Ukuhlinzeka nge-intravenous (indlela ye-intravenous)

Ukugula

I-Atidarsagene autotemcel injection isetyenziselwa ukwelapha abantwana abane-pre-symptomatic late infantile (PSLI), pre-symptomatic early juvenile (PSEJ), noma early symptomatic early juvenile (ESEJ) metachromatic leukodystrophy (MLD). I-Metachromatic leukodystrophy (MLD) yisifo esingavamile sezofuzo esithinta ubuchopho nesistimu yezinzwa esibangelwa ukushoda kwesenzimu ebizwa nge-arylsulfatase A (ARSA). Lolu lwelapha kufanele lunikezwe kuphela ngudokotela wakho noma ngaphansi kokunakekelwa kwakhe okuqondile. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:

Ekwahluleni kokusebenzisa imithi, izingozi zokuthatha imithi kufanele ziqhathaniswe nezinzuzo ezizoletha. Lo ngumqululo owenzayo wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqondile noma oluqondile lokuphazamiseka kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unanoma yiluphi olunye uhlobo lokuqabuka, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zezingane ezizobeka umkhawulo ekusebenziseni ukugxilwa kwe-atidarsagene autotemcel kubantwana. Noma kunjalo, ukuphepha nokuphumelela akukaqiniswa kubantwana abane-MLD ekuqaleni kwabantu abadala. Ayikho imininingwane etholakalayo ngokuphathelene nobudlelwano bobukhulu nemiphumela yokugxilwa kwe-atidarsagene autotemcel kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthola le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlwini elingezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka kube khona ukusebenzisana. Ukusebenzisa utshwala noma utshaba ngezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi: