Yini i-Baclofen: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Baclofen ngumuthi okhulula imisipha osiza ukunciphisa ukuqina kwemisipha nokuqina. Isebenza ngokuthulisa izimpawu zemizwa eyingxenye yomgogodla wakho ezibangela ukuthi imisipha iqine ngokuzenzakalela. Lo muthi oqokiwe ungaletha impumuzo enkulu kubantu ababhekene nezimo ezinjengokuthi i-multiple sclerosis, ukulimala komgogodla, noma i-cerebral palsy.

Yini i-Baclofen?

I-Baclofen ngumuthi oqokiwe okhulula imisipha ongaphansi kohlobo lwemithi ebizwa ngokuthi i-gamma-aminobutyric acid (GABA) agonists. Ilingisa ikhemikhali yobuchopho yemvelo ebizwa ngokuthi i-GABA, esiza ukunciphisa umsebenzi wemizwa emzimbeni wakho wonke. Cabanga ngayo njengesistimu yamabhuleki emnene yezinzwa zakho zemisipha ezingaphezu kwamandla.

Lo muthi waqala ukuthuthukiswa ngeminyaka yawo-1960 futhi ubelokhu usiza abantu ukuthi balawule i-muscle spasticity amashumi eminyaka. Kuthathwa njengenketho yokwelapha ethembekile, efundwe kahle okuthi odokotela bavame ukuyisebenzisa uma imisipha iqina iphazamisa imisebenzi yansuku zonke noma ibangele ukungakhululeki okukhulu.

Isetshenziselwani i-Baclofen?

I-Baclofen ikakhulukazi iqokelwe ukwelapha i-muscle spasticity, okuyilapho imisipha yakho iqina noma iqine ngokuzenzakalela. Le spasticity ingenza ukunyakaza kube nzima futhi kube buhlungu, kuthinte ikhono lakho lokuhamba, ukubhala, noma ukwenza imisebenzi yansuku zonke.

Izimo ezivame kakhulu ukuthi i-baclofen isiza ukuzilawula zihlanganisa i-multiple sclerosis, ukulimala komgogodla, ne-cerebral palsy. Isetshenziselwa futhi ukulimala kobuchopho obunzima, ukululama kwesitroko, kanye nezimo ezithile zofuzo ezithinta ukulawulwa kwemisipha. Udokotela wakho angase akubhale uma uhlangabezana nokuqina kwemisipha, ukuqina okubuhlungu, noma ubunzima bokunyakaza ngenxa yezimo zemizwa.

Abanye odokotela baphinda babhale i-baclofen ngaphandle kwethekhi yezimo ezinjengokuhoxiswa kotshwala noma izinhlobo ezithile zobuhlungu obungapheli. Kodwa-ke, lokhu kusetshenziswa kudinga ukugadwa kwezokwelapha ngokucophelela futhi akuyona izizathu eziyinhloko zokuthi lo muthi wathuthukiswa.

Isebenza Kanjani I-Baclofen?

I-Baclofen isebenza ngokugxila kuma-receptors athile emgogodleni wakho nasebuchosheni obizwa ngokuthi ama-GABA-B receptors. Uma ibopha kula ma-receptors, inciphisa ukukhululwa kwama-neurotransmitters abangela ukuncipha kwemisipha. Lokhu kudala umphumela wokuthulisa ohlelweni lwakho lwezinzwa.

Umuthi uthathwa njengomuthi oqinile phakathi kwemithi ephumuzayo imisipha. Iqondiswe kakhulu kunezinye iziphumuzisi zemisipha ezijwayelekile ngoba isebenza ngqo ohlelweni oluphakathi nendawo kunokuthi ngqo emsipheni. Lokhu kuyenza isebenze ikakhulukazi ekuncipheni kwemisipha okubangelwa izimo ze-neurological.

Ngokuvamile uzoqala ukuzwa imiphumela kungakapheli amahora ambalwa ngemva kokuthatha umthamo wakho wokuqala. Nokho, kungase kuthathe izinsuku eziningana noma amasonto ukuthola umthamo ofanele ohlinzeka ngokuphumula okuhle ngemiphumela emincane. Umzimba wakho ujwayela kancane kancane umuthi, yingakho izinguquko zomthamo zivame ukwenziwa kancane.

Kufanele Ngiyithathe Kanjani I-Baclofen?

Thatha i-baclofen ngendlela eqondile njengoba unqunyelwe udokotela wakho, ngokuvamile kathathu ngosuku ngaphandle noma ngaphandle kokudla. Ungayithatha nobisi noma isidlo esilula uma sithukuthelisa isisu sakho. Umuthi uza ngesimo samaphilisi futhi kufanele ugwinywe wonke ngengilazi yamanzi egcwele.

