Yini i-Aliskiren: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Aliskiren iyimithi kadokotela esiza ukwehlisa umfutho wegazi ophezulu ngokuvimba i-enzyme ethile emzimbeni wakho. Ingowesigaba esiyingqayizivele semithi yomfutho wegazi ebizwa ngokuthi ama-inhibitors aqondile e-renin, asebenza ngendlela ehlukile kunezinye izidakamizwa ezivamile zomfutho wegazi ongase uzizwe.

Le mithi ingaba yithuluzi eliphumelelayo ekuphatheni umfutho wegazi ophezulu lapho ezinye izindlela zokwelapha zingasebenzi kahle zodwa. Udokotela wakho angase akubhalele i-aliskiren njengengxenye yendlela ebanzi yokuvikela inhliziyo yakho nemithambo yegazi emiphumeleni yesikhathi eside yomfutho wegazi ophezulu.

Yini i-Aliskiren?

I-Aliskiren iyimithi kadokotela yomfutho wegazi esebenza ngokuvimba i-renin, i-enzyme ekhiqizwa izinso zakho. Cabanga nge-renin njenge-domino yokuqala ochungechungeni lwezenzo olugcina luphakamisa umfutho wegazi lakho.

Ngokungafani neminye imithi yomfutho wegazi esebenza kamuva kulolu chungechunge lwezenzo, i-aliskiren imisa inqubo ekuqaleni. Lokhu kuyenza ibe usizo ikakhulukazi kubantu abadinga indlela ehlukile yokulawula umfutho wegazi.

Imithi iza ngesimo samaphilisi futhi ivamise ukuthathwa kanye ngosuku. Yenzelwe ukusetshenziswa isikhathi eside njengengxenye yokuqhubeka nokuphathwa komfutho wegazi, hhayi njengokulungiswa okusheshayo kokufundwa okuphezulu ngezikhathi ezithile.

Isetshenziselwani i-Aliskiren?

I-Aliskiren isetshenziswa ikakhulukazi ukwelapha umfutho wegazi ophezulu (i-hypertension) kubantu abadala. Udokotela wakho angase akubhalele uma umfutho wegazi lakho ufunda njalo u-140/90 mmHg noma ngaphezulu, noma uma eminye imithi ingazange yehlise izinombolo zakho ngokwanele.

Le mithi ivame ukubhalwa lapho udinga ukulawulwa okwengeziwe komfutho wegazi ngaphezu kwalokho okutholayo kwezinye izidakamizwa. Ingasetshenziswa yodwa noma ihlanganiswe neminye imithi yomfutho wegazi efana nama-diuretics noma ama-calcium channel blockers.

Ngezinye izikhathi odokotela banikeza i-aliskiren kubantu abaye baba nemiphumela emibi evela kweminye imithi yokwehlisa umfutho wegazi. Njengoba isebenza ngendlela ehlukile, ingase ithandwe kangcono ezigulini ezithile.

Isebenza Kanjani I-Aliskiren?

I-Aliskiren isebenza ngokuvimba i-renin, i-enzyme ekhishwa izinso zakho uma zizwa umfutho wegazi ophansi noma ukwehla kokugeleza kwegazi. Lokhu kuthathwa njengomuthi wokwehlisa umfutho wegazi olunamandla amaphakathi oluqondisa imbangela yendlela eyodwa enkulu yomfutho wegazi.

Lapho i-renin ivalekile, ayikwazi ukuqala uchungechunge olugcina luveza i-angiotensin II, into enamandla eqinisa imithambo yegazi futhi ikhuphule umfutho wegazi. Ngokumisa le nqubo ekuqaleni, i-aliskiren isiza ukugcina imithambo yakho yegazi iphumulele kakhulu.

Umuthi uvame ukuqala ukusebenza kungakapheli amahora ngemva kokuwuthatha, kodwa ungase ungazizwa imiphumela ephelele amasonto ambalwa. Lesi senzo esihamba kancane empeleni siwusizo ngoba sivumela umzimba wakho ukuthi ujwayele ngokushelela emazingeni aphansi omfutho wegazi.

Kufanele Ngiyithathe Kanjani I-Aliskiren?

Thatha i-aliskiren ngendlela enembile njengoba udokotela wakho ekunikeza ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ungayithatha nokudla noma ngaphandle kokudla, kodwa zama ukungaguquguquki ekukhetheni kwakho ukuze ugcine amazinga aqhubekayo emzimbeni wakho.

Gwinya ithebhulethi yonke ngengilazi yamanzi egcwele. Ungagxobi, uhlafune, noma uqhekeze ithebhulethi, ngoba lokhu kungathinta indlela umuthi okhishwa ngayo emzimbeni wakho.

