Yini i-Aminolevulinic Acid Topical: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Aminolevulinic acid topical iyimithi ekhethekile esebenza ngokukhanya esetshenziselwa ukwelapha izimo ezithile zesikhumba, ezivame kakhulu amabala angaphambi komdlavuza abizwa ngokuthi i-actinic keratoses. Lokhu kwelashwa kusebenza ngokwenza amangqamuzana angajwayelekile azwele kakhulu ekukhanyeni, okuvumela odokotela ukuthi bawahlasele futhi bawaqede ngenkathi beshiya isikhumba esinempilo singathinteki kakhulu.

Umuthi uyingxenye yenqubo yezinyathelo ezimbili ebizwa ngokuthi i-photodynamic therapy (PDT). Uzosebenzisa umuthi esikhumbeni sakho, ulinde ukuthi umuncwe, bese uthola ukwelashwa ngokukhanya okuqondiwe okuvela kumhlinzeki wakho wezempilo. Le ndlela inikeza indlela eqondile yokubhekana nezinkinga zesikhumba ngaphandle kwesidingo sokuhlinzwa ezimweni eziningi.

Yini i-Aminolevulinic Acid Topical?

I-Aminolevulinic acid topical iyimithi kadokotela engaphansi kwezigaba zemithi ebizwa ngokuthi ama-photosensitizing agents. Iza njengesixazululo noma i-gel oyisebenzisa ngqo ezindaweni zesikhumba ezithintekile.

Umuthi uqukethe inhlanganisela eyenzeka ngokwemvelo umzimba wakho owenza ngamanani amancane. Uma isetshenziswa esikhumbeni sakho ngamazinga aphezulu, iqongelela ikakhulukazi emangqamuzaneni angajwayelekile noma akhula ngokushesha. Lokhu kuqongelelwa okukhethekile yikho okwenza ukwelashwa kuqondiswe futhi kusebenze.

Cabanga ngayo njengophawu lokugqamisa amangqamuzana anezinkinga. Uma isetshenzisiwe, umuthi ngokuyisisekelo

Udktela wakho angase futhi ancome lokhu kwelashwa ngezinhlobo ezithile zomdlavuza wesikhumba ongajulile, ikakhulukazi i-basal cell carcinoma ezindaweni ezithile. Abanye odokotela bezikhumba bayayisebenzisela ezinye izimo ezinjengokulimala yilanga noma izinhlobo ezithile zama-acne, nakuba lokhu kuyizicelo ezingavamile.

Ukwelashwa kusebenza kahle kakhulu kubantu abanezindawo eziningi endaweni efanayo, njengoba kungelapha lonke uhlobo lwesikhumba ngesikhathi esisodwa. Lokhu kwenza kube usizo ikakhulukazi ezindaweni ezinjengobuso, isikhumba sekhanda, noma izandla lapho ukulimala yilanga kuvame ukugcwala khona.

Isebenza Kanjani I-Aminolevulinic Acid Topical?

Lo muthi usebenza ngenqubo ethakazelisayo esebenzisa amakhemikhali emvelo omzimba wakho. Uma usebenzisa isixazululo esikhumbeni sakho, amaseli angajwayelekile ayawumunca kalula kakhulu kunamaseli anempilo.

Uma isingaphakathi kwamaseli angajwayelekile, i-aminolevulinic acid iguqulela kwinto ebizwa ngokuthi i-protoporphyrin IX. Le nto yenza amaseli azwelwe kakhulu kumaza athile okukhanya. Ngesikhathi sesigaba sokwelashwa ngokukhanya, la maseli azwela kakhulu abhujiswa ngenkathi izicubu ezinempilo ezizungezile zihlala zingenalutho.

Ukwelashwa kuthathwa njengokuqinile ngokulinganisela futhi kuqondiswe kakhulu. Ngokungafani neminye imithi ethinta umzimba wakho wonke, le nto isebenza endaweni kuphela lapho uyisebenzisa khona. Isinyathelo sokusebenza kokukhanya yiso esenza kube ngqo kangako, sivumela udokotela wakho ukuthi agxile ekwelashweni ngqo lapho kudingeka khona kakhulu.

