Yini i-Antihemophilic Factor (Recombinant, PEGylated) - Aucl? Ukusetshenziswa, Imiphumela Eceleni, & Umhlahlandlela Wokwelapha

I-Antihemophilic Factor (Recombinant, PEGylated) - Aucl iyinguqulo eyenziwe e-laboratory yeprotheni yokujiya kwegazi esiza abantu abane-hemophilia A ukumisa ukopha. Lo muthi ushintsha i-clotting factor VIII elahlekile noma enezinkinga edingwa umzimba wakho ukuze wakhe amahlule egazi ngendlela efanele.

Uma wena noma othile omkhathalelayo eno-hemophilia A, lo muthi ungaba yingxenye ebalulekile yokuphatha lesi simo. Isebenza ngokunika umzimba wakho i-clotting factor elahlekile, isiza ekuvikeleni izigameko zokopha eziyingozi futhi ikuvumela ukuthi uphile impilo ejwayelekile.

Yini i-Antihemophilic Factor (Recombinant, PEGylated) - Aucl?

Lo muthi uyinguqulo yokwenziwa ye-factor VIII, iprotheni elidingwa igazi lakho ukuze lijiye kahle. Ingxenye ethi "recombinant" isho ukuthi yenziwe e-laboratory kunokuba ivela kubanikeli begazi labantu, okwenza iphephe ekuthelelaneni ngegazi.

Isici esithi "PEGylated" sibhekisela ekugcotshweni okukhethekile okusiza umuthi ukuthi uhlale egazini lakho isikhathi eside. Lokhu kusho ukuthi ungase udinge imijovo embalwa uma uqhathaniswa neminye imikhiqizo ye-factor VIII, okwenza ukwelashwa kube lula kuwe.

Udokotela wakho uzonikeza lo muthi ngomjovo we-IV (intravenous) ngokuqondile emthanjeni wakho. Umuthi uhamba ngegazi lakho ukusiza igazi lakho ukuthi lijiye uma ulimele noma unezigameko zokopha.

Kuzwakala kanjani ukwelashwa ngalo muthi?

Abantu abaningi bawuthatha kahle lo muthi, futhi ungase ungazizwa okuningi ngesikhathi somjovo wangempela. Inqubo ye-IV ngokuvamile ithatha imizuzu embalwa nje, efana nokuthatha igazi ehhovisi likadokotela.

Abanye abantu bazwa imiphumela emincane engemihle efana nekhanda, isiyezi, noma isicanucanu ngemva kokuthola umjovo. Le mizwa ivame ukunyamalala emahoreni ambalwa futhi ngokuvamile ayibi.

Ungase uqaphele ukuthi ukuphuma kwegazi kwakho kuyeka ngokushesha ngemva kokuthola lo muthi, okungase kulethe impumuzo enkulu uma ubhekene nesiqephu sokuphuma kwegazi. Abantu abaningi babika ukuzizwa benethemba elikhulu ngemisebenzi yabo yansuku zonke bazi ukuthi banalesi sivikelo.

Yini ebangela isidingo salo muthi?

I-Hemophilia A yisimo esiyinhloko esidinga lo muthi. Lesi sifo semvelo sibonisa ukuthi umzimba wakho awenzi amaprotheni e-factor VIII anele, noma i-factor VIII ayisebenzi kahle ukusiza igazi lakho ukuba ligqame.

Lesi simo senzeka ngenxa yezinguquko kujeni ethile enikeza imiyalelo yokwenza i-factor VIII. Njengoba leli jeni litholakala ku-chromosome X, i-hemophilia A ithinta amadoda kaningi kunabesifazane.

Nazi izizathu eziyinhloko zokuthi kungani umuntu angase adinge lo muthi:

• I-hemophilia A eyazuza ngofuzo evela emndenini
• Ushintsho lwemvelo olungazelelwe olubangela ukuntuleka kwe-factor VIII
• Iziqephu zokuphuma kwegazi ezinzima ezidinga ukufakwa ngokushesha kwe-clotting factor
• Ukwelashwa kokuvimbela ukunciphisa ingozi yezinkinga zokuphuma kwegazi
• Ukulungiselela ukuhlinzwa noma izinqubo zamazinyo

Ukuqonda isimo sakho esithile kusiza ithimba lakho lezempilo ukuthi linqume indlela engcono kakhulu yokwelapha wena. Ubunzima be-hemophilia yakho buzothonya ukuthi udinga kangaki lo muthi.

Yiziphi izimo ezilashwa yilo muthi?

Lo muthi ngokuyinhloko welapha i-hemophilia A, kodwa usetshenziswa ngezindlela ezahlukene kuye ngezidingo zakho ezithile. Udokotela wakho angase awubhalele ukuvimbela okuqhubekayo noma ukwelashwa okuphuthumayo kweziqephu zokuphuma kwegazi.