Uma uthatha i-aliskiren nokudla, gwema ukudla okunamafutha amaningi njengoba kunganciphisa ukuthi umzimba wakho umunca kangakanani umuthi. Ukudla okulula noma ukuyithatha esiswini esingenalutho kusebenza kangcono ekumunceni okungcono.

Zama ukuthatha umthamo wakho ngesikhathi esifanayo nsuku zonke ukuze ukusize ukhumbule futhi ugcine amazinga aqhubekayo omuthi ohlelweni lwakho. Abantu abaningi bakuthola kuwusizo ukuyithatha ngesikhathi somsebenzi wabo wasekuseni.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Aliskiren?

I-Aliskiren ngokuvamile inikezwa ukuthi isetshenziswe isikhathi eside, ngokuvamile izinyanga noma iminyaka, njengoba umfutho wegazi ophezulu ngokuvamile uyisimo esingamahlalakhona esidinga ukuphathwa okuqhubekayo. Udokotela wakho uzoqoka isikhathi esifanele ngokusekelwe ekuphenduleni kwakho komuntu ngamunye kanye nempilo yakho yonke.

Ungayeki ukuthatha i-aliskiren ngokuzumayo, ngisho noma uzizwa ungcono noma ukufundwa komfutho wegazi wakho kuthuthuka. Umfutho wegazi ophezulu ngokuvamile awunawo ama-symptoms, ngakho ukuzizwa ulungile akusho ukuthi ungaluyeka umuthi.

Udokotela wakho uzoqapha njalo umfutho wegazi lakho kanye nomsebenzi wezinso ngenkathi uthatha i-aliskiren. Ngokusekelwe kulokhu kuhlolwa, bangase balungise umthamo wakho noma ekugcineni bakudlulisele ohlelweni oluhlukile lokwelashwa.

Abanye abantu bangase badinge ukuthatha imithi yomfutho wegazi impilo yabo yonke, kanti abanye bangase bakwazi ukuyinciphisa noma bayiyeke uma izinguquko zendlela yokuphila zithuthukisa kakhulu impilo yabo yenhliziyo nemithambo yegazi.

Yiziphi Izimo Ezingezinhle ze-Aliskiren?

Njengayo yonke imithi, i-aliskiren ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela eminingi emibi imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nawa ama-side effects avamile ongase uwahlangabezane nawo:

• Ukuqunjelwa noma izitulo ezixekile
• Isiyezi, ikakhulukazi uma usukuma ngokushesha
• Ukukhathala noma ukuzizwa ukhathele
• Ikhanda
• Isicanucanu noma isisu esibuhlungu
• Ubuhlungu emhlane
• Ukhwehlela

Le miphumela emibi ejwayelekile ngokuvamile ixazululeka emasontweni ambalwa njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yisicefe, khuluma nodokotela wakho mayelana nokulungisa umthamo wakho noma isikhathi.

Kukhona nemiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezokwelapha ngokushesha:

• Isiyezi esikhulu noma ukuquleka
• Ukuvuvukala kobuso, izindebe, ulimi, noma umphimbo
• Ubunzima bokuphefumula noma ukugwinya
• Ukuqubuka kwesikhumba noma imihuzuko
• Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile
• Ubuhlungu obukhulu besisu
• Izimpawu zezinkinga zezinso (izinguquko ekuchameni, ukuvuvukala emilenzeni noma ezinyaweni)

Xhumana nomhlinzeki wakho wezempilo ngokushesha uma uhlangabezana nanoma yimaphi alawa maphuzu abucayi. Nakuba engavamile, angabonisa ukusabela okukhulu okudinga ukunakekelwa kwezempilo ngokushesha.

Ubani Ongafanele Athathe I-Aliskiren?

I-Aliskiren ayifaneleki kuwo wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zikwenza kungaphephile ukuyisebenzisa. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-aliskiren uma unesifo sikashukela futhi uphinde usebenzise ama-ACE inhibitors noma ama-ARB (ezinye izinhlobo zemithi yokwehlisa umfutho wegazi). Le nhlanganisela ikhuphula kakhulu ingozi yezinkinga ezinzima zezinso kanye nomfutho wegazi ophansi kakhulu.

Abantu abanezifo ezinzima zezinso noma labo abase-dialysis kufanele bagweme i-aliskiren, njengoba ingenza ngcono ukusebenza kwezinso. Ngokufanayo, uma unomlando wesifo esinzima sesibindi, lo muthi kungenzeka awukufanele.

Abesifazane abakhulelwe akufanele neze bathathe i-aliskiren, njengoba ingabangela ingozi enkulu kumntwana osakhula, okuhlanganisa izinkinga zezinso nomfutho wegazi ophansi. Uma uhlela ukukhulelwa noma uthola ukuthi ukhulelwe ngenkathi uthatha i-aliskiren, xhumana nodokotela wakho ngokushesha.

