Yini i-Axicabtagene Ciloleucel: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Axicabtagene ciloleucel iyindlela yokwelapha umdlavuza eyenza izingxenye zakho zomzimba zokuzivikela zisebenze ukulwa neminye imidlavuza yegazi. Le ndlela yokwelapha entsha, eyaziwa nangokuthi i-CAR-T cell therapy, ithatha amaseli okuzivikela emzimbeni wakho, iwalungise elabhorethri ukuze akwazi ukubona kangcono futhi ahlasela amaseli omdlavuza, bese ebuyiselwa kuwe ngomjovo we-IV.

Lokhu kwelashwa okwenzelwe wena ngqo kumelele intuthuko enkulu ekunakekelweni komdlavuza, kunikeza ithemba ezigulini ezinohlobo oluthile lwe-lymphoma kanye ne-leukemia ezingaphendulanga kwezinye izindlela zokwelapha. Nakuba inqubo iyinkimbinkimbi futhi idinga izikhungo zezokwelapha ezikhethekile, ikhombise impumelelo emangalisayo ekusizeni iziguli ukuthi zifinyelele ekutheni zibe ngcono uma ezinye izindlela sezikhathale.

Yini i-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel wuhlobo lwe-immunotherapy olubizwa nge-CAR-T cell therapy oluguqula amasistimu akho okuzivikela abe yiqembu elinamandla lokulwa nomdlavuza. Ukwelashwa kuhilela ukuqoqa amaseli e-T (uhlobo lweseli elimhlophe legazi) egazini lakho, liwalungise ngokofuzo elabhorethri ekhethekile, bese liwafaka emzimbeni wakho.

Kucabange njengokunikeza amasistimu akho okuzivikela ukuthuthukiswa okuhloswe ngakho. Amaseli e-T alungisiwe ahlelwe ngesamukeli esikhethekile esibizwa nge-chimeric antigen receptor (CAR) esiwusizo ekuqapheleni nasekunamatheleni kuphrotheni ebizwa nge-CD19 etholakala kumaseli athile omdlavuza. Uma lawa maseli athuthukisiwe esebuyele emzimbeni wakho, angaphindaphindeka futhi aqalise ukuhlasela okuphumelelayo ngomdlavuza.

Lokhu kwelashwa kwenziwa ngamunye ngamunye esigulini ngasinye, okwenza kube uhlobo oluqondene ngempela lokwelashwa komdlavuza. Yonke inqubo, kusukela ekuqoqweni kwamaseli kuya ekufakweni, ngokuvamile kuthatha amasonto amaningana futhi idinga ukwelashwa ezikhungweni zezokwelapha ezikhethekile ezinobuchwepheshe be-CAR-T cell therapy.

Isetshenziselwani i-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel ivunyelwe ngokuqondile ukwelapha izinhlobo ezithile zomdlavuza wegazi eziphinde zabuya ngemva kokwelashwa noma ezingaphendulanga emithini ejwayelekile. Izimo ezinkulu ezilashwa yilezi zihlanganisa i-diffuse large B-cell lymphoma, i-primary mediastinal large B-cell lymphoma, kanye ne-high-grade B-cell lymphoma.

Le therapy iphinde isetshenziswe ezigulini ezindala ezinomdlavuza we-follicular lymphoma oqhubekayo noma ongalashwa eziye zama okungenani ezinye izindlela zokwelapha ezimbili. Ngaphezu kwalokho, ingelapha izinhlobo ezithile ze-acute lymphoblastic leukemia kubantu abadala abasebancane kanye nezingane lapho ezinye izindlela zokwelapha zingasebenzanga noma umdlavuza ubuyile.

Udkt wakho ngokuvamile uzoncoma lokhu kwelashwa lapho i-chemotherapy ejwayelekile, imisebe, noma ezinye izindlela zokwelapha eziqondiwe zingaphumelelanga. Kuthathwa njengenketho yokwelapha ezigulini eziphilile ngokwanele ukuthi zingathatha inqubo eqinile futhi zihlangabezane nemibandela ethile yezokwelapha.

Isebenza Kanjani I-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel isebenza ngokuguqula amasosha akho omzimba abe umshini olwa nomdlavuza osebenza kahle kakhulu. Le nqubo iqala lapho odokotela beqoqa amaseli akho e-T ngenqubo ebizwa ngokuthi i-leukapheresis, efana nokunikela ngegazi kodwa kuthatha isikhathi eside njengoba ihlukanisa amaseli athile egazini lakho.

