Yini i-Axitinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Axitinib iyikhambi lomdlavuza eliqondiwe elisiza ukunciphisa ukukhula kwamaseli omdlavuza wezinso. Ingaphansi kweqembu lemithi ebizwa ngokuthi ama-tyrosine kinase inhibitors, asebenza ngokuvimba amaprotheni athile amaseli omdlavuza awadingayo ukuze akhule futhi asakazeke emzimbeni wakho wonke.

Le mithi imelela inketho ebalulekile yokwelapha abantu abanomdlavuza wezinso osuthuthukile, ikakhulukazi lapho ezinye izindlela zokwelapha zingasebenzi kahle njengoba bekulindelekile. Ngenkathi ukuxilongwa ngokwako kungase kuzizwe kukhulu, ukuba nezinketho zokwelapha eziphumelelayo njenge-axitinib kungahlinzeka ngethemba futhi kusize ukwelula izinga lempilo.

Isetshenziselwani i-Axitinib?

I-Axitinib isetshenziswa ikakhulukazi ukwelapha i-renal cell carcinoma ethuthukile, okuyiluphi uhlobo oluvamile lomdlavuza wezinso. Udokotela wakho ngokuvamile uzoncoma le mithi lapho umdlavuza wakho wezinso usakazekele kwezinye izingxenye zomzimba wakho noma lapho ukwelashwa kokuqala kungaphumelelanga.

Le mithi yenzelwe ngqo iziguli ezinomdlavuza oqhubeke ngemuva kokuzama ezinye izindlela zokwelapha eziqondiwe. Kuthathwa njengokwelashwa komugqa wesibili, okusho ukuthi isetshenziswa ngemuva kokuthi indlela yakho yokuqala yokwelapha iyeke ukusebenza ngempumelelo.

Kwezinye izimo, odokotela bangasebenzisa i-axitinib njengengxenye yokwelapha okuhlanganisiwe neminye imithi yomdlavuza. Le ndlela ngezinye izikhathi ingasebenza kangcono kunokusebenzisa noma iyiphi imithi eyodwa yodwa, nakuba i-oncologist yakho izonquma isu elingcono kakhulu lesimo sakho esithile.

Isebenza kanjani i-Axitinib?

I-Axitinib isebenza ngokuvimba amaprotheni amaningi abizwa ngokuthi ama-tyrosine kinases asiza amaseli omdlavuza ukuthi akhule futhi akhe imithambo emisha yegazi. Cabanga ngala maprotheni njengamaphampu kaphethiloli amaseli omdlavuza awasebenzisayo ukuze athole izakhamzimba azidingayo ukuze aphile futhi azande.

Umuthi ugxila kakhulu entweni ebizwa ngokuthi ama-VEGF receptors, afana nezimpawu ezitshela umzimba wakho ukuthi wakhe imithambo emisha yegazi. Amathumba omdlavuza adinga le mithambo yegazi ukuze akhule abe makhulu, ngakho-ke ngokuvala lezi zimpawu, i-axitinib ingasiza ekulambiseni ithumba ngokusetshenziswa kwegazi.

Lokhu kuthathwa njengomuthi olinganiselwe oqinile womdlavuza ongasebenza kahle kubantu abaningi. Kodwa-ke, akuyona into enokhahlo njenge-chemotherapy yendabuko ngoba igxila ngqo ezinqubweni zamaseli omdlavuza kunokuthinta wonke amaseli ahlukanisa ngokushesha emzimbeni wakho.

Kufanele Ngiyithathe Kanjani I-Axitinib?

Thatha i-axitinib njengoba nje udokotela wakho ekunqumele, ngokuvamile kabili ngosuku cishe ngamahora ayi-12 ngaphandle. Ungayithatha nokudla noma ngaphandle kokudla, kodwa zama ukungaguquguquki ekukhetheni kwakho ukusiza ukugcina amazinga aqhubekayo emzimbeni wakho.

Gwinya amaphilisi wonke ngamanzi. Ungawachobozi, uwaphule, noma uwahlafune, ngoba lokhu kungathinta indlela umuthi omuncwa ngayo futhi kubangele imiphumela engemihle. Uma unenkinga yokugwinya amaphilisi, khuluma nethimba lakho lezempilo ngamasu angasiza.

Kungcono ukuthatha i-axitinib ngezikhathi ezifanayo nsuku zonke ukukusiza ukuthi ukhumbule futhi ugcine amazinga aqhubekayo egazini lakho. Abantu abaningi bakuthola kuwusizo ukusetha izikhumbuzi zocingo noma ukuxhumanisa ukuthatha imithi yabo nemisebenzi yansuku zonke efana nokudla noma isikhathi sokulala.