Lo muthi ubhekana nezici eziningana zokuphathwa kwe-hemophilia A:

• I-hemophilia A eqinile enamazinga e-factor VIII angaphansi kuka-1% wokuqhelekile
• I-hemophilia A emaphakathi enamazinga e-factor VIII aphakathi kuka-1-5% wokuqhelekile
• I-hemophilia A emnene enamazinga e-factor VIII aphakathi kuka-5-40% wokuqhelekile
• Izigameko zokuphuma kwegazi emalungeni, emisipheni, noma ezithweni zangaphakathi
• Ukwelashwa kwe-prophylactic ukuvimbela ukuphuma kwegazi okuzenzakalelayo
• Ukuphathwa kwe-Perioperative ngemisebenzi kanye nezinqubo

Umhlinzeki wakho wezempilo uzosebenza nawe ukunquma ukuthi ngabe udinga ukufakwa kwe-prophylactic okujwayelekile noma ukwelashwa kuphela lapho kuvela ukuphuma kwegazi. Lesi sinqumo sincike emlandweni wakho wokuphuma kwegazi kanye nezinto zokuphila.

Ingabe izigameko zokuphuma kwegazi zingaxazululwa ngaphandle kwalo muthi?

Kubantu abane-hemophilia A, izigameko zokuphuma kwegazi ngokuvamile azikwazi ukuxazululwa ngokuphepha zodwa ngaphandle kokufaka esikhundleni se-clotting factor. Umzimba wakho awunayo iphrotheni ebalulekile edingekayo ukwakha amahlule egazi azinzile.

Ukusikeka okuncane noma ukuklwebheka kungase ekugcineni kuyeke ukuphuma kwegazi, kodwa le nqubo ithatha isikhathi eside kakhulu kunokujwayelekile futhi kungaba yingozi. Ukuphuma kwegazi kwangaphakathi, ikakhulukazi emalungeni noma emisipheni, akuvamile ukuyeka ngaphandle kokwelashwa okufanele futhi kungadala umonakalo unomphela.

Ukulinda ukuthi ukuphuma kwegazi kuyeke ngokwemvelo kukubeka engozini yezinkinga ezinzima njengomonakalo wamalunga, ubuthakathaka bemisipha, noma ukuphuma kwegazi kwangaphakathi okusongela impilo. Yingakho ukwelashwa okusheshayo ngokufaka esikhundleni se-factor VIII kubaluleke kakhulu empilweni yakho nokuphepha kwakho.

Lo muthi unikezwa kanjani njengokwelashwa?

Lo muthi unikezwa ngaso sonke isikhathi ngomjovo we-intravenous (IV) ngqo emthanjeni wakho. Le nqubo ngokuvamile ithatha imizuzu embalwa nje futhi ingenziwa esibhedlela, emtholampilo, noma ngisho nasekhaya uma usuqeqeshwe kahle.

Umhlinzeki wakho wokunakekelwa kwezempilo uzobala umthamo wakho oqondile ngokusekelwe esisindweni sakho, ubunzima be-hemophilia yakho, nokuthi uyelapha yini ukopha okusebenzayo noma uvimbela izigameko zesikhathi esizayo. Umuthi uza njengempushana okumele ixutshwe namanzi ahlanzekile ngaphambi kokujova.

Nakhu okuhilelekile enqubweni yokwelashwa:

1. Umhlinzeki wakho wokunakekelwa kwezempilo ulungisa umuthi ngokuxuba impushana namanzi ahlanzekile
2. Bathola umthambo ofanele, ngokuvamile engalweni yakho noma esandleni sakho
3. Umuthi ujovwa kancane kancane ngemizuzu embalwa
4. Uqashwe ngokushesha ukuze uqinisekise ukuthi uyakubekezelela ukwelashwa kahle
5. Indawo yokujova imbozwe ngesibopho esincane

Abantu abaningi bafunda ukuziphatha lo muthi ekhaya, okuhlinzeka ngenkululeko enkulu nokuzimela. Ithimba lakho lokunakekelwa kwezempilo lizohlinzeka ngokuqeqeshwa okuphelele uma ukwelashwa ekhaya kufanele isimo sakho.

Kufanele ngifune nini ukunakekelwa kwezempilo ngenkathi ngisebenzisa lo muthi?

Kufanele uxhumane nomhlinzeki wakho wokunakekelwa kwezempilo ngokushesha uma uhlangabezana nezimpawu zokuphendula komzimba, njengobunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, noma ukusabela okukhulu kwesikhumba. Lezi zimpawu, ngenkathi zingavamile, zidinga ukunakekelwa kwezempilo ngokushesha.

