Yini i-Basiliximab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Basiliximab iyimithi ekhethekile esetshenziselwa ukuvimbela umzimba wakho ukuthi ungawenqabi ilungu elishintshiwe, ikakhulukazi izinso. Inikezwa ngomugqa we-IV (intravenous) ngqo egazini lakho, ngokuvamile esibhedlela ngaphambi nangemva kokuhlinzwa kwakho kokushintshwa.

Le mithi ingeyeqembu elibizwa ngokuthi ama-immunosuppressants, asebenza ngokuthulisa impendulo yomzimba wakho yokuzivikela emzimbeni elungwini elisha. Cabanga ngayo njengokusiza umzimba wakho ukuthi wamukele inso yawo entsha njengomngane kunokuba abe umhlaseli wangaphandle odinga ukulwa naye.

Yini i-Basiliximab?

I-Basiliximab iyisidakamizwa esenziwe elabhorethri esiqondise ngqo amaseli athile omzimba wokuzivikela emzimbeni wakho. Yenzelwe ukulingisa ama-antibody emvelo kodwa ngomsebenzi ogxile kakhulu - ukuvimbela ukwenqatshwa kwelungu ngemva kokushintshwa kwesinso.

Lo muthi yilokho odokotela abakubiza ngokuthi

Ithimba lakho lokufakelwa izitho lizosebenzisa i-basiliximab njengoba kubizwa ngokuthi "ukwelashwa kokungeniswa." Lokhu kusho ukuthi kunikezwa ekuqaleni kohambo lwakho lokufakelwa izitho ukuze kunikezwe ukuvikelwa okuqinile, ngokushesha lapho ingozi yakho yokwenqatshwa iphezulu kakhulu. Umuthi uhlala usetshenziswa kanye neminye imithi ecindezela amasosha omzimba efana ne-cyclosporine, mycophenolate, kanye nama-corticosteroids.

Kwezinye izimo, odokotela bangase futhi basebenzise i-basiliximab ekufakweni kwesibindi, nakuba lokhu kungavamile. Isinqumo sokusebenzisa lo muthi sincike ezingozini zakho ngazinye, impilo yakho yonke, kanye nemithetho yezikhungo zakho zokufakelwa izitho.

Isebenza Kanjani I-Basiliximab?

I-Basiliximab isebenza ngokuvimba okwesikhashana amaseli athile omzimba abizwa ngokuthi ama-T-lymphocytes asebenzayo ekuhlaseleni izinso zakho ezifakelwe. Ithathwa njenge-immunosuppressant enamandla ngokulinganisela enikeza ukuvikelwa okuqondiwe ngaphandle kokuvala ngokuphelele amasosha akho omzimba.

Lapho uthola izinso ezintsha, amasosha akho omzimba ngokwemvelo ayayibona njengento engaphandle futhi afuna ukuyibhubhisa. I-Basiliximab inamathisela kuma-receptors kuma-T-cells okungathi ngokuvamile ahlele lokhu kuhlasela, empeleni abeka la maseli ekhefuna amasonto amaningana.

Umuthi awulimazi unomphela amaseli akho omzimba - uvele uwavimbela ukuthi angasebenzi ngokugcwele ngokumelene nesitho sakho esisha. Lokhu kunika umzimba wakho isikhathi sokuzivumelanisa nokufakelwa izitho ngenkathi eminye imithi yesikhathi eside isebenza. Umphumela wokuvimba uvame ukuhlala amasonto angu-4-6, okuhlanganisa isikhathi esibucayi kakhulu sokwenqatshwa kwasekuqaleni.

Kufanele Ngiyithathe Kanjani I-Basiliximab?

I-Basiliximab ihlala inikezwa ochwepheshe bezempilo ngomugqa we-IV engalweni yakho noma i-catheter emaphakathi. Awukwazi ukuthatha lo muthi ekhaya - idinga ukuphathwa ngokucophelela esibhedlela noma emtholampilo onempahla yokugada efanele.

Umuthi uhlanganiswa nesixazululo se-saline esingenazo izinto eziphilayo futhi unikezwa kancane kancane ngemizuzu engama-20-30. Ithimba lakho lokunakekelwa kwezempilo lizokubuka ngokucophelela ngesikhathi nangemva kokufakwa ngakunye ukuze liqinisekise ukuthi awunazo izimo eziphendulayo ngokushesha. Akudingeki ukuthi uzile noma ugweme ukudla ngaphambi kokuthola i-basiliximab.