Abantu abaningi baqala ngomthamo ophansi, ngokuvamile i-5mg kathathu ngosuku, bese bekhuphuka kancane kancane njengoba kudingeka. Udokotela wakho cishe uzoqhubeka nokwandisa umthamo wakho njalo ezinsukwini ezimbalwa kuze kube yilapho ufinyelela ibhalansi efanele yokuphumula kwezimpawu kanye nemiphumela engalawuleki. Umthamo omkhulu wansuku zonke uvame ukuba cishe i-80mg, kodwa abanye abantu bangase badinge amanani aphezulu ngaphansi kokugadwa kwezokwelapha okuseduze.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqinile ohlelweni lwakho. Uma uyithatha kathathu ngosuku, hlukanisa imithamo ngokulinganayo usuku lonke. Ukuyithatha nokudla kungasiza ukunciphisa ukucasuka kwesisu, kodwa akudingekile ngokuqinile ukuthi umuthi usebenze kahle.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Baclofen?

Ubude besikhathi sokwelashwa nge-baclofen buhlukahluka kakhulu kuye ngesimo sakho esiyisisekelo nokuphendula komuntu ngamunye. Abanye abantu bayayidinga amasonto ambalwa ngesikhathi sokululama ekulimaleni, kanti abanye bangayithatha izinyanga noma iminyaka ukulawula izimo ezingapheli.

Uma usebenzisa i-baclofen ngesimo sesikhashana njengokuthi imisipha iqine ngemuva kokuhlinzwa, ungase uyidinge amasonto ambalwa kuphela. Kodwa-ke, abantu abanezimo ezingapheli njenge-multiple sclerosis noma ukulimala komgogodla bavame ukuyithatha isikhathi eside njengengxenye yohlelo lwabo lokuqhubeka nokwelashwa.

Udokotela wakho uzobuyekeza njalo inqubekela phambili yakho futhi angase alungise umthamo wakho noma axoxe ngokuthi usayidinga yini imithi. Ungayeki ukuthatha i-baclofen ngokuzumayo, ikakhulukazi uma ubuthatha amasonto amaningana. Ukuyeka kungazelelwe kungabangela izimpawu eziyingozi zokuhoxisa ezihlanganisa ukuquleka, ngakho-ke udokotela wakho uzokwenza isimiso sokunciphisa kancane uma udinga ukuyeka.

Yiziphi Imiphumela Eceleni ye-Baclofen?

Njengayo yonke imithi, i-baclofen ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi emasontweni ambalwa okuqala.

Nawa imiphumela emibi ebikwa kaningi ongase uyithole:

• Ukozela noma ukukhathala
• Isiyezi noma ukukhathala
• Ubuthakathaka noma ubuthakathaka bemisipha
• Isicanucanu noma isisu esibuhlungu
• Ikhanda
• Ukuqunjelwa
• Ukuphazamiseka kokulala noma ukuqwasha

Le miphumela emibi evamile ngokuvamile iba ngaphansi uma umzimba wakho ujwayela imithi. Abantu abaningi bathola ukuthi ukuqala ngomthamo ophansi nokwandisa kancane kancane kusiza ukunciphisa le miphumela.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kungabandakanya ukusabela okukhulu komzimba, ukudideka, ukucabanga okungelona iqiniso, noma ubunzima bokuphefumula. Abanye abantu bangase babe nokuguquka kwemizwa, ukucindezeleka, noma imicabango engavamile, ikakhulukazi ngemithamo ephezulu.

Imiphumela emibi engavamile kodwa engathi sína ihlanganisa izinkinga zesibindi, ubuthakathaka obukhulu bemisipha obuthinta ukuphefumula, noma ukuquleka (ikakhulukazi lapho uyeka umuthi ngokushesha). Uma uhlangabezana nobuhlungu besifuba, ukushaya kwenhliziyo okusheshayo, isiyezi esikhulu, noma izimpawu zokusabela komzimba njengesikhumba esibomvu noma ukuvuvukala, xhumana nodokotela wakho ngokushesha.

Ubani Ongafanele Athathwe I-Baclofen?

I-Baclofen ayifanele wonke umuntu, futhi izimo ezithile noma izimo zenza kube yingozi. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-baclofen uma wazi ukuthi unokungezwani komzimba nomuthi noma yiziphi izithako zawo. Abantu abanezifo ezinzima zezinso badinga ukulungiswa okukhethekile komthamo noma bangase bangakwazi ukuwuthatha nhlobo, ngoba umuthi ukhishwa ngezinso.