Funa ukunakekelwa kwezempilo okusheshayo uma uba nokopha okukhulu okungaphenduli emthomeni wakho ojwayelekile wokwelashwa, noma uma uhlangabezana namaphethini okopha angajwayelekile. Lokhu kungase kubonise ukuthi umzimba wakho uthuthukisa ama-antibody ngokumelene nomuthi.

Nazi izimo ezithile ezidinga ukunakekelwa kwezempilo ngokushesha:

• Ukusabela okukhulu komzimba okubandakanya ubunzima bokuphefumula noma ukugwinya
• Ukuphuma kwegazi okuqhubekayo ngaphandle kokwelashwa okufanele kwe-factor VIII
• Izimpawu zamaqhubu egazi njengobuhlungu besifuba, ukuphefumula kanzima, noma ukuvuvukala komlenze
• Ukulimala okungajwayelekile noma ukuphuma kwegazi okubonakala kungaphezu kwamandla
• Umkhuhlane, amaqhafuza, noma izimpawu zokutheleleka endaweni yokujova
• Ikhanda elibuhlungu elibuhlungu, izinguquko embonweni, noma izimpawu ze-neurological

Unganqikazi ukuxhumana nethimba lakho lezempilo nganoma yiziphi izinkathazo mayelana nokwelashwa kwakho. Bakhona ukukusiza ukuthi uphathe isimo sakho ngokuphepha nangempumelelo.

Ziyini izici eziyingozi zokudinga lo muthi?

Isici esiyinhloko esiyingozi sokudinga lo muthi ukuba ne-hemophilia A, okuyisimo esitholakala ngofuzo. Uma unamalungu omndeni ane-hemophilia A, ungase ube sengozini yokuba nesimo ngokwakho.

Njengoba i-hemophilia A ihlobene ne-X chromosome, amadoda maningi amathuba okuthi athinteke ngoba anayo i-X chromosome eyodwa kuphela. Abesifazane bangaba ngabathwali futhi bangase babe nezimpawu ezithambile, kodwa mancane amathuba okuthi babe ne-hemophilia A enzima.

Izici eziningana zithonya amathuba akho okudinga lokhu kwelashwa:

• Umlando womndeni we-hemophilia A noma ezinye izifo zokuphuma kwegazi
• Ukuba yindoda (ngenxa yephethini yefa elixhunywe ku-X)
• Ukuba nonina othwele ngofuzo lwe-hemophilia A
• Izigameko zangaphambilini zokuphuma kwegazi ezidinga ukungenelela kwezokwelapha
• Ukuzibandakanya emisebenzini enengozi enkulu yokulimala
• Isidingo sokuhlinzwa noma izinqubo zamazinyo

Uma unezici eziyingozi ze-hemophilia A, ukwelulekwa ngofuzo kungakusiza ukuthi uqonde kangcono isimo sakho. Ukuxilongwa kwasekuqaleni nokuhlela ukwelashwa okufanele kungathuthukisa kakhulu izinga lempilo yakho.

Ziyini izinkinga ezingaba khona zalokhu kwelashwa?

Ngenkathi le mithi ivame ukuphepha futhi isebenza kahle, njengayo yonke imithi, ngezinye izikhathi ingabangela imiphumela emibi noma izinkinga. Abantu abaningi bayayithanda kahle le mithi, kodwa kubalulekile ukwazi ngezinkinga ezingase zibe khona.

Imiphumela emibi evame kakhulu imnene futhi yesikhashana, okuhlanganisa ikhanda elibuhlungu, isiyezi, noma isicanucanu. Lokhu kuvame ukuzixazulula ngokwako kungakapheli amahora ambalwa okwelashwa.

Izinkinga ezingathi sína zingenzeka, nakuba zingavamile:

• Ukuphendula komzimba okusukela ekucasukeni kwesikhumba okuncane kuya ku-anaphylaxis engathi sína
• Ukuthuthukiswa kwama-inhibitors (ama-antibody enza imithi ingasebenzi kahle)
• Amaqhubu egazi, ikakhulukazi ngemithamo ephezulu noma ukuphathwa njalo
• Ukuphendula endaweni yokujova njengobuhlungu, ukuvuvukala, noma ukutheleleka
• Ushintsho lwezinga lokushaya kwenhliziyo noma umfutho wegazi ngesikhathi sokufakwa
• Izimo ezingavamile zezinkinga zezinso noma izinguquko ekusebenzeni kwesibindi

Ithimba lakho lezempilo likuqapha ngokucophelela lezi zinkinga futhi lilungise uhlelo lwakho lokwelashwa njengoba kudingeka. Ukuhlolwa kwegazi okuvamile kusiza ukuthola noma yiziphi izinkinga ngaphambi kwesikhathi ukuze zixazululwe ngokushesha.

Ingabe le mithi iyasebenza kuzo zonke izinhlobo ze-hemophilia?