Gwema ama-grapefruit nejusi le-grapefruit ngenkathi uthatha lo muthi, ngoba angakhuphula inani le-axitinib egazini lakho futhi abangele imiphumela eminingi engemihle. Ezinye izithelo ze-citrus ezinjengama-orenji namalamula ngokuvamile kulungile ukuzidla.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Axitinib?

Ngokuvamile uzoqhubeka nokuthatha i-axitinib uma nje isiza ukulawula umdlavuza wakho futhi uyayibekezelela kahle. Lokhu kungaba izinyanga noma ngisho neminyaka, kuye ngokuthi umzimba wakho usabela kanjani ekwelashweni.

Udkt. wakho uzoqapha intuthuko yakho ngokuskena njalo nokuhlolwa kwegazi ukuze abone ukuthi imithi isebenza kahle kangakanani. Bazobheka futhi noma yimaphi imiphumela engemihle engase idinge ukulungiswa komthamo wakho noma ukushintshela kwenye indlela yokwelapha.

Abanye abantu bangase badinge ukuphumula okwesikhashana emithini uma behlangabezana nemiphumela emibi ebalulekile. Ithimba lakho lezempilo lingase linciphise umthamo wakho noma lime ukwelashwa amasonto ambalwa ukuvumela umzimba wakho ukuthi ululame, bese uqhubeka uma uzizwa ungcono.

Ungayeki ukuthatha i-axitinib ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala, ngisho noma uzizwa ungaphilile. Ukuyeka kungazelelwe kungavumela umdlavuza wakho ukuthi uqale ukukhula futhi ngokushesha kunokulindelekile.

Yini Imiphumela Emibi ye-Axitinib?

Njengemithi eminingi yomdlavuza, i-axitinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ivamise ukulawuleka ngosekelo olufanele oluvela eqenjini lakho lezempilo.

Nawa amanye amiphumela emibi ongase uyithole ngenkathi uthatha i-axitinib:

• Ukuqunjelwa, okungase kube kubi ngezinye izikhathi
• Umfutho wegazi ophezulu ongase udinge ukuqashwa
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Isicanucanu noma isisu esibuhlungu
• Ukulahlekelwa isifiso sokudla noma ukuncipha kwesisindo
• I-hand-foot syndrome, ebangela ububomvu noma ubuhlungu ezintendeni nasezinyaweni
• Izwi eliphansi noma ukucasuka komphimbo
• Ukukhwehlela noma ukuphefumula kanzima

Iningi lalemiphumela emibi ilula kuya esimweni esiphakathi nendawo futhi ingalawulwa ngemithi noma ukulungiswa kwendlela yokuphila. Ithimba lakho lezempilo lizosebenza nawe ukuthola amasu akusiza ukuthi uzizwe ukhululekile ngangokunokwenzeka.

Nakuba kungavamile, abanye abantu bangase babe nemiphumela emibi engathi sína edinga ukunakekelwa kwezempilo ngokushesha:

• Umfutho wegazi ophezulu obangela ukuqaqamba kwekhanda noma izinguquko embonweni
• Izimpawu zezinkinga zesibindi njengokushintsha kombala wesikhumba sibe phuzi noma umchamo omnyama
• Ukuphuma igazi okungavamile noma ukulimala
• Ukuqunjelwa okukhulu okuholela ekuphelelwe amanzi emzimbeni
• Amaqhubu egazi abangela ubuhlungu besifuba noma ukuvuvukala komlenze
• Izinkinga zenhliziyo ezihlanganisa ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile

Le miphumela emibi engathi sína ayivamile, kodwa kubalulekile ukwazi izimpawu zokuxwayisa. Udokotela wakho uzokugada eduze futhi alungise ukwelashwa kwakho uma kudingeka ukuze akugcine uphephile futhi ukhululekile.

Ubani Ongafanele Athathe I-Axitinib?

I-Axitinib ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Abantu abanezimo ezithile zezempilo bangase badinge ukugwema lo muthi noma bawusebenzise ngokuqapha okwengeziwe.

Akufanele uthathe i-axitinib uma unenkinga yokungezwani nayo noma nganoma yiziphi izithako zayo. Izimpawu zokungezwani komzimba zingahlanganisa ukuqubuka, ukuluma, ukuvuvukala, noma ubunzima bokuphefumula, futhi lokhu kudinga ukunakekelwa kwezempilo ngokushesha.

