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October 10, 2025
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I-Antithymocyte globulin (unogwaja) iyimithi ekhethekile eyenziwe ngama-antibody kanogwaja asiza ukuvimbela amasosha akho omzimba ekuhlaseleni izitho ezitshaliwe noma ekwelapheni izifo ezithile zegazi. Lo muthi onamandla wokucindezela amasosha omzimba usebenza ngokugxila nokunciphisa amaseli athile amasosha omzimba abizwa ngokuthi ama-T-lymphocyte angabangela ukwenqatshwa noma ukulimala kwezicubu ezinempilo.
Ungase uhlangane nalo muthi uma wamukela ukutshalwa kwesitho noma ubhekene ne-aplastic anemia enzima, isimo lapho umnkantsha wakho wamathambo ungakhiqizi amaseli egazi anele. Ngenkathi igama lizwakala liyinkimbinkimbi, licabange njengensiza eyenzelwe ngokucophelela esiza ukuthulisa impendulo yamasosha omzimba esebenza ngokweqile lapho umzimba wakho udinga ukwesekwa okwengeziwe.
I-Antithymocyte globulin (unogwaja), evame ukufushaniswa ngokuthi i-rATG, iyimithi yezinto eziphilayo etholakala konogwaja abaye bagonywa ngamaseli e-T omuntu. Ama-antibody avelayo abese ehlanzwa futhi acutshungulwe abe umuthi ongagxila ngokukhethekile futhi ucindezele ama-T-lymphocyte amasosha akho omzimba.
Lo muthi ungowesigaba semithi ebizwa ngokuthi ama-immunosuppressants, okusho ukuthi ngamabomu ubuthaka izingxenye ezithile zamasosha akho omzimba. Ngenkathi lokhu kungase kuzwakale kukhathaza, empeleni kuyinqubo elawulwa ngokucophelela esiza ukuvimbela umzimba wakho ukuthi unqabe isitho esisha noma ukuhlasela izicubu zawo ezinempilo ezifweni ezithile zegazi.
Ingxenye ethi
Lo muthi unamaphuzu amabili amakhulu emithini yesimanje: ukuvimbela ukwenqatshwa kokufakelwa kwezitho zomzimba kanye nokwelapha i-aplastic anemia eqinile. Zombili lezi zimo zidinga ukuphathwa ngokucophelela kwesistimu yokuzivikela komzimba ukusiza umzimba wakho ukuba uphole noma wamukele izicubu ezintsha.
Ezigulini ezifakelwa izitho zomzimba, i-antithymocyte globulin isiza ukuvimbela isimiso sakho sokuzivikela komzimba ukuba singayiboni isitho esisha njengesingajwayelekile futhi singasihlaseli. Le nqubo, ebizwa ngokuthi ukwenqatshwa, ingaba yingozi empilweni uma ingaphathwa kahle. Umuthi uvame ukusetshenziswa lapho eminye imithi ecindezela amasosha omzimba ingasebenzi kahle yodwa.
Ezimweni ze-aplastic anemia, umnkantsha wakho uyeka ukukhiqiza amaseli egazi anele, ngokuvamile ngenxa yokuthi isimiso sakho sokuzivikela komzimba ngokungaqondile sihlasela amaseli abangela ukukhiqizwa kwegazi. Umuthi usiza ukuthulisa le mpendulo engalungile yamasosha omzimba, unikeze umnkantsha wakho ithuba lokululama futhi uqale ukukhiqiza amaseli egazi anempilo futhi.
Ngokuvamile, odokotela bangase babhale lo muthi kwezinye izimo ze-autoimmune lapho isimiso sokuzivikela komzimba sibangela umonakalo omkhulu ezicutshini ezinempilo. Kodwa-ke, lezi zindlela zokusebenzisa zivame ukugcinelwa amacala aqinile lapho ezinye izindlela zokwelapha zingaphumelelanga.