E laboratory, ososayensi baguqula ngofuzo la maseli e-T ngokungeza i-receptor ekhethekile esebenza njengesistimu ye-GPS yokuthola amaseli omdlavuza. Le receptor, ebizwa nge-CAR, yakhelwe ukuthi ibone futhi ikhiye kuphrotheni ye-CD19 ehlala ngaphezulu kwamaseli athile omdlavuza. Uma isilungisiwe, la maseli akhuliswa futhi andiswe e laboratory emasontweni amaningana.

Lapho amaseli e-T athuthukisiwe eselungele, afakwa emuva egazini lakho nge-IV. Lawa maseli omzimba aqinisiwe abese ezulazula emzimbeni wakho wonke, efuna futhi ebhubhisa amaseli omdlavuza abonisa iphrotheni ye-CD19. Amaseli aguquliwe angaphinda futhi azale ngaphakathi emzimbeni wakho, enze impendulo yomzimba ehlala isikhathi eside ngokuphikisana nomdlavuza.

Lokhu kubhekwa njengokwelashwa okunamandla futhi okuqondiwe ngoba kuhlasela ngqo amaseli omdlavuza ngenkathi ngokuvamile eshiya amaseli anempilo yedwa. Kodwa-ke, amandla ale mpendulo yomzimba asho ukuthi idinga ukuqashwa nokuphathwa ngokucophelela ngamaqembu odokotela abangochwepheshe.

Ngingayithatha kanjani i-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel akuyona into oyithatha ekhaya njengomuthi ovamile. Kunalokho, uzoyithola njengokufakwa okukodwa kwe-intravenous esikhungweni sezokwelapha esikhethekile esiqinisekiswe ukuthi singanikeza ukwelashwa kwamaseli e-CAR-T.

Ngaphambi kokuthola ukufakwa, uzodlula ohlelweni lokulungisa oluvamile olubandakanya i-chemotherapy ukulungisa umzimba wakho ngamaseli e-T aguquliwe. Lokhu kwelashwa kokulungisa kuvame ukwenzeka ezinsukwini ezimbalwa ngaphambi kosuku lwakho oluhleliwe lokufakwa. Uzodinga ukuhlala eduze nesikhungo sokwelapha okungenani amasonto amane ngemuva kokuthola ukwelashwa ukuze uqashwe eduze.

Inqubo yokufakwa uqobo ishesha kakhulu, ngokuvamile ithatha imizuzu engama-30 kuya ehora elilodwa. Kodwa-ke, uzoqashwa eduze ngaphambi, ngesikhathi, nangemuva kwenqubo. Ithimba lakho lezokwelapha lizobheka noma yiziphi izindlela zokuphendula ngokushesha futhi liqinisekise ukuthi uphendula kahle ekwelashweni.

Ngeke udinge ukuthatha imithi ekhethekile ngokudla noma ukugwema iziphuzo ezithile, njengoba lokhu kunikezwa ngqo egazini lakho ngabasebenzi bezempilo. Ithimba lakho lokunakekela lizohlinzeka ngemiyalelo ethile mayelana nokuthi yini ongayilindela kanye nanoma yimaphi amalungiselelo okudingeka uwenze.

Kufanele ngiyithathe isikhathi esingakanani i-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel inikezwa njengomthamo owodwa, kanye kuphela, ngakho-ke awuyithathi ngokuqhubekayo njengeminye imithi. Uma amaseli e-T aguquliwe efakwe emzimbeni wakho, aklanyelwe ukuqhubeka nokusebenza nokuzala ngokwawo ukulwa nomdlavuza.

Imiphumela yalokhu kwelashwa ingahlala izinyanga noma iminyaka, njengoba amaseli e-T athuthukisiwe engahlala emzimbeni wakho futhi anikeze ukuqapha umdlavuza okuqhubekayo. Ezinye iziguli ziye zagcina ukuxolelwa iminyaka eminingana ngemuva kokuthola ukwelashwa okukodwa nje, yize imiphumela yomuntu ngamunye ihluka.

Ngenkathi ngeke uthole imithamo eyengeziwe yokwelashwa uqobo, uzodinga ukuqokwa okuvamile kokulandela ukuqapha impendulo yakho futhi ubheke noma yimaphi imiphumela emibi e-delayed. Ithimba lakho lezokwelapha lizolandela intuthuko yakho ngokuhlolwa kwegazi, ukuskena izithombe, nokuhlolwa komzimba ezinyangeni ezizayo neminyaka.

