Abatacept (indlela ye-intravenous, indlela ye-subcutaneous)
Imikhiqizo etholakalayo
Orencia
Mayelana naleli khambi
Isikhubekiso se-Abatacept sisetshenziswa sodwa noma ngokubambisana nezinye izidakamizwa zokwelapha isifo se-rheumatoid arthritis esiphakathi nendawo esikhulu. I-Abatacept iyasiza ekugcineni ukulimala kwamajozi kungabi kubi kakhulu ngemuva kokusetshenziswa kwezinye izidakamizwa futhi azisebenzi kahle. Isikhubekiso se-Abatacept sisetshenziswa futhi sodwa noma ngokubambisana ne-methotrexate ukwelapha isifo se-polyarticular juvenile idiopathic arthritis (pJIA) esiphakathi nendawo esikhulu. Isikhubekiso se-Abatacept sisetshenziswa futhi sodwa noma ngokubambisana nezinye izidakamizwa ukwelapha isifo se-psoriatic arthritis (PsA) esisebenzayo, okuyiluhlobo lwesifo se-arthritis obangela ubuhlungu nokukhula kwamajozi kanye namabala olukhumba olukhulu ezingxenyeni ezithile zomzimba. Isikhubekiso se-Abatacept sisetshenziswa futhi ngokubambisana nezinye izidakamizwa (ibh. umtholampilo we-calcineurin, i-methotrexate) ukuvimbela isifo se-acute graft-versus-host disease (aGVHD) kubantu abazokwenza i-hematopoietic stem cell transplantation (HSCT) evela kumuphi umnikelo ofanayo noma ongavumelani no-1 allele. Lona umuthi uyatholakala kuphela ngomyalelo wodokotela wakho. Lo mkhiqizo uyatholakala ngezindlela zokwelapha ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekucineni kokusebenzisa imithi, izingozi zokusebenzisa imithi kufanele ziqhathaniswe nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kulo muthi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqondile noma oluthile lokuphazamiseka komzimba kulo muthi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokuphazamiseka komzimba, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zezingane ezizobeka umkhawulo ekusebenziseni ukugxilwa kwe-Abatacept kubantwana abaneminyaka emibili ubudala nangaphezulu ukwelapha i-pJIA, ukwelapha i-PsA, nokuvimbela i-aGVHD. Noma kunjalo, ukuphepha nokusebenza kahle akukaqiniswa kubantwana abaneminyaka engaphansi kwemibili. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezizobeka umkhawulo ekusebenziseni ukugxilwa kwe-Abatacept kubantu abadala. Noma kunjalo, abantu abadala banesizotha kakhulu imiphumela yalo muthi kunabantu abadala abancane futhi banesilinganiso esikhulu sokuthola umdlavuza nokutheleleka okukhulu, okungadinga ukuqapha kubantu abamukela ukugxilwa kwe-Abatacept. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa lo muthi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa lo muthi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izindlela zokuphepha zingadingeka. Uma uthatha lo muthi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa lo muthi nanoma iyiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ukusebenzisa lo muthi nanoma iyiphi imithi elandelayo kungabangela ukwanda kengozi yezinye izingozi ezihambisana nayo, kodwa ukusebenzisa kokubili imithi kungaba ukwelashwa okuhle kuwe. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba nanoma iyiphi imithi kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwalo muthi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Umshula oqeqeshwe kahle noma omunye ochwepheshe wezempilo uzokunika wena noma ingane yakho le miyeke. Lolu lwemiyeke lunikezwa njengesiqhamo phansi kwesikhumba sakho noma ngaphakathi emoyeni. Ukuze kuphathwe isifo sofuba se-rheumatoid, isifo sofuba se-psoriatic, kanye ne-arthritis yabantwana abancane abaningi: Uma le miyeke inikezwa ngemoto yakho yengalo, kufanele ihlanganiswe ngudokotela wakho kancane futhi i-IV yakho kufanele ihlale