Lo muthi usebenza ngokubopha nokuqeda ama-T-lymphocytes, okuyizidlali ezibalulekile ekwazi kwakho isimiso sakho sokuzivikela komzimba ukubona nokuhlasela izinto zangaphandle. Cabanga ngama-T-cells njengabalindi bezokuphepha abaqeqeshwe kakhulu abaqapha umzimba wakho befuna izinsongo.
Uma uthola i-antithymocyte globulin, inamathisela kula ma-T-cells futhi iwabeka ukuba abhujiswe ezinye izingxenye zesimiso sakho sokuzivikela komzimba. Le nqubo inciphisa kakhulu inani lama-T-cells asebenzayo egazini lakho, okusiza ukuwavimbela ukuthi angahlaseli izitho ezifakelwe noma izicubu zakho ezinempilo.
Umuthi uthathwa njengonamandla kakhulu emhlabeni wokucindezela amasosha omzimba. Ngenkathi lawa mandla ewenza asebenze ezimweni ezinzima, futhi kusho ukuthi uzodinga ukuqashwa ngokucophelela ngesikhathi sokwelashwa. Ithimba lakho lezokwelapha lizobheka izimpawu zokuthi amasosha akho omzimba aya ngokuya ecindezelwa kakhulu, okungakushiya ubuthakathaka ekuvikelweni ezifweni.
Imiphumela yalo muthi ingahlala amasonto noma izinyanga ngisho nangemva kokwelashwa, njengoba kuthatha isikhathi ukuthi umzimba wakho ugcwalise kabusha ama-T-cell asusiwe. Lesi senzo esandisiwe empeleni sinenzuzo ezigulini ezinamalungu omzimba, njengoba sinikeza ukuvikelwa okuqhubekayo ekwenqabeni.
Uzothola lo muthi kuphela ngomugqa we-intravenous (IV) esibhedlela noma ekliniki ekhethekile. Awunikezwa njengemithi noma umjovo ongawuthatha ekhaya, njengoba kudinga ukuqashwa ngokucophelela nokufinyelela ngokushesha ekunakekelweni okuphuthumayo uma kudingeka.
Ngaphambi kokufakwa ngakunye, ithimba lakho lezokwelapha cishe lizokunika imithi yokusiza ukuvimbela ukusabela komzimba. Lokhu kungabandakanya ama-antihistamines afana ne-diphenhydramine, ama-corticosteroids, kanye nezinto ezinciphisa umkhuhlane. Lokhu kwelashwa ngaphambi kokwelashwa kusiza umzimba wakho ukuthi ukwazi ukubekezelela umuthi ngokunethezeka.
Inqubo yokufakwa yangempela ihamba kancane futhi inhloso. Umthamo wakho wokuqala ngokuvamile uzonikezwa ngaphezu kwamahora angu-6 noma ngaphezulu, okuvumela ithimba lakho lezokwelapha ukuthi libheke ngokucophelela noma yikuphi ukusabela okukhathazayo. Uma ukwazi ukubekezelela umthamo wokuqala kahle, imithamo elandelayo inganikezwa ngokushesha kancane, kodwa ngaphezu kwamahora amaningana.
Ngesikhathi sokufakwa, uzoxhunywa emishinini yokuqapha elandela izimpawu zakho ezibalulekile, okuhlanganisa izinga lokushaya kwenhliziyo, umfutho wegazi, kanye namazinga omoya-mpilo. Umnakekeli uzokuhlola njalo futhi akubuze nganoma yiziphi izimpawu ongase uzithole, njengamakhaza, isicanucanu, noma ubunzima bokuphefumula.
Akudingeki ukhathazeke ngokudla ukudla okuthile ngaphambi noma ngesikhathi sokwelashwa, nakuba ukuhlala unamanzi kubalulekile. Ithimba lakho lezokwelapha lizohlinzeka ngemiyalelo ethile mayelana nokudla nokuphuza ngokusekelwe ohlelweni lwakho lokwelashwa olujwayelekile nokuthi uzizwa kanjani.
