Yini i-Abemaciclib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Abemaciclib iyikhambi lomdlavuza eliqondiswe ngqo elisiza ukunciphisa ukukhula kweminye imidlava yomdlavuza wamabele. Ingaphansi kohlobo lwemithi ebizwa ngokuthi ama-CDK4/6 inhibitors, asebenza ngokuvimba amaprotheni amaseli omdlavuza awadingayo ukuze azale futhi asabalale.

Le mithi imelela intuthuko enkulu ekwelashweni komdlavuza wamabele, inikeza ithemba ezigulini eziningi uma ihlanganiswe nezinye izindlela zokwelapha. Ake sihlolisise konke okudingeka ukwazi ngale mithi ebalulekile ngendlela okulula ukuyiqonda.

Yini i-Abemaciclib?

I-Abemaciclib iyikhambi lomdlavuza elithathwa ngomlomo eliqondise amaprotheni athile kumaseli omdlavuza. Yenzelwe ukuphazamisa ikhono leseli lomdlavuza lokuzala nokukhula ngokuvimba amaprotheni amabili abizwa ngokuthi i-CDK4 ne-CDK6.

Cabanga ngala maprotheni njengezimpawu zokuthi “hamba” ezitshela amaseli omdlavuza ukuthi azale. Ngokuvimba lezi zimpawu, i-abemaciclib isiza ukunciphisa noma ukumisa umdlavuza ekukhuleni nasekusabalaleni kwezinye izingxenye zomzimba wakho.

Le mithi ithathwa njenge-targeted therapy, okusho ukuthi ihlasela ngqo amaseli omdlavuza kunokuthinta wonke amaseli azalanayo ngokushesha emzimbeni wakho njengoba kwenza i-chemotherapy yendabuko.

Isetshenziselwani i-Abemaciclib?

I-Abemaciclib isetshenziswa ikakhulukazi ukwelapha umdlavuza wamabele omuhle we-hormone receptor, i-HER2-negative. Lolu hlobo oluthile lomdlavuza wamabele lukhula ngokusabela kuma-hormone afana ne-estrogen ne-progesterone.

Udokotela wakho angase akunike le mithi ezimweni eziningana. Ivame ukusetshenziswa lapho umdlavuza wamabele usabalale kwezinye izingxenye zomzimba wakho (umdlavuza wamabele oyi-metastatic) noma lapho kunengozi enkulu yokuthi umdlavuza ubuye ngemva kokwelashwa kokuqala.

Imithi ingasetshenziswa yodwa noma ihlanganiswe nezinye izindlela zokwelapha umdlavuza, kuye ngesimo sakho esithile. Udokotela wakho we-oncologist uzoqoka indlela engcono kakhulu yokwelapha ngokusekelwe ezintweni ezithile zomdlavuza wakho nempilo yakho yonke.

Isebenza Kanjani I-Abemaciclib?

I-Abemaciclib isebenza ngokugxila emjikelezweni weseli, okuyinqubo ezinqamula ngayo amaseli ukuze ahlukaniswe futhi ande. Ivimba ngokuqondile amaprotheni e-CDK4 kanye ne-CDK6 asebenza njengama-accelerator okukhula kwamaseli omdlavuza.

Lapho lawa maprotheni evinjwa, amaseli omdlavuza abambeka esigabeni esibizwa nge-G1, lapho engakwazi ukuqhubekela phambili esinyathelweni esilandelayo sokuhlukaniswa kwamaseli. Lokhu ngempumelelo kubeka amabhuleki ekwandeni kwamaseli omdlavuza.

Njengokwelashwa okuqondiwe, i-abemaciclib ithathwa njengeqinile ngokulinganisela kodwa ngokuvamile ibangela imiphumela emibi embalwa kunama-chemotherapy endabuko. Yenzelwe ukuthi iqonde kakhulu esenzweni sayo, igxile kumaseli omdlavuza ngenkathi isindisa amaseli anempilo amaningi.

Kufanele Ngiyithathe Kanjani I-Abemaciclib?

I-Abemaciclib iza ngamaphilisi owathatha ngomlomo, ngokuvamile kabili ngosuku cishe ngamahora ayi-12 ahlukene. Ungayithatha ngokudla noma ngaphandle kokudla, kodwa zama ukuyithatha ngendlela efanayo ngaso sonke isikhathi ukuze uvumelane.

Gwinya amaphilisi wonke ngenkomishi yamanzi. Ungawachobozi, uwaphule, noma uwahlafune, ngoba lokhu kungathinta indlela umuthi ogxiliswa ngayo emzimbeni wakho.

Udokotela wakho uzoqala ngomthamo othile osuselwe esimweni sakho futhi angawulungisa ngokuhamba kwesikhathi. Kubalulekile ukuthatha umuthi njengoba unjalo, ngisho noma uzizwa kahle.

