Yini i-Amitriptyline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Amitriptyline iyimithi kadokotela eyilungu leqembu lezidakamizwa ezibizwa ngokuthi ama-tricyclic antidepressants. Ngenkathi yaqala ukuthuthukiswa ukwelapha ukucindezeleka, odokotela manje bavame ukuyincoma ngezimo ezihlukahlukene ezihlanganisa ubuhlungu obungapheli, ama-migraines, kanye nezinkinga zokulala. Le mithi eguquguqukayo isebenza ngokuthinta amakhemikhali athile ebuchosheni bakho kanye nohlelo lwakho lwezinzwa, okungasiza ukuthuthukisa imizwa nokunciphisa izimpawu zobuhlungu.

Yini i-Amitriptyline?

I-Amitriptyline iyi-tricyclic antidepressant esetshenziswe ngokuphepha amashumi eminyaka ukwelapha izimo eziningi zempilo. Iza njengamaphilisi omlomo owathatha ngomlomo, ngokuvamile kanye ngosuku ngaphambi kokulala. Umuthi usebenza ngokwandisa amazinga e-neurotransmitters ethile ebuchosheni bakho, ikakhulukazi i-serotonin ne-norepinephrine, edlala indima ebalulekile ekulawuleni imizwa nasekuqondeni ubuhlungu.

Lo muthi ubhekwa njengenketho yamandla aphakathi nendawo phakathi kwama-antidepressants kanye nemithi yobuhlungu. Udokotela wakho uzoqala ngomthamo ophansi futhi angawunyusa kancane kancane ngokuya ngendlela ozosabela ngayo nokuthi yisiphi isimo eselashwayo.

Isetshenziselwani i-Amitriptyline?

I-Amitriptyline ilapha izimo eziningi ezihlukene, nakuba udokotela wakho ezoyincoma ngokuya ngezidingo zakho ezithile. Ukusetshenziswa okuvame kakhulu kufaka phakathi ukucindezeleka, izimo zobuhlungu obungapheli, nokuvimbela i-migraine.

Nazi izimo eziyinhloko i-amitriptyline engasiza ngazo:

• Ukucindezeleka kanye nezinkinga zemizwa
• Izimo zobuhlungu obungapheli njenge-fibromyalgia nobuhlungu be-neuropathic
• Ukuvimbela ikhanda le-migraine
• Ikhanda lokungezwani
• Izinkinga zokulala nokuqwasha
• I-Irritable bowel syndrome (IBS)

Ngokuvamile, odokotela bangase babhalele i-amitriptyline ngezifo zokukhathazeka, i-post-traumatic stress disorder (PTSD), noma izifo ezithile zokudla. Umhlinzeki wakho wezempilo uzonquma ukuthi lo muthi ulungele yini isimo sakho esithile.

Isebenza Kanjani I-Amitriptyline?

I-Amitriptyline isebenza ngokuvimba ukuthathwa kabusha kwe-serotonin kanye ne-norepinephrine ebuchosheni bakho. Cabanga ngalokhu njengezithunywa zamakhemikhali ezisiza amaseli ezinzwa ukuthi axhumane. Lapho i-amitriptyline ivimbela lawa makhemikhali ukuthi angangeni emuva emaseleni ezinzwa, yandisa ukutholakala kwawo ebuchosheni bakho.

Lokhu kwanda kokutholakala kwama-neurotransmitters kungasiza ukuthuthukisa imizwa yakho uma ubhekene nokucindezeleka. Ezimweni zobuhlungu, i-amitriptyline ishintsha indlela izimpawu zobuhlungu ezihamba ngayo ohlelweni lwakho lwezinzwa, okwenza zingabi namandla. Umuthi futhi unomphumela wokuthulisa, yingakho uvame ukuthathwa ngesikhathi sokulala futhi ungase usize ngezinkinga zokulala.