Kufanele Ngiyithathe Kanjani I-Aminolevulinic Acid Topical?

Lo muthi uhlala usetshenziswa futhi ulawulwa endaweni yezokwelapha ngaphansi kokuqondisa kochwepheshe. Ngeke uthathe lo muthi ekhaya nawe. Umhlinzeki wakho wezempilo uzophatha yonke inqubo yokusebenzisa nokwelashwa.

Ngaphambi kokuba uqokwe, kuzodingeka ukuthi ugweme ukuchayeka elangeni amahora angama-24 kuya kwangama-48. Udokotela wakho uzoqhubula indawo yokwelashwa ngokucophelela futhi angase asuse ngobumnene noma iyiphi isikhumba esixekile, esiqhekekayo ukuze asize umuthi ungene kangcono. Umuthi ube usufakwa ngqo ezindaweni ezithintekile futhi umbozwe ngendwangu yokuvikela.

Ngokuvamile uzolinda ihora elingu-1 kuya kwamahora amathathu ukuze umuthi umuncwe, kuye ngokuthi yisiphi isimo eselashwayo. Ngesikhathi lesi, kuzodingeka ukuthi uhlale ekamelweni elikhanyiswe kancane ukuze uvimbele ukusebenza ngaphambi kwesikhathi komuthi. Ngemuva kwesikhathi sokulinda, udokotela wakho uzosusa indwangu yokugqoka bese efaka ukwelashwa okuthile kokukhanya ukuze kusebenze umuthi.

Kufanele Ngithathe Isikhathi Esingakanani I-Aminolevulinic Acid Topical?

Iseshini ngayinye yokwelashwa nge-aminolevulinic acid topical ngokuvamile ukusetshenziswa kwesikhathi esisodwa ngesikhathi sokuvakasha kwakho ehhovisi. Umuthi awudingi ukusetshenziswa nsuku zonke okuphindaphindiwe njengokwelashwa okuningi okungaphezulu.

Noma kunjalo, ungase udinge amaseshini amaningi okwelashwa ahlukaniswe amasonto ambalwa ukuze uthole imiphumela engcono kakhulu. Udokotela wakho uzohlola ukusabela kwesikhumba sakho ngemuva kweseshini ngayinye futhi anqume ukuthi ngabe ukwelashwa okwengeziwe kuyadingeka yini. Abantu abaningi badinga amaseshini angu-1 kuya kwangu-3 esewonke, yize lokhu kuhluka ngokuya ngesimo eselashwayo nokuthi isikhumba sakho sisabela kanjani.

Imiphumela yokwelashwa ngakunye iyaqhubeka nokusebenza izinsuku eziningana ngemuva kokuvakasha kwakho njengoba isikhumba sakho silulama futhi amaseli angajwayelekile esusiwe. Udokotela wakho uzohlela ama-aphoyintimenti okulandelayo ukuze aqaphe inqubekela phambili yakho futhi anqume ukuthi ngabe ukwelashwa okwengeziwe kuyadingeka yini.

Yiziphi Imiphumela Eceleni Ye-Aminolevulinic Acid Topical?

Abantu abaningi bathola izinga elithile lokusabela kwesikhumba ngesikhathi nangemuva kokwelashwa, okuyisibonakaliso sokuthi umuthi uyasebenza. Le miphumela ngokuvamile yesikhashana futhi ilawuleka ngokunakekelwa okufanele.

Imiphumela eseceleni evame kakhulu ongase uhlangabezane nayo ihlanganisa ukusha, ukubhoboza, noma ubuhlungu ngesikhathi sokwelashwa ngokukhanya. Abantu abaningi bachaza lokhu njengokufana nomuzwa wokusha yilanga. Ungase futhi uqaphele ukubomvu, ukuvuvukala, nokuxebuka ezindaweni eziphathwayo izinsuku eziningana ngemuva kokwelashwa.

