Yini i-Abciximab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Abciximab iyimithi enamandla esiza ekuvikeleni ukwakheka kwamahlule egazi ngesikhathi sokuhlinzwa okukhulu kwenhliziyo. Iwumuthi okhethekile odokotela abawusebenzisayo ezibhedlela uma wenza ukwelashwa okuthile kwenhliziyo njenge-angioplasty noma ukufakwa kwe-stent.

Lo muthi usebenza ngokuvimba amaseli amancane egazi abizwa ngokuthi ama-platelet ukuthi anamathelane. Cabanga ngayo njengesihlangu sesikhashana esigcina igazi lakho ligeleza kahle ngesikhathi esibucayi lapho ukwakheka kwamahlule kungaba yingozi.

Yini i-Abciximab?

I-Abciximab ngumuthi kadokotela ongaphansi kweqembu elibizwa ngokuthi ama-platelet inhibitors. Yilokho odokotela abakubiza ngokuthi “i-monoclonal antibody” - okuyiphrotheni eyenziwe e-lab ehloselwe izingxenye ezithile zamaseli akho egazi.

Uzothola lo muthi kuphela esibhedlela ngomugqa we-IV. Akuyona into oyithatha ekhaya noma oyilanda ekhemisi. Ithimba lezokwelapha likuqapha ngokucophelela ngenkathi ulithola.

Lo muthi unamandla kakhulu futhi usebenza ngokushesha uma ungena egazini lakho. Yenzelwe ukusetshenziswa kwesikhashana ngesikhathi sokuhlinzwa okuthile lapho ukuvimbela amahlule egazi kubaluleke kakhulu.

Isetshenziselwani i-Abciximab?

Odokotela ngokuyinhloko basebenzisa i-abciximab ngesikhathi sokuhlinzwa kwenhliziyo ukuvimbela amahlule egazi ayingozi. Ivame kakhulu ukunikezwa ngesikhathi se-percutaneous coronary intervention (PCI) - izinqubo lapho odokotela bevula khona imithambo yenhliziyo evaliwe.

Izimo eziyinhloko lapho ungase uthole khona i-abciximab zihlanganisa i-angioplasty, lapho odokotela bekhukhumeza ibhaluni elincane ukuze bavule imithambo evaliwe, nokufakwa kwe-stent, lapho befaka khona amashubhu amancane e-mesh ukuze bavule imithambo. Isetshenziswa futhi ngesikhathi sezinhlobo ezithile zezinqubo ze-catheterization yenhliziyo.

Ngezinye izikhathi odokotela bayayibhala kubantu abanezindlela eziphuthumayo zenhliziyo, ikakhulukazi uma usengozini enkulu yokuthuthukisa amahlule. Udokotela wakho wenhliziyo angase futhi ayincomise uma une-angina engazinzile - ubuhlungu besifuba obenzeka ngokungalindelekile.

Isebenza Kanjani I-Abciximab?

I-Abciximab isebenza ngokuvimba ama-receptors athile kuma-platelets akho abizwa ngokuthi ama-GP IIb/IIIa receptors. Lawa ma-receptors anjengeziteshi zokumisa lapho ama-platelets ngokuvamile exhumana khona ukuze akhe amahlule.

Lapho i-abciximab inamathisela kula ma-receptors, ivimbela ama-platelets ukuthi angaxhumani ndawonye. Lokhu kubaluleke kakhulu ngesikhathi senqubo yenhliziyo ngoba amathuluzi namadivayisi asetshenziswayo ngezinye izikhathi angabangela ukwakheka kwegazi okungafuneki.

Lo muthi uthathwa njengomqina kakhulu - unamandla kakhulu kunama-blood thinners avamile afana ne-aspirin. Inikeza ukuvikelwa okukhulu kodwa okwesikhashana ekugcineni, okuyilokho kanye okudingekayo ngesikhathi sezinqubo eziyingozi.

Imiphumela iqala ngemizuzu embalwa ngemuva kokuqala ukufakwa kwe-IV. Ikhono legazi lakho lokugcina lihlala lincishiswe kakhulu amahora amaningana, ngisho nangemva kokuthi umuthi uyekisiwe.

Kufanele Ngiyithathe Kanjani I-Abciximab?

Awuzithathi wena i-abciximab - ngaso sonke isikhathi inikezwa ochwepheshe bezokwelapha abaqeqeshiwe esibhedlela. Umuthi uza ngomugqa we-IV, ngokuvamile engalweni yakho noma esandleni sakho.

