Yini i-Antihemophilic Factor (Recombinant, Porcine Sequence)? Ukusetshenziswa, Izinzuzo, & Umhlahlandlela Wokwelapha

I-Antihemophilic Factor (Recombinant, Porcine Sequence) iyimithi ekhethekile eyenzelwe ukusiza abantu abane-hemophilia A ukulawula izigameko zokuphuma kwegazi. Lokhu kwelashwa okusindisa impilo kusebenza ngokufaka esikhundleni se-clotting factor umzimba wakho owudingayo ukuze umise ukuphuma kwegazi ngendlela efanele.

Uma wena noma othile omkhathalelayo enikwe le mithi, cishe ubhekene nokuphazamiseka okuyinkimbinkimbi kokuphuma kwegazi okudinga ukuphathwa ngokucophelela. Ukuqonda ukuthi le mithi isebenza kanjani kungakusiza uzizwe uqiniseka ngokwengeziwe ngokunakekelwa okutholayo.

Yini i-Antihemophilic Factor (Recombinant, Porcine Sequence)?

Le mithi iyinguqulo eyenziwe ngumuntu ye-Factor VIII, iphrotheni esiza igazi lakho ukuba ligqame ngokujwayelekile. Ibizwa ngokuthi "porcine sequence" ngoba isuselwe kunguqulo yengulube yale clotting factor, esebenza ngendlela efana ne-human Factor VIII.

Udokotela wakho unquma lolu hlobo oluthile uma umzimba wakho usuthuthukise ama-antibodies ngokumelene nokwelashwa okuvamile kwe-human Factor VIII. Cabanga ngayo njengecebo lokusekela elingasiza igazi lakho ukuba ligqame ngisho nalapho okunye ukwelashwa kungasebenzi kahle.

Umuthi uza njengempushana exutshwa ngamanzi ahlanzekile futhi inikezwe nge-IV ngqo emgudwini wakho wegazi. Lokhu kuqinisekisa ukuthi ifinyelela emzimbeni wakho ngokushesha uma uyidinga kakhulu.

Kuzizwa kanjani ukwelashwa ngale mithi?

Inqubo yokufaka ngempela izizwa ifana nokuthola noma iyiphi imithi ye-IV. Ngokuvamile uzoyithola esibhedlela, emtholampilo, noma esikhungweni sokwelapha esikhethekile lapho abahlinzeki bezempilo bengakuqapha ngokucophelela.

Abantu abaningi bachaza ukuthi okuhlangenwe nakho kukhululekile. Ukufakwa kwe-IV kungase kubangele ukucinana okufushane, kodwa umuthi ngokwawo ngokuvamile awubangeli ukuphatheka kabi ngokushesha ngesikhathi sokufakwa.

Ungase uqaphele ukuthi izigameko zokuphuma kwegazi ziqala ukuthuthuka kungakapheli amahora ambalwa ngemva kokwelashwa. Iziguli eziningi zizwa zikhululekile ngoba zazi ukuthi zinenketho esebenzayo uma ukwelashwa okuvamile kunganele.

Yini ebangela isidingo salolu hlobo olukhethekile lokwelashwa?

Udokotela wakho ukunika lo muthi uma une-hemophilia A enezinto ezivimbayo. Lokhu kusho ukuthi amasosha akho omzimba athathe izidakamizwa ezihlasela futhi ziqede ukwelashwa okuvamile kwe-Factor VIII.

Izinto eziningana zingaholela ekuthuthukisweni kwezinto ezivimbayo, futhi kubalulekile ukuqonda ukuthi lokhu akuyona into oyibangele noma ongayivimbela:

• Izici zemvelo ezenza abanye abantu bakwazi ukuthuthukisa izinto ezivimbayo
• Ukuvezwa okuphindaphindiwe ekwelashweni kwe-Factor VIII ngokuhamba kwesikhathi
• I-hemophilia A eqinile, evame ukudinga ukwelashwa okuvame kakhulu
• Ukwahluka okuthile kwemvelo ngaphakathi kofuzo lwakho lwe-Factor VIII
• Ukusabela komzimba ngamunye okuhluka kumuntu nomuntu

Ukuba nezinto ezivimbayo akusho ukuthi wenze okuthile okungalungile. Kumane nje ukuthi amasosha omzimba abanye abantu asabela kanjani ekwelashweni, futhi yingakho izinketho ezinjengale factor esekelwe ezingulubeni zikhona.