Omama abancelisa ngamabele kufanele futhi bagweme i-aliskiren, njengoba kungaziwa ukuthi umuthi udlulela obisini futhi ungase uthinte ingane encelisayo.

Amagama Omkhiqizo we-Aliskiren

I-Aliskiren iyatholakala ngaphansi kwegama lomkhiqizo elithi Tekturna e-United States. Le yindlela evame kakhulu yokuyala umuthi futhi yilokho okungenzeka ukuthi uzokubona ebhodleleni lakho lemithi.

Kukhona futhi umuthi ohlanganisiwe obizwa nge-Tekturna HCT, oqukethe kokubili i-aliskiren kanye ne-hydrochlorothiazide (i-diuretic). Lokhu kuhlanganiswa kusetshenziswa uma iziguli zidinga yomibili imithi ukuze zilawule ngempumelelo umfutho wegazi lazo.

Izinhlobo ezivamile ze-aliskiren nazo ziyatholakala, eziqulathe isithako esifanayo esisebenzayo kodwa zingabiza ngaphansi kunenguqulo yegama lomkhiqizo. Umuthi wakho wezidakamizwa angakusiza ukuthi uqonde ukuthi ngabe inketho ejwayelekile ilungile yini kuwe.

Ezinye izindlela ze-Aliskiren

Uma i-aliskiren ingakulungele noma ingasebenzi kahle ngokwanele, kunezinketho eziningi zemithi yomfutho wegazi etholakalayo. Udokotela wakho angakusiza ukuthi uthole enye indlela engcono kakhulu esekelwe ezidingweni zakho ezithile kanye nomlando wakho wezokwelapha.

Ama-ACE inhibitors afana ne-lisinopril noma i-enalapril avame ukuba yizindlela zokwelapha zokuqala zomfutho wegazi ophezulu. Zisebenza ngokuvimba isinyathelo esihlukile endleleni efanayo i-aliskiren eqondise kuyo, futhi abantu abaningi bazamukela kahle.

Ama-ARBs (Angiotensin Receptor Blockers) afana ne-losartan noma i-valsartan anikeza enye inketho. Le mithi ivimba imiphumela ye-angiotensin II ezingeni le-receptor futhi ngokuvamile inemiphumela emibi embalwa kune-ACE inhibitors.

Ama-calcium channel blockers afana ne-amlodipine noma i-nifedipine asebenza ngokukhulula imithambo yegazi ngendlela ehlukile ngokuphelele. Zisebenza ikakhulukazi kubantu abanezinkinga ezithile zesigqi senhliziyo.

Ama-diuretics (amaphilisi amanzi) afana ne-hydrochlorothiazide asiza ukwehlisa umfutho wegazi ngokunciphisa ivolumu yamanzi emithanjeni yakho yegazi. Zivame ukusetshenziswa ngokuhlangana neminye imithi yomfutho wegazi ukuze kulawulwe kangcono.

Ingabe i-Aliskiren ingcono kune-Lisinopril?

I-Aliskiren ne-lisinopril yomibili imithi yomfutho wegazi esebenzayo, kodwa isebenza ngezindlela ezihlukene futhi inezinzuzo ezihlukene. Akukho noyedwa

ILisinopril iyi-ACE inhibitor esetshenziswe amashumi eminyaka futhi inocwaningo oluningi olusekela ukusebenza kwayo. Ivame ukukhethwa njengokwelashwa kokuqala ngoba ifundwe kahle, ivame ukubekezelelwa kahle, futhi itholakala ngesimo esivamile.

I-Aliskiren ingase ithandwe uma uke waba nemiphumela emibi evela kuma-ACE inhibitors afana ne-lisinopril, ikakhulukazi ukukhwehlela okomile okuqhubekayo. Njengoba i-aliskiren isebenza ekuqaleni emgudwini womfutho wegazi, ingase isebenze kahle kwabanye abantu.

Nokho, i-lisinopril inezinzuzo eziqinisekisiwe ezingaphezu kokulawulwa komfutho wegazi, okuhlanganisa ukuvikelwa kwabantu abanenhliziyo ehlulekayo nesifo sezinso esihlobene nesifo sikashukela. I-Aliskiren ayinayo ucwaningo oluningi olusekela lezi zinzuzo ezengeziwe.

Udokotela wakho uzocabangela izinto ezifana nezinye izimo zakho zezokwelapha, imithi yamanje, umlando wemiphumela emibi, nezindleko lapho enquma phakathi kwalezi zinketho. Ngezinye izikhathi ukuzama yomibili imithi ngokuhamba kwesikhathi kuyasiza ukunquma ukuthi iyiphi esebenza kahle kuwe.

Imibuzo Evame Ukubuzwa Nge-Aliskiren

Ingabe i-Aliskiren iphephile kubantu abanesifo sikashukela?