Ithimba lakho lezokwelapha lizoqala ngomthamo wokulayisha, okuyimali enkulu yokuqala enikezwa ngokushesha. Lokhu kulandelwa ukufakwa okuqhubekayo okuletha amanani amancane emahoreni amaningana.

Akudingeki ukhathazeke ngemikhawulo yokudla ngaphambi kokuthola i-abciximab. Kodwa-ke, udokotela wakho angase akucele ukuthi ugweme imithi ethile noma izithasiselo ezingandisa ingozi yokopha.

Abasebenzi bokunakekela bazokuqapha eduze kuyo yonke inqubo. Bazohlola izimpawu zakho ezibalulekile njalo futhi baqaphele noma yiziphi izimpawu zokopha noma ezinye izinkinga.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Abciximab?

Ukwelashwa nge-Abciximab kuhlala isikhathi esifushane, ngokuvamile kuthatha amahora angu-12 kuya kwangu-24. Isikhathi esiqondile sincike kunqubo yakho ethile kanye nezici eziyingozi zomuntu ngamunye.

Iziguli eziningi zithola umuthi cishe amahora angu-12 ngemuva kokuqedwa kwenqubo yazo yenhliziyo. Kwezinye izimo, ikakhulukazi izinqubo eziyinkimbinkimbi, udokotela wakho angase andise ukwelashwa kuze kube amahora angu-24.

Ithimba lakho lezokwelapha lizinquma isikhathi esiqondile ngokusekelwe endleleni inqubo yakho eyahamba ngayo kanye nokuphendula komzimba wakho. Bazocabangela izici ezinjengengozi yokopha nokuthi inhliziyo yakho iphila kahle kangakanani.

Lapho ukumnika kuyeka, imiphumela yomuthi iyancipha kancane kancane ngosuku olulandelayo noma ezimbili. Ikhono legazi lakho elivamile lokujiya libuyela, kodwa lokhu kwenzeka kancane ukuze kuqinisekiswe ukuphepha kwakho.

Yiziphi Imiphumela Eceleni ye-Abciximab?

Umphumela obaluleke kakhulu we-abciximab ukuphuma igazi, okungahluka kusuka kokuncane kuya kokukhulu. Lokhu kwenzeka ngoba umuthi ngamabomu unciphisa ikhono legazi lakho lokujiya.

Nawa ama-side effects avamile ongase uwathole:

• Ukuphuma igazi endaweni ye-IV noma indawo yokufaka i-catheter
• Ukulimala kalula esikhumbeni sakho
• Ukucasuka noma ukuqina kwesisu okuncane
• Ikhanda noma isiyezi
• Ubuhlungu emhlane, ikakhulukazi endaweni yenqubo
• Umfutho wegazi ophansi

Le miphumela ngokuvamile iyaphathwa futhi iqashwe eduze yithimba lakho lezempilo. Iningi liyazixazulula ngokwalo njengoba umuthi ususwa ohlelweni lwakho.

Imiphumela emibi kakhulu kodwa engavamile idinga ukunakekelwa kwezokwelapha ngokushesha:

• Ukuphuma igazi okukhulu okungami ngengcindezi
• Igazi emchameni wakho noma endleni
• Ukuphuma igazi okungavamile ezinsinini zakho noma emakhaleni
• Ubuhlungu obukhulu besifuba noma ukuphefumula kanzima
• Izimpawu zokushaywa unhlangothi njengokudideka okungazelelwe noma ubuthakathaka
• Ukuphendula okukhulu komzimba okungalindelekile okunezinduna noma ubunzima bokuphefumula

Iqembu lakho lezokwelapha liqeqeshwe ukubona nokwelapha lezi zinkinga ngokushesha. Banemithi nezinqubo ezilungele ukuguqula imiphumela ye-abciximab uma kudingeka.

Izinkinga ezingavamile kodwa ezingathi sína zingabandakanya ukopha okukhulu kwangaphakathi noma i-thrombocytopenia - ukwehla okuyingozi kwenani lama-platelet. Lokhu kwenzeka ngaphansi kuka-1% weziguli kodwa kudinga ukungenelela ngokushesha.

Ubani Ongafanele Athathe I-Abciximab?

I-Abciximab ayiphephile kuwo wonke umuntu, ikakhulukazi labo abanezimo ezenza ingozi yokopha ikhule. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokunquma ukuthi ilungele yini wena.

Akufanele uthole i-abciximab uma unokopha okusebenzayo noma yikuphi emzimbeni wakho. Lokhu kufaka phakathi ukopha okubonakalayo njengokopha ngamakhala noma ukopha okufihliwe njengezilonda zesisu.