Ubude besikhathi sokwelashwa buhlukahluka kakhulu kuye ngesimo sakho esithile nokuthi usabela kahle kangakanani emuthini. Abantu abaningi bathola umuthi izinsuku eziyi-3 kuya kweziyi-14, nakuba isimiso esiqondile sincike ekutheni uyelashwa yini ukwenqatshwa kokufakelwa noma i-aplastic anemia.
Ezineziguli ezifakelwe, ezihlangabezana nokwenqatshwa, ukwelashwa kungase kube kufushane futhi kube nzima kakhulu, ngokuvamile kuthatha izinsuku eziyi-3 kuya kweziyi-7. Odokotela bakho bazogada izivivinyo zegazi nezimpawu zokwenqatshwa ukuze banqume ukuthi unikezwe nini umuthi owanele wokulawula ukusabela komzimba ekuguleni.
Uma uthola ukwelashwa nge-aplastic anemia, inkambo ingase ibe yinde, ingase idlulele ezinsukwini eziyi-10 kuya kweziyi-14. Ithimba lakho lezokwelapha lizobe liqaphela izibalo zakho zegazi ngokucophelela ukuze libone ukuthi umnkantsha wakho wamathambo usabela kanjani ekucindezelweni komzimba ekuguleni.
Kubalulekile ukuqonda ukuthi ngisho nangemva kokuqeda ukuthola umuthi, imiphumela yawo iyaqhubeka amasonto noma izinyanga. Uhlelo lwakho lomzimba lokuzivikela emzimbeni luzokwakha kabusha kancane kancane ama-T-cells asusiwe, kodwa le nqubo ithatha isikhathi. Ngesikhathi sokululama, uzodinga ukuqapha okuqhubekayo futhi ungase udinge eminye imithi ukuvimbela izifo.
Njengayo yonke imithi enamandla, i-antithymocyte globulin ingabangela imiphumela ehlukahlukene, kusukela ekusabeleni okulula ngesikhathi sokufakwa kuya ezinkingeni ezingathi sína. Ukuqonda okulindelekile kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungabaxwayisa nini ithimba lakho lezokwelapha.
Imiphumela emibi evame kakhulu yenzeka ngesikhathi noma ngemuva nje kokufakwa, futhi ngokuvamile iyaphathwa ngokunakekelwa okusekelayo. Lezi zimo zenzeka ngoba amasosha akho omzimba asabela emaphrotheni angaphandle emuthini, yize enzelwe ukukusiza.
Nawa amanye emiphumela emibi ongase uyithole ngesikhathi sokwelashwa:
Lezi zimo ezihlobene nokufakwa ngokuvamile ziba zimbi kakhulu ngomthamo wokuqala futhi zivame ukulawuleka kalula ngokwelashwa okulandelayo. Ithimba lakho lezokwelapha lizolungisa imithi yakho yangaphambi kokwelashwa kanye nezinga lokufakwa ukuze kuncishiswe le miphumela.
Imiphumela emibi ebucayi ingase ivele ngesikhathi sokwelashwa noma emasontweni alandelayo ngemuva kokuthatha umuthi wakho. Lezi zinkinga zidinga ukunakekelwa kwezokwelapha ngokushesha nokuqapha ngokucophelela:
Abanye abantu bahlangabezana nalokho okubizwa nge-cytokine release syndrome, lapho umuthi uqala ukusabela okukhulu komzimba okungabangela umkhuhlane, ukwehla kwengcindezi yegazi, nobunzima bokuphefumula. Nakuba lokhu kuzwakala kusabisa, ithimba lakho lezokwelapha lilungele kahle ukulawula lokhu kusabela uma kwenzeka.
Imiphumela yesikhathi eside ingabandakanya ingozi eyengeziwe yezinye izinhlobo zomdlavuza, ikakhulukazi ama-lymphomas, ngenxa yokucindezelwa komzimba okude. Nokho, le ngozi idinga ukulinganiswa nezinzuzo zokwelapha isimo sakho esingaphansi, futhi odokotela bakho bazoxoxa ngalokhu okulungele wena.