Nawa imiphumela eseceleni ongase uhlangabezane nayo, ihlelwe kusukela kwemvamisa kakhulu kuya kwemvamisa encane:

Imiphumela eseceleni evame kakhulu:

• Umuzwa wokusha noma wokubhoboza ngesikhathi sokwelashwa ngokukhanya
• Ukubomvu nokuvuvukala endaweni yokwelashwa
• Ukuxebuka noma ukuhlukana kwesikhumba amasonto angu-1-2
• Ubumnyama besikhashana noma ukukhanya kwesikhumba esiphathwayo
• Ubuhlungu obuncane kuya kobumodareyithi obuvamise ukufinyelela ezingeni eliphezulu emahoreni angu-24

Imiphumela eseceleni engavamile:

• Ukuvela kwama-blister noma ukuba neqweqwe endaweni ephathwayo
• Ikhanda noma isiyezi
• Isicanucanu (ngokuvamile sincane)
• Ukuqina kokuzwela elangeni izinsuku eziningana
• Ushintsho lwesikhashana ekuthunjweni kwesikhumba

Imiphumela eseceleni engavamile kodwa ebucayi:

• Ukuphendula okukhulu komzimba okune-rash ebanzi noma ubunzima bokuphefumula
• Ubuhlungu obukhulu, obuqhubekayo obuphazamisa imisebenzi yansuku zonke
• Izimpawu zokutheleleka njengobomvu, ukubomvu okwandayo, noma imigqa ebomvu
• Ushintsho olungapheli emibaleni yesikhumba noma ekuthunjweni
• Ukuvuvukala okukhulu okuthinta umbono (lapho welapha izindawo zobuso)

Imiphumela eminingi eseceleni iyanyamalala emasontweni angu-1-2 njengoba isikhumba sakho silulama. Udokotela wakho uzohlinzeka ngemiyalelo ethile yokunakekela ngemuva kokwelashwa ukusiza ukunciphisa ukungakhululeki futhi kukhuthaze ukuphola. Xhumana nomhlinzeki wakho wezempilo uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo noma uma imiphumela eseceleni ibonakala ibucayi kakhulu kunokulindelekile.

Ubani okungafanele athathe i-Aminolevulinic Acid Topical?

Le nyango alifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi liyakufanela yini isimo sakho esithile. Into ebaluleke kakhulu ukuthi ngabe unezimo ezenza uzwe ukuzwela okungavamile ekukhanyeni noma ungakwazi ukubekezelela inqubo yokwelashwa.

Akufanele wamukele le nyango uma une-porphyria, isifo segazi esingavamile esithinta indlela umzimba wakho oqhubula ngayo izinhlanganisela ezithile. Abantu abaziwa ukuthi banezinto abazwelana nazo ku-aminolevulinic acid noma ezinye izithako zomuthi kufanele futhi bagweme le nyango.

Ezinye izimo nezimo ezingase zenze le nyango ingafaneleki kuwe:

Izimo ezingavumelekile ngokuphelele:

• I-Porphyria noma ezinye izifo ezithinta ukukhishwa kwe-porphyrin
• Ukuzwelana okwaziwayo ku-aminolevulinic acid noma izithako zomuthi
• Ukukhulelwa noma ukuncelisa (ukuphepha akukamiswanga)
• Izindawo zesikhumba ezinokutheleleka okusebenzayo noma amanxeba avulekile
• Ukungakwazi ukugwema ukuchayeka elangeni ngesikhathi esidingekayo

Izimo ezidinga ukuqapha okwengeziwe:

• Izifo ze-Autoimmune ezithinta isikhumba
• Ukusetshenziswa kwamanje kwemithi enyusa ukuzwela elangeni
• Umlando wokulimala okungavamile noma ukwakheka kwe-keloid
• Isikhumba esilula kakhulu esisha kalula
• Ukusetshenziswa kwamuva kwemithi ethile yezinduna efana ne-isotretinoin

Udokotela wakho uzobukeza umlando wakho wezokwelapha ophelele nemithi yamanje ngaphambi kokuncoma le nyango. Qiniseka ukuthi usho yonke imithi kadokotela, imithi etholakala ngaphandle kwemvume kadokotela, kanye nezithasiselo ozithathayo, njengoba ezinye zingakhuphula ukuzwela kwakho ekukhanyeni.

Amagama Omkhiqizo we-Aminolevulinic Acid Topical

Igama lomkhiqizo elivame ukunqunywa kakhulu le-aminolevulinic acid topical yi-Levulan Kerastick. Le fomula iza njengesixazululo esisetshenziswa ngqo esikhumbeni kusetshenziswa isicelo esikhethekile.

Elinye uhlobo olutholakalayo yi-Ameluz, oluza njengefomula ye-gel. Yomibili imithi iqukethe isithako esifanayo esisebenzayo kodwa ingase ibe nezindlela zokusebenzisa ezihlukile noma ukugxila. Udokotela wakho uzokhetha ifomula efanele kakhulu ngokusekelwe esimweni sakho esithile nendawo yokwelapha.

Le mithi yegama lomkhiqizo yakhelwe ngqo ukwelapha nge-photodynamic futhi itholakala kuphela kubahlinzeki bezempilo. Umuthi uhlala usetshenziswa endaweni yezokwelapha, ngakho ngeke uthathe imiyalelo yokuyisa ekhaya.

Ezinye Izindlela Zokwelapha I-Aminolevulinic Acid Topical

Ezinye izinketho zokwelapha ziyatholakala zezimo ezivame ukwelatshwa nge-aminolevulinic acid topical. Udokotela wakho angase acabangele lezi zindlela ezinye ngokusekelwe esimweni sakho esithile, uhlobo lwesikhumba, kanye nemigomo yokwelapha.

Ukwelashwa kwendabuko kufaka phakathi i-cryotherapy (ukuqandisa nge-liquid nitrogen), engasebenza kahle ezindaweni ezithile kodwa ingase ibangele izibazi ezengeziwe. Ama-ejenti e-chemotherapy topical afana ne-5-fluorouracil noma i-imiquimod asebenza amasonto amaningana futhi angelapha izindawo ezinkulu kodwa ngokuvamile abangela ukucasuka kwesikhumba okukhulu.

Ezinye izindlela ezinye okufanele zixoxwe nodokotela wakho zifaka:

Izinketho Zokuhlinzwa:

• I-Curettage kanye ne-electrodesiccation yezilonda ngazinye
• Ukususwa kwezindawo ezinkulu noma ezingabazisayo
• Ukuhlinzwa kwe-Mohs ngezinhlobo ezithile zomdlavuza wesikhumba

Ezinye Izindlela Ezingahlinzwa:

• Ukwelashwa nge-laser kusetshenziswa izinhlobo ezahlukene ze-laser
• Ama-chemical peels okulimala kwelanga okusabalale kakhulu
• Ama-retinoids topical okuvimbela nokwelapha okulula
• I-Methyl aminolevulinate (MAL-PDT), enye inketho yokwelapha nge-photodynamic

Inketho ngayinye yokwelapha inezinzuzo zayo kanye nezinto okufanele zicatshangelwe. Udokotela wakho uzokusiza ukuthi ulinganise izinto ezifana nokusebenza kahle, isikhathi sokululama, imiphumela engaba khona, kanye nezindleko lapho ukhetha indlela engcono kakhulu yesimo sakho.

Ingabe i-Aminolevulinic Acid Topical ingcono kunezinye izindlela zokwelapha?

I-Aminolevulinic acid topical inikeza izinzuzo eziningi eziyingqayizivele eziyenza ikhange kakhulu ezimweni ezithile. Ukwelashwa kungabhekana nezindawo eziningi ngasikhathi sinye futhi ngokuvamile kushiya izibazi ezincane uma kuqhathaniswa nezinketho zokuhlinzwa.

Uma kuqhathaniswa ne-cryotherapy noma ukususwa ngokuhlinzwa, i-photodynamic therapy ivame ukukhiqiza imiphumela emihle yezimonyo, ikakhulukazi ezindaweni ezibonakalayo njengobuso. Ukwelashwa futhi akuhlaseli kangako kunokuhlinzwa futhi kungaphindwa uma kunesidingo ngaphandle kwengozi enkulu yezinkinga.