I-Aliskiren ingasetshenziswa ngokuphepha kubantu abanesifo sikashukela, kodwa ngemikhawulo ebalulekile. Uma unesifo sikashukela, akufanele uthathe i-aliskiren kanye nama-ACE inhibitors noma ama-ARB, njengoba le nhlanganisela ikhulisa kakhulu ingozi yezinkinga zezinso nomfutho wegazi ophansi ngokuyingozi.

Kubantu abanesifo sikashukela abangathathi ama-ACE inhibitors noma ama-ARB, i-aliskiren ingaba yindlela enhle yokulawula umfutho wegazi. Udokotela wakho uzoqapha ukusebenza kwezinso zakho eduze, njengoba isifo sikashukela sesivele sibeka ingcindezi ezinso.

Izivivinyo zegazi ezivamile zokuhlola ukusebenza kwezinso namazinga e-potassium abaluleke kakhulu uma unesifo sikashukela futhi uthatha i-aliskiren. Lokhu kusiza ukubamba noma yiziphi izinkinga ezingaba khona ekuqaleni.

Ngingenzani uma ngithatha i-Aliskiren eningi ngengozi?

Uma ngabe uthatha i-aliskiren eningi ngengozi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa kahle. Ukuthatha okuningi kungadala ukwehla kwengcindezi yegazi okuyingozi, okungenzeka kungabangeli zimpawu ngokushesha.

Izimpawu zokweqisa zingabandakanya isiyezi esikhulu, ukuquleka, isicanucanu, noma ukuzizwa ubuthakathaka kakhulu. Uma uhlangabezana nalezi zimpawu, funa usizo lwezempilo oluphuthumayo ngokushesha.

Ungazami ukuthi "lungisa" ukweqisa ngokweqa imithamo yesikhathi esizayo. Kunalokho, thola isiqondiso sezokwelapha sokuthi ungaqala kanjani kabusha isimiso sakho sokuthatha imithi ngokuphepha.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Aliskiren?

Uma weqa umthamo we-aliskiren, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, weqa umthamo oweqiwe bese uqhubeka nesimiso sakho esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo oweqiwe, ngoba lokhu kungadala ukuthi ingcindezi yakho yegazi yehle kakhulu. Kungcono ukweqa umthamo owodwa kunokubeka engozini yokweqisa.

Uma uvame ukukhohlwa imithamo, zama ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukhumbule. Ukuthatha imithi nsuku zonke ngokuqhubekayo kubalulekile ekugcineni ingcindezi yakho yegazi ilawulwa kahle.

Ngingayeka Nini Ukuthatha I-Aliskiren?

Kufanele uyeke kuphela ukuthatha i-aliskiren ngaphansi kokuqondisa kukadokotela wakho, ngisho noma ukufundwa kwengcindezi yakho yegazi kuthuthukile. Ingcindezi yegazi ephezulu ngokuvamile yisimo esingamahlalakhona esidinga ukwelashwa okuqhubekayo ukuvimbela izinkinga.

Udokotela wakho angase acabange ukunciphisa noma ukuyeka i-aliskiren uma wenze izinguquko ezinkulu zokuphila eziye zathuthukisa impilo yakho yenhliziyo nemithambo yegazi, njengokulahlekelwa isisindo esikhulu, ukuzivocavoca njalo, noma ukuthuthukiswa kokudla.

Ungalokothi uyeke ukuthatha i-aliskiren ngokuzumayo, ngoba lokhu kungadala ukuthi ingcindezi yakho yegazi ikhuphuke emazingeni ayingozi. Uma kudingeka izinguquko emithini yakho, udokotela wakho uzokwenza uhlelo lokulungisa ukwelashwa kwakho ngokuphepha.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngithatha I-Aliskiren?

Noma amanani amancane otshwala angase abe kahle, kungcono ukukhawulela ukusetshenziswa kotshwala ngenkathi uthatha i-aliskiren. Utshwala bungathuthukisa imiphumela yokwehlisa umfutho wegazi yomuthi, okungenzeka kubangele isiyezi noma ukwehla okuyingozi komfutho wegazi.

Uma uphuza utshwala, kwenze ngokulinganisela futhi unake ukuthi uzizwa kanjani. Qaphela ikakhulukazi lapho usukuma, njengoba inhlanganisela ye-aliskiren notshwala ingakhuphula ingozi yakho yesiyezi noma ukuquleka.

Xhumana nodokotela wakho mayelana nokuthi yiliphi izinga lokusetshenziswa kotshwala, uma likhona, eliphephile kuwe ngenkathi uthatha i-aliskiren. Bangakunikeza isiqondiso esiqondene nawe esisekelwe empilweni yakho yonke neminye imithi ongase uyithathe.