Kubalulekile ukuqonda ukuthi i-amitriptyline ayisebenzi ngokushesha. Kungase kudingeke ukuthi uyithathe amasonto amaningana ngaphambi kokuzwa izinzuzo zayo ezigcwele, ikakhulukazi ekucindezelekeni noma ezimweni zobuhlungu obungapheli.

Kufanele Ngiyithathe Kanjani I-Amitriptyline?

Thatha i-amitriptyline ngendlela udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngesikhathi sokulala. Umuthi ungakwenza ukozela, ngakho ukuwuthatha ngaphambi kokulala kusiza ukunciphisa ukozela emini ngenkathi kungenzeka ukuthi kuthuthukisa ikhwalithi yakho yokulala.

Ungayithatha i-amitriptyline ngaphandle noma ngaphandle kokudla, kodwa ukuyithatha nesnakhi esincane noma ukudla kungasiza ukunciphisa isisu esibuhlungu. Gwinya ithebhulethi yonke nengilazi yamanzi egcwele. Ungayichobozi, uhlafune, noma uyiphule ithebhulethi ngaphandle uma udokotela wakho ekutshela ngqo ukuthi wenze kanjalo.

Zama ukuthatha umuthi wakho ngesikhathi esifanayo njalo kusihlwa ukusiza umzimba wakho ukuthi ujwayele isimiso. Uma uqala i-amitriptyline, udokotela wakho cishe uzoqala ngomthamo ophansi futhi awunyuse kancane kancane emasontweni amaningana ukuze athole inani elifanele lakho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Amitriptyline?

Isikhathi sokwelashwa nge-amitriptyline siyahluka kakhulu kuye ngesimo sakho nokuthi usabela kanjani emuthini. Ngokucindezeleka, kungase kudingeke ukuthi uyithathe okungenani izinyanga eziyisithupha kuya ngonyaka ngemuva kokuthi izimpawu zakho zithuthuke ukuvimbela ukuphindeka.

Uma usebenzisa i-amitriptyline ngenxa yezinhlungu ezingapheli noma ukuvimbela i-migraine, kungase kudingeke ukuthi uyithathe izinyanga eziningana noma isikhathi eside. Abanye abantu bathola ukuthi ukuyisebenzisa isikhathi eside kuyasiza ekuphatheni izimo eziqhubekayo. Udokotela wakho uzobuyekeza njalo inqubekela phambili yakho futhi angase alungise uhlelo lwakho lokwelashwa ngokufanele.

Ungayeki ukuthatha i-amitriptyline ngokuzumayo, ngisho noma uzizwa ungcono. Ukuyeka kungazelelwe kungabangela izimpawu zokuhoxisa njengokuphatheka kabi ikhanda, isicanucanu, ikhanda, nezimpawu ezinjenge-flu. Udokotela wakho uzokusiza ukuthi unciphise kancane kancane umthamo wakho uma sekuyisikhathi sokuyeka umuthi.

Ziyini Imiphumela Eceleni Ye-Amitriptyline?

Njengayo yonke imithi, i-amitriptyline ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi imnene futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini emasontweni ambalwa okuqala.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa:

• Ukozela noma ukuthula
• Umlomo owomile
• Ukuqunjelwa
• Ukubona okungacacile
• Ukukhuluphala
• Isiyezi, ikakhulukazi uma usukuma
• Ubunzima bokuchama

Le miphumela ivame ukulawuleka futhi ithambekele ekunciphiseni ngokuhamba kwesikhathi. Ukuphuza amanzi amaningi, ukudla ukudla okunothile nge-fiber, nokusukuma kancane ezindaweni zokuhlala noma zokulala kungasiza ekunciphiseni ezinye zalezi zinkinga.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho ngokushesha uma uhlangabezana nokushaya kwenhliziyo okungajwayelekile, isiyezi esibi, ukudideka, ukuphuma kwegazi okungajwayelekile noma ukulimala, noma izimpawu zezinkinga zesibindi njengokuphuzi kwesikhumba noma amehlo.