isikhathi esingamaminithi angu-30. Uzophinde uthole le miyeke ngemva kwamasonto amabili kanye namasonto amane ngemva kwesilinganiso sakho sokuqala bese uthola yonke imihla engama-4 ngemva kwalokho. Ukuvimbela isifo esibuhlungu se-graft-versus-host (aGVHD): Lolu lwemiyeke lunikezwa ngemoto yakho yengalo. Kufanele ihlanganiswe ngudokotela wakho kancane futhi i-IV yakho kufanele ihlale isikhathi esingamaminithi angu-60 ngosuku ngaphambi kokuthola ukutshalwa kwakho (Usuku -1). Uzophinde uthole le miyeke ezinsukwini eziyi-5, 14, kanye nama-28 ngemva kokutshalwa. I-Abatacept inganikezwa njengesiqhamo phansi kwesikhumba. Ngezinye izikhathi inganikezwa ekhaya kubantu abangadingi ukuba esibhedlela. Uma wena noma ingane yakho usebenzisa le miyeke ekhaya, udokotela wakho noma ushilo uzokufundisa ukuthi ungayilungiselela kanjani futhi uyihlanganise kanjani le miyeke. Qiniseka ukuthi uyayiqonda ngokuphelele indlela yokusebenzisa le miyeke. Lolu lwemiyeke luza nemiyalo yokuqondisa. Funda futhi ulandele le miyalo ngokucophelela. Buza udokotela wakho noma umthengisi wemithi uma unemibuzo. Uma usebenzisa le miyeke ekhaya, uzoboniswa izindawo zomzimba lapho le siqhamo singanikezwa khona. Sebenzisa indawo ehlukile yomzimba njalo lapho uzinikeza wena noma ingane yakho isiqhamo. Gcina ulandelela ukuthi unikeza kuphi isiqhamo ngasinye ukuze uqiniseke ukuthi uqala izindawo zomzimba. Lokhu kuzosiza ukuvimbela izinkinga zesikhumba. Lolu lwemiyeke luyatholakala ngezindlela ezintathu: ibhodlela (isitsha seglasi), isiqhamo esigcwalisiwe, noma i-ClickJect ™ autoinjector. Isiqhamo esigcwalisiwe ne-ClickJect ™ autoinjector yizindlela zokulinganisa ongazisebenzisa ekhaya. Hlola ulwemiyeke oluku-syringe egcwalisiwe noma i-ClickJect ™ autoinjector. Kufanele ibe sobala futhi ingenalutho noma ibe mnyama kancane. Ungayisebenzisi uma ihlanganiswe, ihlanganiswe, noma uma ubona izicucu kuyo. Ungayisebenzisi i-syringe egcwalisiwe noma i-ClickJect ™ autoinjector uma ibukeka iqhekekile noma iphukile. Vumela imizuzu engama-30 ukuze i-syringe ifudumele kumazinga okushisa kwegumbi. Ungayifudumisi le miyeke nganoma iyiphi enye indlela. Susa kuphela uma usulungele ukusebenzisa. Qiniseka ukuthi inani lolwemiyeke oluku-syringe egcwalisiwe liwela noma liphezulu nje kumugqa wokugcwalisa. Uma i-syringe inganalo inani elifanele lolwemiyeke, ungayisebenzisi. Ungayihlanganisi ezindaweni zesikhumba ezipinki, ezibomvu, ezibuhlungu, ezinqunu, noma ezinzima, noma ezinamabala noma amamaki okuqina. Inani lemiyeke kuzoba ehlukile kubantu abahlukene. Landela imiyalo yedokotela wakho noma imiyalo elabelini. Ulwazi olulandelayo luhlanganisa kuphela izilinganiso ezimaphakathi zale miyeke. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani lemiyeke oyithatha lixhomeke emandleni emiyeke. Futhi, inani lezingxenye oyithatha nsuku zonke, isikhathi esivunyelwe phakathi kwezingxenye, nobude besikhathi othatha le miyeke kuya ngenkinga yezokwelapha oyisebenzisela le miyeke. Lolu lwemiyeke kufanele lunikezwe ngesikhathi esibekiwe. Uma uphuthelwa yisilinganiso noma ukhohlwe ukusebenzisa imithi yakho, shayela udokotela wakho noma umthengisi wemithi ukuze uthole imiyalo. Gcina esiqandisini. Ungayiganduki. Gcina kude nezingane. Ungagcini imithi esele iphelile noma imithi engasadingeki. Buza ochwepheshe bezempilo ukuthi kufanele uyilahla kanjani noma iyiphi imithi ongayisebenzisi. Phonsa izimpumputhe ezisetshenzisiwe esitsheni esiqinile, esivalekile lapho izimpumputhe zingakwazi ukugqwala khona. Gcina lesi sitsha kude nezingane nezilwane ezifuywayo.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.