Ukuqapha okukhethekile kuyadingeka kubantu abanomlando wokuquleka, izimo zempilo yengqondo, noma ukusetshenziswa kwezidakamizwa. Umuthi unganciphisa umkhawulo wakho wokuquleka futhi ungase uqhubekisele phambili ukucindezeleka noma ukukhathazeka kwabanye abantu. Abantu abanezifo zesibindi nabo badinga ukuqashwa ngokucophelela, njengoba umuthi ungathinta ukusebenza kwesibindi.

Abesifazane abakhulelwe nabancelisayo kufanele baxoxe ngezingozi nezinzuzo nodokotela wabo. Ngenkathi i-baclofen ingangena obisini lwebele, isinqumo sokuyisebenzisa ngesikhathi sokukhulelwa noma ukuncelisa sincike ekutheni izinzuzo zidlula yini izingozi ezingaba khona kumntwana.

Abantu abadala bangase babe nobuzwela obengeziwe emiphumeleni ye-baclofen, ikakhulukazi ukozela nokudideka. Bavame ukudinga imithamo ephansi nokuqashwa okuvame kakhulu ukuvimbela ukuwa noma ezinye izinkinga.

Amagama Omkhiqizo we-Baclofen

I-Baclofen itholakala ngaphansi kwamagama amaningi emikhiqizo, nakuba inguqulo ejwayelekile ivame kakhulu ukunqunywa. Igama lomkhiqizo elaziwa kakhulu yi-Lioresal, okuyigama lomkhiqizo wokuqala lapho umuthi wethulwa okokuqala.

Amanye amagama emikhiqizo afaka i-Gablofen ne-Kemstro, nakuba lokhu kungase kungatholakali kuwo wonke amazwe. I-Kemstro yithebhulethi ekhethekile echithwa ngomlomo encibilika olimini lwakho, okungasiza abantu abanobunzima bokugwinya amaphilisi.

Inguqulo ejwayelekile ye-baclofen isebenza kahle njengezinguqulo zegama lomkhiqizo futhi ngokuvamile iyonga kakhulu. Ikhemisi lakho lingase lishintshe ngokuzenzakalelayo inguqulo ejwayelekile ngaphandle uma udokotela wakho ecela ngokuqondile igama lomkhiqizo.

Ezinye izindlela ze-Baclofen

Uma i-baclofen ingasebenzi kahle kuwe noma idala imiphumela emibi, imithi eminingi ehlukile ingelapha ukukhubazeka kwemisipha. Ukukhetha okunye kuncike esimweni sakho esithile, eminye imithi oyithathayo, kanye nokuphendula kwakho ngakunye.

I-Tizanidine iyinye imisipha ephumuzayo esebenza ngendlela ehlukile ku-baclofen futhi ingase ithuthukiswe kangcono ngabanye abantu. Isebenza ikakhulukazi kuma-muscle spasms futhi ivame ukusetshenziselwa izimo ezinjengokuthi i-multiple sclerosis noma ukulimala komgogodla.

I-Diazepam, i-benzodiazepine, nayo ingasiza ekukhubazekeni kwemisipha kodwa ithwala ingozi enkulu yokuncika nokuthula. Ngokuvamile isetshenziselwa izikhathi ezimfushane noma ezimweni ezithile lapho eminye imithi ingasebenzi.

Ezinye izindlela ezingezona imithi zifaka ukwelashwa ngokomzimba, ukwelashwa komsebenzi, kanye nezindlela ezihlukahlukene zokujova. Ukujova kwe-Botulinum toxin kungasebenza kahle kakhulu ekukhubazekeni kwemisipha okwendawo, ngenkathi amaphampu e-intrathecal baclofen aletha umuthi ngokuqondile emanzini omgogodla ezimweni ezinzima.

Ingabe i-Baclofen ingcono kune-Tizanidine?

Kokubili i-baclofen ne-tizanidine ziyizithuthukisi zemisipha ezisebenzayo, kodwa zisebenza ngezindlela ezihlukene futhi zingase zifaneleke kangcono kubantu abahlukene. Ukukhetha phakathi kwazo kuncike esimweni sakho esithile, ezinye izinto zezempilo, nokuthi usabela kanjani emuthini ngamunye.

I-Baclofen ivame ukusebenza kahle kakhulu ekushayweni kwemisipha okubangelwa izimo zomgogodla, kuyilapho i-tizanidine ingase isebenze kangcono ekushayweni kwemisipha okuhlobene nokulimala kobuchopho noma ezinye izimo ezithile ze-neurological. I-Tizanidine ivame ukukhethwa lapho ukuthuliswa kuyinkinga enkulu, njengoba kungase kubangele ukozela okuncane kune-baclofen kwabanye abantu.