Uma uhlanza kungakapheli ihora ngemuva kokuthatha umthamo wakho, ungathathi omunye umthamo. Linda kuze kube yisikhathi somthamo wakho olandelayo ohleliwe bese uqhubeka neshejuli yakho ejwayelekile.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Abemaciclib?

Ubude bokwelashwa nge-abemaciclib buhlukahluka kumuntu nomuntu futhi buxhomeke ekutheni umuthi usebenza kahle kangakanani nokuthi uwuthola kanjani. Abanye abantu bangayithatha izinyanga, kanti abanye bangayidinga iminyaka.

Udokotela wakho uzoqapha ukusabela kwakho emuthini ngokuhlolwa okuvamile, ukuhlolwa kwegazi, kanye nezifundo zokucabanga. Bazobheka izimpawu zokuthi umdlavuza uyasabela ekwelashweni futhi baqaphele noma yimiphi imiphumela emibi ekhathazayo.

Ukwelashwa kuvame ukuqhubeka uma nje imithi isiza ukulawula umdlavuza wakho futhi ungaqali ukuzwa imiphumela engalawuleki. Ithimba lakho lezempilo lizosebenza nawe ukuthola ibhalansi efanele.

Yini Imiphumela Eceleni ye-Abemaciclib?

Njengayo yonke imithi, i-abemaciclib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi okulindelekile kungakusiza uzizwe ulungile futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo.

Imiphumela emibi evame kakhulu ivame ukulawuleka ngosekelo olufanele nokuqapha okuvela eqenjini lakho lezokwelapha:

• Ukuqunjelwa (umphumela ovamile kakhulu, othinta iziguli eziningi)
• Ukukhathala nokuzizwa ukhathele
• Ukucanuzela kwenhliziyo nokuncipha kwesifiso sokudla
• Ukwehla kwesibalo samaseli amhlophe egazi (i-neutropenia)
• Ikhanda
• Ukuqina noma ukulahlekelwa izinwele
• Ukuphalaza
• Izilonda zomlomo

Udokotela wakho uzokuqapha eduze ngale miphumela futhi angahlinzeka ngemithi noma ngamasu okusiza ukuwalawula. Imiphumela eminingi emibi ingeyesikhashana futhi iyathuthuka njengoba umzimba wakho ujwayela imithi.

Eminye imiphumela emibi engavamile kodwa ebucayi idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi ukuqunjelwa okukhulu okungathuthuki ngokwelashwa, izimpawu zokutheleleka njengomkhuhlane noma ama-chills, ukuphuma kwegazi okungavamile noma ukulimala, nokukhathala okukhulu okuphazamisa imisebenzi yansuku zonke.

Amaqhubu egazi, nakuba engavamile, angenza nge-abemaciclib. Qaphela izimpawu ezinjengokuphefumula ngokushesha, ubuhlungu besifuba, ukuvuvukala komlenze, noma ubuhlungu emlenzeni wakho.

Ubani Ongafanele Athatha I-Abemaciclib?

I-Abemaciclib ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ikufanele yini. Izimo ezithile zezokwelapha nezimo zingenza le mithi ingaphephile noma ingasebenzi kahle.

Akufanele uthathe i-abemaciclib uma uyiguliswa yiyo noma yiziphi izithako zayo. Abantu abanezinkinga ezinkulu zesibindi kungenzeka bangakwazi ukuthatha le mithi ngokuphepha, njengoba icutshungulwa esibindini.

Ukukhulelwa nokuncelisa yizinto ezibalulekile okufanele zicatshangelwe. I-Abemaciclib ingalimaza umntwana ongakazalwa, ngakho-ke uzodinga ukusebenzisa izindlela zokuvimbela inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nesikhathi esithile ngemuva kokuyeka umuthi.

Udokotela wakho uzobheka neminye imithi oyithathayo, njengoba eminye imithi ingasebenzisana ne-abemaciclib futhi ithinte ukuthi isebenza kahle kangakanani noma ikhulise ingozi yemiphumela emibi.

Amagama Omkhiqizo we-Abemaciclib

I-Abemaciclib itholakala ngaphansi kwegama lomkhiqizo elithi Verzenio. Lolu uhlobo oluvame kakhulu olubhalwa ngudokotela lomuthi futhi lukhiqizwa yi-Eli Lilly and Company.

Lapho uthola umuthi wakho, uzobona igama elithi

Kokubili i-abemaciclib ne-palbociclib ziyizivimbeli eziphumelelayo ze-CDK4/6, kodwa zinezinye izinto ezingase zenze enye ikufaneleke kangcono kunenye. Akukho noyedwa othi "ungcono" ngokujwayelekile - ukukhetha okungcono kuncike esimweni sakho.

I-Abemaciclib ingathathwa ngokuqhubekayo (nsuku zonke), kuyilapho i-palbociclib ivame ukuthathwa izinsuku ezingama-21 zilandelwe ikhefu lezinsuku eziyi-7. Abanye abantu bakhetha ukuthatha imithi ngokuqhubekayo, kuyilapho abanye bekujabulela ukuthatha ikhefu.