Uma umdlavuza ubuyela noma ungasabeli ngokwanele ekwelashweni kokuqala, udokotela wakho angaxoxa ngezinye izinketho zokwelashwa. Kwezinye izimo, iziguli zingahle zifanelekele enye i-CAR-T cell therapy noma ezinye izindlela zokwelapha ezintsha, kodwa lokhu kuncike ezimweni zomuntu ngamunye nezinto zezokwelapha.

Yini Imiphumela Emibi ye-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel ingabangela imiphumela emibi ebalulekile ngoba idala impendulo enamandla yokuzivikela emzimbeni wakho. Imiphumela emibi evame kakhulu futhi engaba yingozi yi-cytokine release syndrome nezinkinga ze-neurological, yingakho uzodinga ukuqapha eduze esikhungweni sezokwelapha esikhethekile.

Ukuqonda le miphumela emibi engaba khona kungakusiza ukuthi uqaphele okulindelekile nokuthi nini okufanele ufune ukunakekelwa kwezempilo ngokushesha. Ithimba lakho lezempilo lizokuqapha eduze futhi lizoba nokwelashwa okutholakalayo ukuphatha le miphumela uma kwenzeka.

Imiphumela emibi evame kakhulu ihlanganisa:

• I-Cytokine release syndrome, ebanga umkhuhlane, amaqhwa, ubunzima bokuphefumula, kanye nomfutho wegazi ophansi
• Imiphumela ye-neurological efana nokudideka, ubunzima bokukhuluma, ukuquleka, noma izinguquko ezingqondweni
• Ukwehla kwamaseli amhlophe egazi, okwandisa ingozi yokutheleleka
• Ukwehla kwama-platelet, okuholela ekulimaleni kalula noma ekopheni
• Ukukhathala nobuthakathaka
• Isicanucanu nokuncipha kwesifiso sokudla
• Ukukhathazeka kwekhanda nobuhlungu bemisipha

Imiphumela emibi engathi sína kodwa engavamile ingabandakanya ukutheleleka okukhulu, izinkinga zenhliziyo, kanye nokwehla kwamaseli egazi isikhathi eside. Ezinye iziguli zingase zibe ne-tumor lysis syndrome, lapho amaseli omdlavuza ewohloka ngokushesha futhi akhiphe izinto ezingathinta ukusebenza kwezinso.

Imiphumela yesikhathi eside isafundwa, kodwa ezinye iziguli zingase zibe namazinga aphansi aqhubekayo amaseli athile omzimba, okungase kuthinte ikhono labo lokulwa nezifo. Ithimba lakho lezokwelapha lizogada ukululama kwesistimu yakho yokuzivikela futhi lingase lincomende ukwelashwa kokuvimbela njenge-immunoglobulin replacement therapy uma kudingeka.

Imiphumela ye-neurological engavamile kodwa engathi sína ingabandakanya ukuvuvukala kobuchopho, ukuquleka, noma izinguquko esimweni sengqondo ezingase zidinge ukunakekelwa okukhulu. Le miphumela yingakho izikhungo zokwelapha zinezimiso ezikhethekile namaqembu anolwazi lokuphatha izinkinga ngokushesha nangempumelelo.

Ubani Ongafanele Athole i-Axicabtagene Ciloleucel?

I-Axicabtagene ciloleucel ayifanele wonke umuntu, futhi ithimba lakho lezokwelapha lizohlola ngokucophelela ukuthi ungumuntu ofanelekayo yini kulokhu kwelashwa. Abantu abanezifo ezisebenzayo, ezingalawuleki noma izinkinga ezinzima zenhliziyo, yamaphaphu, noma yesibindi kungenzeka abafaneleki kulokhu kwelashwa.

Ngeke ube ngumuntu ofanelekayo uma unesifo esisebenzayo sohlangothi lwezinzwa oluphakathi, izimo ezithile ze-autoimmune, noma uma usebenzisa imithi ecindezela amasosha akho omzimba. Abesifazane abakhulelwe noma abancelisa ngamabele akufanele bathole lokhu kwelashwa, njengoba kungalimaza ingane esakhula.