Abantu abaningi bathola umthamo wabo wokuqala kungakapheli amahora angu-2 ngaphambi kokuba kuqale ukuhlinzwa kwabo kokufakelwa. Umthamo wesibili uvame ukunikezwa ezinsukwini ezi-4 ngemuva kokufakelwa, yize udokotela wakho angase alungise lesi sikhathi ngokuya ngokululama kwakho kanye nanoma yiziphi izinkinga.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Basiliximab?

Iziguli eziningi zithola i-basiliximab isikhathi esifushane kakhulu - ngokuvamile imithamo emibili nje enikezwa ngosuku olu-4 oluhlukene. Umthamo wokuqala unikezwa ngaphambi kokuhlinzwa kwakho kokufakelwa, futhi umthamo wesibili unikezwa ngosuku lwesine ngemuva kokufakelwa kwakho.

Ngokungafani neminye imithi yakho yokufakelwa ozoyithatha nsuku zonke impilo yakho yonke, i-basiliximab yenzelwe ukuhlinzeka ngesivikelo sesikhashana, esinamandla ngesikhathi esiyingozi kakhulu. Ngemuva kwemithamo yakho emibili, ngeke usathola i-basiliximab, kodwa uzoqhubeka nokuthatha eminye imithi yakho yokucindezela amasosha omzimba njengoba kunqunywe.

Imiphumela ye-basiliximab iyaqhubeka nokusebenza emzimbeni wakho amasonto amaningana ngemuva komthamo wakho wokugcina. Lesi sivikelo esandisiwe sisiza ukuxhumanisa igebe ngenkathi eminye imithi yakho ifinyelela ekusebenzeni kwayo okuphelele futhi umzimba wakho uzivumela ezinso ezintsha.

Yiziphi Imiphumela Eceleni Ye-Basiliximab?

Abantu abaningi bayayibekezelela kahle i-basiliximab, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi izimo ezinzima azivamile, futhi ithimba lakho lokunakekelwa kwezempilo lizokuqapha ngokucophelela ngesikhathi sokwelashwa.

Nawa amanye imiphumela emibi ejwayelekile ongase uyithole, futhi khumbula ukuthi eminingi yalezi ingahle ihlobane nokuhlinzwa kwakho kokufakelwa noma eminye imithi oyithathayo:

• Ukuqaqamba kwekhanda nokukhathala okuvamile
• Isicanucanu noma isisu esibuhlungu
• Ukuqunjelwa noma isifo sohudo
• Ukuvuvukala ezandleni zakho, ezinyaweni, noma emilenzeni
• Ubunzima bokulala
• Isiyezi noma ukuzizwa unovalo
• Ubuhlungu noma ukuzwela endaweni yokujova

Lezi zimpawu zivame ukuba mnene futhi zesikhashana. Ithimba lakho lokufakelwa izitho lingakusiza ukuthi ubhekane nanoma yikuphi ukungakhululeki ngokunakekelwa okusekelayo nokulungiswa kweminye imithi yakho uma kudingeka.

Abanye abantu bangase babe nemiphumela emibi ekhathazayo edinga ukunakekelwa kwezempilo ngokushesha. Lokhu akuvamile kodwa kubalulekile ukuqaphela:

• Izimpawu zokungezwani komzimba nezinto ezithile njengokuqubuka, ukuluma, noma ubunzima bokuphefumula
• Ukuvuvukala okukhulu ebusweni, ezindebeni, olimini, noma emqaleni
• Ukuphuma kwegazi okungavamile noma ukulimala
• Izimpawu zokutheleleka njengomkhuhlane, amahlaba, noma umphimbo obuhlungu oqhubekayo
• Ubuhlungu obukhulu besisu noma ukuhlanza okuqhubekayo
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile

Uma uqaphela noma yiziphi zalezi zimpawu, xhumana nethimba lakho lokufakelwa izitho ngokushesha. Zihlomele ukukusiza ukuthi unqume ukuthi izimpawu zihlobene yini ne-basiliximab noma ezinye izici zokwelashwa kwakho.

Ubani Ongafanele Athathe I-Basiliximab?

I-Basiliximab ayifanele wonke umuntu, futhi ithimba lakho lokufakelwa izitho lizobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyincoma. Akufanele uthole lo muthi uma unokungezwani komzimba ne-basiliximab noma yiziphi izingxenye zayo.

Abantu abanezifo eziqhubekayo, ezingathi sína ngokuvamile badinga ukuthi lezo zinto ziphathwe ngaphambi kokuthola i-basiliximab. Njengoba umuthi ucindezela amasosha akho omzimba, ungenza ukutheleleka okukhona kube kubi kakhulu noma kube nzima ukukwelapha.

