Yini i-Angiotensin II: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Angiotensin II iyimithi enamandla esetshenziswa ezibhedlela ukwelapha umfutho wegazi ophansi ngokuyingozi ongayiphenduli eminye imithi. Le hormone eyenziwe ngamachweba isebenza ngokucinisa imithambo yegazi emzimbeni wakho wonke, okusiza ukunyusa umfutho wegazi uma wehla ezingeni elibeka ukuphila engozini. Ngokuvamile igcinelwe izimo eziphuthumayo lapho umfutho wakho wegazi wehle kakhulu kangangokuthi izitho ezibalulekile azitholi igazi elanele.

Yini i-Angiotensin II?

I-Angiotensin II iyinguqulo eyenziwe ngumuntu ye-hormone umzimba wakho oyikhiqiza ngokwemvelo ukusiza ukulawula umfutho wegazi. Uma uphilile, izinso zakho nezinye izitho zenza le hormone ukugcina umfutho wakho wegazi uzinzile. Inguqulo yomuthi isebenza ngendlela efanayo ne-hormone yakho yemvelo, kodwa igxilile kakhulu futhi inamandla.

Lo muthi ungowesigaba esibizwa ngokuthi ama-vasopressors, okusho ukuthi icindezela imithambo yegazi ukuze inyuse umfutho wegazi ngokushesha. Ngokungafani nemithi yomfutho wegazi ongase uyithathe ekhaya, le iyodwa inikezwa kuphela nge-IV emagumbini okunakekelwa okukhulu. Ithathwa njengokwelashwa kokugcina uma ezinye izindlela zingasebenzi ukuzinzisa umfutho wakho wegazi.

Isetshenziselwani i-Angiotensin II?

I-Angiotensin II iphatha umfutho wegazi ophansi kakhulu, obizwa nangokuthi i-hypotension, obeka impilo yakho engozini. Lokhu kuvamile ukwenzeka uma umfutho wakho wegazi wehla kakhulu kangangokuthi inhliziyo yakho, ubuchopho, izinso, nezinye izitho ezibalulekile azikwazi ukuthola igazi elidingayo ukuze lisebenze kahle.

Udokotela wakho angase asebenzise lo muthi uma uhlangabezana ne-distributive shock, isimo esibucayi lapho imithambo yakho yegazi iba nokuphumula okuningi futhi ayikwazi ukugcina umfutho ofanele. Lokhu kuvamile ukwenzeka ngesikhathi sokutheleleka okukhulu, ukuhlinzwa okukhulu, noma ngemva kokulimala okukhulu. Eminye imithi ejwayelekile yomfutho wegazi kanye noketshezi lwe-IV abukwazanga ukubuyisela umfutho wakho emazingeni aphephile.

Umuthi usetshenziswa futhi uma unesifo sokushaqeka se-septic, lapho ukutheleleka okukhulu kubangela ukuthi imithambo yakho yegazi idilathe kakhulu. Kulezi zimo, amasistimu omzimba wakho wemvelo wokugcina umfutho wegazi awehlulwe, futhi udinga usizo oluphuthumayo ukuvimbela ukulimala kwezitho.

Isebenza Kanjani I-Angiotensin II?

I-Angiotensin II isebenza ngokubopha kuma-receptors athile ezindongeni zemithambo yakho yegazi, okubangela ukuthi anciphise futhi anciphise. Cabanga ngakho njengokucinisa ipayipi lengadi - lapho ukuvuleka kuncipha, umfutho wamanzi agelezayo uyanda. Lo mphumela wokunciphisa wenzeka ngemizuzu ngemva kokuthola umuthi.

Lokhu kuthathwa njengomuthi onamandla kakhulu ngoba uqondisa ngqo ezindleleni ezifanayo umzimba wakho ozisebenzisela ukulawula umfutho wegazi. Lapho umfutho wegazi lakho wehla ngendlela eyingozi, umzimba wakho uzama ukwenza okwengeziwe kwaleli homoni ngokwawo, kodwa ngezinye izikhathi awukwazi ukuhambisana. Umuthi unikeza uhlelo lwakho ukukhuthaza okwengeziwe olukudingayo.