Isimo sakho sempilo sibaluleke kakhulu ekunqumeni ukuthi uyakufanelekela yini. Abantu ababuthakathaka kakhulu noma abanezifo eziningi ezingathi sína kungenzeka bangakwazi ukumelana nokuqapha okukhulu nemiphumela engase ibe khona. Udokotela wakho uzohlola isimo sakho sokusebenza nokuqina kwakho konke ukuze uthole ukwelashwa.

Ubudala ngokwawo akudingeki ukuthi bube yisithiyo, kodwa abadala bangase babhekane nezingozi eziphakeme futhi badinge ukuhlolwa okucophelelayo. Ithimba lakho lezokwelapha lizocabangela izimo zakho ngazinye, okuhlanganisa nezici zomdlavuza wakho, ukwelashwa kwangaphambilini, nezinto eziphathelene nempilo yakho siqu lapho kunqunywa ukuthi le therapy ikufanele yini.

Igama Lomkhiqizo le-Axicabtagene Ciloleucel

I-Axicabtagene ciloleucel ithengiswa ngaphansi kwegama lomkhiqizo elithi Yescarta. Leli gama lomkhiqizo lisetshenziswa abahlinzeki bezempilo nasemibhalweni yezokwelapha uma bebhekisela kule therapy ethile yamaseli e-CAR-T.

I-Yescarta yenziwa yi-Kite Pharma, okuyingxenye ye-Gilead Sciences. Umuthi utholakala kuphela ngezikhungo zokwelapha ezikhethekile eziqinisekiswe ukuthi zingawunikeza ngendlela ephephile nephumelelayo ama-therapy amaseli e-CAR-T.

Lapho nixoxa ngezinketho zakho zokwelashwa nethimba lakho lezempilo, bangase babhekisele kuyo nganoma yiliphi igama. Kokubili i-Yescarta ne-axicabtagene ciloleucel zibhekisela ekwelashweni komdlavuza okwenziwe ngendlela oyiphilayo okusebenzisa amaseli akho omzimba aguquliwe ukulwa nomdlavuza.

Ezinye izindlela ze-Axicabtagene Ciloleucel

Ezinye izindlela eziningana zama-therapy amaseli e-CAR-T ziyatholakala njengezinye izindlela ze-axicabtagene ciloleucel, kuye ngohlobo oluthile lomdlavuza wakho nesimo sezempilo. I-Tisagenlecleucel (Kymriah) enye i-therapy yamaseli e-CAR-T eqondise imidlavuza ye-CD19-positive futhi ingaba yindlela yokwelapha ezinye iziguli.

I-Lisocabtagene maraleucel (Breyanzi) iyindlela entsha yokwelapha ngamaseli e-CAR-T evunyelwe ngamanye ama-lymphomas futhi ingase icatshangelwe ngokusekelwe ezimweni zakho. Ngayinye yalezi zindlela zokwelapha inezinqubo zokukhiqiza ezihlukile kancane futhi ingase ibe namaphrofayili ahlukene emiphumeleni.

Ngaphandle kwezindlela zokwelapha ngamaseli e-CAR-T, ezinye izinketho zokwelapha zingase zihlanganise izindlela zokwelapha ngamakhemikhali zendabuko, izindlela zokwelapha eziqondiwe, noma izivivinyo zemitholampilo eziphenya ngezindlela ezintsha. Ukufakelwa kwamaseli esiqu kungase kucatshangelwe kwabanye iziguli, nakuba lokhu kuncike ezintweni eziningi ezihlanganisa iminyaka yakho, impilo yonke, nezici zomdlavuza.

Udokotela wakho we-oncologist uzoxoxa ngezinketho ezifanele kakhulu isimo sakho esithile, ecabangela izici ezinjengohlobo lomdlavuza wakho, ukwelashwa kwangaphambilini, impilo yonke, nezintandokazi zomuntu siqu. Isinqumo sivame ukubandakanya ukulinganisa izinzuzo ezingaba khona ngokumelene nezingozi nemiphumela emibi.

Ingabe i-Axicabtagene Ciloleucel Ingcono Kune-Tisagenlecleucel?

Kokubili i-axicabtagene ciloleucel ne-tisagenlecleucel ziyizindlela zokwelapha ngamaseli e-CAR-T ezisebenza kahle eziqondise imidlavuza ye-CD19-positive, kodwa zinezinye izinto ezingafani ekukhiqizeni kwazo nasekusetshenzisweni okuvunyelwe. Ukuqhathanisa okuqondile kuyinselele ngoba zifundwe ezigulini ezehlukene kanye nezivivinyo zemitholampilo.