Abantu abanezimo ezithile zezokwelapha bangase badinge ukuqapha okukhethekile noma ukulungiswa komthamo lapho bethatha i-axitinib:

• Umfutho wegazi ophezulu ongagadiwe
• Isifo senhliziyo noma umlando wezinkinga zenhliziyo
• Isifo sesibindi noma ama-enzyme esibindi aphakeme
• Izinkinga zezinso ezingaphezu komdlavuza ngokwawo
• Umlando wamaqhubu egazi noma unhlangothi
• Izifo zokuphuma igazi noma ukuhlinzwa kwamuva
• Izinkinga ze-thyroid

Abesifazane abakhulelwe akufanele bathathe i-axitinib ngoba ingalimaza ingane esakhula. Uma ukwazi ukukhulelwa, uzodinga ukusebenzisa izindlela zokulawula inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nesikhathi esithile ngemva kwalokho.

Omama abancelisa izingane nabo kufanele bagweme lo muthi, ngoba ungangena obisini futhi ulimaze ingane encelisayo. Ithimba lakho lezempilo lingaxoxa ngezindlela zokudla eziphephile uma kudingeka.

Igama Lomkhiqizo Le-Axitinib

I-Axitinib ithengiswa ngaphansi kwegama lomkhiqizo elithi Inlyta yi-Pfizer. Le yindlela evame kakhulu yokubhalwa komuthi, futhi iza ngesimo samaphilisi ngamandla ahlukene.

Noma ngabe uthola igama lomkhiqizo noma inguqulo ejwayelekile kungancika ekuhlinzekweni komshwalense wakho kanye nekhemisi. Zombili lezi zinhlobo ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo emzimbeni wakho.

Ikhemisi lakho lingashintsha i-axitinib ejwayelekile ngegama lomkhiqizo ngaphandle uma udokotela wakho ebhalela ngqo ukuthi "igama lomkhiqizo kuphela" emiyalweni yakho. Uma unezinkathazo ngokushintsha phakathi kwezinhlobo zomkhiqizo nezijwayelekile, xoxa ngalokhu nethimba lakho lokunakekelwa kwezempilo.

Ezinye izindlela ze-Axitinib

Uma i-axitinib ingasebenzi kahle kuwe noma ibangela imiphumela emibi, ezinye izinketho zokwelapha ziyatholakala ngomdlavuza wezinso oqhubekayo. Udokotela wakho we-oncologist angasiza ekunqumeni ukuthi iyiphi enye indlela engaba ngcono esimweni sakho esithile.

Ezinye izinketho zokwelapha eziqondiwe zihlanganisa imithi efana ne-sunitinib, pazopanib, noma i-cabozantinib, esebenza ngezindlela ezifanayo kodwa ingase ibe nemiphumela emibi ehlukene. Abanye abantu bayayibekezelela kangcono imithi ethile kunenye, ngisho nangaphakathi kwesigaba esifanayo semithi.

Imithi yokwelapha yokuzivikela emzimbeni efana ne-nivolumab noma i-pembrolizumab imele enye indlela yokwelapha esiza amasosha akho omzimba ukuthi alwe nomdlavuza. Le mithi isebenza ngendlela ehlukile kune-axitinib futhi ingasebenza ngisho noma ukwelashwa okuqondiwe kungasebenzi kahle.

Udokotela wakho angase futhi acabangele ukwelashwa okuhlanganisiwe okusebenzisa izinhlobo ezimbili ezihlukene zemithi ndawonye. Lezi zinhlanganisela ngezinye izikhathi zingasebenza kangcono kunemithi eyodwa, nakuba zingase futhi zibangele imiphumela emibi eyengeziwe.

Ingabe i-Axitinib ingcono kune-Sunitinib?

Kokubili i-axitinib ne-sunitinib ziyimithi esebenzayo yomdlavuza wezinso, kodwa zisebenza kancane ngendlela ehlukile futhi zinezinhlobo ezihlukene zemiphumela emibi. Akukho noyedwa "ongcono" kunomunye - ukukhetha okungcono kuncike esimweni sakho ngasinye.

I-Axitinib ivame ngokuqhelekileyo njengonyango olusezingeni lesibini emva kwamanye amayeza afana ne-sunitinib ayekile ukusebenza ngokufanelekileyo. Olunye uphando lucebisa ukuba i-axitinib inganceda abantu baphile ixesha elide ngaphandle kokuba umhlaza wabo uqhubeke xa kuthelekiswa nezinye iindlela zonyango olusezingeni lesibini.