Umuthi futhi usiza izinso zakho ukuthi zibambe i-sodium namanzi amaningi, okwandisa inani eliphelele legazi ohlelweni lwakho. Inani eliningi legazi elihlanganiswe nemithambo yegazi encane idala umfutho odingekayo ukuze igazi ligeleze kahle kuzo zonke izitho zakho futhi.

Kufanele Ngiyithathe Kanjani I-Angiotensin II?

Ngeke uzithathele wena lo muthi - unikezwa kuphela ochwepheshe bezokwelapha abaqeqeshiwe endaweni yasesibhedlela. Umuthi uza njengempushana exhutshwe ngamanzi ahlanzekile futhi unikezwe ngomugqa we-IV ngokuqondile emgudwini wakho wegazi. Ithimba lakho lezokwelapha lizobala ngokucophelela umthamo ofanele ngokusekelwe esisindweni sakho nokuthi umzimba wakho usabela kanjani.

Umuthi unikezwa njengokudonsa okuqhubekayo, okusho ukuthi ugeleza ngokuqinile ku-IV yakho kunokuthi konke ngesikhathi esisodwa. Abahlengikazi bakho bazogada umfutfo wakho wegazi njalo futhi balungise umthamo njengoba kudingeka. Umgomo uwukukhuphula umfutho wegazi lakho ube sezingeni eliphephile ngaphandle kokwenza libe phezulu kakhulu.

Njengoba le yimithi ephuthumayo, akudingeki ukhathazeke ngokuyithatha nokudla noma ngezikhathi ezithile. Ithimba lakho lezokwelapha liphatha lonke uhlelo lokuthatha imithi kanye nezinqumo zokulinganisa ngokuya ngesimo sakho somzuzu ngomzuzu.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Angiotensin II?

Ubude bokwelashwa buqondana ngokuphelele nokuthi umzimba wakho usabela ngokushesha kangakanani futhi ululama kanjani kunoma yini ebangela ukwehla kwengcindezi yegazi lakho. Abantu abaningi badinga lo muthi amahora ambalwa kuya ezinsukwini ezimbalwa ngenkathi odokotela besebenza ukulungisa inkinga ekhona. Ithimba lakho lezokwelapha lizokwehlisa kancane kancane umthamo njengoba ingcindezi yakho yegazi izinzile.

Abanye abantu bangase bayidinge amahora ambalwa nje uma besabela kahle ekwelashweni kwembangela ekhona. Abanye bangase bayidinge izinsuku eziningana, ikakhulukazi uma belwa nokutheleleka okukhulu noma belulama emsebenzini omkhulu wokuhlinzwa. Odokotela bakho bazohlala behlola ukuthi usayidinga yini imithi.

Umgomo uhlala ukukuyeka lo muthi ngokushesha nje lapho kuphephile ukwenza kanjalo. Ithimba lakho lezokwelapha lizobheka izimpawu zokuthi umzimba wakho usulungele ukugcina ingcindezi yegazi uwedwa futhi, bese wehlisa kancane umthamo uze ungabe usawudinga.

Yiziphi Imiphumela Eceleni Ye-Angiotensin II?

Njengayo yonke imithi enamandla, i-Angiotensin II ingabangela imiphumela emibi, yize ithimba lakho lezokwelapha likuqapha eduze ukuze libambe futhi liphathe noma yiziphi izinkinga ngokushesha. Imiphumela emibi evame kakhulu yenzeka ngoba imithi iyasebenza - ikhuphula ingcindezi yakho yegazi futhi ishintsha indlela igazi eligijima ngayo emzimbeni wakho.