Abantu abathile akufanele bathole lo muthi ngenxa yengozi eyengeziwe yezinkinga ezinzima. Ithimba lakho lezokwelapha lizobuyekeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ngaphambi kokuncoma ukwelashwa.
Akufanele uthole i-antithymocyte globulin uma wazi ukuthi unokungezwani nezinto ezinama-protein kanogwaja noma uma uke waba nokusabela okukhulu kulo muthi esikhathini esidlule. Noma ngabe awukaze uveze ngqo kuma-protein kanogwaja, odokotela bakho bangase benze ukuhlolwa kokungezwani komzimba uma bekhathazekile ngokusabela okungenzeka.
Abantu abanezifo ezisebenzayo, ezingalawuleki ngokuvamile akufanele bathole lo muthi ngoba uzocindezela ngokuqhubekayo amasosha abo omzimba lapho ewadinga kakhulu ukulwa nesifo. Nokho, kwezinye izimo, odokotela bangase banqume ukuthi izinzuzo zidlula izingozi futhi banikeze umuthi kanye nokwelashwa okunamandla kwesifo.
Nawa amanye amakhondishini angase enze lo muthi ungafaneleki kuwe:
Iminyaka yakho kanye nesimo sempilo yakho konke kubuye kudlale indima ebalulekile ekunqumeni ukuthi le mithi ilungele wena yini. Abantu abadala kanye nabantu abanezimo eziningi zempilo bangase badinge ukucatshangelwa okukhethekile nokuqapha eduze ngesikhathi sokwelashwa.
Le mithi itholakala ngaphansi kwegama lomkhiqizo elithi Thymoglobulin, elenziwa yi-Genzyme Corporation. Lena yindlela esetshenziswa kakhulu ezibhedlela nasemithini yokufakelwa e-United States.
Ungase futhi uzwe abahlinzeki bezempilo bekhuluma ngayo ngesifinyezo sayo, i-rATG, okusho ukuthi i-rabbit antithymocyte globulin. Lokhu kusiza ukuyihlukanisa nemithi efanayo etholakala kweminye imithombo yezilwane, njenge-horse antithymocyte globulin.
Ngokungafani nemithi eminingi enamagama amaningi omkhiqizo noma izinguqulo ezivamile, i-antithymocyte globulin (rabbit) itholakala ikakhulukazi njenge-Thymoglobulin. Le mithi ekhethekile idinga izinqubo ezithile zokukhiqiza nokulawulwa kwekhwalithi okwenza izinguqulo ezivamile zingavamile.
Imithi eminingi ehlukile ingahlinzeka ngokucindezelwa komzimba okufanayo, nakuba ngamunye enezinto zawo ezisetshenziswa ngqo kanye namaphrofayili emiphumela emibi. Udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe esimweni sakho esithile kanye nomlando wezokwelapha.
Kubantu abathole ukufakelwa, ezinye izindlela zokucindezela amasosha omzimba zihlanganisa i-horse antithymocyte globulin (Atgam), esebenza ngendlela efanayo kodwa ivela emthonjeni wezilwane ohlukile. Abanye abantu bayayibekezelela kangcono kunenye, futhi udokotela wakho angashintsha phakathi kwazo ngokusekelwe ekuphenduleni kwakho.
I-Alemtuzumab (Campath) ngomunye umuthi wemvelo oqondise amaseli omzimba, nakuba usebenza ngendlela ehlukile. Ngezinye izikhathi isetshenziselwa izimo ezifanayo kodwa inezinzuzo zayo eziyingqayizivele nezingozi ezizocatshangelwa ithimba lakho lezokwelapha.
Ngokuqondile i-aplastic anemia, ezinye izinketho zokwelapha zingabandakanya:
Ukukhetha phakathi kwalezi zindlela kuncike ezintweni ezifana nobudala bakho, impilo yonke, ukutholakala kwabanikeli bomnkantsha wamathambo, nokuthi isimo sakho sibi kangakanani. Ithimba lakho lezokwelapha lizoxoxa ngalezi zinketho nawe ukuze lithole indlela enikeza ibhalansi engcono kakhulu yokusebenza kahle nokuphepha.