Udokotela wakho uzophinda acabangele i-basiliximab ngokucophelela uma unomlando womdlavuza, ikakhulukazi imidlavuza yegazi efana ne-lymphoma. Ngenkathi umuthi ungabangeli ngokuqondile umdlavuza, ungenza ngcono ingozi yakho ngokucindezela ukugadwa komzimba.

Abesifazane abakhulelwe badinga ukucatshangelwa okukhethekile, njengoba i-basiliximab idlula i-placenta futhi ingamthinta umntwana osakhula. Uma ukhulelwe noma uhlela ukukhulelwa, xoxa lokhu ngokucophelela nethimba lakho lokufakelwa ukuze ulinganise izingozi nezinzuzo.

Amagama Omkhiqizo we-Basiliximab

I-Basiliximab itholakala ikakhulukazi ngaphansi kwegama lomkhiqizo elithi Simulect, elenziwa yi-Novartis. Lena yindlela esetshenziswa kakhulu ezibhedlela nakumaziko okufakelwa emhlabeni wonke.

Ngokungafani neminye imithi enamagama amaningi omkhiqizo, i-basiliximab inokuhlukahluka okulinganiselwe komkhiqizo ngoba iyimithi ekhethekile ye-biologic esetshenziswa ezindaweni ezithile zezokwelapha. Ikhemisi lakho lesibhedlela ngokuvamile lizogcina i-Simulect, nakuba lingase lisebenzise izinhlobo ezivamile ngezikhathi ezithile uma zitholakala.

Uma nixoxa ngemithi yakho nabahlinzeki bezempilo, ungase ubazwe bekhuluma nge-“basiliximab” noma “Simulect” - le yimithi efanayo. Okubalulekile ukuqonda ukuthi imithi yenzani kunokukhumbula amagama athile omkhiqizo.

Ezinye izindlela ze-Basiliximab

Eminye imithi eminingi ingase isebenze indima efanayo ekuvikeleni ukwenqatshwa kokufakelwa, nakuba ithimba lakho lokufakelwa lizokhetha ngokusekelwe esimweni sakho esithile kanye nezici eziyingozi. Lezi zindlela zokwelapha zisebenza ngezindlela ezihlukene kodwa zihlanganyela umgomo wokuvikela izinso zakho ezintsha.

I-Antithymocyte globulin (ATG) ingenye inketho yokwelapha yokungeniswa enikeza ukucindezelwa okubanzi komzimba. Ivame ukusetshenziselwa iziguli ezingozini enkulu yokwenqatshwa kodwa iza nemiphumela eminingi engaba khona kuno-basiliximab.

Ezinye izikhungo zokufakelwa zisebenzisa i-alemtuzumab (Campath) njengenye indlela yokwelapha yokungeniswa. Le mithi inikeza ukucindezelwa okunamandla kakhulu komzimba kodwa ngokuvamile igcinelwe izimo ezithile ngenxa yemiphumela yayo enamandla.

Iqembu lakho lokufakelwa amalungu omzimba lingase futhi licabange ukusebenzisa imithamo ephezulu yezinto ezivimbela ukuzivikela emzimbeni ezivamile njenge-tacrolimus noma i-mycophenolate esikhundleni sokwelashwa kokungeniswa, kuye ngobungozi bakho bomuntu ngamunye kanye nemithetho yesikhungo.

Ingabe i-Basiliximab Ingcono Kune-Antithymocyte Globulin?

Kokubili i-basiliximab ne-antithymocyte globulin (ATG) ziyindlela yokwelapha yokungeniswa esebenzayo, kodwa zisebenza ngendlela ehlukile futhi zifanele izimo ezihlukene zesiguli. I-Basiliximab ivame ukubangela imiphumela emincane futhi ngokuvamile kulula ukuyibekezelela.

I-ATG inikeza ukucindezelwa okubanzi nokujulile kokuzivikela emzimbeni, okungaba usizo ezigulini ezinobungozi obukhulu bokwenqatshwa. Kodwa-ke, futhi yandisa ingozi yokutheleleka nezinye izinkinga ngoba icindezela amasosha omzimba kakhulu.

I-Basiliximab inikeza ukucindezelwa okuhloswe ngqo kokuzivikela emzimbeni ngengozi ephansi yokutheleleka okukhulu nezinye izinkinga. Lokhu kuyenza ibe yindlela enhle yokukhetha iziguli ezinobungozi obujwayelekile ezingadingi ukucindezelwa okujulile okuhlinzekwa yi-ATG.