Uma uthatha i-amitriptyline yokucindezeleka, qaphela ukuthi abanye abantu, ikakhulukazi labo abangaphansi kweminyaka engu-25, bangase babe nemicabango yokuzibulala eyanda lapho beqala umuthi. Lolu hlobo lwengozi lukhulu kakhulu emasontweni ambalwa okuqala ukwelashwa, ngakho-ke qhubeka uxhumana nodokotela wakho ngalesi sikhathi.

Obani okungafanele bathathe i-Amitriptyline?

I-Amitriptyline ayifanele wonke umuntu, futhi udokotela wakho uzocabangela ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile nemithi kungenza i-amitriptyline ingaphephile noma ingasebenzi kahle.

Akufanele uthathe i-amitriptyline uma usanda kuba nesifo senhliziyo, unezinkinga ezithile zokushaya kwenhliziyo, noma uthatha ama-MAO inhibitors (uhlobo lwe-antidepressant). Abantu abane-narrow-angle glaucoma, ukugcinwa komchamo okukhulu, noma ukungezwani okwaziwayo kuma-tricyclic antidepressants kufanele futhi bagweme lo muthi.

Udokotela wakho uzosebenzisa ukuqapha okwengeziwe uma unezifo zenhliziyo, izinkinga zesibindi noma izinso, izifo zokuvuvukala, i-bipolar disorder, noma umlando wemicabango yokuzibulala. Abantu abadala bangase bazwe imiphumela emibi kakhulu futhi bangase badinge imithamo ephansi noma ukuqapha okuningi.

Uma ukhulelwe noma uncelisa, xoxa ngezingozi nezinzuzo nodokotela wakho. Ngenkathi i-amitriptyline ingasetshenziswa ngesikhathi sokukhulelwa uma kunesidingo, idlulela obisini futhi ingase ithinte ingane encelisayo.

Amagama Omkhiqizo we-Amitriptyline

I-Amitriptyline itholakala ngaphansi kwamagama amaningi omkhiqizo, nakuba inguqulo ejwayelekile ivame ukunqunywa. E-United States, ungase uyibone imakethwa njenge-Elavil, nakuba leli gama lomkhiqizo lingasetshenziswa kakhulu manje.

Amakhemisi amaningi athwala inguqulo ejwayelekile ye-amitriptyline, equkethe isithako esifanayo esisebenzayo futhi esebenza ngempumelelo njengezinguqulo zegama lomkhiqizo. Imithi ejwayelekile ivamise ukuba ibize kancane futhi ilawulwa yizindinganiso zokuphepha ezifanayo njengemithi yegama lomkhiqizo.

Ibhodlela lakho lemithi lizokhombisa ngokucacile ukuthi ngabe uthola i-amitriptyline ejwayelekile noma inguqulo yegama lomkhiqizo. Uma unezinkathazo ngokushintsha phakathi kwezinhlobo ezijwayelekile nezegama lomkhiqizo, xoxa ngalokhu nomphathi wakho wamapharmacy noma udokotela.

Ezinye izindlela ze-Amitriptyline

Imithi eminingi ehlukile ingelapha izimo ezifanayo ne-amitriptyline, yize ukukhetha okungcono kuncike esimweni sakho esithile nokuthi usabela kanjani ekwelashweni okuhlukene. Udokotela wakho angase acabange ezinye izinketho uma i-amitriptyline ingasebenzi kahle kuwe noma idala imiphumela engathandeki.

Ngeminyaka yokucindezeleka, ezinye izindlela zihlanganisa ezinye izidambisi zokucindezeleka ze-tricyclic njenge-nortriptyline noma i-desipramine, engase idale imiphumela emincane. Izidambisi zokucindezeleka ezintsha njenge-SSRIs (ama-selective serotonin reuptake inhibitors) njenge-sertraline noma i-fluoxetine nazo ziyizinketho.