Yiziphi izimo ezidinga lokhu kwelashwa okuthile?

Lo muthi wenzelwe ngqo abantu abane-hemophilia A abaye bathuthukisa izinto ezivimbayo ku-human Factor VIII. Udokotela wakho ngokuvamile uzokuncoma uma ukwelashwa okujwayelekile kungalawuli ukuphuma kwegazi kwakho ngempumelelo.

Ungase udinge lokhu kwelashwa uma uhlangabezana nezigameko zokuphuma kwegazi ngaphandle kokwelashwa okuvamile kwe-Factor VIII. Isetshenziselwa futhi izinqubo zokuhlinzwa lapho ukwelashwa kwakho kwamanje kungahlinzeki ngosizo olwanele lokujiya kwegazi.

Abanye abantu basebenzisa lokhu njengesixazululo sesikhashana ngenkathi bethola ukwelashwa kokubekezelelana komzimba, okuhlose ukunciphisa amazinga ezinto ezivimbayo ngokuhamba kwesikhathi. Ithimba lakho lokunakekelwa kwezempilo lizothola indlela engcono kakhulu ngokusekelwe esimweni sakho esithile.

Ingabe izigameko zokuphuma kwegazi zingaqeda ngaphandle kokwelashwa lokhu?

Kubantu abane-hemophilia A kanye nezithiyo, izigameko zokuphuma kwegazi azivamile ukuqeda ngokwazo. Ngaphandle kokufaka esikhundleni esifanele se-clotting factor, ngisho nokulimala okuncane kungaba izimo ezingathi sína zezokwelapha.

Ngenkathi umzimba wakho unezinqubo zokuphulukisa zemvelo, azanele uma ungenayo i-Factor VIII eyanele. Yingakho ukwelashwa okusheshayo ngokufaka esikhundleni se-clotting factor esisebenzayo kubaluleke kangaka.

Ukulinda ukuthi ukuphuma kwegazi kuyeke ngokwemvelo kungaholela ezinkingeni ezinjengomonakalo wamalunga, ukuphuma kwegazi kwangaphakathi, noma ezinye izinkinga ezinkulu zempilo. Yingakho ukufinyelela ezinkethweni zokwelapha ezisebenzayo njenge-factor esekelwe ezingulubeni kubalulekile ekuphepheni kwakho.

Ingabe le mithi inikezwa kanjani?

Lokhu kwelashwa kunikezwa njalo nge-intravenously, okusho ngqo egazini lakho ngomugqa we-IV. Le nqubo ivame ukwenzeka endaweni yezokwelapha lapho ochwepheshe abaqeqeshiwe bengaqapha impendulo yakho.

Nakhu ongakulindela ngesikhathi sokwelashwa:

1. Abahlinzeki bezempilo bazolungisa umuthi ngokuxuba impushana ngamanzi ahlanzekile
2. Bazokwakha ukufinyelela kwe-IV, ngokuvamile engalweni yakho
3. Umuthi ufakwa kancane kancane ngemizuzu embalwa
4. Uzoqashwa nganoma yiziphi izimphendulo ezisheshayo
5. Ukuqapha okulandelayo kuqhubeka nokuhlola ukusebenza kokwelashwa

Umthamo kanye nemvamisa kuncike ezidingweni zakho ezithile, ubukhulu bokuphuma kwegazi kwakho, nokuthi umzimba wakho usabela kanjani ekwelashweni. Ithimba lakho lezokwelapha lizokwenza uhlelo olwenzelwe wena olusebenza kahle kakhulu esimweni sakho.

Yini indlela yokuphatha yezokwelapha?

Ukuphathwa kwezokwelapha kuhilela ukunakekelwa okubanzi okungaphezu komuthi ngokwawo. Ithimba lakho lezempilo lizosebenza nawe ukuthuthukisa isu eliphelele lokwelapha.

Odokotela bakho bazohlala beqapha amazinga akho e-inhibitor futhi balungise izinhlelo zokwelapha ngokufanele. Bangase futhi bahlele nodokotela abangochwepheshe abanjengochwepheshe begazi, odokotela abahlinzayo bamathambo, noma ezinye izazi ngokuya ngezidingo zakho.