Ngokumalunga nemiphumo emibi, i-axitinib inokubangela ukudinwa okuncinci kunye neengxaki ezimbalwa zokubala igazi kune-sunitinib. Nangona kunjalo, i-axitinib inokuba ngaphezulu kokubangela uxinzelelo lwegazi oluphezulu kunye norhudo kwabanye abantu.

U-oncologist wakho uza kuqwalasela izinto ezinjengempilo yakho iyonke, unyango oludlulileyo, kunye nezinto ozikhethayo xa usenza isigqibo phakathi kwawo la mayeza. Injongo kukufumana unyango olungenakwenzeka ukukunceda ngelixa lubangela iingxaki ezimbalwa kumgangatho wakho wobomi.

Imibuzo Ebuzwa Rhoqo Nge-Axitinib

Ngaba i-Axitinib Ikhuselekile Kubantu Abanoxinzelelo Lwegazi Oluphezulu?

I-Axitinib ingasetyenziswa ngabantu abanoxinzelelo lwegazi oluphezulu, kodwa ifuna ukuhlolwa ngononophelo ukusukela ekubeni amayeza anokunyusa uxinzelelo lwegazi nangaphezulu. Ugqirha wakho uza kufuna ukuqinisekisa ukuba uxinzelelo lwakho lwegazi lulawulwa kakuhle ngaphambi kokuqala unyango.

Uya kufuna ukuhlolwa rhoqo koxinzelelo lwegazi ngexesha lonyango, kwaye ugqirha wakho unokulungisa amayeza akho oxinzelelo lwegazi okanye idosi ye-axitinib xa kuyimfuneko. Uninzi lwabantu lunokulawula le mpembelelo embi ngempumelelo ngokuhlolwa okufanelekileyo kunye nokulungiswa kwamayeza.

Ndingenza ntoni ukuba ngempazamo ndisebenzisa i-Axitinib eninzi kakhulu?

Ukuba ngempazamo uthatha i-axitinib eninzi kakhulu, qhagamshelana nogqirha wakho okanye uye egumbini likaxakeka kwangoko. Musa ukulinda ukubona ukuba uyagula, njengoko ukugqithisa kunokuba nzulu nokuba awuqapheli iimpawu kwangoko.

Zisa ibhotile yamayeza nawe ukuze ababoneleli bezempilo bazi kanye ukuba uthathe ntoni nokuba yimalini. Ngelixa ulinde uncedo lwezonyango, ungazami ukuzenza uhlanze ngaphandle kokuba uqeqeshwe ngokukodwa ukuba wenze njalo ngumsebenzi wezempilo.

Ndingenza ntoni ukuba ndiphoswa idosi ye-Axitinib?

Uma uphuthelwa umthamo futhi sekudlule amahora angaphansi kwangu-6 kusukela lapho obufanele uwuthatha, qhubeka uthathe umthamo ophuthelwe. Uma sekudlule amahora angaphezu kwangu-6, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni.

Ngingayeka nini ukuthatha i-Axitinib?

Kufanele uyeke kuphela ukuthatha i-axitinib uma udokotela wakho ekutshela ukuthi kuphephile ukwenza kanjalo. Lokhu kuvame ukwenzeka uma umdlavuza wakho uqhubeka ngaphandle kokwelashwa, uma uba nemiphumela emibi engathi sína, noma uma unquma ukushintshela kwenye indlela yokwelapha.

Udokotela wakho uzosebenzisa ukuskena okujwayelekile nokuhlolwa kwegazi ukuze aqaphe ukuthi umuthi usebenza kahle kangakanani. Bazoxoxa nganoma yiziphi izinguquko ohlelweni lwakho lokwelashwa nawe futhi bachaze ukucabanga okusemva kwezincomo zabo.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Axitinib?

Ngokuvamile kungcono ukukhawulela ukusetshenziswa kotshwala ngenkathi uthatha i-axitinib, njengoba kokubili kungathinta isibindi sakho. Amanani amancane otshwala ngokuvamile alungile kubantu abaningi, kodwa kufanele uxoxe ngesimo sakho esithile nethimba lakho lokunakekelwa kwezempilo.

Uma ukhetha ukuphuza ngezikhathi ezithile, qaphela ukuthi uzizwa kanjani futhi ubheke noma yiziphi izimpawu ezingavamile. Abanye abantu bathola ukuthi utshwala bubenza bazizwe bekhathele kakhulu noma benesicanucanu ngenkathi beqhubeka nokwelashwa komdlavuza, ngakho-ke kubalulekile ukulalela umzimba wakho.