-calcium yegazi uma iqhathaniswa ne-teriparatide, okungaba nenzuzo kwabanye abantu. Yomibili imithi inokusebenza okufanayo ekwakheni ukuminyana kwamathambo nokunciphisa ingozi yokuphuka.

Amaphrofayili emiphumela emibi afana kakhulu phakathi kwemithi emibili, kokubili kubangela ukusabela endaweni yokujova, isicanucanu, nesiyezi kwabanye abantu. Udokotela wakho uzocabangela umlando wakho wezokwelapha, eminye imithi oyithathayo, nezintandokazi zakho siqu lapho ekhetha phakathi kwazo.

Izindleko nokumbozwa komshuwalense kungase futhi kuthinte isinqumo, njengoba lezi zinto zingahluka kakhulu phakathi kwemithi ehlukene nezinhlelo zomshuwalense.

Imibuzo Evame Ukubuzwa Nge-Abaloparatide

Ingabe i-Abaloparatide iphephile kubantu abanezifo zenhliziyo?

I-Abaloparatide ngokuvamile ithathwa njengephephile kubantu abanezifo zenhliziyo, kodwa udokotela wakho uzodinga ukuhlola isimo sakho senhliziyo esithile. Umuthi ngokuvamile awubangeli imiphumela emibi ehlobene nenhliziyo kubantu abaningi.

Noma kunjalo, uma unezifo zenhliziyo ezinzima noma uthatha imithi eminingi yenhliziyo, udokotela wakho angase afune ukukuqapha eduze lapho uqala i-abaloparatide. Abanye abantu bangase bahlangabezane nesiyezi, okungase kuthinte labo abanezimo zenhliziyo ezithile.

Njalo yazisa udokotela wakho ngayo yonke imithi yenhliziyo oyithathayo, njengoba bezofuna ukuqinisekisa ukuthi akukho ukusebenzisana nokuthi isimo senhliziyo yakho sizinzile ngaphambi kokuqala lokhu kwelashwa kokwakha amathambo.

Ngingenzani uma ngiphuthelwa ngisebenzisa i-Abaloparatide eningi kakhulu?

Uma ngabe ujezisa i-abaloparatide eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma umhlinzeki wakho wezempilo ngokushesha. Ukuthatha okuningi kakhulu kungase kubangele amazinga e-calcium aphakeme egazini lakho, okungaba yingozi.

Qaphela izimpawu zamazinga aphezulu e-calcium, okuhlanganisa ukoma ngokweqile, ukuya ngaphezulu njalo, isicanucanu, ukuhlanza, ukuqunjelwa, noma ukudideka. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa usizo lwezokwelapha ngokushesha.

Ungazami "ukulungisa" ukweqisa ngokweqa imithamo yesikhathi esizayo. Kunalokho, landela isiqondiso sikadokotela wakho sokuthi ungaluqala nini kabusha uhlelo lwakho olujwayelekile lokulinganisa. Gcina ukupakishwa komuthi unawe lapho ufuna usizo lwezokwelapha ukuze abahlinzeki bezempilo bazi kahle ukuthi uthatheni ini nokuthi uthathe okungakanani.

Ngingenzani Uma Ngeqe Umthamo We-Abaloparatide?

Uma ugeqa umthamo we-abaloparatide, yithathe ngokushesha lapho ukhumbula ngalo lolo suku. Uma sekuyilanga elilandelayo, weqa umthamo ogeqiwe bese uqhubeka nohlelo lwakho olujwayelekile ngosuku olulandelayo.

Ungalokothi uthathe imithamo emibili ngosuku olufanayo ukuze ulungise umthamo ogeqiwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi, ikakhulukazi amazinga e-calcium aphakeme. Kungcono ukweqa umthamo owodwa kunokuphinda kabili.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise uhlelo lokusebenza lokukhumbuza imithi. Ukulinganisa nsuku zonke okuqhubekayo kusiza ukugcina amazinga aqinile omuthi emzimbeni wakho ukuze uthole imiphumela engcono yokwakha amathambo.

Ngingayeka Nini Ukuthatha I-Abaloparatide?

Kufanele uyeke kuphela ukuthatha i-abaloparatide ngaphansi kwesiqondiso sikadokotela wakho. Umuthi uvame ukunikezwa iminyaka engama-24, futhi ukuyeka ngaphambi kwesikhathi kungasho ukuthi awutholi izinzuzo ezigcwele zokwakha amathambo.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokuskena ukuminyana kwamathambo futhi angase ancome ukuyeka uma uhlangabezana nemiphumela emibi ebalulekile noma uma ukuminyana kwamathambo akho kuthuthuke ngokwanele. Kodwa-ke, lesi sinqumo kufanele senziwe ngaso sonke isikhathi kanye nomhlinzeki wakho wezempilo.

Uma uyeka ukusebenzisa i-abaloparatide, udokotela wakho cishe uzoncoma ukushintshela kwenye imithi ye-osteoporosis ukuze ugcine amandla amathambo owatholile. Lokhu kwelashwa okulandelayo kubalulekile ngoba izinzuzo ze-abaloparatide zingancipha ngaphandle kokwelashwa okuqhubekayo okonga amathambo.

Ngingahamba ne-Abaloparatide?

Yebo, ungahamba ne-abaloparatide, kodwa kudinga ukuhlela okuthile ngoba imithi idinga ukugcinwa efrijini. Uma uhamba, sebenzisa iphakethe lokupholisa noma isikhwama esivaliwe ukuze ugcine izinga lokushisa elifanele.

Ekuhambeni ngomoya, thwala imithi yakho emthwalweni wakho wesandla kunokuba emithwalweni ehloliwe ukuvimbela amazinga okushisa adlulele. Letha incwadi evela kudokotela wakho echaza isidingo sakho somuthi kanye nezinto zokujova.

Uma uhamba ngaphesheya kwemikhakha yesikhathi, zama ukugcina isimiso sakho sokulinganisa ngokusondela ngangokunokwenzeka. Ungase udinge ukulungisa kancane kancane isikhathi sakho sokujova ezinsukwini ezimbalwa ukuze uvumelane nesikhathi sakho esisha ngenkathi ugcina imithamo cishe ngamahora angama-24 ngaphandle.