Abanye abantu bayazuza ekwelashweni kokubekezelelana komzimba kanye nalolu hlobo lokwelashwa. Le ndlela ihlose ukuqeqesha kabusha amasosha akho omzimba ukuthi amukele ukwelashwa okuvamile kwe-Factor VIII futhi, nakuba kungathatha izinyanga noma iminyaka ukuthi isebenze.

Kufanele ufune nini ukunakekelwa kwezempilo ngokushesha?

Kufanele uthinte umhlinzeki wakho wezempilo ngokushesha uma uhlangabezana nanoma yiziphi izimpawu zokuphuma kwegazi okukhulu, ikakhulukazi uma ukwelashwa kwakho okuvamile kungasebenzi ngempumelelo.

Funa ukunakekelwa okuphuthumayo ngokushesha uma uqaphela lezi zimpawu zokuxwayisa:

• Ikhanda elibuhlungu elibuhlungu noma ukudideka, okungase kubonise ukuphuma kwegazi ebuchosheni
• Ukuphefumula kanzima noma ubuhlungu besifuba
• Ubuhlungu obukhulu besisu noma ukuvuvukala
• Ama-bruises amakhulu noma andayo ngokushesha
• Ukuphuma kwegazi okungayeki ngezinyathelo ezijwayelekile
• Ukuvuvukala kwamalunga okuba kubi nakakhulu naphezu kokwelashwa

Unganqikazi ukufinyelela eqenjini lakho lezokwelapha uma unezinkathazo mayelana nokuphuma kwegazi noma impendulo yokwelashwa. Ukungenelela kwangaphambi kwesikhathi kuhlale kungcono kunokulinda ukubona ukuthi izimpawu ziyathuthuka yini.

Yiziphi izici eziyingozi zokudinga lokhu kwelashwa?

Izici eziningana zikhuphula amathuba okuthi ungase udinge le ndlela yokwelapha ekhethekile. Ukuqonda lokhu kungakusiza wena nethimba lakho lezempilo ukuthi nihlele ukunakekelwa kwakho.

Izici eziyingozi eziyinhloko zihlanganisa ukuba ne-hemophilia A eqinile, evame ukudinga ukwelashwa kwe-Factor VIII okuvame kakhulu. Abantu abanezinhlobonhlobo ezithile zofuzo nabo maningi amathuba okuthi bazokwakha ama-inhibitors ngokuhamba kwesikhathi.

Ukuqala ukwelashwa nge-Factor VIII esemncane, ukuba namalungu omndeni anezithiyo, nokudinga izikhathi zokwelashwa ezinzima (njengangesikhathi sokuhlinzwa) kungakhuphula nengozi yakho. Kodwa-ke, khumbula ukuthi abantu abaningi abanalezi zici eziyingozi abasoze bazithuthukise izithiyo.

Ziyini izinkinga ezingenzeka?

Njengayo yonke imithi, lokhu kwelashwa kungaba nemiphumela emibi, nakuba izinkinga ezinzima zingavamile uma zisetshenziswa ngaphansi kokuqondiswa okufanele kwezokwelapha.

Abanye abantu bahlangabezana nokusabela okuncane njengomkhuhlane, ama-chills, noma isicanucanu ngesikhathi noma ngemva nje kokufakwa. Lezi zimpawu zivame ukulawuleka futhi zivame ukuncipha ngokuphindaphinda ukwelashwa.

Izinkinga ezingathi sína kodwa ezingavamile zingabandakanya ukusabela komzimba noma ukuthuthukiswa kwama-antibody amasha ngokumelene ne-porcine factor. Ithimba lakho lezokwelapha liqapha lezi zinto ezingenzeka futhi liyazi ukuthi lingazilawula kanjani uma zenzeka.

Ingabe lokhu kwelashwa kuyasebenza nge-hemophilia A enezithiyo?

Lo muthi ngokuvamile usebenza kahle kakhulu kubantu abane-hemophilia A abaye bathuthukisa izithiyo ekwelashweni okuvamile kwe-Factor VIII. Iziguli eziningi zithola ukuthuthuka okukhulu ekulawuleni ukuphuma kwegazi.