I-Axicabtagene ciloleucel ivunyelwe ngamanye ama-lymphomas futhi ibonise amazinga aphezulu okusabela ezivivinyweni zemitholampilo. I-Tisagenlecleucel ivunyelwe kokubili amanye ama-lymphomas kanye nezinhlobo ezithile ze-leukemia, okuyinika uhla olubanzi lokusetshenziswa okuvunyelwe. Ukukhetha phakathi kwazo kuvame ukuncika ohlotsheni lomdlavuza wakho oluthile nezici zezokwelapha zomuntu ngamunye.

Izinqubo zokukhiqiza ziyahluka kancane, okungase kuthinte ukuthi ukwelashwa kwakho kungalungiswa futhi kuphathwe ngokushesha kangakanani. Zombili izindlela zokwelapha zinezinhlobo ezifanayo zemiphumela emibi, okuhlanganisa i-cytokine release syndrome nemiphumela ye-neurological, nakuba imvamisa nobukhulu kungase kuhluke phakathi kwabantu.

Iqembu lakho lezokwelapha lizokuncoma inketho efanele kakhulu ngokusekelwe ekuxilongweni kwakho okuthile, ukwelashwa kwangaphambilini, impilo yonke, nokutholakala kokwelashwa ngakunye esikhungweni sakho sokwelapha. Zombili zimele intuthuko enkulu ekwelashweni komdlavuza futhi zisize iziguli eziningi ukuthi zifinyelele ekutheni zithuthuke.

Imibuzo Evame Ukubuzwa Mayelana ne-Axicabtagene Ciloleucel

Ingabe i-Axicabtagene Ciloleucel iphephile kubantu abanezifo zenhliziyo?

I-Axicabtagene ciloleucel idinga ukuhlolwa ngokucophelela kubantu abanezifo zenhliziyo ngoba ukwelashwa kungabangela imiphumela yenhliziyo nemithambo yegazi. I-cytokine release syndrome eyenzeka ngezinye izikhathi ingathinta ukusebenza kwenhliziyo, okubangela ukwehla kwegazi, ukushaya kwenhliziyo okusheshayo, noma ezinye izinkinga zenhliziyo.

Udokotela wakho wenhliziyo kanye nodokotela wezifo zomdlavuza bazosebenzisana ukuze bahlole ukuthi isimo sakho senhliziyo sizinzile ngokwanele yini kulokhu kwelashwa. Bazocabangela izinto ezinjengokusebenza kwenhliziyo yakho, imithi yamanje, nempilo yonke yenhliziyo nemithambo yegazi. Ezinye iziguli ezinemibandela yenhliziyo elawulwa kahle zingase zibe ngabazongenela ukwelashwa ngokubhekwa okufanele nokunakekelwa okusekelayo.

Uma uthola lolu kwelashwa ngesimo senhliziyo, uzodinga ukuqapha okuthuthukisiwe kwenhliziyo ngesikhathi nangemva kokufakwa. Ithimba lakho lezokwelapha lizoba nezimiso zokulawula noma yiziphi izinkinga zenhliziyo nemithambo yegazi ezingase zivele ngesikhathi sokwelashwa.

Ngingenzani uma ngithola i-Axicabtagene Ciloleucel eningi ngengozi?

Ukweqisa kwe-axicabtagene ciloleucel akunakwenzeka ngoba ilungiswa ngokuqondile isiguli ngasinye futhi inikezwa ochwepheshe bezokwelapha abaqeqeshiwe endaweni yasesibhedlela elawulwayo. Umthamo ubhalwa ngokucophelela ngokusekelwe esisindweni sakho somzimba kanye nokubalwa kwamaseli, futhi ukufakwa kuqashwe eduze yizisebenzi zezempilo eziqeqeshiwe.

Uma bekukhona iphutha lokulinganisa, izimpawu zizofana nemiphumela emibi ejwayelekile kodwa kungenzeka ibe nzima kakhulu. Lokhu kungabandakanya i-cytokine release syndrome enamandla kakhulu, imiphumela emibi yezinzwa, noma ukwehla okukhulu kwenani legazi.