Uma usebenzisa i-amitriptyline ngenxa yobuhlungu obungapheli, ezinye izindlela zingabandakanya i-gabapentin, i-pregabalin, noma i-duloxetine. Ukuvimbela i-migraine, udokotela wakho angase aphakamise i-topiramate, i-propranolol, noma imithi emisha eqondene ne-migraine.

Isinqumo sokushintsha imithi kufanele senziwe njalo nomhlinzeki wakho wezempilo, ongakusiza ukuthi ulinganise izinzuzo nezingozi zezinketho zokwelashwa ezihlukene ngokususelwa ezidingweni zakho.

Ingabe i-Amitriptyline ingcono kune-Nortriptyline?

I-Amitriptyline ne-nortriptyline zombili ziyizidambisi zokucindezeleka ze-tricyclic ezisebenza ngendlela efanayo, kodwa zomehluko obalulekile. I-Nortriptyline empeleni iyi-metabolite ye-amitriptyline, okusho ukuthi umzimba wakho uguqula i-amitriptyline ethile ibe yi-nortriptyline.

I-Nortriptyline ngokuvamile idala imiphumela emincane kuno-amitriptyline, ikakhulukazi ukuthula okuncane, umlomo owomile, nokuzuza isisindo. Lokhu kwenza i-nortriptyline ibe yindlela engcono kubantu abazwela emiphumeleni noma abadinga ukuhlala beqaphile emini.

Noma kunjalo, imiphumela ye-amitriptyline yokuthulisa ingaba usizo uma ubhekene nezinkinga zokulala kanye nezinye izimo zakho. Ukukhetha phakathi kwale mithi kuncike ezimpawini zakho ezithile, ukubekezelelana nemiphumela emibi, kanye nemigomo yokwelashwa.

Udokotela wakho uzocabangela izinto ezinjengobudala bakho, ezinye izimo zezokwelapha, kanye nokuphendula kwemithi yangaphambilini lapho enquma phakathi kwe-amitriptyline ne-nortriptyline. Zombili le mithi iyasebenza, futhi ukukhetha okuthi "kungcono" yilokho okusebenza kahle kakhulu esimweni sakho somuntu ngamunye.

Imibuzo Evame Ukubuzwa Mayelana ne-Amitriptyline

Ingabe i-Amitriptyline iphephile ezigulini zenhliziyo?

I-Amitriptyline idinga ukucatshangelwa ngokucophelela uma unesifo senhliziyo, njengoba singathinta ukushaya kwenhliziyo yakho nomfutho wegazi. Umuthi ungabangela izinguquko emisebenzini kagesi yenhliziyo yakho, okungase kube yinkinga kubantu abanezimo ezithile zenhliziyo.

Uma unesifo senhliziyo, udokotela wakho cishe uzo-oda i-electrocardiogram (ECG) ngaphambi kokuqala i-amitriptyline futhi angase aqaphe ukusebenza kwenhliziyo yakho njalo. Bangase bakhethe umthamo ophansi noma batusa omunye umuthi ophephe kakhulu enhliziyweni yakho.

Ungalokothi uqale noma uyeke i-amitriptyline ngaphandle kokubonisana nodokotela wakho uma unezinkinga zenhliziyo. Izinzuzo zokwelashwa zingase zidlule izingozi ezimweni eziningi, kodwa lesi sinqumo sidinga ukugadwa kwezokwelapha ngokucophelela.

Ngingenzani uma ngiphuzile i-Amitriptyline eningi ngengozi?

Uma ngengozi uthatha i-amitriptyline eningi, funa ukunakekelwa kwezokwelapha ngokushesha ngokushayela izinombolo eziphuthumayo noma ukuya egumbini eliphuthumayo eliseduze. Ukweqisa i-Amitriptyline kungaba kubi futhi kungase kubeke ukuphila engozini.