Kodwa-ke, ezinye izindlela zokwelapha zingase zifaneleke ezimweni ezithile. Izinketho zokuhlinzwa zingase zibe ngcono ezilondeni eziqine kakhulu noma ezindaweni lapho kusolwa khona umdlavuza. Imithi ye-Topical efana ne-imiquimod ingase ithandwe kubantu abafuna ukuphatha ukwelashwa ekhaya, nakuba ngokuvamile idinga izikhathi zokwelashwa ezinde.

Ukwelashwa okungcono kakhulu ngempela kuncike ezintweni zakho ngazinye: usayizi nendawo yezilonda zakho, uhlobo lwesikhumba sakho, ukubekezelelana kwakho nemiphumela emibi, kanye nokucatshangelwa kwendlela yakho yokuphila. Udokotela wakho wesikhumba angakusiza ukuthi uqonde ukuthi i-aminolevulinic acid topical iqhathaniswa kanjani nezinye izinketho zesimo sakho esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Aminolevulinic Acid Topical

Ingabe i-Aminolevulinic Acid Topical iphephile kubantu abanesifo sikashukela?

Abantu abanesifo sikashukela ngokuvamile bangathola ukwelashwa nge-aminolevulinic acid topical, kodwa udokotela wakho uzodinga ukucabangela impilo yakho yonke nekhono lokuphulukisa. Isifo sikashukela ngezinye izikhathi singanciphisa ukuphulukiswa kwamanxeba, okungase kuthinte ukululama kwakho ekwelashweni.

Umhlinzeki wakho wokunakekelwa kwezempilo uzonaka kakhulu ukuthi isifo sakho sikashukela silawulwa kahle kangakanani nokuthi ngabe unazo yini izinkinga ezithinta isikhumba sakho noma ukujikeleza kwegazi. Isifo sikashukela esilawulwa kahle ngokuvamile asikuvimbeli ukuthi uthole lokhu kwelashwa, kodwa udokotela wakho angase aqaphe ukuphulukiswa kwakho ngokusondelene kunokujwayelekile.

Uma unesifo sikashukela, qiniseka ukuthi uxoxa ngokuphathwa kukashukela wegazi lakho kanye nanoma yiziphi izinkinga ezihlobene nesikhumba nodokotela wakho ngaphambi kokwelashwa. Ukulawulwa okuhle kukashukela wegazi ngaphambi nangemva kokwelashwa kungasiza ukuthuthukisa ukuphola kwakho futhi kunciphise ingozi yezinkinga.

Kufanele ngenzeni uma ngizwa ubuhlungu obukhulu ngesikhathi sokwelashwa?

Ukungakhululeki okuthile ngesikhathi sesigaba sokwelashwa ngokukhanya kuvamile futhi kulindelekile, kodwa ubuhlungu obukhulu obuzizwa bungenakubekezeleka kufanele bubhekwane ngokushesha. Umhlinzeki wakho wezempilo angakwazi ukumisa noma ukulungisa ukwelashwa ngokukhanya ukuze kwenze kube lula ukukubekezelela.

Ngesikhathi sokwelashwa, xhumana ngokukhululekile nethimba lakho lezempilo mayelana nezinga lobuhlungu bakho. Bangase bakwazi ukusebenzisa amadivayisi okupholisa, ukulungisa amandla okukhanya, noma banikeze izikhathi zokuphumula ezimfushane ukusiza ukuphatha ukungakhululeki. Khumbula ukuthi ingxenye yokwelashwa ngokukhanya ivame ukuthatha imizuzu engu-16-17 kuphela, ngakho ukungakhululeki okukhulu kungokwesikhashana.

Ngemva kokwelashwa, udokotela wakho uzonikeza imiyalelo ethile yokuphatha ubuhlungu ekhaya. Lokhu ngokuvamile kuhlanganisa ama-compresses abandayo, izidambisi zobuhlungu ezingathengwa ngaphandle kwemithi kadokotela, kanye nokunakekelwa kwesikhumba okumnene. Uma ubuhlungu buba bukhulu noma buqhubeka ezinsukwini ezilandelayo ukwelashwa, xhumana nomhlinzeki wakho wezempilo ngokushesha.

Kufanele ngenzeni uma ngiphuthelwa iseshini yokwelashwa ehleliwe?