I-porcine-based factor isebenza kahle ngoba ihluke ngokwanele ku-human Factor VIII kangangokuthi ama-antibody akho akhona ngokuvamile awawazi futhi awawahlasi ngokushesha. Lokhu kuyinika ithuba lokusiza igazi lakho ukuthi ligqame kahle.

Kodwa-ke, abanye abantu bangase bagcine bethuthukisa ama-antibody ngokumelene ne-porcine factor futhi. Ithimba lakho lokunakekelwa kwezempilo liqapha lokhu ngokucophelela futhi lingashintsha uhlelo lwakho lokwelashwa uma kudingeka.

Yini lokhu kwelashwa okungadidaniswa nayo?

Lokhu kwelashwa okukhethekile kuhluke kakhulu kweminye imithi ye-hemophilia, kodwa kungase kube nokudideka mayelana nezinhlobo ezahlukene zemikhiqizo ye-Factor VIII etholakalayo.

Abantu ngezinye izikhathi bayakudida nezinto ezinjengama-ejenti okudlula ngqo njenge-Factor VIIa noma ama-prothrombin complex concentrates, asebenza ngendlela ehlukile ukusiza igazi ukuba liqine. Nakuba lezi zinto nazo zisetshenziselwa iziguli ezinama-inhibitor, zinezindlela ezihlukene zokusebenza.

Iphinde ihluke emithini yokwelapha yokubekezelelana komzimba, nakuba lezi zindlela zokwelapha zombili ngezinye izikhathi zisetshenziswa ndawonye. Ithimba lakho lezempilo lizochaza ngokucacile ukuthi yiziphi izindlela zokwelapha ozitholayo nokuthi kungani ngamunye ebalulekile ekunakekelweni kwakho.

Imibuzo Evame Ukubuzwa

Kuthatha isikhathi esingakanani ukuthi umuthi usebenze?

Abantu abaningi baqaphela ukuthuthuka ekulawuleni ukuphuma kwegazi kungakapheli amahora ambalwa ngemva kokuthola umjovo. Umuthi uqala ukusebenza ngokushesha emsingeni wakho wegazi, kodwa kungase kuthathe isikhathi ukubona imiphumela ephelele ekuphumeni kwegazi okusebenzayo.

Ngingahamba ngezinyawo ngenkathi ngisebenzisa lo muthi?

Yebo, kodwa kudinga ukuhlelwa ngokucophelela nethimba lakho lezempilo. Kuzodingeka ukuthi uhlele ukutholakala komuthi lapho uya khona futhi uphethe imibhalo efanele mayelana nezidingo zakho zezokwelapha. Izikhungo eziningi zokwelapha zingasiza ekuxhumaniseni ukunakekelwa ngezikhungo kwezinye izindawo.

Ngizowudinga lo muthi kuze kube phakade?

Akudingeki. Abanye abantu basebenzisa lokhu njengesixazululo sesikhashana ngenkathi bethola imithi yokwelapha yokubekezelelana komzimba, okuhlose ukuqeda ama-inhibitor ngokuhamba kwesikhathi. Abanye bangase bawudinge isikhathi eside uma ama-inhibitor abo eqhubeka. Isimo sakho ngasinye sizokunqumela indlela engcono kakhulu.

Ingabe zikhona izinto okufanele ngizivikele ekudleni ngenkathi ngithola lo muthi?

Ngokuvamile azikho izinto ezithile okufanele uzivikele ekudleni ezihlobene nalo muthi. Kodwa-ke, ukugcina ukudla okunempilo kusekela impilo yonke nokuphulukiswa. Ithimba lakho lezempilo lizokunikeza isiqondiso uma unezidingo ezithile zokudla okunomsoco.

Kwenzekani uma ngiphuthelwa umuthi ohleliwe?

Xhumana nomhlinzeki wakho wezempilo ngokushesha uma uphuthelwa ukwelashwa okuhleliwe, ikakhulukazi uma uhlangabezana nezimpawu zokuphuma igazi. Bazokusiza ukuthi unqume inkambo engcono kakhulu yokwenza futhi kungase kudingeke ukuthi balungise isimiso sakho sokwelashwa ukuze baqinisekise ukuphepha kwakho.