Nansi imiphumela emibi ongase ube nayo ngenkathi uthola lo muthi:

• Ukucasuka noma ukuzwa ukugula esiswini sakho
• Ikhanda njengoba ingcindezi yakho yegazi ilungiswa
• Ukuzwa ukukhathazeka noma ukungazinzi
• Ushintsho ezingeni lokushaya kwenhliziyo
• Ushintsho oluncane ekusebenzeni kwezinso
• Ukwanda okwesikhashana kwamazinga kashukela egazini

Le miphumela ejwayelekile ivamise ukuthuthuka njengoba umzimba wakho ujwayela umuthi futhi isimo sakho sizinzile. Ithimba lakho lezokwelapha liyazi ukuthi lingalindela lezi zimpendulo futhi lizokusiza uzizwe ukhululekile ngangokunokwenzeka.

Imiphumela emibi engathi sína ingenzeka, nakuba ingavamile uma umuthi unikezwa ngendlela efanele esibhedlela. Lokhu kuhlanganisa amahlule egazi akheka ngenxa yokuthi imithambo yakho yegazi iqine kakhulu, noma izinkinga zokugeleza kwegazi emunweni wakho, izinzwane, noma ezinye izindawo uma umthamo mkhulu kakhulu.

Ngokuvamile, abanye abantu bangase babe nokusabela okukhulu komzimba, ukushaya kwenhliziyo okungajwayelekile, noma izinkinga zokugeleza kwegazi ezingxenyeni ezibalulekile zomzimba. Ithimba lakho lezokwelapha liqapha zonke lezi zinto ezingenzeka futhi lingashintsha ukwelashwa kwakho ngokushesha uma kudingeka.

Ubani Ongafanele Athathwe I-Angiotensin II?

Udokotela wakho uzocabangela ngokucophelela ukuthi lo muthi ukufanele yini ngokuya ngesimo sakho esithile. Ngokuvamile, abantu abanezifo zenhliziyo ezithile noma izifo zokujiya kwegazi kungenzeka bangabi ngabantu abafanelekayo kulokhu kwelashwa. Kodwa-ke, ezimweni ezisongela impilo, izinzuzo zivame ukwedlula izingozi.

Uma unomlando wamahlule egazi, ithimba lakho lezokwelapha lizohlola ingozi yokwanda kwezinkinga zokujiya kwegazi ngokumelene nesidingo esiphuthumayo sokuphakamisa umfutho wegazi lakho. Bangase basebenzise eminye imithi ukuvimbela amahlule ngenkathi uthola i-Angiotensin II.

Abantu abanezinhlobo ezithile zesifo senhliziyo noma labo abake bahlaselwa yinhliziyo muva nje bangase badinge ukuqashwa okukhethekile noma ezinye izindlela zokwelashwa. Odokotela bakho bazobuyekeza umlando wakho wezokwelapha ophelele ngaphambi kokunquma ukuthi lo muthi uyindlela engcono kakhulu yesimo sakho.

Njengoba lo muthi ophuthumayo, ngisho nabantu abangase bawugweme ngokujwayelekile bangawuthola uma impilo yabo isengozini ngokushesha. Ithimba lakho lezokwelapha lizokwenza lezi zinqumo ngokusekelwe kulokho okungenzeka kakhulu ukukusiza ukuba usinde futhi ululame.

Amagama Omkhiqizo we-Angiotensin II

Igama lomkhiqizo wale mithi yi-Giapreza, okuyiyona kuphela engavunyelwe yi-FDA njengamanje e-United States. Lokhu kusiza ukuqinisekisa ukuthi uthola umkhiqizo oqhubekayo, osezingeni eliphezulu uma udinga lokhu kwelashwa okusindisa impilo.

Ukuba negama lomkhiqizo elilodwa futhi kwenza kube lula ukuthi ithimba lakho lezokwelapha likwazi ukuxhumana mayelana nokwelashwa kwakho futhi kuqinisekisa ukuthi wonke umuntu usebenzisa ifomula efanayo. Umuthi uza ngamavial abahlengikazi abawagcina esandleni sezimo eziphuthumayo.