Amaphrofayili emiphumela emibi afana kodwa awefani. I-Abemaciclib kungenzeka idale isifo sohudo, kuyilapho i-palbociclib ingase idale ukwehla kwamaseli amhlophe egazi okudinga ukulungiswa komthamo.

Udokotela wakho we-oncologist uzocabangela izinto ezinjengobunjalo bomdlavuza wakho, impilo yakho yonke, eminye imithi oyithathayo, nendlela yakho yokuphila lapho encoma ukuthi iyiphi imithi engase ikusebenzele kangcono.

Imibuzo Evame Ukubuzwa Mayelana ne-Abemaciclib

Ingabe i-Abemaciclib iphephile kubantu abanezifo zenhliziyo?

I-Abemaciclib ngokuvamile ithathwa njengephephile kubantu abanezifo zenhliziyo, njengoba ngokuvamile ayibangeli imiphumela emibi ehlobene nenhliziyo. Kodwa-ke, udokotela wakho uzofuna ukukuqapha eduze uma unezinkinga zenhliziyo ezikhona.

Abanye abantu abathatha i-abemaciclib bangase bahlangabezane nokukhathala, okungase kukhathaze uma unenhliziyo ehlulekayo. Udokotela wakho we-cardiologist kanye ne-oncologist bazosebenzisana ukuqinisekisa ukuthi isimo senhliziyo yakho silawulwa kahle ngesikhathi sokwelashwa komdlavuza.

Kubalulekile ukutshela udokotela wakho nganoma yimiphi imithi yenhliziyo oyithathayo, njengoba eminye ingase ihlangane ne-abemaciclib noma idinge ukulungiswa komthamo.

Ngingenzani uma ngiphuthelwa ngengozi ngithatha i-Abemaciclib eningi kakhulu?

Uma ngengozi uthatha i-abemaciclib eningi kakhulu kunaleyo ebekiwe, xhumana nodokotela wakho noma usokhemisi ngokushesha, ngisho noma uzizwa kahle. Ukuthatha okuningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi engathi sína.

Ungazami ukwenza ngaphandle komthamo owengeziwe ngokweqa umthamo wakho olandelayo ohleliwe. Kunalokho, landela imiyalelo kadokotela wakho mayelana nendlela yokuqhubeka ngokuphepha.

Uma uhlangabezana nezimpawu ezinzima njengokuhlanza okuqhubekayo, isifo sohudo esinzima, noma izimpawu zokutheleleka, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Abemaciclib?

Uma weqa umthamo we-abemaciclib, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo owuqeqile bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze wenze ngaphandle komthamo owuqeqile, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma ungaqiniseki ngesikhathi, xhumana nomhlinzeki wakho wezempilo ukuze uthole isiqondiso.

Cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukukusiza ukhumbule imithamo yakho. Ukuqina kubalulekile ukuze imithi isebenze ngempumelelo.

Ngingayeka Nini Ukuthatha I-Abemaciclib?

Kufanele uyeke kuphela ukuthatha i-abemaciclib lapho udokotela wakho ekutshela ukuthi kuphephile ukwenza kanjalo. Noma ngabe uzizwa kahle, imithi ingase isasebenza ukulawula umdlavuza wakho.

Udokotela wakho uzohlola njalo ukuthi ukwelashwa kusebenza kahle kangakanani ngokusebenzisa ukuhlolwa kwegazi, izifundo zokucabanga, kanye nokuhlolwa komzimba. Bazocabangela ukuyeka imithi uma umdlavuza wakho uqhubeka naphezu kokwelashwa noma uma uthola imiphumela emibi engathí sina.

Abanye abantu bangase badinge ukuphumula okwesikhashana emithini ukuze bavumele imizimba yabo ukuthi ilulame emiphumeleni emibi, kodwa lokhu kufanele kwenziwe ngaphansi kokuqondiswa kwezokwelapha.

Ngingakwazi Ukuphuza Utywala Ngenkathi Ngithatha I-Abemaciclib?

Ngenkathi kungekho ukuxhumana okuqondile phakathi kwe-abemaciclib notshwala, ngokuvamile kunconywa ukukhawulela ukusetshenziswa kotshwala ngesikhathi sokwelashwa komdlavuza. Utywala bungenza buthuthukise eminye imiphumela emibi efana nesicanucanu nokukhathala.

Kokubili i-abemaciclib notshwala kucutshungulwa yisibindi sakho, ngakho ukuphuza utshwala kungase kubeke ingcindezi eyengeziwe kulesi sitho. Uma ukhetha ukuphuza, kwenze ngokulinganisela futhi uxoxe ngakho nethimba lakho lezempilo.

Udokotela wakho angakunikeza iseluleko esiqondene nawe ngokusekelwe empilweni yakho yonke, eminye imithi oyithathayo, nokuthi ukwelashwa nge-abemaciclib ukuthatha kanjani.