Abantu abanezimo ezithile zezokwelapha badinga ukugwema lo muthi ngokuphelele:

• Ukuhlinzwa okukhulu kwakamuva phakathi namasonto angu-6 adlule
• Umlando wokushaywa unhlangothi phakathi neminyaka emi-2 edlule
• Umfutho wegazi ophezulu ongagadiwe kakhulu
• Izifo zokopha ezaziwayo njenge-hemophilia
• Isifo sesibindi noma sezinso esibi kakhulu
• Umkhuhlane oqhubekayo onengozi yokopha
• Ukulimala kwakamuva noma ukulimala ekhanda

Udokotela wakho uzophinda aqaphele uma uthatha eminye imithi yokunciphisa igazi. Inhlanganisela ingakhuphula kakhulu ingozi yokopha ngaphezu kwamazinga aphephile.

Abesifazane abakhulelwe ngokuvamile akufanele bathole i-abciximab ngaphandle uma izinzuzo zicacisa ukuthi zidlula izingozi. Umuthi ungaweqa i-placenta futhi ungase uthinte ingane esakhula.

Ubudala bodwa abuyona into ekuvimbayo, kodwa abadala bangase badinge ukulungiswa komthamo noma ukuqapha okwengeziwe ngenxa yokwanda kokuzwela kokopha.

Amagama Omkhiqizo we-Abciximab

I-Abciximab yaziwa kakhulu ngegama layo lomkhiqizo elithi ReoPro. Lena inguqulo yokuqala futhi esetshenziswa kakhulu yomuthi ezibhedlela.

Ngokungafani nemithi eminingi, i-abciximab ayinayo amagama amaningi emikhiqizo noma izinhlobo ezivamile. I-ReoPro ihlala iyindlela ejwayelekile esetshenziswa ezikhungweni zezokwelapha emhlabeni wonke.

Uma nixoxa ngemithi yakho nodokotela, bangase babhekisele kuyo nganoma yiliphi igama - abciximab noma ReoPro. Zombili lezi zisho zibhekisela emuthini ofanayo onemiphumela efanayo nokulinganisa.

Ezinye izindlela ze-Abciximab

Eminye imithi eminingana ingahlinzeka ngendlela efanayo yokuvimbela ukujiya kwegazi ngesikhathi senqubo yenhliziyo. Udokotela wakho angase akhethe ezinye izindlela ngokusekelwe esimweni sakho esithile kanye nezici eziyingozi.

I-Eptifibatide ne-tirofiban ezinye izindlela ezisebenza ngendlela efanayo ne-abciximab. Nazo zingabavimbeli be-GP IIb/IIIa receptor kodwa zinesikhathi esifushane sokusebenza.

Abanye odokotela bakhetha lezi zindlela ngoba imiphumela yazo iyaphela ngokushesha uma kwenzeka izinkinga zokuphuma kwegazi. Kodwa-ke, kungenzeka zingabi namandla njenge-abciximab ezinqubweni eziyingozi kakhulu.

Eminye imithi yokunciphisa igazi efana ne-heparin noma i-bivalirudin isebenza ngezindlela ezihlukene. Udokotela wakho wenhliziyo uzokhetha inketho engcono kakhulu ngokusekelwe ohlotsheni lwenqubo yakho kanye nephrofayili yengozi yomuntu ngamunye.

Ingabe i-Abciximab Ingcono Kune-Clopidogrel?

I-Abciximab ne-clopidogrel zisebenza ngendlela ehlukile futhi zisebenzela izinhloso ezihlukene ekunakekelweni kwenhliziyo. Abayona izimbangi eziqondile - esikhundleni salokho, zivame ukusetshenziswa ndawonye ukuze kuvikelwe ngokugcwele.

I-Abciximab inikeza ukuvikelwa okusheshayo, okunamandla kokujiya kwegazi ngesikhathi sezinqubo, kuyilapho i-clopidogrel inikeza ukuvikelwa kwesikhathi eside okuthathwa ekhaya. Cabanga nge-abciximab njengokuvikelwa okuphuthumayo kanye ne-clopidogrel njengokunakekelwa kwansuku zonke.

Ezimweni eziphuthumayo ngesikhathi sezinqubo zenhliziyo, i-abciximab ngokuvamile isebenza kahle ngoba isebenza ngokushesha futhi ngokugcwele. I-Clopidogrel ithatha izinsuku ukufinyelela ekusebenzeni ngokugcwele.

Kodwa-ke, i-clopidogrel iphephe kakhulu ukusetshenziswa isikhathi eside futhi ayidingi ukuqashwa esibhedlela. Udokotela wakho ngokuvamile uzosebenzisa zombili - i-abciximab ngesikhathi senqubo yakho kanye ne-clopidogrel amasonto noma izinyanga ngemva kwalokho.