Ezinye Izindlela Zokwelapha I-Angiotensin II

Lapho umfutho wegazi lakho wehla ngendlela eyingozi, odokotela banemithi eminingana abangayizama ngaphambi kokusebenzisa i-Angiotensin II. Ezinye izindlela ezivamile zihlanganisa i-norepinephrine, i-epinephrine, ne-vasopressin - konke okusebenza ngezindlela ezehlukile zokukhuphula umfutho wegazi.

I-Norepinephrine ivame ukuba yinto yokuqala okhethwayo ngoba isetshenziswe isikhathi eside futhi odokotela banolwazi oluningi ngayo. Kodwa-ke, abanye abantu abasabeli kahle ku-norepinephrine, okuyilapho udokotela wakho angashintshela khona ku-Angiotensin II noma ayifake ohlelweni lwakho lokwelashwa.

I-Vasopressin isebenza ngama-receptors ahlukene kune-Angiotensin II, ngakho-ke ngezinye izikhathi ukusebenzisa zombili ndawonye kungasebenza kangcono kunanoma iyiphi yazo iyodwa. Ithimba lakho lezokwelapha lizozama izinhlanganisela ezahlukene ukuze lithole ukuthi yini esebenza kahle esimweni sakho esithile.

Kwezinye izimo, odokotela bangase futhi basebenzise i-dopamine noma i-phenylephrine, nakuba lezi zivame ukuthathwa njengezingasebenzi kahle ekwehleni komfutho wegazi okungadinga i-Angiotensin II. Ukukhetha kuncike kulokho okubangela ukwehla komfutho wegazi lakho nokuthi umzimba wakho usabela kanjani ekwelashweni okuhlukene.

Ingabe i-Angiotensin II Ingcono Kune-Norepinephrine?

Zombili le mithi ziyizinketho ezinhle kakhulu zokwelapha umfutho wegazi ophansi kakhulu, kodwa zisebenza ngezindlela ezihlukene emzimbeni wakho. Ucwaningo lwakamuva luphakamisa ukuthi i-Angiotensin II ingase ibe usizo olukhulu kubantu abangaphenduli kahle ku-norepinephrine kuphela, ikakhulu labo abanomshini we-septic.

I-Norepinephrine ibilokhu iyindlela yokwelapha ejwayelekile iminyaka eminingi futhi isebenza kahle kubantu abaningi. Kodwa-ke, i-Angiotensin II inikeza enye inketho lapho i-norepinephrine inganele noma ibangela imiphumela eminingi engemihle. Abanye abantu basabela kangcono emuthini owodwa kunomunye.

Ithimba lakho lezokwelapha lizovame ukuzama i-norepinephrine kuqala ngoba linolwazi oluningi ngayo, kodwa lingashintshela ku-Angiotensin II noma liyengeze uma umfutho wakho wegazi ungathuthuki ngokwanele. Ukukhetha okungcono kuncike ngokuphelele esimweni sakho ngasinye nokuthi umzimba wakho usabela kanjani.

Kwezinye izimo, ukusebenzisa zombili le mithi ndawonye kusebenza kangcono kunanoma iyiphi eyodwa. Le ndlela yokuhlanganisa ivumela odokotela ukuthi basebenzise imithamo ephansi yomuthi ngamunye ngenkathi besafinyelela imigomo yomfutho wegazi oyidingayo ukuze ululame.

Imibuzo Evame Ukubuzwa Nge-Angiotensin II

Ingabe i-Angiotensin II iphephile kubantu abanezifo zenhliziyo?

Abantu abanezifo zenhliziyo bangathola i-Angiotensin II lapho impilo yabo isengozini ngenxa yomfutho wegazi ophansi, kodwa badinga ukuqapha okwengeziwe. Umuthi ungenza inhliziyo isebenze kanzima ngoba wenza inhliziyo isebenze kanzima ukuze ipompe igazi ngemithambo yegazi enciphile.