Iqembu lakho lokufakelwa amalungu omzimba lizocabangela izinto ezinjengobudala bakho, impilo yonke, ukusebenza kwezinso, kanye nezici eziqondile zobungozi lapho ukhetha phakathi kwalezi zinketho. Akukho mithi enye “engcono” - ukukhetha okungcono kuncike ezimweni zakho zomuntu ngamunye.

Imibuzo Evame Ukubuzwa Mayelana ne-Basiliximab

Ingabe i-Basiliximab Iphephile Kubantu Abanesifo Sikashukela?

Yebo, i-basiliximab ngokuvamile iphephile kubantu abanesifo sikashukela. Umuthi awuthinti ngokuqondile amazinga kashukela egazini njengeminye imithi ecindezela amasosha omzimba, ikakhulukazi ama-corticosteroids avame ukusetshenziswa kanye nawo.

Kodwa-ke, ukuphathwa kwakho isifo sikashukela kungase kudingeke ukuqapha eduze ngesikhathi sokufakelwa kwakho amalungu omzimba ngoba ukucindezeleka okuvela emsebenzini wokuhlinzwa neminye imithi kungathinta ukulawulwa koshukela egazini. Ithimba lakho lokufakelwa amalungu omzimba lizosebenza nodokotela wakho we-endocrinologist ukuze alungise imithi yakho yesifo sikashukela njengoba kudingeka.

Ngingenzani uma ngamukela i-Basiliximab eningi ngengozi?

Njengoba i-basiliximab inikezwa ochwepheshe bezempilo endaweni elawulwayo, ukweqisa ngengozi akuvamile kakhulu. Umuthi unikezwa ngokucophelela ngokuya ngesisindo somzimba wakho futhi unikezwa kancane ngaphansi kokuqashwa kwezokwelapha.

Uma ukhathazekile ngobuningi obutholile, khuluma nethimba lakho lokufakelwa ngokushesha. Bangabuyekeza amarekhodi akho okulinganisa futhi bakuqaphele nganoma yiziphi izimpawu ezingavamile. Akukho umuthi oqondile we-basiliximab, ngakho ukwelashwa kungagxila ekunakekelweni okusekelayo uma kudingeka.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Basiliximab?

Ukuphuthelwa umthamo we-basiliximab kuyakhathaza ngoba umuthi unikezwa ngeshejuli eqondile kakhulu ukuvikela izinso zakho ezifakelwe. Xhumana nethimba lakho lokufakelwa ngokushesha uma uphuthelwa umthamo wakho wesibili ohleliwe.

Odokotela bakho bazodinga ukuhlola ukuthi sekudlule isikhathi esingakanani kusukela kumthamo wakho ophuthelwe nokuthi ngabe kusazuzisa yini ukuwunikeza. Bangase balungise eminye imithi yakho yokucindezela amasosha omzimba ukuze kubuyiselwe umthamo we-basiliximab ophuthelwe.

Ngingayeka nini ukuthatha i-Basiliximab?

Akudingeki ukhathazeke ngokuyeka i-basiliximab ngoba inikezwa kabili kuphela ngesikhathi senqubo yakho yokufakelwa. Ngemva kwemithamo yakho emibili ehleliwe, ngeke usathola i-basiliximab.

Imiphumela yomuthi izophelelwa yisikhathi kancane kancane emasontweni amaningana, okuyingxenye yohlelo lokwelapha oluhlosiwe. Eminye imithi yakho yokucindezela amasosha omzimba izoqhubeka nokuhlinzeka ngokuvikela njengoba imiphumela ye-basiliximab iphela.

Ngingakwazi yini ukuthola imithi yokugoma ngenkathi ngithatha i-Basiliximab?

Imithi yokugoma ephilayo kufanele igwenywe ngenkathi i-basiliximab isebenza ohlelweni lwakho futhi kuyo yonke imithi yakho yokucindezela amasosha omzimba. Lokhu kuhlanganisa imithi yokugoma efana ne-MMR, i-varicella, kanye nemithi yokugoma umkhuhlane wamakhala.

Imigomo engasebenzi (njengemijovo yomkhuhlane, imigomo yepneumonia, nemigomo ye-COVID-19) ngokuvamile iphephile futhi iyatuswa, yize ingase ingasebenzi kahle ngenkathi amasosha akho omzimba ecindezelwe. Ithimba lakho lokufakelwa izitho lizokuqondisa ngesikhathi esingcono kakhulu sokuthola imigomo edingekayo.