Le mithi yenzelwe ngqo i-hemophilia A futhi ayisebenzi kwezinye izinhlobo ze-hemophilia. I-Hemophilia A ihilela ukuntuleka kwe-factor VIII, okuyilokho kanye le mithi ekufakayo.

Uma une-hemophilia B (ebizwa nangokuthi isifo sikaKhisimusi), uzodinga imithi ehlukile equkethe i-factor IX esikhundleni se-factor VIII. Ukusebenzisa uhlobo olungalungile lwe-clotting factor ngeke lusize izigameko zakho zokuphuma kwegazi.

Udokotela wakho uzoqinisekisa uhlobo lwakho oluthile lwe-hemophilia ngokuhlolwa kwegazi ngaphambi kokukuyalela le mithi. Lokhu kuqinisekisa ukuthi uthola ukwelashwa okufanele kakhulu isimo sakho.

Yini le mithi engase ididaniswe nayo?

Lo muthi ungase udidaniswe neminye imikhiqizo ye-clotting factor, ikakhulukazi ezinye izinhlobo ze-factor VIII ezingenawo umvalelo we-PEGylated. Ngenkathi le mithi isebenza ngezinhloso ezifanayo, ingase idinge izinhlelo zokulinganisa ezihlukene.

Abanye abantu bangase badide lokhu kwelashwa nemikhiqizo ye-factor IX esetshenziselwa i-hemophilia B, noma neminye imikhiqizo yegazi efana ne-plasma entsha eqandisiwe. Kodwa-ke, ngamunye walokhu kwelashwa usebenza ngendlela ehlukile futhi usetshenziselwa izimo ezithile.

Kubalulekile ukuhlala uqinisekisa ukuthi uthola umuthi olungile wohlobo lwakho oluthile lwe-hemophilia. Umhlinzeki wakho wezempilo uzoqinisekisa ukuthi uthola ukwelashwa okulungile, kodwa ungasiza ngokubuza imibuzo futhi uhlale unolwazi ngemithi yakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Antihemophilic Factor (Recombinant, PEGylated) - Aucl

Ingabe umuthi uhlala isikhathi esingakanani emzimbeni wami?

Ukuvalwa kwe-PEGylated kusiza lo muthi ukuthi uhlale egazini lakho isikhathi eside kunezinhlobo zemikhiqizo ye-factor VIII yendabuko. Abantu abaningi bagcina amazinga okuvikela izinsuku ezi-2-3 ngemuva komjovo, nakuba lokhu kuhluka ngokuya ngezinto zomuntu ngamunye njengokusebenza komzimba wakho kanye nezinga lomsebenzi.

Ngingahamba ngenkathi ngisebenzisa lo muthi?

Yebo, ungaqhubeka nokuhamba ngenkathi usebenzisa lo muthi, kodwa uzodinga ukuhlela kusengaphambili. Umhlinzeki wakho wezempilo angakusiza ukuthi ulungiselele ukuhlinzekwa komuthi futhi anikeze imibhalo yokuphepha esikhumulweni sezindiza. Abantu abaningi bahamba ngempumelelo emhlabeni wonke ngenkathi bephatha i-hemophilia yabo.

Ngizodinga lo muthi impilo yami yonke?

I-Hemophilia A yisimo sempilo yonke, ngakho-ke abantu abaningi badinga ukwelashwa okuqhubekayo ngokufaka esikhundleni se-clotting factor. Kodwa-ke, izindlela zokwelashwa zingashintsha ngokuhamba kwesikhathi ngokuya ngocwaningo olusha kanye nezidingo zakho zomuntu ngamunye. Ithimba lakho lezempilo lizobuyekeza njalo uhlelo lwakho lokwelashwa.

Ingabe zikhona izinto okufanele ngizigweme ngenkathi ngisebenzisa lo muthi?

Lo muthi empeleni ukwenza ukwazi ukubamba iqhaza emisebenzini eminingi ngokuphepha ngokunikeza ukuvikelwa okungcono kokopha. Nokho, usadingeka ukuthi ugweme imisebenzi enobungozi obukhulu engase ibangele ukulimala okukhulu. Umhlinzeki wakho wokunakekelwa kwezempilo angakunikeza iseluleko ngokuguqulwa komsebenzi ngokuya ngesimo sakho esithile.

Ingabe lo muthi ungasebenzisana neminye imithi engiyithathayo?

Lo muthi unezinto ezimbalwa zokusebenzisana nemithi, kodwa kufanele ngaso sonke isikhathi wazise abahlinzeki bakho bezempilo ngayo yonke imithi kanye nezithasiselo ozithathayo. Eminye imithi ethinta ukujiya kwegazi ingase idinge ukulungiswa komthamo uma isetshenziswa kanye nokufaka esikhundleni se-factor VIII.