Le mithi emibili isebenza ngendlela ehlukile futhi ivame ukusetshenziselwa izinjongo ezihlukene, ngakho ukuqhathanisa ngokuqondile akuhlali kuqondile. Zombili ziyizidakamizwa ezicindezela amasosha omzimba, kodwa ziqondise izingxenye ezihlukene zesistimu yakho yomzimba futhi zinezici ezihlukene eziqinile nezibuthakathaka.
I-Antithymocyte globulin ngokuvamile inamandla futhi isebenza ngokushesha kune-cyclosporine, okwenza ibe usizo ezimweni eziphuthumayo njengokwenqatshwa okukhulu kokufakelwa noma i-aplastic anemia esongela impilo. Nokho, lokhu kwanda kwamandla kusho nokuthi ithwala izingozi eziphakeme zemiphumela emibi engathí sina nezinkinga.
I-Cyclosporine, ngakolunye uhlangothi, ngokuvamile isetshenziselwa ukucindezelwa komzimba isikhathi eside futhi ingathathwa njengepilisi ekhaya. Ivame ukukhethwa ngemuva kokuhlinzwa noma ezimweni ezingapheli ezidinga ukucindezelwa komzimba okuqhubekayo ngaphandle kwemiphumela enamandla ye-antithymocyte globulin.
Ezimweni eziningi, le mithi ayisetshenziswa njengezinye izindlela kodwa njengokwelashwa okwengezayo. Ungase uthole i-antithymocyte globulin ngesikhathi senkinga bese udlulela ku-cyclosporine ukuze ulawulwe isikhathi eside.
Ithimba lakho lezokwelapha lizocabangela izinto ezinjengokuphuthuma kwesimo sakho, ikhono lakho lokuthatha imithi yomlomo, ukubekezelelana kwakho nemiphumela emibi, kanye nemigomo yakho yokwelashwa isikhathi eside lapho unquma phakathi kwalezi zinketho.
Lo muthi ungasetshenziswa kubantu abanezifo zezinso, kodwa udinga ukuqapha ngokucophelela futhi mhlawumbe ukulungiswa komthamo. Njengoba izinso zakho zisiza ukucubungula nokususa umuthi, ukuncipha komsebenzi wezinso kungathinta ukuthi umuthi uhlala isikhathi esingakanani ohlelweni lwakho futhi kungenzeka ukuthi kwandise ingozi yemiphumela emibi.
Ithimba lakho lezokwelapha lizogada ngokusondelene ukusebenza kwezinso zakho ngokusebenzisa ukuhlolwa kwegazi ngaphambi, ngesikhathi, nangemva kokwelashwa. Bangase balungise umthamo noma izinga lokufakwa ngokuya ngokuthi izinso zakho zisebenza kahle kangakanani. Kwezinye izimo, izinzuzo zokwelashwa zidlula izingozi, ngisho nakubantu abanezinkinga ezinkulu zezinso.
Njengoba lo muthi unikezwa kuphela ezindaweni ezilawulwayo zesibhedlela ochwepheshe bezokwelapha abaqeqeshiwe, ukweqisa ngengozi akuvamile kakhulu. Kodwa-ke, uma uthola okuningi kunokuhlosiwe, ithimba lakho lezokwelapha lizokwenza ngokushesha ukunakekelwa okusekelayo ukuze kulawulwe noma yiziphi izinkinga.
Ukwelashwa kwe-overdose ngokuvamile kuhilela ukuqapha eduze izimpawu zakho ezibalulekile, ukubalwa kwegazi, kanye nokusebenza kwezitho. Akukho umuthi oqondile we-antithymocyte globulin, ngakho ukunakekelwa kugxila ekusekeleni umzimba wakho ngenkathi usebenza ngemithi futhi ulawula noma yimaphi imiphumela emibi evela.