Izimpawu zokweqisa i-amitriptyline zihlanganisa ukozela okukhulu, ukudideka, ukushaya kwenhliziyo okungajwayelekile, ubunzima bokuphefumula, ukuhlaselwa, noma ukulahlekelwa ukwazi. Ungalindi ukubona ukuthi izimpawu ziyavela yini - thola usizo ngokushesha uma uthathe ngaphezu komthamo wakho obekiwe.

Ukuvimbela ukweqisa umthamo ngengozi, gcina imithi yakho esitsheni sayo sokuqala ngamalebula acacile, futhi cabanga ukusebenzisa umhleli wamaphilisi uma usebenzisa imithi eminingi. Uma unzima ukukhumbula ukuthi ngabe uyithathile yini umthamo wakho, buza usokhemisi wakho ngamasistimu okukhumbuza.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Amitriptyline?

Uma uphuthelwa umthamo wakho wasemini we-amitriptyline, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Ungathathi umthamo ophindwe kabili ukuze ulungise lowo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi.

Uma ukhumbula umthamo ophuthelwe ekuseni, ngokuvamile kungcono ukuwushaya indiva bese uqhubeka nohlelo lwakho olujwayelekile ngalobo busuku. Ukuthatha i-amitriptyline emini kungabangela ukozela okukhulu futhi kuthinte ikhono lakho lokusebenza ngokujwayelekile.

Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho noma usokhemisi mayelana namaqhinga okukusiza ukuthi ukhumbule. Ukusetha i-alamu yokulala noma ukusebenzisa uhlelo lokusebenza lokukhumbuza imithi kungaba amathuluzi awusizo ekugcineni umkhuba wakho.

Ngingayeka Nini Ukuthatha I-Amitriptyline?

Isinqumo sokuyeka i-amitriptyline kufanele senziwe ngaso sonke isikhathi ngesiqondiso sikadokotela wakho, njengoba isikhathi sincike esimweni sakho nokuthi usabele kanjani ekwelashweni. Ngokucindezeleka, ngokuvamile uzodinga ukuqhubeka nomuthi okungenani izinyanga eziyisithupha ngemuva kokuthi izimpawu zakho zithuthuke.

Uma usebenzisa i-amitriptyline ngenxa yezinhlungu ezingapheli noma ukuvimbela i-migraine, ungase udinge ukwelashwa isikhathi eside. Abanye abantu bayazuza ekuyithatheni iminyaka, kanti abanye banganciphisa kancane umthamo wabo ngemuva kokuthi isimo sabo sizinzile.

Lapho sekuyisikhathi sokuyeka, udokotela wakho uzokwenza isimiso sokunciphisa ukuze anciphise kancane umthamo wakho emasontweni amaningana noma izinyanga. Lokhu kusiza ukuvimbela izimpawu zokuhoxisa futhi kuvumela umzimba wakho ukuthi ujwayele kancane ukusebenza ngaphandle komuthi.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngithatha I-Amitriptyline?

Kungcono ukugwema utshwala ngenkathi uthatha i-amitriptyline, njengoba zombili lezi zinto zingadala ukozela nokuzola. Ukuzihlanganisa kungakhuphula kakhulu le miphumela, kukwenze ubuthongo kakhulu futhi kungenzeka kuthinte ukuxhumana kwakho nokwahlulela kwakho.

Utshwala bungase futhi buqhubekisele phambili izimpawu zokucindezeleka nokukhathazeka, okungenzeka kuphazamise inqubekela phambili yakho yokwelashwa. Uma uthatha i-amitriptyline ngenxa yokucindezeleka, ukusetshenziswa kotshwala kungakwenza kube nzima ukufeza ukuthuthuka kwemizwa okufunayo.

Uma ukhetha ukuphuza utshwala ngezikhathi ezithile, zinciphise ngamanani amancane futhi uqaphele ukuthi le nhlanganisela ikuthinta kanjani. Ungalokothi ushayele noma usebenzise imishini uma uphuze utshwala ngenkathi uthatha i-amitriptyline, futhi xoxa ngokusebenzisa kwakho utshwala ngokukhululekile nomhlinzeki wakho wezempilo.