Imibuzo Evame Ukubuzwa Mayelana ne-Abciximab

Ingabe i-Abciximab iphephile kubantu abanesifo sikashukela?

I-Abciximab ingaphephela abantu abanesifo sikashukela, kodwa kudingeka izinyathelo zokuphepha ezengeziwe. Isifo sikashukela singathinta impilo yemithambo yegazi nokuphola, okuzocatshangelwa ngokucophelela ithimba lakho lezokwelapha.

Abantu abanesifo sikashukela bangase babe sengozini enkulu yokopha. Odokotela bakho bazokuqapha eduze futhi bangase balungise umthamo noma ubude bokwelashwa.

Uma unesifo sikashukela i-retinopathy - izinkinga zamehlo ezivela esifweni sikashukela - udokotela wakho uzoba qaphele kakhulu. Lesi simo singakhuphula ingozi yokopha emehlweni.

Ngingenzani uma ngithola i-Abciximab eningi ngengozi?

Awukwazi ukuthola i-abciximab eningi ngengozi ngoba ochwepheshe bezokwelapha abaqeqeshiwe balawula umthamo. Kodwa-ke, uma kwenzeka ukweqisa, ukungenelela kwezokwelapha ngokushesha kuyatholakala.

Izibhedlela zinezimiso ezithile zokuguqula imiphumela ye-abciximab. Lokhu kungabandakanya ukumpontshelwa kwamaphlatelethi noma eminye imithi ebuyisela ukujiya kwegazi okuvamile.

Ithimba lezokwelapha liqapha amazinga okujiya kwegazi lakho ngesikhathi sokwelashwa. Bangakwazi ukuthola ngokushesha uma imithi inemiphumela enamandla kakhulu futhi ilungise ngokufanele.

Ngingenzani uma ngiphuthelwa umthamo we-Abciximab?

Ukuphuthelwa umthamo we-abciximab akuyona into okudingeka ukhathazeke ngayo. Umuthi unikezwa ngokuqhubekayo nge-IV, ngakho ithimba lezokwelapha lilawula isikhathi.

Uma kukhona ukuphazamiseka ekufakweni kwakho kwe-IV, abahlengikazi bakho bazokuqala kabusha ngokushesha. Bazohlola ukuthi ngabe udinga yini eminye imithi ukuze ugcine ukuvikeleka.

Iqembu lakho lezokwelapha linesimiso sokubhekana nanoma yikuphi ukuphazamiseka ekwelashweni. Bazoqinisekisa ukuthi uthola umthamo ofanele wemithi ngokuya ngesimo sakho.

Ngingayeka nini ukuthatha i-Abciximab?

Awunqumi ukuthi uyeka nini ukuthatha i-abciximab - iqembu lakho lezokwelapha lenza lesi sinqumo ngokusekelwe enqubweni yakho nokululama. Imithi ngokuvamile iyeka ngokuzenzakalelayo ngemva kwesikhathi esinqunyiwe.

Iziguli eziningi zithola i-abciximab amahora angu-12 kuya kwangu-24 ngemva kwenqubo yazo yenhliziyo. Udokotela wakho uzochaza isikhathi esiqondile ngokusekelwe ekutheni ululama kahle kangakanani kanye nobungozi bakho bokopha.

Ngaphambi kokuyeka imithi, iqembu lakho lezokwelapha lizoqinisekisa ukuthi indawo yenqubo yakho izinzile futhi awukho engozini enkulu yokuthuthukisa amahlule. Bazoqhubeka bekuqapha ngisho nangemva kokuphela kokufakwa.

Ngingashayela ngemva kokuthola i-Abciximab?

Akufanele ushayele okungenani amahora angu-24 ngemva kokuthola i-abciximab, futhi cishe isikhathi eside ngokuya ngenqubo yakho. Imithi ingabangela isiyezi futhi ikhulise ubungozi bakho bokopha uma ulimele.

Abantu abaningi abathola i-abciximab bayalulama ezinqubweni zenhliziyo ezidinga izinsuku eziningana zokuphumula. Udokotela wakho uzokutshela ukuthi kuphephile nini ukuqala kabusha imisebenzi ejwayelekile efana nokushayela.

Ngemva kokuthi imithi isiphelile, kungase kudingeke ukuthi ugweme ukushayela kuze kube yilapho indawo yenqubo yakho iphola ngokugcwele. Lokhu kukuvikela ezinkingeni uma udinga ukubhuleka ngokushesha noma ukunyakaza ngokushesha.