Ithimba lakho lezokwelapha lingakunika imithi yokusekela umfutho wegazi lakho, ukwelapha izifo ngendlela eqinile, noma ukuhlinzeka ngokumpontshelwa igazi uma ukubalwa kwegazi lakho kwehle kakhulu. Okubalulekile ukubona ngokushesha nokunakekelwa okusekelayo okuphelele.
Ukuphuthelwa umthamo kuyinkinga eyinhloko yeqembu lakho lezokwelapha kunokuthi kube yinto okudingeka ukhathazeke ngayo ngqo. Njengoba umuthi unikezwa endaweni yasesibhedlela, abahlinzeki bakho bezempilo bazolawula isimiso sakho sokulinganisa futhi benze izinguquko uma kudingeka.
Uma umthamo ulibaziseka ngezizathu zezokwelapha, njengomkhuhlane noma ezinye izinkinga, odokotela bakho bazonquma isikhathi esingcono sokuqala kabusha ukwelashwa. Ngezinye izikhathi bangase balungise inani eliphelele lemithamo noma banwebe isikhathi sokwelashwa ukuze baqinisekise ukuthi uthola inzuzo ephelele yokwelapha.
Into ebaluleke kakhulu ukuxhumana nethimba lakho lezokwelapha mayelana nanoma yiziphi izinkathazo noma izimpawu ozozithola ezingase zithinte isimiso sakho sokwelashwa.
Awuvamile ukuthi “uyeke” lo muthi ngomqondo wendabuko, njengoba unikezwa njengenkambo ethile yokwelashwa ezinsukwini eziningana kunokuba ube njengomuthi wansuku zonke oqhubekayo. Uma usuqedile inkambo yakho echaziwe, umuthi uqhubeka usebenza ohlelweni lwakho amasonto noma izinyanga.
Odokotela bakho bazonquma ukuthi ngabe usutholile yini imithi eyanele ngokusekelwe ekutheni usabela kanjani emithini. Ukuze kulashwe ukwenqatshwa kokufakelwa, bazoqapha izimpawu zokwenqatshwa egazini lakho kanye nange-biopsies. Ukuze kulashwe i-aplastic anemia, bazoqapha ukubalwa kwegazi lakho ukuze babone ukuthi umnkantsha wakho uyalulama yini.
Ngemuva kokuqeda ukwelashwa, uzoqhubekela kweminye imithi yokuphatha isimo sakho isikhathi eside. Lokhu kungabandakanya imithi yokucindezela amasosha omzimba ngomlomo, imithi esekelayo, noma ukuqapha njalo ngaphandle kokwelashwa okwengeziwe okusebenzayo.
Kufanele ugweme imigomo ephilayo ngesikhathi sokwelashwa kanye nezinyanga eziningana ngemuva kwalokho, njengoba amasosha akho omzimba acindezelwe kungenzeka angakwazi ukubhekana ngendlela ephephile ngamabhayirusi noma amagciwane abuthakathaka kule migomo. Imigomo ephilayo ihlanganisa izinto ezinjengomkhuhlane, amagciwane e-mumps, rubella, chickenpox, kanye nemigomo yomkhuhlane wamakhala.
Imigomo engasebenzi, efana nomjovo womkhuhlane, umgomo we-pneumonia, kanye nemigomo ye-COVID-19, ngokuvamile iphephe kakhulu kodwa kungenzeka ingasebenzi kahle ngenkathi amasosha akho omzimba ecindezelwe. Ithimba lakho lezokwelapha lizokweluleka ngesikhathi esingcono kakhulu sokuthola imigomo edingekayo.
Kubalulekile ukuxoxa ngesimo sakho sokugoma nodokotela bakho ngaphambi kokuqala ukwelashwa, njengoba bengase batusa imigomo ethile ngaphambi kwalokho uma isimo sakho sivumela ukubambezeleka ekwelashweni.
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