Uma udinga ukuphuthelwa iseshini yokwelashwa ehleliwe, xhumana nehhovisi likadokotela wakho ngokushesha ngangokunokwenzeka ukuze uhlele kabusha. Isikhathi phakathi kokwelashwa singabaluleka emiphumeleni engcono kakhulu, ngakho-ke umhlinzeki wakho wezempilo uzofuna ukulungisa uhlelo lwakho lokwelashwa ngendlela efanele.

Ukuphuthelwa iseshini eyodwa ngokuvamile ngeke kuphazamise umphumela wakho wokwelashwa wonke, kodwa kungase kulibazise imiphumela yakho yokugcina. Udokotela wakho angase ancome ukuhlukanisa izikhathi ezisele ngendlela ehlukile noma engeze iseshini yokwelashwa eyengeziwe ukuze kuzuzwe umphumela obufunwa.

Zama ukuhlela kabusha ngaphakathi kwesikhathi esifanele, okungcono phakathi kwamasonto ambalwa okuqokwa kwakho kokuqala. Ukubambezeleka okude phakathi kokwelashwa kungase kudingeke ukuqala uchungechunge lokwelashwa futhi, kuye ngesimo sakho esithile nokuphendula kwakho emaseshini adlule.

Ngingayeka nini ukukhathazeka ngokuzwela elangeni ngemva kokwelashwa?

Ukwanda kwakho kokuzwela elangeni kuvamile ukuhlala amahora angama-24 kuya kwangama-48 ngemva kokwelashwa, nakuba abanye abantu behlala bezwela isonto elilodwa. Ngesikhathi lesi, ngisho nokuchayeka elangeni okufushane kungabangela ukusha okukhulu noma kwenze kube kubi ukusabela kwesikhumba sakho ekwelashweni.

Hlela ukuhlala ngaphakathi endlini noma ezindaweni ezinomthunzi phakathi namahora emini okungenani izinsuku ezimbili zokuqala ngemva kokwelashwa. Uma kudingeka uphume ngaphandle, gqoka izingubo ezivikelayo ezimboza izindawo eziphathwe ngokuphelele. I-sunscreen ejwayelekile ayanele ngalesi sikhathi sokuzwela okukhulu.

Udokotela wakho uzokunikeza isiqondiso esithile mayelana nokuthi ungaqala nini ukuchayeka elangeni okujwayelekile. Ngisho nangemva kokuthi isikhathi sokuqala sokuzwela sidlula, izindawo eziphathwe zingase zihlale zizwela kakhulu elangeni amasonto amaningana, ngakho qhubeka usebenzisa ukuvikelwa okuhle elangeni njengoba isikhumba sakho silulama.

Ngingasebenzisa yini izimonyo noma imikhiqizo yokunakekela isikhumba ezindaweni eziphathwe?

Kuzodingeka ukugwema imikhiqizo eminingi yokunakekela isikhumba nezimonyo ezindaweni eziphathwe izinsuku ezimbalwa zokuqala ngemva kokwelashwa. Isikhumba sakho sizobe silulama ekwelashweni, futhi ukwengeza imikhiqizo engase icasukise kungaphazamisa le nqubo noma kubangele ukuvuvukala okwengeziwe.

Udokotela wakho uzohlinzeka ngemiyalelo ethile mayelana nemikhiqizo ongayisebenzisa ngesikhathi sokwelashwa. Ngokuvamile, lokhu kuhlanganisa izihlanzi ezithambile kanye nezithambisi eziklanyelwe isikhumba esizwelayo. Gwema imikhiqizo equkethe utshwala, amakha, noma izithako ezisebenzayo njenge-retinoids noma ama-acids kuze kube yilapho isikhumba sakho selulame.

Ngokuvamile ungaqhubeka nomkhuba wakho wokunakekela isikhumba nokuzithambisa uma ukukhishwa kwesikhumba nokubomvu kokuqala sekudlulile, ngokuvamile phakathi kwamasonto angu-1-2. Qala kancane ngemikhiqizo emnene bese uqhubeka kancane kancane nomkhuba wakho ovamile njengoba ukubekezelelana kwesikhumba sakho kuthuthuka.