Izinhlelo zokulinganisa nazo ziyahluka. I-Baclofen ivame ukuthathwa kathathu ngosuku, kuyilapho i-tizanidine ingathathwa njalo emahoreni ayisithupha kuya kwayisishiyagalombili. Abanye abantu bathola ukuthi olunye uhlelo lulula kakhulu kunolunye olusekelwe emsebenzini wabo wansuku zonke.

Udokotela wakho uzocabangela izinto ezinjengomsebenzi wezinso zakho, eminye imithi oyithathayo, nendlela yakho yokuphila lapho unquma phakathi kwalezi zinketho. Ngezinye izikhathi, abantu bazama yomibili imithi ngezikhathi ezihlukene ukuze babone ukuthi iyiphi esebenza kangcono esimweni sabo esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Baclofen

Ingabe i-Baclofen iphephile kubantu abanezifo zezinso?

I-Baclofen idinga ukulungiswa komthamo kubantu abanezifo zezinso ngoba umuthi ukhishwa ngezinso. Uma izinso zakho zingasebenzi kahle, umuthi ungenza ukuthi unqwabelane emzimbeni wakho futhi ubangele imiphumela emibi eyengeziwe.

Udokotela wakho cishe uzo-oda ukuhlolwa kwegazi ukuze ahlolisise ukusebenza kwezinso zakho ngaphambi kokuqala i-baclofen futhi angase aqhubeke nokugada ngenkathi uyithatha. Abantu abanezinkinga zezinso ezincane bangavame ukuthatha i-baclofen ngokuphepha ngomthamo oncishisiwe, kuyilapho labo abanezifo zezinso ezinzima bangase badinge ukucabangela ezinye izindlela zokwelapha.

Ngingenzani uma ngithatha i-Baclofen eningi ngengozi?

Uma ngempela uthatha i-baclofen eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha i-baclofen eningi kungabangela izimpawu eziyingozi ezihlanganisa ukozela okukhulu, ukudideka, ubunzima bokuphefumula, noma ngisho nokoma.

Ungazami ukuzenza uhlanze noma uthathe eminye imithi ukuze ulwe nokweqisa. Kunalokho, funa ukunakekelwa kwezokwelapha ngokushesha. Uma umuntu engazi lutho, enobunzima bokuphefumula, noma ekhombisa izimpawu zokweqisa okukhulu, shayela izinsiza eziphuthumayo ngokushesha.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Baclofen?

Uma uphuthelwa umthamo we-baclofen, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe umthamo ophindwe kabili ukuze ulungise okushodayo, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni neshejuli yakho yemithi.

Ngingayeka Nini Ukuthatha I-Baclofen?

Kufanele uyeke kuphela ukuthatha i-baclofen ngaphansi kokuqondisa kukadokotela wakho, ikakhulukazi uma ubuthathe isikhathi esingaphezu kwamasonto ambalwa. Ukuyeka kungazelelwe kungabangela izimpawu zokuhoxiswa eziyingozi ezihlanganisa ukuquleka, ukucabanga ngamanga, kanye nokuhlangana kwemisipha okukhulu.

Udokotela wakho uzokwenza ishejuli yokunciphisa kancane kancane enciphisa kancane umthamo wakho ezinsukwini eziningana noma emasontweni. Lokhu kuvumela umzimba wakho ukuthi uzivumelanise ngokuphephile namazinga anciphayo omuthi. Inqubo yokunciphisa ingathatha isikhathi eside uma ubuthatha imithamo ephezulu noma usebenzisa umuthi isikhathi eside.

Ngingashayela Ngenkathi Ngithatha I-Baclofen?

I-Baclofen ingabangela ukozela, isiyezi, nokuncipha kokuqapha, ikakhulukazi lapho uqala ukuyithatha noma lapho umthamo wakho ukhuphuka. Le miphumela ingalimaza ikhono lakho lokushayela ngokuphepha noma ukusebenzisa imishini.

Kufanele ukugweme ukushayela uze wazi ukuthi i-baclofen ikuthinta kanjani wena siqu. Abanye abantu bajwayela imithi phakathi nezinsuku ezimbalwa futhi bangakwazi ukuqhubeka nemisebenzi yabo ejwayelekile, kanti abanye bangase baqhubeke nokuzwa ukuzola okwenza ukushayela kungaphephile. Njalo qinisekisa ukuphepha futhi ucabangele ezinye izindlela zokuthutha uma uzizwa ukozela noma ungaqinile.