Ithimba lakho lezokwelapha lizobheka ukusebenza kwenhliziyo yakho ngokucophelela lisebenzisa ama-monitor futhi lingashintsha umthamo kaningi. Bangase futhi basebenzise eminye imithi ukuvikela inhliziyo yakho ngenkathi uthola lokhu kwelashwa. Isinqumo sifinyelela ekulinganiseni ingozi esheshayo yomfutho wegazi ophansi oyingozi ngokumelene nokucindezeleka okungenzeka enhliziyweni yakho.

Ngingenzani uma ngithola i-Angiotensin II eningi ngengozi?

Akudingeki ukhathazeke ngokuthola umthamo omningi walo muthi ngoba unikezwa kuphela ochwepheshe bezokwelapha abaqeqeshiwe abakuqapha njalo. Uma umfutho wegazi lakho unyuka kakhulu, ithimba lakho lezokwelapha lizokwehlisa ngokushesha umthamo noma limise umuthi okwesikhashana.

Imiphumela ye-Angiotensin II iyaphela ngokushesha uma umthamo wehlisiwe, ngokuvamile ngemizuzu. Ithimba lakho lezokwelapha linesimiso sokubhekana nanoma yiziphi izinkinga zomthamo futhi lingasebenzisa eminye imithi ukuze kulwe nemiphumela eyeqile uma kudingeka.

Kwenziwani Uma Umthamo We-Angiotensin II Uphuthelwa?

Njengoba lo muthi unikezwa njengokuthululwa kwe-IV okuqhubekayo esibhedlela, akukho okuthi "umthamo ophuthelwe" ngomqondo wendabuko. Uma i-IV iyeka ukusebenza nganoma yisiphi isizathu, ithimba lakho lezokwelapha lizobona ngokushesha ngokusebenzisa ukuqapha okuqhubekayo futhi lizoyiqala kabusha ngokushesha.

Umfutho wakho wegazi uqashwa njalo ngenkathi wamukela lo muthi, ngakho noma yikuphi ukuphazamiseka ekwelashweni kungatholwa futhi kulungiswe ngemizuzu. Ithimba lezokwelapha linamaphrojekthi okusekela nezindawo zokufinyelela ze-IV ezingezinye ezilungele uma kudingeka.

Ngingayeka nini ukuthatha i-Angiotensin II?

Ithimba lakho lezokwelapha lizinquma ukuthi kuphephile nini ukuyeka lo muthi ngokusekelwe ekutheni umfutho wakho wegazi uzinzile kangakanani nokuthi ngabe imbangela eyinhloko yomfutho wakho wegazi ophansi iselashiwe yini. Lokhu kuvame ukwenzeka kancane kancane emahoreni amaningana noma ezinsukwini njengoba isimo sakho sithuthuka.

Inqubo yokuyeka ihlanganisa ukunciphisa kancane umthamo kunokuyeka kungazelelwe. Lokhu kunika umzimba wakho isikhathi sokuzivumelanisa futhi kuvimbela umfutho wakho wegazi ukuthi wehle futhi. Odokotela bakho bazokubuka ngokucophelela ngesikhathi sale nqubo yokuyeka ukuqinisekisa ukuthi usukulungele.

Ingabe i-Angiotensin II ingabangela izinkinga zesikhathi eside?

Abantu abaningi abathola i-Angiotensin II ababi nazinkinga zesikhathi eside ngenxa yomuthi ngokwawo. Kodwa-ke, izimo ezibucayi zezokwelapha ezidinga lokhu kwelashwa ngezinye izikhathi zingadala imiphumela ehlala njalo. Ithimba lakho lezokwelapha ligxila ekusebenziseni umuthi isikhathi esifushane ngangokunokwenzeka ukunciphisa noma yiziphi izingozi ezingaba khona.

Into ebaluleke kakhulu ukuthi lo muthi ungasindisa impilo uma uwudinga. Noma yiziphi izingozi zesikhathi eside ezingaba khona zivame ukuba zincane kakhulu kunengozi esheshayo yokungelaphi umfutho wegazi ophansi ngendlela eyingozi. Odokotela bakho bazoxoxa nganoma yikuphi ukukhathazeka mayelana nemiphumela yesikhathi eside ngokusekelwe esimweni sakho esithile.