Njengoba uthola lokhu kwelashwa esikhungweni sezokwelapha esikhethekile esiqhubekayo, noma yiziphi izinkinga zizobonwa ngokushesha futhi zelashwe ithimba lakho lezokwelapha. Banamaphrothokholi nemithi etholakalayo yokuphatha ukusabela okukhulu futhi banikeze ukunakekelwa okusekelayo njengoba kudingeka.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Axicabtagene Ciloleucel?

Ukuphuthelwa umthamo we-axicabtagene ciloleucel ngokuvamile akuyona into ekhathazayo ngoba inikezwa njengokumnika okukodwa, okungavami esibhedlela. Ukwelashwa kuhlelwe ngokucophelela, futhi uzongeniswa esikhungweni sezokwelapha ngokuqondile ngale nqubo.

Uma ngasizathu esithile ukumnika kwakho okuhleliwe kudingeka kuhlehliswe ngenxa yokugula, ukutheleleka, noma ezinye izinkinga zezokwelapha, ithimba lakho lezempilo lizolihlela kabusha uma usuzinzile ngokwezokwelapha. Isikhathi siyavumelana uma nje amaseli akho alungisiwe esahlala esebenza, nakuba kunemingcele yokuthi amaseli aguquliwe angagcinwa isikhathi esingakanani.

Ithimba lakho lezokwelapha lizoxhumana nawe mayelana nanoma yiziphi izinguquko zeshejuli futhi liqinisekise ukuthi uthola ukwelashwa kwakho ngesikhathi esifanele kakhulu sempilo yakho nokuphepha kwakho. Bazophinda baqaphe isimo sakho ngenkathi belinde ukumnika okuhlehlisiwe.

Ngingayeka nini Ukuthatha i-Axicabtagene Ciloleucel?

Akudingeki uyeke ukuthatha i-axicabtagene ciloleucel ngoba inikezwa njengokumnika okukodwa, hhayi njengomuthi oqhubekayo. Uma amaseli e-T aguquliwe efakwe emzimbeni wakho, aqhubeka esebenza ngokuzimela ukulwa namaseli omdlavuza.

Imiphumela yokwelashwa ingahlala izinyanga noma iminyaka, njengoba amaseli e-T athuthukisiwe engahlala futhi ande emzimbeni wakho. Ngeke kudingeke ukuthi usebenzise imithi yansuku zonke ehlobene namaseli e-CAR-T ngokwawo, yize ungase udinge eminye imithi esekelayo noma ukwelashwa.

Ukunakekelwa kwakho okulandelayo kuzogxila ekuqapheni impendulo yakho ekwelashweni nasekuphatheni noma yimiphi imiphumela eqhubekayo. Ithimba lakho lezokwelapha lizolandela inqubekela phambili yakho ngokuqokwa okuvamile, ukuhlolwa kwegazi, kanye nezifundo zokucabanga ukuqinisekisa ukuthi ukwelashwa kusebenza ngempumelelo nokubheka noma yiziphi izinkinga ezihlehlisiwe.

Ngingahamba Ngemva Kokuthola I-Axicabtagene Ciloleucel?

Ukwenza uhambo kuvinjelwe okungenani amasonto amane ngemva kokuthola i-axicabtagene ciloleucel ngoba udinga ukuhlala eduze nesikhungo sokwelashwa ukuze uqashwe eduze. Lesi sikhathi sibalulekile ekubhekeni imiphumela emibi engathi sína efana ne-cytokine release syndrome noma izinkinga zemizwa ezidinga ukunakekelwa kwezokwelapha ngokushesha.

Ngemva kwesikhathi sokuqala sokuqapha, ikhono lakho lokuhamba lizoxhomeka ekululameni kwakho nasekuhlolweni udokotela wakho ngesimo sakho. Kuzodingeka ukuthi uzinze ngokwezokwelapha ngamanani amahle egazi futhi ungabi nazinkinga eziqhubekayo ngaphambi kokuthi uvunyelwe ukuhamba.

Uma uhamba kamuva, kubalulekile ukuthwala ulwazi mayelana nokwelashwa kwakho futhi ube nokufinyelela ekunakekelweni kwezokwelapha okuqondayo ukwelashwa kwamaseli e-CAR-T. Ithimba lakho lezokwelapha lingakunikeza isifinyezo sokwelashwa kanye nolwazi lokuxhumana oluphuthumayo ongabelana ngalo nabahlinzeki bezempilo uma kudingeka ngenkathi uhamba.